@metapredict.bsky.social
Pinned
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
Jacques et al. conducted a thorough meta-analysis integrating multi-omics data from
over 1,000 participants to identify distinctive molecular signatures in human skeletal
muscle adaptation to various ...
www.cell.com
Old presented as new @cellreports.bsky.social
Flattering sports scientists finally listening re sample-size
Led by a king of citation fraud @nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors
www.cell.com/cell-reports...
Flattering sports scientists finally listening re sample-size
Led by a king of citation fraud @nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors
www.cell.com/cell-reports...
Reposted
Just a reminder.
When most detectable genes change in a transcriptomic study the principles of global normalisation fail - blind use of code is dumb.
Baseline VO2max doesn't predict gains in VO2max & changes in gene expression without evidence physiological adaptation are of dubious meaning.
When most detectable genes change in a transcriptomic study the principles of global normalisation fail - blind use of code is dumb.
Baseline VO2max doesn't predict gains in VO2max & changes in gene expression without evidence physiological adaptation are of dubious meaning.
September 2, 2025 at 7:59 AM
Just a reminder.
When most detectable genes change in a transcriptomic study the principles of global normalisation fail - blind use of code is dumb.
Baseline VO2max doesn't predict gains in VO2max & changes in gene expression without evidence physiological adaptation are of dubious meaning.
When most detectable genes change in a transcriptomic study the principles of global normalisation fail - blind use of code is dumb.
Baseline VO2max doesn't predict gains in VO2max & changes in gene expression without evidence physiological adaptation are of dubious meaning.
Reposted
Less IL6, better cardiovascular health - inhibiting IL6 gooood (exercise related homeopathic increases irrelevant at best, bad at worst)
"The greatest trick the devil ever pulled was convincing the world she was an honest scientist" Keyser Soze?
www.nature.com/articles/s44...
"The greatest trick the devil ever pulled was convincing the world she was an honest scientist" Keyser Soze?
www.nature.com/articles/s44...
IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk - Nature Cardiovascular Research
Zhang et al. show that genetically simulated IL-6 inhibition is associated with a reduced risk of cardiovascular disease and no increase in infection risk, supporting the use of emerging pharmacologic...
www.nature.com
August 26, 2025 at 9:18 PM
Less IL6, better cardiovascular health - inhibiting IL6 gooood (exercise related homeopathic increases irrelevant at best, bad at worst)
"The greatest trick the devil ever pulled was convincing the world she was an honest scientist" Keyser Soze?
www.nature.com/articles/s44...
"The greatest trick the devil ever pulled was convincing the world she was an honest scientist" Keyser Soze?
www.nature.com/articles/s44...
Less IL6, better cardiovascular health - inhibiting IL6 gooood (exercise related homeopathic increases irrelevant at best, bad at worst)
"The greatest trick the devil ever pulled was convincing the world she was an honest scientist" Keyser Soze?
www.nature.com/articles/s44...
"The greatest trick the devil ever pulled was convincing the world she was an honest scientist" Keyser Soze?
www.nature.com/articles/s44...
IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk - Nature Cardiovascular Research
Zhang et al. show that genetically simulated IL-6 inhibition is associated with a reduced risk of cardiovascular disease and no increase in infection risk, supporting the use of emerging pharmacologic...
www.nature.com
August 26, 2025 at 9:18 PM
Less IL6, better cardiovascular health - inhibiting IL6 gooood (exercise related homeopathic increases irrelevant at best, bad at worst)
"The greatest trick the devil ever pulled was convincing the world she was an honest scientist" Keyser Soze?
www.nature.com/articles/s44...
"The greatest trick the devil ever pulled was convincing the world she was an honest scientist" Keyser Soze?
www.nature.com/articles/s44...
Reposted
DNA methylation clocks were always known to be confound by genetics (the Illumina assay is a repurposed SNP chip after all)
Here established (white ppl) DNAm "aging" clocks fall apart in other ethnicities (& as usual don't explain much clinical variation in anyone)
www.biorxiv.org/content/10.1...
Here established (white ppl) DNAm "aging" clocks fall apart in other ethnicities (& as usual don't explain much clinical variation in anyone)
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 20, 2025 at 7:54 AM
DNA methylation clocks were always known to be confound by genetics (the Illumina assay is a repurposed SNP chip after all)
Here established (white ppl) DNAm "aging" clocks fall apart in other ethnicities (& as usual don't explain much clinical variation in anyone)
www.biorxiv.org/content/10.1...
