Jeff Saucerman
@jsauce7.bsky.social
Professor of Biomedical Engineering and Cardiovascular Medicine at UVA. Systems biology to discover drugs for heart disease. Hiking with my dog in Shenandoah NP, around Charlottesville. https://engineering.virginia.edu/faculty/jeffrey-saucerman
Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
November 1, 2025 at 12:14 AM
Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
October 3, 2025 at 8:24 PM
How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
Spooky fall day in Shenandoah NP
October 1, 2025 at 1:35 AM
Spooky fall day in Shenandoah NP
Finally, check out the eye candy! Awesome multi-channel live-cell videos analyzed with machine learning segmentation and tracking. Shows the complex fates that cells commit to. 3/3
September 18, 2025 at 12:03 AM
Finally, check out the eye candy! Awesome multi-channel live-cell videos analyzed with machine learning segmentation and tracking. Shows the complex fates that cells commit to. 3/3
Paradoxically, heart failure involves both cell death and growth. How does a cell decide? In a paper at JMCC Plus led by Bryan Chun and Lavie Ngo, we find that rather than dying following hypertrophy, stressed cardiomyocytes commit early to either grow or die.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 18, 2025 at 12:00 AM
Paradoxically, heart failure involves both cell death and growth. How does a cell decide? In a paper at JMCC Plus led by Bryan Chun and Lavie Ngo, we find that rather than dying following hypertrophy, stressed cardiomyocytes commit early to either grow or die.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 1, 2025 at 11:54 AM
Happy to share our latest preprint, "Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury", in collaboration with Matthew Wolf's lab, led by Bryce Murillo and Alex Young! www.biorxiv.org/content/10.1...
August 26, 2025 at 9:24 PM
Happy to share our latest preprint, "Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury", in collaboration with Matthew Wolf's lab, led by Bryce Murillo and Alex Young! www.biorxiv.org/content/10.1...
Sunset showers at Shenandoah NP
August 17, 2025 at 8:58 PM
Sunset showers at Shenandoah NP
We find that LLM-generated networks reconstruct 24-58% of the structure of literature-curated networks. When challenged to predict perturbation responses from independent literature, LLM-generated networks validate at 5-26% compared to 77-95% validation accuracy with literature-curated models. 2/
July 29, 2025 at 6:13 PM
We find that LLM-generated networks reconstruct 24-58% of the structure of literature-curated networks. When challenged to predict perturbation responses from independent literature, LLM-generated networks validate at 5-26% compared to 77-95% validation accuracy with literature-curated models. 2/
Do large language models understand how cells work? To find out, we built a pipeline that generates logic-based models of signaling networks using general purpose LLMs GPT, Gemini, or Claude. We benchmarked LLM-generated networks against 3 large-scale literature-curated and validated networks. 1/
July 29, 2025 at 6:11 PM
Do large language models understand how cells work? To find out, we built a pipeline that generates logic-based models of signaling networks using general purpose LLMs GPT, Gemini, or Claude. We benchmarked LLM-generated networks against 3 large-scale literature-curated and validated networks. 1/
And Baltimore science museum!
July 26, 2025 at 5:56 PM
And Baltimore science museum!
On my way to AHA #BCVS25 in Baltimore! Come see Bryce Murillo present on a drug for DYRK1A that induces cardiomyocyte cell cycling in network models, isolated cardiomyocytes, and after myocardial infarction. Wed 9:39 am.
July 22, 2025 at 3:21 PM
On my way to AHA #BCVS25 in Baltimore! Come see Bryce Murillo present on a drug for DYRK1A that induces cardiomyocyte cell cycling in network models, isolated cardiomyocytes, and after myocardial infarction. Wed 9:39 am.
Here's his tomb, in Luxor. Ancient Egypt was more impressive than I imagined. Modern Cairo less so.
July 20, 2025 at 10:03 PM
Here's his tomb, in Luxor. Ancient Egypt was more impressive than I imagined. Modern Cairo less so.
A few pics from my trip to Egypt. Cairo, Luxor, Alexandria
July 20, 2025 at 9:59 PM
A few pics from my trip to Egypt. Cairo, Luxor, Alexandria
July 15, 2025 at 12:48 AM
Is this where they hide the cancelled funds for biomedical research and humanitarian aid?
July 9, 2025 at 12:07 AM
Is this where they hide the cancelled funds for biomedical research and humanitarian aid?