Jeff Saucerman
@jsauce7.bsky.social
Professor of Biomedical Engineering and Cardiovascular Medicine at UVA. Systems biology to discover drugs for heart disease. Hiking with my dog in Shenandoah NP, around Charlottesville. https://engineering.virginia.edu/faculty/jeffrey-saucerman
Pinned
Happy New Year! Just 5 days until the 4th Netflux and Network Biology Virtual Conference on Jan 7, 1-5 pm ET. Please share. Agenda and free registration at: tinyurl.com/netfluxnet2026
Happy New Year! Just 5 days until the 4th Netflux and Network Biology Virtual Conference on Jan 7, 1-5 pm ET. Please share. Agenda and free registration at: tinyurl.com/netfluxnet2026
January 2, 2026 at 1:36 PM
Happy New Year! Just 5 days until the 4th Netflux and Network Biology Virtual Conference on Jan 7, 1-5 pm ET. Please share. Agenda and free registration at: tinyurl.com/netfluxnet2026
Reposted by Jeff Saucerman
Accepted ms on modeling human atrial disease posted @dev-journal.bsky.social just now. Congratulations to @irfankathiriya.bsky.social @jsauce7.bsky.social and team! @gladstoneinst.bsky.social @ucsfanesthesia.bsky.social journals.biologists.com/dev/article-...
Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease
While atrial septal defects (ASDs) and atrial fibrillation (AF) present differently, there is evidence that they share some genetic basis. Here, we used directed differentiation of human induced pluri...
journals.biologists.com
December 19, 2025 at 6:32 PM
Accepted ms on modeling human atrial disease posted @dev-journal.bsky.social just now. Congratulations to @irfankathiriya.bsky.social @jsauce7.bsky.social and team! @gladstoneinst.bsky.social @ucsfanesthesia.bsky.social journals.biologists.com/dev/article-...
Snowy hike to Hawksbill Summit, Shenandoah NP
December 14, 2025 at 3:32 AM
Snowy hike to Hawksbill Summit, Shenandoah NP
Always fun collaborating on networks of cardiac development with Irfan, @benoitbruneau.bsky.social, and team!
good new this morning: manuscript accepted! Final form of this pubmed.ncbi.nlm.nih.gov/40894762/ coming soon to @dev-journal.bsky.social. Congratulations to everyone from @ucsanfrancisco.bsky.social @ucsfanesthesia.bsky.social @gladstoneinst.bsky.social, and Alex Clark in @jsauce7.bsky.social's lab.
Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease - PubMed
There is evidence for a shared genetic basis of atrial septal defects (ASDs) and atrial fibrillation (AF), but it remains unclear how genetic susceptibility leads to these distinct human atrial diseases. Here, we used directed differentiation of human induced pluripotent stem cell to ventricular or …
pubmed.ncbi.nlm.nih.gov
December 10, 2025 at 11:09 PM
Always fun collaborating on networks of cardiac development with Irfan, @benoitbruneau.bsky.social, and team!
The 4th Netflux and Network Biology Virtual Conference is coming, Jan 7! Talks on network modeling across methods and biological systems. Free! tinyurl.com/netfluxnet2026
December 10, 2025 at 2:56 AM
The 4th Netflux and Network Biology Virtual Conference is coming, Jan 7! Talks on network modeling across methods and biological systems. Free! tinyurl.com/netfluxnet2026
Winter wonderland 🥾❄️
December 6, 2025 at 7:29 PM
Winter wonderland 🥾❄️
Announcing the 4th Netflux and Network Biology Virtual Conference, Jan 7! Free registration and abstract submission (Dec 12). Live demo of the new user-friendly Netflux webapp, student talks, keynote by Suzanne Gaudet (Novartis): bit.ly/4i1eQD6
November 15, 2025 at 2:10 PM
Announcing the 4th Netflux and Network Biology Virtual Conference, Jan 7! Free registration and abstract submission (Dec 12). Live demo of the new user-friendly Netflux webapp, student talks, keynote by Suzanne Gaudet (Novartis): bit.ly/4i1eQD6
Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
November 1, 2025 at 12:14 AM
Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
October 3, 2025 at 8:24 PM
How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
Spooky fall day in Shenandoah NP
October 1, 2025 at 1:35 AM
Spooky fall day in Shenandoah NP
Paradoxically, heart failure involves both cell death and growth. How does a cell decide? In a paper at JMCC Plus led by Bryan Chun and Lavie Ngo, we find that rather than dying following hypertrophy, stressed cardiomyocytes commit early to either grow or die.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 18, 2025 at 12:00 AM
Paradoxically, heart failure involves both cell death and growth. How does a cell decide? In a paper at JMCC Plus led by Bryan Chun and Lavie Ngo, we find that rather than dying following hypertrophy, stressed cardiomyocytes commit early to either grow or die.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
@j-muncie-vasic.bsky.social and @benoitbruneau.bsky.social show that MEF2C is not a one trick pony- it distinctly regulates different regions of heart tube formation. Glad @aclark.bsky.social and I could contribute gene regulatory networks that predict mechanisms.