Here established (white ppl) DNAm "aging" clocks fall apart in other ethnicities (& as usual don't explain much clinical variation in anyone)
www.biorxiv.org/content/10.1...
DNA methylation clocks were always known to be confound by genetics (the Illumina assay is a repurposed SNP chip after all)
Here established (white ppl) DNAm "aging" clocks fall apart in other ethnicities (& as usual don't explain much clinical variation in anyone)
www.biorxiv.org/content/10.1...
Here established (white ppl) DNAm "aging" clocks fall apart in other ethnicities (& as usual don't explain much clinical variation in anyone)
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 20, 2025 at 7:54 AM
DNA methylation clocks were always known to be confound by genetics (the Illumina assay is a repurposed SNP chip after all)
Here established (white ppl) DNAm "aging" clocks fall apart in other ethnicities (& as usual don't explain much clinical variation in anyone)
www.biorxiv.org/content/10.1...
Here established (white ppl) DNAm "aging" clocks fall apart in other ethnicities (& as usual don't explain much clinical variation in anyone)
www.biorxiv.org/content/10.1...
Reposted
Reposted
3/3 @cbmr.science #StenoDiabetes #Novo Nordisk
Aside from this, the trial design is flawed. It's well established the IS response to a training program (single arm) are >> heterogeneous, i.e. mean differences between small subgroups, on different treatments, can't be attributed to protocol alone 🤦♂️
Aside from this, the trial design is flawed. It's well established the IS response to a training program (single arm) are >> heterogeneous, i.e. mean differences between small subgroups, on different treatments, can't be attributed to protocol alone 🤦♂️
April 21, 2025 at 9:47 AM
3/3 @cbmr.science #StenoDiabetes #Novo Nordisk
Aside from this, the trial design is flawed. It's well established the IS response to a training program (single arm) are >> heterogeneous, i.e. mean differences between small subgroups, on different treatments, can't be attributed to protocol alone 🤦♂️
Aside from this, the trial design is flawed. It's well established the IS response to a training program (single arm) are >> heterogeneous, i.e. mean differences between small subgroups, on different treatments, can't be attributed to protocol alone 🤦♂️
Reposted
@cbmr.science #StenoDiabetes #Novo Nordisk
2/3 How do u publish a study like this & not cite the largest HIT study in over-weight, sedentary adults (doi.org/10.3389/fend...) with varying degrees of IR, where they identified a molecular signature related (doi.org/10.1093/nar/...) to reversal of IR?
2/3 How do u publish a study like this & not cite the largest HIT study in over-weight, sedentary adults (doi.org/10.3389/fend...) with varying degrees of IR, where they identified a molecular signature related (doi.org/10.1093/nar/...) to reversal of IR?
April 21, 2025 at 9:46 AM
@cbmr.science #StenoDiabetes #Novo Nordisk
2/3 How do u publish a study like this & not cite the largest HIT study in over-weight, sedentary adults (doi.org/10.3389/fend...) with varying degrees of IR, where they identified a molecular signature related (doi.org/10.1093/nar/...) to reversal of IR?
2/3 How do u publish a study like this & not cite the largest HIT study in over-weight, sedentary adults (doi.org/10.3389/fend...) with varying degrees of IR, where they identified a molecular signature related (doi.org/10.1093/nar/...) to reversal of IR?
Reposted
1/3 High-intensity interval training improves insulin sensitivity
in individuals with prediabetes
academic.oup.com/ejendo/artic...
Danish researchers, Knop, Vilsboll et al once again proving they have either no access to Pubmed, or they are happy to dishonestly reflect the state of the literature
in individuals with prediabetes
academic.oup.com/ejendo/artic...
Danish researchers, Knop, Vilsboll et al once again proving they have either no access to Pubmed, or they are happy to dishonestly reflect the state of the literature
April 21, 2025 at 9:42 AM
1/3 High-intensity interval training improves insulin sensitivity
in individuals with prediabetes
academic.oup.com/ejendo/artic...
Danish researchers, Knop, Vilsboll et al once again proving they have either no access to Pubmed, or they are happy to dishonestly reflect the state of the literature
in individuals with prediabetes
academic.oup.com/ejendo/artic...
Danish researchers, Knop, Vilsboll et al once again proving they have either no access to Pubmed, or they are happy to dishonestly reflect the state of the literature
Reposted
Differences in fibre recruitment render the current interpretation of this small study mute.
