Jeff Saucerman
@jsauce7.bsky.social
Professor of Biomedical Engineering and Cardiovascular Medicine at UVA. Systems biology to discover drugs for heart disease. Hiking with my dog in Shenandoah NP, around Charlottesville. https://engineering.virginia.edu/faculty/jeffrey-saucerman
Pinned
Happy New Year! Just 5 days until the 4th Netflux and Network Biology Virtual Conference on Jan 7, 1-5 pm ET. Please share. Agenda and free registration at: tinyurl.com/netfluxnet2026
Happy New Year! Just 5 days until the 4th Netflux and Network Biology Virtual Conference on Jan 7, 1-5 pm ET. Please share. Agenda and free registration at: tinyurl.com/netfluxnet2026
January 2, 2026 at 1:36 PM
Happy New Year! Just 5 days until the 4th Netflux and Network Biology Virtual Conference on Jan 7, 1-5 pm ET. Please share. Agenda and free registration at: tinyurl.com/netfluxnet2026
Reposted by Jeff Saucerman
Accepted ms on modeling human atrial disease posted @dev-journal.bsky.social just now. Congratulations to @irfankathiriya.bsky.social @jsauce7.bsky.social and team! @gladstoneinst.bsky.social @ucsfanesthesia.bsky.social journals.biologists.com/dev/article-...
Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease
While atrial septal defects (ASDs) and atrial fibrillation (AF) present differently, there is evidence that they share some genetic basis. Here, we used directed differentiation of human induced pluri...
journals.biologists.com
December 19, 2025 at 6:32 PM
Accepted ms on modeling human atrial disease posted @dev-journal.bsky.social just now. Congratulations to @irfankathiriya.bsky.social @jsauce7.bsky.social and team! @gladstoneinst.bsky.social @ucsfanesthesia.bsky.social journals.biologists.com/dev/article-...
Snowy hike to Hawksbill Summit, Shenandoah NP
December 14, 2025 at 3:32 AM
Snowy hike to Hawksbill Summit, Shenandoah NP
Making the Right Moves is great www.hhmi.org/sites/defaul...
www.hhmi.org
December 13, 2025 at 3:57 PM
Making the Right Moves is great www.hhmi.org/sites/defaul...
Always fun collaborating on networks of cardiac development with Irfan, @benoitbruneau.bsky.social, and team!
good new this morning: manuscript accepted! Final form of this pubmed.ncbi.nlm.nih.gov/40894762/ coming soon to @dev-journal.bsky.social. Congratulations to everyone from @ucsanfrancisco.bsky.social @ucsfanesthesia.bsky.social @gladstoneinst.bsky.social, and Alex Clark in @jsauce7.bsky.social's lab.
Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease - PubMed
There is evidence for a shared genetic basis of atrial septal defects (ASDs) and atrial fibrillation (AF), but it remains unclear how genetic susceptibility leads to these distinct human atrial diseases. Here, we used directed differentiation of human induced pluripotent stem cell to ventricular or …
pubmed.ncbi.nlm.nih.gov
December 10, 2025 at 11:09 PM
Always fun collaborating on networks of cardiac development with Irfan, @benoitbruneau.bsky.social, and team!
The 4th Netflux and Network Biology Virtual Conference is coming, Jan 7! Talks on network modeling across methods and biological systems. Free! tinyurl.com/netfluxnet2026
December 10, 2025 at 2:56 AM
The 4th Netflux and Network Biology Virtual Conference is coming, Jan 7! Talks on network modeling across methods and biological systems. Free! tinyurl.com/netfluxnet2026
More snow hike pics, Percival's Island, #Lynchburg
December 6, 2025 at 7:35 PM
More snow hike pics, Percival's Island, #Lynchburg
Winter wonderland 🥾❄️
December 6, 2025 at 7:29 PM
Winter wonderland 🥾❄️
Here's the comparison of time-evolving phase portraits of cardiac differentiation in WT (2 saddlenode bifurcations: mono->bi->new monostable) vs. Brm-KO (reversal of 1 saddlenode bifurcation: mono->bi->old bistable)
December 5, 2025 at 6:32 PM
Here's the comparison of time-evolving phase portraits of cardiac differentiation in WT (2 saddlenode bifurcations: mono->bi->new monostable) vs. Brm-KO (reversal of 1 saddlenode bifurcation: mono->bi->old bistable)
Still, I'm very excited by the potential for more generalized Waddington/energy landscapes such as yours for revealing a wide range of transition types.
