M. Lorenza Rusciano
@mlrusciano.bsky.social
Molecular Biologist, PhD Candidate in the @arnonelab.bsky.social at @szndohrn.bsky.social. Evodevo & Echinoderms lover.
Reposted by M. Lorenza Rusciano
Glad to see our phoronid genome study featured on the cover of @currentbiology.bsky.social! It shows how genome structure can be used to test competing hypotheses of nested topology and how derived structural changes provide evidence for monophyly.
www.cell.com/current-biol...
www.cell.com/current-biol...
November 17, 2025 at 4:25 PM
Glad to see our phoronid genome study featured on the cover of @currentbiology.bsky.social! It shows how genome structure can be used to test competing hypotheses of nested topology and how derived structural changes provide evidence for monophyly.
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by M. Lorenza Rusciano
Bizarre Creature With 'All-Body Brain' Challenges What We Know About Evolution of Nervous Systems
Bizarre Creature With 'All-Body Brain' Challenges What We Know About Evolution of Nervous Systems
What other animals have we underestimated?
www.iflscience.com
November 12, 2025 at 8:54 PM
Bizarre Creature With 'All-Body Brain' Challenges What We Know About Evolution of Nervous Systems
Reposted by M. Lorenza Rusciano
My book 'The Tree of Life' is published in the USA and Canada today.
Available as book, on kindle and as audio.
I would be really grateful for reposts.
www.amazon.com/Tree-Life-So...
www.amazon.ca/Tree-Life-So...
Available as book, on kindle and as audio.
I would be really grateful for reposts.
www.amazon.com/Tree-Life-So...
www.amazon.ca/Tree-Life-So...
November 11, 2025 at 12:01 PM
My book 'The Tree of Life' is published in the USA and Canada today.
Available as book, on kindle and as audio.
I would be really grateful for reposts.
www.amazon.com/Tree-Life-So...
www.amazon.ca/Tree-Life-So...
Available as book, on kindle and as audio.
I would be really grateful for reposts.
www.amazon.com/Tree-Life-So...
www.amazon.ca/Tree-Life-So...
I am extremely happy to have contributed to this. Proud of @perievodevo.bsky.social & Jack! 👏🏻
Our study, just published in #ScienceAdvances and funded by @hfspo.bsky.social, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Single-nucleus profiling highlights the all-brain echinoderm nervous system
A sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.
www.science.org
November 6, 2025 at 8:27 AM
I am extremely happy to have contributed to this. Proud of @perievodevo.bsky.social & Jack! 👏🏻
Reposted by M. Lorenza Rusciano
I am beyond excited to share that my postdoc project @szndohrn.bsky.social and the @arnonelab.bsky.social is now available in #ScienceAdvances @science.org. www.science.org/doi/10.1126/...
November 5, 2025 at 7:02 PM
I am beyond excited to share that my postdoc project @szndohrn.bsky.social and the @arnonelab.bsky.social is now available in #ScienceAdvances @science.org. www.science.org/doi/10.1126/...
Reposted by M. Lorenza Rusciano
Thrilled to share my newest perspective article with @arnonelab.bsky.social in @dev-journal.bsky.social
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
In preprints: cell type-specific gene regulation through the lens of echinoderms
One of the most intriguing questions in developmental biology is how a single cell, the zygote, gives rise to hundreds or millions of distinct cell types during embryogenesis. Decades of research have...
journals.biologists.com
November 3, 2025 at 3:02 PM
Thrilled to share my newest perspective article with @arnonelab.bsky.social in @dev-journal.bsky.social
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted by M. Lorenza Rusciano
New preprint out! Evolutionarily conserved transcriptional regulators control monoaminergic neuron development.
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
Evolutionarily conserved transcriptional regulators control monoaminergic neuron development
To what extent conserved developmental programs specify homologous cell types is a central question in biology. Here, we address this by focusing on reconstructing monoaminergic neuron development in ...
doi.org
October 30, 2025 at 9:42 AM
New preprint out! Evolutionarily conserved transcriptional regulators control monoaminergic neuron development.
