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Simon Mitchell
@mitchell.science
1.3K followers 760 following 43 posts
Cancer systems biology lab @bsmsmedschool.bsky.social | @UKRI.org Future Leaders Fellow | Director of @SussexCancer.org | Frontiers in Immunology Speciality Chief Editor: Systems Immunology
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Simon Mitchell @mitchell.science · Dec 6
Excited to share a new pre-print led by the incredible PhD student Aimilia Vareli.
biorxiv.org/content/10.1...
She asked why drugs that kill cancer cells in blood don't kill them in lymph nodes? How we can fix that?
🧵🧪
@sussexcancer.org
@bsmsmedschool.bsky.social @sussexuni.bsky.social
mitchell.science
Excited to have been promoted to Professor in Cancer Systems Biology at @bsmsmedschool.bsky.social, University of Sussex, @uniofbrighton.bsky.social
October 9, 2025 at 8:20 PM
Reposted by Simon Mitchell
sussexcancer.org
👩‍🔬 We’re hiring! Join a dynamic team driving innovation in blood cancer research at the University of Sussex. Collaborate with experts, grow your skills in protein biochemistry, and contribute to vital discoveries.

👉 Apply here: www.jobs.ac.uk/job/DOP599/r...
Research Technician – Protein Biochemistry at University of Sussex
Discover Research Technician – Protein Biochemistry jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.
www.jobs.ac.uk
September 12, 2025 at 10:00 AM
Reposted by Simon Mitchell
jasmeenoberoi.bsky.social
🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.

📅 Deadline: 29th September 2025.

🙏 Please share with anyone who might be interested.
Research Technician – Protein Biochemistry at University of Sussex
Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
September 9, 2025 at 8:35 AM
mitchell.science
New paper led by Aimilia Vareli out now.
nature.com/articles/s41...
The lymphoma microenvironment stops BH3-mimetics working.
In vitro/vivo/silico, we find inhibition of NFκB makes BH3-mimetics great again.🧵
@sussexbcr.bsky.social @bsmsmedschool.bsky.social @leukaemiauk.bsky.social @sussexcancer.org
Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL - Cell Death & Disease
Cell Death & Disease - Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL
nature.com
August 18, 2025 at 11:05 AM
mitchell.science
New paper led by @ejayawant.bsky.social 🎉
We review:
- how computational biology is helping us understand lymphoma,
- how machine learning and cell simulations make sense of vast amounts of data,
- how models can personalise treatments to each person with lymphoma.
portlandpress.com/biochemsoctr...
July 4, 2025 at 4:02 PM
Reposted by Simon Mitchell
sussexcancer.org
Artist’s blood cancer treatment inspires powerful new exhibition at University of Brighton, @bsmsmedschool.bsky.social

www.brighton.ac.uk/news/2025/ar...
Artist’s blood cancer treatment inspires powerful new exhibition at University of Brighton
A University of Brighton graduate has turned his own cancer journey into a striking art installation exploring illness and the duality of medical treatment.
www.brighton.ac.uk
June 10, 2025 at 9:39 PM
Reposted by Simon Mitchell
sussexcancer.org
Multiple positions currently open for applications but with imminent dealines:
- PhD studentship with Sally Wheelwright on cancer-related fatigue.
- PhD studentship with Chris Pepper on multiple myeloma.
- Postdoc with @mitchell.science
on cancer systems biology.
sussexcancer.org/jobs
jobs — Sussex Cancer Research Centre
sussexcancer.org
May 28, 2025 at 9:18 AM
mitchell.science
Excited to announce that thanks to securing a UKRI FLF follow-on award (mitchell.science/talk/566k-fo...)
✨We are hiring✨
3-year systems biology (wet/dry) postdoc, to pioneer new approaches to personalised medicine.
Learn more + apply (before 29 June):
mitchell.science/talk/recruit...

Plz share
Recruiting for a post doc on a UKRI Future Leaders fellowship project | Mitchell Lab
We are really excited to be advertising for an enthusiastic and committed post doc to work on a wet lab/dry lab project applying systems biology to mulitple diseases. Deadline 29th June.
mitchell.science
May 27, 2025 at 6:44 PM
Reposted by Simon Mitchell
ejayawant.bsky.social
🧵1/
🔬 A postdoc in numbers (and life beyond the lab)
As I wrap up my postdoc with @mitchell.science at @bsmsmedschool.bsky.social, I've been reflecting on everything that’s changed since I started in 2021. A lot can happen in a few years…
May 21, 2025 at 12:34 PM
mitchell.science
so lovely to be at @cshlnews.bsky.social for the Systems Immunology Meeting.
Great venue and even better science.
April 23, 2025 at 7:08 PM
mitchell.science
Congrats Okan!

I’m using the old “stand one step down” trick here.
rhysmorganlab.bsky.social Rhys Morgan @rhysmorganlab.bsky.social · Apr 10
Major congrats to Dr#3 from our group Okan Sevim who passed his PhD viva yesterday.