Excited to share that our manuscript “MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis” is now online @genesdev.bsky.social !
genesdev.cshlp.org/content/earl...
(1/n)
genesdev.cshlp.org/content/earl...
(1/n)
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
September 5, 2025 at 12:01 AM
@j-muncie-vasic.bsky.social and @benoitbruneau.bsky.social show that MEF2C is not a one trick pony- it distinctly regulates different regions of heart tube formation. Glad @aclark.bsky.social and I could contribute gene regulatory networks that predict mechanisms.
September 1, 2025 at 11:54 AM
Happy to share our latest preprint, "Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury", in collaboration with Matthew Wolf's lab, led by Bryce Murillo and Alex Young! www.biorxiv.org/content/10.1...
August 26, 2025 at 9:24 PM
Happy to share our latest preprint, "Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury", in collaboration with Matthew Wolf's lab, led by Bryce Murillo and Alex Young! www.biorxiv.org/content/10.1...
Sunset showers at Shenandoah NP
August 17, 2025 at 8:58 PM
Sunset showers at Shenandoah NP
Do large language models understand how cells work? To find out, we built a pipeline that generates logic-based models of signaling networks using general purpose LLMs GPT, Gemini, or Claude. We benchmarked LLM-generated networks against 3 large-scale literature-curated and validated networks. 1/
July 29, 2025 at 6:11 PM
Do large language models understand how cells work? To find out, we built a pipeline that generates logic-based models of signaling networks using general purpose LLMs GPT, Gemini, or Claude. We benchmarked LLM-generated networks against 3 large-scale literature-curated and validated networks. 1/
On my way to AHA #BCVS25 in Baltimore! Come see Bryce Murillo present on a drug for DYRK1A that induces cardiomyocyte cell cycling in network models, isolated cardiomyocytes, and after myocardial infarction. Wed 9:39 am.
July 22, 2025 at 3:21 PM
On my way to AHA #BCVS25 in Baltimore! Come see Bryce Murillo present on a drug for DYRK1A that induces cardiomyocyte cell cycling in network models, isolated cardiomyocytes, and after myocardial infarction. Wed 9:39 am.
A few pics from my trip to Egypt. Cairo, Luxor, Alexandria
July 20, 2025 at 9:59 PM
A few pics from my trip to Egypt. Cairo, Luxor, Alexandria
July 15, 2025 at 12:48 AM
"The Faculty Senate expresses no confidence in the Board of Visitors for not protecting the University and its president from outside interference, ..."
www.forbes.com/sites/michae...
www.forbes.com/sites/michae...
University Of Virginia Faculty Vote No Confidence In Governing Board
The University of Virginia Faculty Senate has voted it has no confidence in the school’s Board of Visitors by a margin of 46 to 6, with 8 senators abstaining.
www.forbes.com
July 14, 2025 at 2:15 AM
"The Faculty Senate expresses no confidence in the Board of Visitors for not protecting the University and its president from outside interference, ..."
www.forbes.com/sites/michae...
www.forbes.com/sites/michae...
Reposted by Jeff Saucerman
Public comment on this new "no animal only studies" is open here:
www.fda.gov/news-events/...
It closes next Monday.
www.fda.gov/news-events/...
It closes next Monday.
July 8, 2025 at 7:32 PM
Public comment on this new "no animal only studies" is open here:
www.fda.gov/news-events/...
It closes next Monday.
www.fda.gov/news-events/...
It closes next Monday.