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
Reposted by M. Lorenza Rusciano
First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution
Nature Reviews Neuroscience - Recent studies have shed further light on the evolutionary origins of chemical synapses, In this Review, Colgren and Burkhardt explore how ancient proteins were...
rdcu.be
October 27, 2025 at 6:48 PM
First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
🤯
Fast. Simple. High-fidelity IF.
The HCR™ HiFi Encoder gives you the power to encode any unmodified primary in just 10 minutes at RT. Use your existing antibodies and achieve high-fidelity multiplex IF with HCR™ Gold.
🔬Place your HCR™ Gold IF order here: tinyurl.com/57f8nmb8
The HCR™ HiFi Encoder gives you the power to encode any unmodified primary in just 10 minutes at RT. Use your existing antibodies and achieve high-fidelity multiplex IF with HCR™ Gold.
🔬Place your HCR™ Gold IF order here: tinyurl.com/57f8nmb8
October 23, 2025 at 7:44 PM
🤯
Reposted by M. Lorenza Rusciano
We‘re thrilled to be involved in this great open science initiative; @mlrusciano.bsky.social really enjoyed testing this tool in sea urchins!
How can we see the cells that make up a living organism? Membrane-localising tags can drive fluorescent proteins to the cell's outer membrane, making their outlines visible. But the tags don't work well in all organisms. How do you find one for your species of interest? 🧵
Check our latest preprint
Check our latest preprint
A toolkit for testing membrane-localising tags across species
Transgenic markers and tools have revolutionised how we study cells and developing organisms. Some of the elements needed to construct those tools are universally applicable (e.g. fluorescent proteins...
www.biorxiv.org
October 23, 2025 at 8:40 AM
We‘re thrilled to be involved in this great open science initiative; @mlrusciano.bsky.social really enjoyed testing this tool in sea urchins!
Reposted by M. Lorenza Rusciano
We identified efficient membrane-localising tags in each of the 10 animals we tested. A few tags worked in every species!
The project was also an exciting venture into open science – sharing resources openly before publication – and collaborating with >10 labs studying different organisms.
3/4
The project was also an exciting venture into open science – sharing resources openly before publication – and collaborating with >10 labs studying different organisms.
3/4
October 23, 2025 at 8:16 AM
We identified efficient membrane-localising tags in each of the 10 animals we tested. A few tags worked in every species!
The project was also an exciting venture into open science – sharing resources openly before publication – and collaborating with >10 labs studying different organisms.
3/4
The project was also an exciting venture into open science – sharing resources openly before publication – and collaborating with >10 labs studying different organisms.
3/4
Reposted by M. Lorenza Rusciano
Project started a year ago, when we gathered a set of 11 tags, made them easy to test as mRNA that can be injected in eggs, and sent to 30 labs around the world. We present the results of testing these tags in animals as diverse as sea urchin, beetle, crustacean, worm, sea anemone & jellyfish.
2/4
2/4
October 23, 2025 at 8:16 AM
Project started a year ago, when we gathered a set of 11 tags, made them easy to test as mRNA that can be injected in eggs, and sent to 30 labs around the world. We present the results of testing these tags in animals as diverse as sea urchin, beetle, crustacean, worm, sea anemone & jellyfish.
2/4
2/4
Reposted by M. Lorenza Rusciano
How can we see the cells that make up a living organism? Membrane-localising tags can drive fluorescent proteins to the cell's outer membrane, making their outlines visible. But the tags don't work well in all organisms. How do you find one for your species of interest? 🧵
Check our latest preprint
Check our latest preprint
A toolkit for testing membrane-localising tags across species
Transgenic markers and tools have revolutionised how we study cells and developing organisms. Some of the elements needed to construct those tools are universally applicable (e.g. fluorescent proteins...
www.biorxiv.org
October 23, 2025 at 8:16 AM
How can we see the cells that make up a living organism? Membrane-localising tags can drive fluorescent proteins to the cell's outer membrane, making their outlines visible. But the tags don't work well in all organisms. How do you find one for your species of interest? 🧵
Check our latest preprint
Check our latest preprint
Reposted by M. Lorenza Rusciano
Hot off the press! Our latest work on the evolution of facultative symbiosis in stony corals, focusing on a remarkable Mediterranean species: Oculina patagonica.
