@metapredict.bsky.social
Reposted
3/3 @cbmr.science #StenoDiabetes #Novo Nordisk
Aside from this, the trial design is flawed. It's well established the IS response to a training program (single arm) are >> heterogeneous, i.e. mean differences between small subgroups, on different treatments, can't be attributed to protocol alone 🤦♂️
Aside from this, the trial design is flawed. It's well established the IS response to a training program (single arm) are >> heterogeneous, i.e. mean differences between small subgroups, on different treatments, can't be attributed to protocol alone 🤦♂️
April 21, 2025 at 9:47 AM
3/3 @cbmr.science #StenoDiabetes #Novo Nordisk
Aside from this, the trial design is flawed. It's well established the IS response to a training program (single arm) are >> heterogeneous, i.e. mean differences between small subgroups, on different treatments, can't be attributed to protocol alone 🤦♂️
Aside from this, the trial design is flawed. It's well established the IS response to a training program (single arm) are >> heterogeneous, i.e. mean differences between small subgroups, on different treatments, can't be attributed to protocol alone 🤦♂️
Reposted
@cbmr.science #StenoDiabetes #Novo Nordisk
2/3 How do u publish a study like this & not cite the largest HIT study in over-weight, sedentary adults (doi.org/10.3389/fend...) with varying degrees of IR, where they identified a molecular signature related (doi.org/10.1093/nar/...) to reversal of IR?
2/3 How do u publish a study like this & not cite the largest HIT study in over-weight, sedentary adults (doi.org/10.3389/fend...) with varying degrees of IR, where they identified a molecular signature related (doi.org/10.1093/nar/...) to reversal of IR?
April 21, 2025 at 9:46 AM
@cbmr.science #StenoDiabetes #Novo Nordisk
2/3 How do u publish a study like this & not cite the largest HIT study in over-weight, sedentary adults (doi.org/10.3389/fend...) with varying degrees of IR, where they identified a molecular signature related (doi.org/10.1093/nar/...) to reversal of IR?
2/3 How do u publish a study like this & not cite the largest HIT study in over-weight, sedentary adults (doi.org/10.3389/fend...) with varying degrees of IR, where they identified a molecular signature related (doi.org/10.1093/nar/...) to reversal of IR?
The details matter; while I suspected this 7% was best case scenario - it seems informative censoring could have influenced the results to the point that there was no real benefit of exercise (excess censoring in the exercise arm; exercise killed off the weak?)
June 2, 2025 at 3:37 PM
The details matter; while I suspected this 7% was best case scenario - it seems informative censoring could have influenced the results to the point that there was no real benefit of exercise (excess censoring in the exercise arm; exercise killed off the weak?)
Exercise scientists eh. Even here, when there's a clearly a very positive story they have to bs about 'better than drugs' when it's not a primary prevention cancer trial. Expected that cardio metabolic risk factors contribute to further risk. As good as it gets for an exercise study
June 1, 2025 at 7:20 PM
Exercise scientists eh. Even here, when there's a clearly a very positive story they have to bs about 'better than drugs' when it's not a primary prevention cancer trial. Expected that cardio metabolic risk factors contribute to further risk. As good as it gets for an exercise study
90% of science should be making sure the assay is valid and reproducible
May 31, 2025 at 10:41 PM
90% of science should be making sure the assay is valid and reproducible