Phosphoproteomics Uncovers Exercise Intensity-Specific Skeletal Muscle Signaling Networks Underlying High-Intensity Interval Training in Healthy Male Participants
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Phosphoproteomics Uncovers Exercise Intensity-Specific Skeletal Muscle Signaling Networks Underlying High-Intensity Interval Training in Healthy Male Participants - Sports Medicine
Background In response to exercise, protein kinases and signaling networks are engaged to blunt homeostatic threats generated by acute contraction-induced increases in skeletal muscle energy and oxyge...
link.springer.com
April 21, 2025 at 9:28 PM
Differences in fibre recruitment render the current interpretation of this small study mute.
Reposted
More deceptive data funded by @novonordiskfond
link.springer.com/article/10.1...
No matching of physical activity or VO2max means this isn't T2DM, this is an unreliable story.
> 20yr ago Mootha also presented something as T2DM, when online the hidden VO2max data explained all of the OXPHOS story
link.springer.com/article/10.1...
No matching of physical activity or VO2max means this isn't T2DM, this is an unreliable story.
> 20yr ago Mootha also presented something as T2DM, when online the hidden VO2max data explained all of the OXPHOS story
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia
Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...
link.springer.com
April 29, 2025 at 6:33 PM
More deceptive data funded by @novonordiskfond
link.springer.com/article/10.1...
No matching of physical activity or VO2max means this isn't T2DM, this is an unreliable story.
> 20yr ago Mootha also presented something as T2DM, when online the hidden VO2max data explained all of the OXPHOS story
link.springer.com/article/10.1...
No matching of physical activity or VO2max means this isn't T2DM, this is an unreliable story.
> 20yr ago Mootha also presented something as T2DM, when online the hidden VO2max data explained all of the OXPHOS story
Reposted
Old presented as new @cellreports.bsky.social
Flattering sports scientists finally listening re sample-size
Led by a king of citation fraud @nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors
www.cell.com/cell-reports...
Flattering sports scientists finally listening re sample-size
Led by a king of citation fraud @nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors
www.cell.com/cell-reports...
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
Jacques et al. conducted a thorough meta-analysis integrating multi-omics data from
over 1,000 participants to identify distinctive molecular signatures in human skeletal
muscle adaptation to various ...
www.cell.com
May 31, 2025 at 10:39 PM
Old presented as new @cellreports.bsky.social
Flattering sports scientists finally listening re sample-size
Led by a king of citation fraud @nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors
www.cell.com/cell-reports...
Flattering sports scientists finally listening re sample-size
Led by a king of citation fraud @nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors
www.cell.com/cell-reports...
Reposted
A retraction by Oncotarget, but the journal is taking all the credit for my 2020 findings!
"Oncotarget’s Image Forensics analysis identified multiple instances of image manipulations".
What a crappy move from Oncotarget.
HT: @thatsregrettab1.bsky.social
pubpeer.com/publications...
"Oncotarget’s Image Forensics analysis identified multiple instances of image manipulations".
What a crappy move from Oncotarget.
HT: @thatsregrettab1.bsky.social
pubpeer.com/publications...
May 31, 2025 at 10:23 PM
A retraction by Oncotarget, but the journal is taking all the credit for my 2020 findings!
"Oncotarget’s Image Forensics analysis identified multiple instances of image manipulations".
What a crappy move from Oncotarget.
HT: @thatsregrettab1.bsky.social
pubpeer.com/publications...
"Oncotarget’s Image Forensics analysis identified multiple instances of image manipulations".
What a crappy move from Oncotarget.
HT: @thatsregrettab1.bsky.social
pubpeer.com/publications...
Old presented as new @cellreports.bsky.social
Flattering sports scientists finally listening re sample-size
Led by a king of citation fraud @nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors
www.cell.com/cell-reports...
Flattering sports scientists finally listening re sample-size
Led by a king of citation fraud @nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors
www.cell.com/cell-reports...
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
Jacques et al. conducted a thorough meta-analysis integrating multi-omics data from
over 1,000 participants to identify distinctive molecular signatures in human skeletal
muscle adaptation to various ...
www.cell.com
May 31, 2025 at 10:39 PM
Old presented as new @cellreports.bsky.social
Flattering sports scientists finally listening re sample-size
Led by a king of citation fraud @nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors
www.cell.com/cell-reports...