🪸 🌊
#evobio #corals #coralbiology
www.nature.com/articles/s41...
🪸 🌊
#evobio #corals #coralbiology
www.nature.com/articles/s41...
October 15, 2025 at 8:29 PM
Hot off the press! Our latest work on the evolution of facultative symbiosis in stony corals, focusing on a remarkable Mediterranean species: Oculina patagonica.
🪸 🌊
#evobio #corals #coralbiology
www.nature.com/articles/s41...
🪸 🌊
#evobio #corals #coralbiology
www.nature.com/articles/s41...
Reposted by M. Lorenza Rusciano
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 24, 2025 at 3:12 PM
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by M. Lorenza Rusciano
In the latest paper, @cagricevrim.bsky.social, @berylbiologist.bsky.social & Ko succeeded in imaging the entire course of leg regeneration and @mlrusciano.bsky.social & @almazan.bsky.social developed HCR to identify specific cell types after imaging. elifesciences.org/articles/107... 4/6
Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs
Live imaging allows tracking cellular behaviours and cell fates during the entire course of leg regeneration, spanning approximately one week, in a crustacean model.
elifesciences.org
August 8, 2025 at 5:39 PM
In the latest paper, @cagricevrim.bsky.social, @berylbiologist.bsky.social & Ko succeeded in imaging the entire course of leg regeneration and @mlrusciano.bsky.social & @almazan.bsky.social developed HCR to identify specific cell types after imaging. elifesciences.org/articles/107... 4/6
Reposted by M. Lorenza Rusciano
Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
August 8, 2025 at 5:39 PM
Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
Reposted by M. Lorenza Rusciano
Do you want to understand how developmental programs are encoded in animal genomes? Join our lab at the @szndohrn.bsky.social for a PhD project to unravel the developmental dynamics in sea urchins during the metamorphosis from larva to juvenile.
Deadline JUNE 14th!
www.szn.it/index.php/it...
Deadline JUNE 14th!
www.szn.it/index.php/it...
May 21, 2025 at 2:31 PM
Do you want to understand how developmental programs are encoded in animal genomes? Join our lab at the @szndohrn.bsky.social for a PhD project to unravel the developmental dynamics in sea urchins during the metamorphosis from larva to juvenile.
Deadline JUNE 14th!
www.szn.it/index.php/it...
Deadline JUNE 14th!
www.szn.it/index.php/it...
Reposted by M. Lorenza Rusciano
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature
The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...
www.nature.com
May 7, 2025 at 3:23 PM
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
Reposted by M. Lorenza Rusciano
It's only mid-April, but course season at the MBL is already underway! 🔬
Gene Regulatory Networks for Development started on April 6 and wraps up later this week 🧬 Congrats to this year's cohort! 👏
📲 Read more about the GRN course: bit.ly/3Wi6LQE
Gene Regulatory Networks for Development started on April 6 and wraps up later this week 🧬 Congrats to this year's cohort! 👏
📲 Read more about the GRN course: bit.ly/3Wi6LQE
April 16, 2025 at 10:30 PM
It's only mid-April, but course season at the MBL is already underway! 🔬
Gene Regulatory Networks for Development started on April 6 and wraps up later this week 🧬 Congrats to this year's cohort! 👏
📲 Read more about the GRN course: bit.ly/3Wi6LQE
Gene Regulatory Networks for Development started on April 6 and wraps up later this week 🧬 Congrats to this year's cohort! 👏
📲 Read more about the GRN course: bit.ly/3Wi6LQE
Reposted by M. Lorenza Rusciano
Also a blast from the past! Another preprint is now available from my first postdoc in the @arnonelab.bsky.social at @szndohrn.bsky.social www.biorxiv.org/content/10.1...