December 5, 2025 at 4:40 PM
Still, I'm very excited by the potential for more generalized Waddington/energy landscapes such as yours for revealing a wide range of transition types.
In contrast, as @benoitbruneau.bsky.social noted the original Waddington diagram only shows pitchfork bifurcations (2 stable states split off from 1)
December 5, 2025 at 4:39 PM
In contrast, as @benoitbruneau.bsky.social noted the original Waddington diagram only shows pitchfork bifurcations (2 stable states split off from 1)
Great questions, agreed! There are a number of possible transition types. I think this demo by my daughter of how Brahma KO breaks the second saddle node bifurcation was surprisingly our most intuitive.
December 5, 2025 at 4:37 PM
Great questions, agreed! There are a number of possible transition types. I think this demo by my daughter of how Brahma KO breaks the second saddle node bifurcation was surprisingly our most intuitive.
Yes this is very cool! Our Brahma model was more focused and hypothesis driven, but would be cool to see if this data driven approach can find the saddle node bifurcations automatically.
December 4, 2025 at 5:29 PM
Yes this is very cool! Our Brahma model was more focused and hypothesis driven, but would be cool to see if this data driven approach can find the saddle node bifurcations automatically.
I think "should" is very important during review. "Suffering happens in the gap we hold between the expectations we have (of preliminary data) and reality."
— Poppy Jamie
— Poppy Jamie
December 2, 2025 at 3:05 AM
I think "should" is very important during review. "Suffering happens in the gap we hold between the expectations we have (of preliminary data) and reality."
— Poppy Jamie
— Poppy Jamie
Would love to see a survey on what percent of an NIH grant should already be completed as preliminary data.
December 2, 2025 at 12:29 AM
Would love to see a survey on what percent of an NIH grant should already be completed as preliminary data.
Sure thanks will DM!
November 15, 2025 at 3:50 PM
Sure thanks will DM!
Announcing the 4th Netflux and Network Biology Virtual Conference, Jan 7! Free registration and abstract submission (Dec 12). Live demo of the new user-friendly Netflux webapp, student talks, keynote by Suzanne Gaudet (Novartis): bit.ly/4i1eQD6
November 15, 2025 at 2:10 PM
Announcing the 4th Netflux and Network Biology Virtual Conference, Jan 7! Free registration and abstract submission (Dec 12). Live demo of the new user-friendly Netflux webapp, student talks, keynote by Suzanne Gaudet (Novartis): bit.ly/4i1eQD6
Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
November 1, 2025 at 12:14 AM
Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
These show that neuregulin-1 induces cardiomyocyte Feret elongation via sustained PI3K signaling, while transient p38 signaling increases cell size but not shape. This study leverages experimental-computational methods to dissect how signaling dynamics distinctly regulate cell size vs. shape. 3/3
October 3, 2025 at 8:27 PM
These show that neuregulin-1 induces cardiomyocyte Feret elongation via sustained PI3K signaling, while transient p38 signaling increases cell size but not shape. This study leverages experimental-computational methods to dissect how signaling dynamics distinctly regulate cell size vs. shape. 3/3
We first characterized the proteomic, gene expression, and phenotypic responses of cardiomyocytes (including our new cell shape metric Feret elongation) to diverse ligands. We integrated this data with data-driven and mechanistic computational models, validated with new perturbation experiments. 2/
October 3, 2025 at 8:26 PM
We first characterized the proteomic, gene expression, and phenotypic responses of cardiomyocytes (including our new cell shape metric Feret elongation) to diverse ligands. We integrated this data with data-driven and mechanistic computational models, validated with new perturbation experiments. 2/
How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
October 3, 2025 at 8:24 PM
How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
I would say that tracks but...
October 1, 2025 at 1:37 AM
I would say that tracks but...