Jeff Saucerman
@jsauce7.bsky.social
Professor of Biomedical Engineering and Cardiovascular Medicine at UVA. Systems biology to discover drugs for heart disease. Hiking with my dog in Shenandoah NP, around Charlottesville. https://engineering.virginia.edu/faculty/jeffrey-saucerman
Pinned
Jeff Saucerman
@jsauce7.bsky.social
· Apr 7
Terrific paper by post-doc @aclark.bsky.social in @plos.org
Comp Biol. This tutorial enables students and biologists to simulate biological networks with our tool Netflux, no programming required! #sysbio #cardiosky 🧪
Comp Biol. This tutorial enables students and biologists to simulate biological networks with our tool Netflux, no programming required! #sysbio #cardiosky 🧪
Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
November 1, 2025 at 12:14 AM
Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
October 3, 2025 at 8:24 PM
How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
Spooky fall day in Shenandoah NP
October 1, 2025 at 1:35 AM
Spooky fall day in Shenandoah NP
Paradoxically, heart failure involves both cell death and growth. How does a cell decide? In a paper at JMCC Plus led by Bryan Chun and Lavie Ngo, we find that rather than dying following hypertrophy, stressed cardiomyocytes commit early to either grow or die.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 18, 2025 at 12:00 AM
Paradoxically, heart failure involves both cell death and growth. How does a cell decide? In a paper at JMCC Plus led by Bryan Chun and Lavie Ngo, we find that rather than dying following hypertrophy, stressed cardiomyocytes commit early to either grow or die.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
@j-muncie-vasic.bsky.social and @benoitbruneau.bsky.social show that MEF2C is not a one trick pony- it distinctly regulates different regions of heart tube formation. Glad @aclark.bsky.social and I could contribute gene regulatory networks that predict mechanisms.
Excited to share that our manuscript “MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis” is now online @genesdev.bsky.social !
genesdev.cshlp.org/content/earl...
(1/n)
genesdev.cshlp.org/content/earl...
(1/n)
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
September 5, 2025 at 12:01 AM
@j-muncie-vasic.bsky.social and @benoitbruneau.bsky.social show that MEF2C is not a one trick pony- it distinctly regulates different regions of heart tube formation. Glad @aclark.bsky.social and I could contribute gene regulatory networks that predict mechanisms.
September 1, 2025 at 11:54 AM
Happy to share our latest preprint, "Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury", in collaboration with Matthew Wolf's lab, led by Bryce Murillo and Alex Young! www.biorxiv.org/content/10.1...
August 26, 2025 at 9:24 PM
Happy to share our latest preprint, "Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury", in collaboration with Matthew Wolf's lab, led by Bryce Murillo and Alex Young! www.biorxiv.org/content/10.1...
Sunset showers at Shenandoah NP
August 17, 2025 at 8:58 PM
Sunset showers at Shenandoah NP
Do large language models understand how cells work? To find out, we built a pipeline that generates logic-based models of signaling networks using general purpose LLMs GPT, Gemini, or Claude. We benchmarked LLM-generated networks against 3 large-scale literature-curated and validated networks. 1/
July 29, 2025 at 6:11 PM
Do large language models understand how cells work? To find out, we built a pipeline that generates logic-based models of signaling networks using general purpose LLMs GPT, Gemini, or Claude. We benchmarked LLM-generated networks against 3 large-scale literature-curated and validated networks. 1/
On my way to AHA #BCVS25 in Baltimore! Come see Bryce Murillo present on a drug for DYRK1A that induces cardiomyocyte cell cycling in network models, isolated cardiomyocytes, and after myocardial infarction. Wed 9:39 am.
July 22, 2025 at 3:21 PM
On my way to AHA #BCVS25 in Baltimore! Come see Bryce Murillo present on a drug for DYRK1A that induces cardiomyocyte cell cycling in network models, isolated cardiomyocytes, and after myocardial infarction. Wed 9:39 am.
