MolinariLab-ER
LightNews LightNews
molinarilab-er.bsky.social
MolinariLab-ER
@molinarilab-er.bsky.social
120 followers 74 following 25 posts
Endoplasmic reticulum; protein folding and quality control; ERAD and ERLAD for proteasomal and lysosomal protein degradation from the ER; ER-phagy, Recov-ER-phagy and ONM-phagy; organelle fragmentation; IDRs; HaloTag; … My opinions
Posts Replies Media Videos
Pinned
molinarilab-er.bsky.social
MolinariLab-ER @molinarilab-er.bsky.social · Aug 4
Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux
Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...
rdcu.be
molinarilab-er.bsky.social
Our last work on ER-to-Lysosome-Associated Degradation (ERLAD). CNX:FAM134B:VAPA:ORP1L:RAB7 contact site between the biosynthetic compartment (ER) and the degradative endolysosomes. Removing disease-causing, proteasome-resistant misfolded proteins from our cells.

www.tandfonline.com/doi/epdf/10....
CNX:FAM134B-driven ERLAD of ATZ polymers proceeds via enhanced formation of VAPA:ORP1L:RAB7 contact sites between ER and endolysosomes
You have to enable JavaScript in your browser's settings in order to use the eReader.
www.tandfonline.com
October 30, 2025 at 4:15 PM
molinarilab-er.bsky.social
Organellophagy receptors display cytoplasmic intrinsically disordered regions (IDRS). The IDRs of ER-phagy and mitophagy receptors are interchangeable, required and sufficient for ER and mitochondria fragmentation that precedes lysosomal clearance of the organelle’s portions.
rdcu.be/eF5DR
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux
Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...
rdcu.be
September 13, 2025 at 4:52 PM
molinarilab-er.bsky.social
An interesting study from the ETH-Zurich

ethz.ch/en/news-and-...
Why the foam on Belgian beers lasts so long
ETH Zurich researchers have found the holy grail of brewing: the formula for stable beer foam. But it's not just breweries that will benefit from these findings.
ethz.ch
August 27, 2025 at 2:59 AM
Reposted by MolinariLab-ER
smhsci.bsky.social
Come join us @science.org. We’re looking for a new editor to look after infectious disease and microbiome submissions.
Check out this Associate or Senior Editor opportunity recruiting.ultipro.com/AME1123ASEM/...
recruiting.ultipro.com
August 22, 2025 at 8:02 PM
molinarilab-er.bsky.social
From Switzerland to Portugal … and back. 🤔
August 21, 2025 at 7:37 AM
Reposted by MolinariLab-ER
natcellbio.nature.com
💫NEW: @molinarilab-er.bsky.social & co examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as a net negative charge, that promote fragmentation.
bit.ly/4fLWe99
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux - Nature Cell Biology
Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as ...
bit.ly
August 19, 2025 at 10:56 AM
Reposted by MolinariLab-ER
molinarilab-er.bsky.social
Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux
Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...
rdcu.be
August 4, 2025 at 11:41 AM
molinarilab-er.bsky.social
Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux
Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...
rdcu.be
August 4, 2025 at 11:41 AM
Reposted by MolinariLab-ER
ericchevet.bsky.social
@olzmannlab.bsky.social @tgalli.bsky.social @demangelab.bsky.social @agostinislab.bsky.social @abdourachidthiam.bsky.social @molinarilab-er.bsky.social @hennelab.bsky.social @jdejuan-sanz.bsky.social
July 24, 2025 at 12:47 PM
Reposted by MolinariLab-ER
profmarciniak.bsky.social
🚨 Job alert

We’re looking for a communications manager for the LifeArc Rare Respiratory Disease Centre. Deadline for applications 1st August

@lifearc.bsky.social

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Research Communications Manager
We’re looking for a Research Communications Manager to help shape and share the ground breaking work of the LifeArc Centre for Rare Respiratory Diseases and our Pandemic Science Hub (PSH) based in the...
elxw.fa.em3.oraclecloud.com
July 25, 2025 at 12:58 PM
Reposted by MolinariLab-ER
jimhurley.bsky.social
The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem
The expanding repertoire of ESCRT functions in cell biology and disease - Nature
This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.
tinyurl.com
June 25, 2025 at 6:24 PM
Reposted by MolinariLab-ER
hessofarhan.bsky.social
Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine www.cell.com/trends/molec...
The endoplasmic reticulum proteostasis network and bone disease
Bone homeostasis relies on the coordinated activity of osteoblasts and osteoclasts that balances bone formation and resorption, and of osteocytes for biomechanical sensing and hormone secretion. A key...
www.cell.com
July 11, 2025 at 9:22 AM
Reposted by MolinariLab-ER
hessofarhan.bsky.social
Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX
Targeting proteostasis in multiple myeloma through inhibition of LTK
Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK
rdcu.be
July 9, 2025 at 5:55 PM
molinarilab-er.bsky.social
ATZ polymers elicit intervention of CNX:FAM134B-LC3II segregation complexes + formation of VAPA-ORP1L-RAB7 membrane contact sites to facilitate Syntaxin18/VAMP8-driven fusion of ER and endolysosomal membrane. One of the ER-to-Lysosome-Associated Degradation flavors.
www.biorxiv.org/content/10.1...
The involvement of the ER-phagy receptor FAM134B in membrane contact sites between ER and endolysosomes promotes ERLAD
Membrane contact sites (MCS) between organelles maintain the proximity required for controlled exchange of small molecules and ions yet preventing fusion events that would compromise organelles identi...
www.biorxiv.org
July 9, 2025 at 4:53 PM
Reposted by MolinariLab-ER
profmarciniak.bsky.social
We've just posted a new preprint:

"A GCN1-independent activator of the kinase GCN2"
July 4, 2025 at 6:57 PM
Reposted by MolinariLab-ER
robertarkowitz.bsky.social
Excellent opportunity for interdisciplinary scientists. Please repost...

www.linkedin.com/posts/instit...
🔬 📢 3 Interdisciplinary Research Chair Positions Open in Nice, France! | institut de Biologie Valrose - iBV
🔬 📢 3 Interdisciplinary Research Chair Positions Open in Nice, France! Join the DYNABIO Cluster of Excellence at Université Côte d’Azur and launch your independent research program at the crossroads ...
www.linkedin.com
July 3, 2025 at 5:51 PM
molinarilab-er.bsky.social
I would like to warmly thank the ALPHA-1 Foundation for the important support allocated to our research project “Understanding the Molecular Mechanisms of Lysosomal Clearance of ATZ Polymers".

A1F recognizes 2025 Grant Award Recipients during ATS

alpha1.org/a1f-recogniz...
A1F recognizes 2025 Grant Award Recipients during ATS  - Alpha-1 Foundation
On Monday, May 19th, 2025, the Alpha-1 Foundation (A1F) hosted its annual A1F Grants Award Reception at the San Francisco [...]Read More... from A1F recognizes 2025 Grant Award Recipients during ATS
alpha1.org
July 2, 2025 at 6:38 AM
Reposted by MolinariLab-ER
neal-lab.bsky.social
Huge thanks to @gthibault.bsky.social and Julie Hollien for organizing a warm, welcoming FASEB ER meeting filled with incredible science! Excited that I will carry the torch as a co-organizer for the 2027 meeting….can’t wait! @faseborg.bsky.social
June 12, 2025 at 6:42 PM
Reposted by MolinariLab-ER
olzmannlab.bsky.social
What a terrific FASEB ER meeting! Exceptional science and community! ❤️ Plus we got to see sea turtles nesting on the beach and a spaceX rocket launch! Cool!
June 12, 2025 at 10:01 PM
molinarilab-er.bsky.social
Early morning discussion about see turtles with Jeff Brodsky. FASEB Endoplasmic Reticulum meeting, Melbourne, Florida.
@faseborg.bsky.social
June 12, 2025 at 9:32 PM
molinarilab-er.bsky.social
Ilaria Fregno from @molinarilab-er.bsky.social is studying the client specific ER-to-Lysosome-Associated Degradation pathways that are engaged by large misfolded proteins (e.g., Serpins polymers, pro-collagen variants and many others) that fail to enter ERAD.
May 30, 2025 at 11:03 AM
molinarilab-er.bsky.social
Somatic escape variants of alpha1 antitrypsin. Great presentation by Lily Wu @profmarciniak.bsky.social
May 30, 2025 at 8:43 AM
molinarilab-er.bsky.social
Here we are.
profmarciniak.bsky.social Stefan Marciniak @profmarciniak.bsky.social · May 28
Here is Brescia 🇮🇹 for #Euroserpin2025

Already meeting loads of old friends including @molinarilab-er.bsky.social
May 28, 2025 at 11:04 AM
molinarilab-er.bsky.social
Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing.
N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology
www.nature.com/articles/s41...
N-glycan-dependent protein maturation and quality control in the ER - Nature Reviews Molecular Cell Biology
N-glycosylation of secretory pathway proteins in the ER is crucial for their maturation and quality control. Recent insights into the enzymes and chaperones that facilitate N-glycosylation have expand...
www.nature.com
May 22, 2025 at 4:45 PM
Reposted by MolinariLab-ER
germline.bsky.social
📣 🥳 🧑‍💻 Our department is hiring:

Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark

Deadline June 1st

Thanks for sharing!

mbg.au.dk/en/news-and-...
Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University
mbg.au.dk
May 16, 2025 at 12:35 PM