Flattering sports scientists finally listening re sample-size
Led by a king of citation fraud @nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors
www.cell.com/cell-reports...
Reposted
How is ScienceGuardians different from PubPeer?
Several PubPeer users have been able to register on ScienceGuardians and post the exact same type of concerns.
Why is PubPeer "unaccountable" and "malicious" and SG "respectful" and "accountable"?
I see absolutely no difference.
Several PubPeer users have been able to register on ScienceGuardians and post the exact same type of concerns.
Why is PubPeer "unaccountable" and "malicious" and SG "respectful" and "accountable"?
I see absolutely no difference.
May 2, 2025 at 8:55 PM
How is ScienceGuardians different from PubPeer?
Several PubPeer users have been able to register on ScienceGuardians and post the exact same type of concerns.
Why is PubPeer "unaccountable" and "malicious" and SG "respectful" and "accountable"?
I see absolutely no difference.
Several PubPeer users have been able to register on ScienceGuardians and post the exact same type of concerns.
Why is PubPeer "unaccountable" and "malicious" and SG "respectful" and "accountable"?
I see absolutely no difference.
The playbook for a good paper on Aging or Ageing
May 1, 2025 at 4:01 PM
The playbook for a good paper on Aging or Ageing
Reposted
The do’s and don’ts of scientific image editing
Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.
@sarareardon.bsky.social reports
www.nature.com/articles/d41...
Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.
@sarareardon.bsky.social reports
www.nature.com/articles/d41...
The do’s and don’ts of scientific image editing
Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.
www.nature.com
April 30, 2025 at 6:54 AM
The do’s and don’ts of scientific image editing
Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.
@sarareardon.bsky.social reports
www.nature.com/articles/d41...
Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.
@sarareardon.bsky.social reports
www.nature.com/articles/d41...
The results, based on 1 mouse strain are interesting but life-long reduction in NAD+ doesn't in itself challenge that loss of NAD+ in humans doesn't a) have consequences or b) respond to supplemental intervention.
As usual, headline below is more marketing than clinical science.
As usual, headline below is more marketing than clinical science.
In @cp-cellmetabolism.bsky.social: Mice retained normal muscle function and health even though their NAD+ levels were reduced by 85%. Given that NAD levels drop by only up to 30% through ageing, the findings challenge the health benefits claimed by supplement companies.
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
NAD depletion in skeletal muscle does not impair tissue integrity and function or
accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels.
Muscle structure, metabolism, ...
www.cell.com
May 1, 2025 at 2:41 PM
The results, based on 1 mouse strain are interesting but life-long reduction in NAD+ doesn't in itself challenge that loss of NAD+ in humans doesn't a) have consequences or b) respond to supplemental intervention.
As usual, headline below is more marketing than clinical science.
As usual, headline below is more marketing than clinical science.
Same issue with every positive TG/KO mouse story - one strain, life long accommodation to the defect.
On different genetics, different diet or different housing temperature who knows 🤷♂️
Broader question is how often are KO/TG mice on one background informative ?
And of course #justinmice
On different genetics, different diet or different housing temperature who knows 🤷♂️
Broader question is how often are KO/TG mice on one background informative ?
And of course #justinmice
May 1, 2025 at 2:33 PM
Same issue with every positive TG/KO mouse story - one strain, life long accommodation to the defect.
On different genetics, different diet or different housing temperature who knows 🤷♂️
Broader question is how often are KO/TG mice on one background informative ?
And of course #justinmice
On different genetics, different diet or different housing temperature who knows 🤷♂️
Broader question is how often are KO/TG mice on one background informative ?
And of course #justinmice
Reposted
Taking the Mick...
2025: Muscle fiber Myc is dispensable for muscle growth
rdcu.be/egQbm
2024: MYC is sufficient for muscle growth
www.embopress.org/doi/full/10....
2013: MYC was negatively linked to RT growth
doi.org/10.1371/jour...
2025: Muscle fiber Myc is dispensable for muscle growth
rdcu.be/egQbm
2024: MYC is sufficient for muscle growth
www.embopress.org/doi/full/10....
2013: MYC was negatively linked to RT growth
doi.org/10.1371/jour...
Muscle fiber Myc is dispensable for muscle growth and its forced expression severely perturbs homeostasis
Nature Communications - The transcription factor Myc stimulates growth in many cells. This study shows that Myc expression is essential in muscle stem cells to support muscle growth, but is neither...
rdcu.be
April 8, 2025 at 8:23 AM
Taking the Mick...