A few pics from my trip to Egypt. Cairo, Luxor, Alexandria
July 20, 2025 at 9:59 PM
A few pics from my trip to Egypt. Cairo, Luxor, Alexandria
July 15, 2025 at 12:48 AM
"The Faculty Senate expresses no confidence in the Board of Visitors for not protecting the University and its president from outside interference, ..."
www.forbes.com/sites/michae...
www.forbes.com/sites/michae...
University Of Virginia Faculty Vote No Confidence In Governing Board
The University of Virginia Faculty Senate has voted it has no confidence in the school’s Board of Visitors by a margin of 46 to 6, with 8 senators abstaining.
www.forbes.com
July 14, 2025 at 2:15 AM
"The Faculty Senate expresses no confidence in the Board of Visitors for not protecting the University and its president from outside interference, ..."
www.forbes.com/sites/michae...
www.forbes.com/sites/michae...
Reposted by Jeff Saucerman
Public comment on this new "no animal only studies" is open here:
www.fda.gov/news-events/...
It closes next Monday.
www.fda.gov/news-events/...
It closes next Monday.
July 8, 2025 at 7:32 PM
Public comment on this new "no animal only studies" is open here:
www.fda.gov/news-events/...
It closes next Monday.
www.fda.gov/news-events/...
It closes next Monday.
Reposted by Jeff Saucerman
On June 17, 2012, following the unjustified forced resignation of an effective university president, the University of Virginia’s Faculty Senate voted 68 to 2 to demand her reinstatement. Nine days later, the president was reinstated.
Today the Faculty Senate votes on the same issue again.
Today the Faculty Senate votes on the same issue again.
July 11, 2025 at 12:21 PM
On June 17, 2012, following the unjustified forced resignation of an effective university president, the University of Virginia’s Faculty Senate voted 68 to 2 to demand her reinstatement. Nine days later, the president was reinstated.
Today the Faculty Senate votes on the same issue again.
Today the Faculty Senate votes on the same issue again.
Appreciating finally being back home, hiking in the Blue Ridge with my dog, an A+ burrito (Alex's), and thunderstorms.
June 28, 2025 at 9:16 PM
Appreciating finally being back home, hiking in the Blue Ridge with my dog, an A+ burrito (Alex's), and thunderstorms.
Sad to see the Trump admin force resignation of UVA President Ryan. No due process, just hurried political attacks to undermine values of free expression and knowledge on which Thomas Jefferson founded UVA.
www.nytimes.com/2025/06/27/u...
www.nytimes.com/2025/06/27/u...
University of Virginia President Resigns Under Pressure From Trump Administration
www.nytimes.com
June 28, 2025 at 11:20 AM
Sad to see the Trump admin force resignation of UVA President Ryan. No due process, just hurried political attacks to undermine values of free expression and knowledge on which Thomas Jefferson founded UVA.
www.nytimes.com/2025/06/27/u...
www.nytimes.com/2025/06/27/u...
Reposted by Jeff Saucerman
I'm thrilled to share the newest paper from the Yang Lab! Ever wonder how bacterial metabolism affects antibiotic resistance #AMR? In this study, Barry Li, a former MD/PhD student in the lab, took on this question using a systems and #synthetic_biology approach. 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bioenergetic stress potentiates antimicrobial resistance and persistence - Nature Communications
The bactericidal action of some antibiotics is associated with increased ATP consumption, cellular respiration, and reactive oxygen species formation. Here, Li et al. show that constitutive hydrolysis...
www.nature.com
June 9, 2025 at 7:15 PM
I'm thrilled to share the newest paper from the Yang Lab! Ever wonder how bacterial metabolism affects antibiotic resistance #AMR? In this study, Barry Li, a former MD/PhD student in the lab, took on this question using a systems and #synthetic_biology approach. 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Really enjoyed my first cardiovascular development @weinsteinconf.bsky.social, followed by a trip to the Milwaukee Art Museum
May 17, 2025 at 8:00 PM
Really enjoyed my first cardiovascular development @weinsteinconf.bsky.social, followed by a trip to the Milwaukee Art Museum
