Miro Astore
@miroastore.bsky.social
Postdoc @rockefeller. Making cryoEM into a tool for RNA biophysics one molecules at a time.
Hello world! It's been a true joy to work on this with Michael. Both him and cryoJAX are things to keep an eye on. They're going to make amazing things happen in cryo and beyond.
November 14, 2025 at 6:46 PM
Hello world! It's been a true joy to work on this with Michael. Both him and cryoJAX are things to keep an eye on. They're going to make amazing things happen in cryo and beyond.
Reposted by Miro Astore
CryoJAX - A Cryo-Electron Microscopy Image Simulation Library in JAX www.biorxiv.org/content/10.1101/2025.10.23.682564v1 #cryoem
October 25, 2025 at 11:29 AM
CryoJAX - A Cryo-Electron Microscopy Image Simulation Library in JAX www.biorxiv.org/content/10.1101/2025.10.23.682564v1 #cryoem
Reposted by Miro Astore
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 12:05 AM
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
I'm very excited to announce that I've just joined Steve_Bonilla's lab at @rockefelleruniv.bsky.social. With the help of @pilarcossio.bsky.social and colleagues at @flatironinstitute.org. I'll be developing cryoEM into a quantitative method to study RNA biophysics.
September 14, 2025 at 2:58 PM
I'm very excited to announce that I've just joined Steve_Bonilla's lab at @rockefelleruniv.bsky.social. With the help of @pilarcossio.bsky.social and colleagues at @flatironinstitute.org. I'll be developing cryoEM into a quantitative method to study RNA biophysics.
Reposted by Miro Astore
The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 24, 2025 at 7:38 PM
The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
biorxiv.org/content/10.110
biorxiv.org/content/10.110
biorxiv.org
July 23, 2025 at 9:43 PM
That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
biorxiv.org/content/10.110
biorxiv.org/content/10.110
Super excited for this one! Great job guys.
Check out our recent preprint 👇on counting particles to estimate populations in #cryoem: noise can bias the estimates; with Luke Evans & a great team.
Counting particles could give wrong probabilities in Cryo-Electron Microscopy https://www.biorxiv.org/content/10.1101/2025.03.27.644168v1
March 30, 2025 at 1:37 PM
Super excited for this one! Great job guys.
Reposted by Miro Astore
That’s a wrap on the 2025 Cold Spring Harbor CryoEM course! Huge thanks to the amazing students for your enthusiasm, the TAs for your dedication, and the invited lecturers for sharing your expertise. Keep pushing the boundaries of single particle EM - excited to see what you all accomplish next!
March 19, 2025 at 5:55 PM
That’s a wrap on the 2025 Cold Spring Harbor CryoEM course! Huge thanks to the amazing students for your enthusiasm, the TAs for your dedication, and the invited lecturers for sharing your expertise. Keep pushing the boundaries of single particle EM - excited to see what you all accomplish next!
Watch out world. I can pipette now.
We’ve seen some good grids and some bad at the CSHL #CryoEM course, but I think we all agree that @miroastore.bsky.social should be awarded the 2025 “worst grid” award. But for someone who never held a pipette prior to this course he also deserves the “most improved” award - keep it up Miro!
March 16, 2025 at 3:51 AM
Watch out world. I can pipette now.
Reposted by Miro Astore
Saturday night and the lab is in full swing as the participants of the CSHL #CryoEM course prepare for the final competition - solve the structure of a mystery protein in less than 4 hours.
March 16, 2025 at 12:52 AM
Saturday night and the lab is in full swing as the participants of the CSHL #CryoEM course prepare for the final competition - solve the structure of a mystery protein in less than 4 hours.
Come work in a great place with great people. Loads of fun projects and ideas.
We are hiring a Flatiron Research Fellow in the Structural Molecular Biophysics team! Experience with cryoEM and/or membrane protein simulations are a plus! Happy to chat in person with anyone at #bps2025 ! apply.interfolio.com/160227
Apply - Interfolio
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apply.interfolio.com
February 17, 2025 at 5:48 PM
Come work in a great place with great people. Loads of fun projects and ideas.
Reposted by Miro Astore
Join leaders from CCDC, ICDD, ICSD, and RCSB PDB on February 12 to learn how data management impacts future research
register.gotowebinar...
register.gotowebinar...
February 5, 2025 at 5:50 PM
Join leaders from CCDC, ICDD, ICSD, and RCSB PDB on February 12 to learn how data management impacts future research
register.gotowebinar...
register.gotowebinar...
Reposted by Miro Astore
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 6, 2024 at 8:39 AM
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Miro Astore
November 19, 2024 at 1:27 PM