2025: Muscle fiber Myc is dispensable for muscle growth
rdcu.be/egQbm
2024: MYC is sufficient for muscle growth
www.embopress.org/doi/full/10....
2013: MYC was negatively linked to RT growth
doi.org/10.1371/jour...
2025: Muscle fiber Myc is dispensable for muscle growth
rdcu.be/egQbm
2024: MYC is sufficient for muscle growth
www.embopress.org/doi/full/10....
2013: MYC was negatively linked to RT growth
doi.org/10.1371/jour...
Reposted
Light touch review assured for all molecular & genomic data.
📣 CALL FOR PAPERS 📣
Organised by @pgreenhaff.bsky.social & focusing on:
🚑 Injury and rehabilitation
⛰️ Altitude physiology
🦵 Muscle adaptation
🚴 Exercise training
💉 Pharmacological interventions
⚙️ Body composition
🔗 buff.ly/2sVbnLk
Organised by @pgreenhaff.bsky.social & focusing on:
🚑 Injury and rehabilitation
⛰️ Altitude physiology
🦵 Muscle adaptation
🚴 Exercise training
💉 Pharmacological interventions
⚙️ Body composition
🔗 buff.ly/2sVbnLk
April 9, 2025 at 10:00 AM
Light touch review assured for all molecular & genomic data.
Reposted
Claimed mitochondrial phenotype in mild cognitive impairment
doi.org/10.14814/phy...
Yet lack of physical activity measures renders study invalid.
Seems physiology journals can't do physiology - more interested in making money your social gatherings than good science?
@physoc.bsky.social
doi.org/10.14814/phy...
Yet lack of physical activity measures renders study invalid.
Seems physiology journals can't do physiology - more interested in making money your social gatherings than good science?
@physoc.bsky.social
Absolute substrate oxidation rates are lower in older adults with amnestic mild cognitive impairment
Previous studies in individuals with mild cognitive impairment suggest that they may have altered systemic metabolic function at rest; however, metabolic function during aerobic exercise is not fully...
doi.org
April 24, 2025 at 7:13 AM
Claimed mitochondrial phenotype in mild cognitive impairment
doi.org/10.14814/phy...
Yet lack of physical activity measures renders study invalid.
Seems physiology journals can't do physiology - more interested in making money your social gatherings than good science?
@physoc.bsky.social
doi.org/10.14814/phy...
Yet lack of physical activity measures renders study invalid.
Seems physiology journals can't do physiology - more interested in making money your social gatherings than good science?
@physoc.bsky.social
Reposted
Human Skeletal Muscle Disuse Atrophy has Profound and Negative Effects on the Muscle Metabolome and Lipidome
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
Human Skeletal Muscle Disuse Atrophy has Profound and Negative Effects on the Muscle Metabolome and Lipidome | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Soci...
We investigated how short-term muscle disuse altered the skeletal muscle metabolome, lipidome and transcriptome in middle-aged adults. We report that the energy metabolism pathways: Nicotinate and nic...
journals.physiology.org
April 29, 2025 at 6:01 PM
Human Skeletal Muscle Disuse Atrophy has Profound and Negative Effects on the Muscle Metabolome and Lipidome
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
More deceptive data funded by @novonordiskfond
link.springer.com/article/10.1...
No matching of physical activity or VO2max means this isn't T2DM, this is an unreliable story.
> 20yr ago Mootha also presented something as T2DM, when online the hidden VO2max data explained all of the OXPHOS story
link.springer.com/article/10.1...
No matching of physical activity or VO2max means this isn't T2DM, this is an unreliable story.
> 20yr ago Mootha also presented something as T2DM, when online the hidden VO2max data explained all of the OXPHOS story
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia
Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...
link.springer.com
April 29, 2025 at 6:33 PM
More deceptive data funded by @novonordiskfond
link.springer.com/article/10.1...
No matching of physical activity or VO2max means this isn't T2DM, this is an unreliable story.
> 20yr ago Mootha also presented something as T2DM, when online the hidden VO2max data explained all of the OXPHOS story
link.springer.com/article/10.1...
No matching of physical activity or VO2max means this isn't T2DM, this is an unreliable story.
> 20yr ago Mootha also presented something as T2DM, when online the hidden VO2max data explained all of the OXPHOS story