A super talented researcher, it’s been a privilege to serve as Okan’s supervisor from MSc to PhD in @biochembiomeduos.bsky.social @sussex.ac.uk

Many thanks to examiners @mitchell.science & @mardakheh.bsky.social
April 10, 2025 at 10:57 AM
Reposted by Simon Mitchell
laurencepearl.bsky.social
I will be talking about our new cancer genomics toolkit DepMine at the first meeting of the @sussexcancer.org Sussex Cancer Research Centre Computational Biology Group today - new career trajectory ok so far 🤞
April 10, 2025 at 7:04 AM
Reposted by Simon Mitchell
sussexcancer.org
Exciting to see SCRC Creative Community Engagement project led by Deborah Humphrey, and Karina Patfield, highlighted on BBC news.
"Words from the Waiting Room offers cancer patients, survivors, and supporters a safe environment to express themselves"
sussexcancer.org/news/bbc-new...
BBC News, South East covers Words from the Waiting Room. — Sussex Cancer Research Centre
Creative Community Engagement project led by Deborah Humphrey, and Karina Patfield highlighted on BBC news. Words from the Waiting Room offers cancer patients, survivors, and supporters a safe enviro...
sussexcancer.org
March 25, 2025 at 11:12 AM
Reposted by Simon Mitchell
sussexcancer.org
Latest newsletter:
- PhD studentships deadline: 24th March
- Kick-off of the SCRC Computational Cancer Research themed meetings
- Sussex Brain Tumour Research launch
- Custom artwork inspired by your research
- Lightning lecture competition
And more!
sussexcancer.curated.co/issues/9#start
Custom artwork, lightning lecture competition, new theme launch, and exciting events.
Reminder: studentship deadline 24th March, computational and brain tumour meetings, creative community engagement.
sussexcancer.curated.co
March 18, 2025 at 1:34 PM
mitchell.science
Proud moment from Arran Pack's graduation.
It's so rewarding to see our lab's first PhD student graduate, and I couldn't have asked for a better first student.
Job well done Arran!
🤜🤛
February 14, 2025 at 12:10 PM
Reposted by Simon Mitchell
sussexbcr.bsky.social
🎓Graduation news! 🎓

Some of the HaemTeam were at @bsmsmedschool.bsky.social graduation this week celebrating new Drs. The @andreapepper.bsky.social @chrispepper68.bsky.social team were celebrating Eleni Ladikou and Kim Sharp PhD graduation, whilst @mitchell.science were toasting Arran Pack grad!
February 13, 2025 at 11:35 AM
Reposted by Simon Mitchell
sussexcancer.org
It is #WorldCancerDay
We are excited to announce our funded research projects, a new community engagement strategy, creative award winners, and interviews.

sussexcancer.org/news/announc...

@bsmsmedschool.bsky.social @sussexuni.bsky.social @uniofbrighton.bsky.social @eshtnhs.bsky.social
Updates from the Sussex Cancer Research Centre on World Cancer Day. — Sussex Cancer Research Centre
The theme of World Cancer Day 2025 is “United by Unique”, which places people at the centre of care and their stories at the heart of the conversation. Today the Sussex Cancer Research Centre (SCR...
sussexcancer.org
February 4, 2025 at 7:01 AM
mitchell.science
This is devastating.
Grant review panels not meeting completely halts scientific progress
3 people at the inauguration had their wealth increase by $233 billion between them since the election, while scientists and people with disease are abandoned.
www.science.org/content/arti...
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing “a lot of uncertainty, fear, and panic”
www.science.org
January 23, 2025 at 6:17 PM
Reposted by Simon Mitchell
sussexcancer.org
New position available: Research Fellow in Cancer Studies!
Work on a cutting edge research project funded by @bloodcanceruk.bsky.social.
Applications close on January 26th.
www.SussexCancer.org/jobs
January 13, 2025 at 6:29 PM
Reposted by Simon Mitchell
jsauce7.bsky.social
Thoughts from leaders of systems #immunology how mechanistic models can leverage omics/ML for deeper understanding of how our immune system works #sysbio @cp-cellsystems.bsky.social
www.cell.com/cell-systems...
What unique insights can modeling approaches capture about the immune system?
The immune system, optimized by evolution to maintain health and prevent disease, is remarkably good at what it does. It detects pathogens and monitors physiological stresses with a sensitivity and selectivity that far surpasses that of man-made biosensors. It then mounts potent yet precise responses, enabling the body to maintain homeostasis amid varying internal milieu and external threats.
www.cell.com
December 23, 2024 at 6:34 PM
Reposted by Simon Mitchell
robjohnnoble.bsky.social
Do you like trees? Fancy quantifying tree shapes in terms of diversity, balance, average outdegree, etc. so you can compare them with each other or with models? Even if they have very different leaf counts? And accounting for branch lengths and polytomies? We have an easy solution for you.

1/n
A minimum parsimony speciation tree.
December 19, 2024 at 10:53 AM
mitchell.science
Excited to share a new pre-print led by the incredible PhD student Aimilia Vareli.
biorxiv.org/content/10.1...
She asked why drugs that kill cancer cells in blood don't kill them in lymph nodes? How we can fix that?
🧵🧪
@sussexcancer.org
@bsmsmedschool.bsky.social @sussexuni.bsky.social
December 6, 2024 at 6:18 PM
Reposted by Simon Mitchell
sussexcancer.org
Today we celebrate our inspirational co-director Professor Melanie Flint m as she gives her inaugural lecture @brightonuni.bsky.social
An incredible scientist, leader, mentor, and all around amazing person.
December 4, 2024 at 8:21 PM
mitchell.science
My Dad, @cliffmitchell.bsky.social was sick of friends and relatives getting duped by bad British newspaper front pages. So he made a website to debunk the worst offenders.
If you have the same problem (don’t we all) you might find this handy!
slippery.news
Slippery News
Headlines Matter!
slippery.news
December 3, 2024 at 10:56 PM
Reposted by Simon Mitchell
sussexcancer.org
A new fully-funded PhD studentship has just been advertised to investigate links between stress and blood cancer.
Join a new collaboration between @bsmsmedschool.bsky.social and @brightonuni.bsky.social and be part of @sussexcancer.org
Deadline 31st January.
sussexcancer.org/jobs
December 3, 2024 at 2:20 PM