March 28, 2025 at 9:36 PM
Also a blast from the past! Another preprint is now available from my first postdoc in the @arnonelab.bsky.social at @szndohrn.bsky.social www.biorxiv.org/content/10.1...
Reposted by M. Lorenza Rusciano
New preprint from my Postdoc in Zak Swartz’s lab at the @mblscience.bsky.social, in collaboration with Carsten Wolff and @. www.biorxiv.org/content/10.1...
March 28, 2025 at 9:32 PM
New preprint from my Postdoc in Zak Swartz’s lab at the @mblscience.bsky.social, in collaboration with Carsten Wolff and @. www.biorxiv.org/content/10.1...
Reposted by M. Lorenza Rusciano
Single Nucleus Profiling Highlights the All-Brain Echinoderm Nervous System https://www.biorxiv.org/content/10.1101/2025.03.24.644250v1
March 28, 2025 at 1:34 PM
Single Nucleus Profiling Highlights the All-Brain Echinoderm Nervous System https://www.biorxiv.org/content/10.1101/2025.03.24.644250v1
Reposted by M. Lorenza Rusciano
Excited to share our latest work!
@arnonelab.bsky.social
, @John Kirwan, @Ina Arnone. We investigated the impact of light on the phenotypic response to food in sea urchin larvae.
Check it out here: www.frontiersin.org/journals/eco....
@szndohrn.bsky.social, #SZN, #seaurchin, #ecoevodevo
@arnonelab.bsky.social
, @John Kirwan, @Ina Arnone. We investigated the impact of light on the phenotypic response to food in sea urchin larvae.
Check it out here: www.frontiersin.org/journals/eco....
@szndohrn.bsky.social, #SZN, #seaurchin, #ecoevodevo
Frontiers | Phenotypic response to food availability in sea urchin larvae and impact of light during development and growth
www.frontiersin.org
March 20, 2025 at 1:03 PM
Excited to share our latest work!
@arnonelab.bsky.social
, @John Kirwan, @Ina Arnone. We investigated the impact of light on the phenotypic response to food in sea urchin larvae.
Check it out here: www.frontiersin.org/journals/eco....
@szndohrn.bsky.social, #SZN, #seaurchin, #ecoevodevo
@arnonelab.bsky.social
, @John Kirwan, @Ina Arnone. We investigated the impact of light on the phenotypic response to food in sea urchin larvae.
Check it out here: www.frontiersin.org/journals/eco....
@szndohrn.bsky.social, #SZN, #seaurchin, #ecoevodevo
Reposted by M. Lorenza Rusciano
🔬 PhD Opportunity in Evolutionary Cell Biology!
Interested in how cell types evolve? Join us to investigate placozoan cell types using advanced microscopy, single-cell omics, and functional assays!
Apply here: euraxess.ec.europa.eu/jobs/323665
#PhDPosition #EvolutionaryBiology #CellBiology🧪
Interested in how cell types evolve? Join us to investigate placozoan cell types using advanced microscopy, single-cell omics, and functional assays!
Apply here: euraxess.ec.europa.eu/jobs/323665
#PhDPosition #EvolutionaryBiology #CellBiology🧪
PhD Position in Evolutionary Cell Biology
Group description:The Comparative Cell Biology Lab (Najle Lab), at Universitat Internacional de Catalunya (UIC), investigates themolecular underpinnings of cellular and organismal complexity from func...
euraxess.ec.europa.eu
March 11, 2025 at 8:13 AM
🔬 PhD Opportunity in Evolutionary Cell Biology!
Interested in how cell types evolve? Join us to investigate placozoan cell types using advanced microscopy, single-cell omics, and functional assays!
Apply here: euraxess.ec.europa.eu/jobs/323665
#PhDPosition #EvolutionaryBiology #CellBiology🧪
Interested in how cell types evolve? Join us to investigate placozoan cell types using advanced microscopy, single-cell omics, and functional assays!
Apply here: euraxess.ec.europa.eu/jobs/323665
#PhDPosition #EvolutionaryBiology #CellBiology🧪