Michael Ferraro
@mcferraro.bsky.social
Doctoral candidate, NeuRA & UNSW Medicine
Reposted by Michael Ferraro
www.medrxiv.org/content/10.1...
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
INSPECT-SR: a tool for assessing trustworthiness of randomised controlled trials
The integrity of evidence synthesis is threatened by problematic randomised controlled trials (RCTs). These are RCTs where there are serious concerns about the trustworthiness of the data or findings....
www.medrxiv.org
September 5, 2025 at 6:11 PM
www.medrxiv.org/content/10.1...
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
Reposted by Michael Ferraro
To do no harm, we must first “know harms”
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
To do no harm, we must first “know harms”. The challenge of ... : PAIN
An abstract is unavailable.
dx.doi.org
September 3, 2025 at 6:50 AM
To do no harm, we must first “know harms”
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
Reposted by Michael Ferraro
Is medical practice ahead of the evidence?
Out today 🚨 Our Cochrane review of 67 RCTs finds no clear evidence of benefit for ketamine or other NMDA antagonists for chronic pain. IV ketamine associated with risk of psychotomimetic effects, nausea, and vomiting. doi.org/10.1002/1465...
Ketamine and other NMDA receptor antagonists for chronic pain - Ferraro, MC - 2025 | Cochrane Library
Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.
doi.org
August 21, 2025 at 2:56 AM
Is medical practice ahead of the evidence?
Reposted by Michael Ferraro
Out today 🚨 Our Cochrane review of 67 RCTs finds no clear evidence of benefit for ketamine or other NMDA antagonists for chronic pain. IV ketamine associated with risk of psychotomimetic effects, nausea, and vomiting. doi.org/10.1002/1465...
Ketamine and other NMDA receptor antagonists for chronic pain - Ferraro, MC - 2025 | Cochrane Library
Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.
doi.org
August 18, 2025 at 6:12 AM
Out today 🚨 Our Cochrane review of 67 RCTs finds no clear evidence of benefit for ketamine or other NMDA antagonists for chronic pain. IV ketamine associated with risk of psychotomimetic effects, nausea, and vomiting. doi.org/10.1002/1465...
Ketamine and other NMDA receptor antagonists for chronic pain - Ferraro, MC - 2025 | Cochrane Library
Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.
doi.org
August 18, 2025 at 2:39 AM
Out today 🚨 Our Cochrane review of 67 RCTs finds no clear evidence of benefit for ketamine or other NMDA antagonists for chronic pain. IV ketamine associated with risk of psychotomimetic effects, nausea, and vomiting. doi.org/10.1002/1465...
Reposted by Michael Ferraro
Despite a large body of new evidence, our best treatments for neuropathic pain continue to provide only modest benefits, write Michael Ferraro and Dr Nadia Soliman
buff.ly/F5irUsl
buff.ly/F5irUsl
July 24, 2025 at 10:02 PM
Despite a large body of new evidence, our best treatments for neuropathic pain continue to provide only modest benefits, write Michael Ferraro and Dr Nadia Soliman
buff.ly/F5irUsl
buff.ly/F5irUsl
One-Page Patient Fact Sheets for Low Back Pain in Primary Care url:https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2836549?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=072425
July 24, 2025 at 6:25 AM
One-Page Patient Fact Sheets for Low Back Pain in Primary Care url:https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2836549?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=072425
Reposted by Michael Ferraro
Despite a large body of new evidence, our best treatments for neuropathic pain continue to provide only modest benefits, write Michael Ferraro and Dr Nadia Soliman
buff.ly/F5irUsl
buff.ly/F5irUsl
July 21, 2025 at 6:00 AM
Despite a large body of new evidence, our best treatments for neuropathic pain continue to provide only modest benefits, write Michael Ferraro and Dr Nadia Soliman
buff.ly/F5irUsl
buff.ly/F5irUsl
Reposted by Michael Ferraro
🥁 This week, we submitted to BMC medicine our stage 2 registered report "Efficacy and safety of esketamine for ‘treatment-resistant depression’: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-controlled trials". 🧵
Efficacy and safety of esketamine for treatment resistant depression: registered report for a Systematic Review with an Individual Patient Data Meta-analysis of Randomized, Double-Blind, Placebo-Contr...
Background In 2019, the FDA and EMA approved intranasal esketamine for treatment resistant depression (TRD). The current study re–evaluated its efficacy and safety. Methods This registered report pres...
www.medrxiv.org
July 18, 2025 at 6:54 AM
🥁 This week, we submitted to BMC medicine our stage 2 registered report "Efficacy and safety of esketamine for ‘treatment-resistant depression’: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-controlled trials". 🧵
Reposted by Michael Ferraro
RCT: Among patients with low back pain, a nondirective information sheet listing treatment options improved patient-reported preparedness for decision-making more than a directive advice sheet. https://ja.ma/4nUr96z
July 17, 2025 at 3:20 PM
RCT: Among patients with low back pain, a nondirective information sheet listing treatment options improved patient-reported preparedness for decision-making more than a directive advice sheet. https://ja.ma/4nUr96z
Reposted by Michael Ferraro
One-Page Patient Fact Sheets for Low Back Pain in Primary Care
Fact sheets do better than regular advice to support shared decision making!
jamanetwork.com/journals/jam...
Fact sheets do better than regular advice to support shared decision making!
jamanetwork.com/journals/jam...
One-Page Patient Fact Sheets for Low Back Pain in Primary Care
This randomized clinical trial compares the effects of 1-page fact sheets that adopt either an information-listing approach or a direct advice approach on management of low back pain to prepare patien...
jamanetwork.com
July 17, 2025 at 10:43 PM
One-Page Patient Fact Sheets for Low Back Pain in Primary Care
Fact sheets do better than regular advice to support shared decision making!
jamanetwork.com/journals/jam...
Fact sheets do better than regular advice to support shared decision making!
jamanetwork.com/journals/jam...
Reposted by Michael Ferraro
Delighted that the editors of 15 Pain and Anaesthesiology have chosen to endorse and amplify the ENTRUST-PE framework. More info here: www.linkedin.com/pulse/entrus...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social @ukrio.bsky.social @coarassessment.bsky.social
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social @ukrio.bsky.social @coarassessment.bsky.social
ENTRUST-PE: endorsement by senior editors of 15 Pain and Anaesthesiology Journals
We are beyond delighted that the ENTRUST-PE framework has been endorsed by the Editors in Chief of 15 International Pain and Anaesthesiology journals. Those editors are copublishing, across the journa...
www.linkedin.com
July 16, 2025 at 3:00 PM
Delighted that the editors of 15 Pain and Anaesthesiology have chosen to endorse and amplify the ENTRUST-PE framework. More info here: www.linkedin.com/pulse/entrus...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social @ukrio.bsky.social @coarassessment.bsky.social
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social @ukrio.bsky.social @coarassessment.bsky.social
Reposted by Michael Ferraro
#PAIN joins with other editors of pain-related journals to affirm our editorial commitment to trust and integrity in science. Read our joint statement at bit.ly/4lj3b3b
July 14, 2025 at 12:00 PM
#PAIN joins with other editors of pain-related journals to affirm our editorial commitment to trust and integrity in science. Read our joint statement at bit.ly/4lj3b3b
Reposted by Michael Ferraro
Editorial: The editors-in-chief from @thejournalofpain.bsky.social & other pain/anesthesia journals come together to align and strengthen initiatives to enhance research integrity, trust, and impact across our field.
Full: doi.org/10.1016/j.jp...
Full: doi.org/10.1016/j.jp...
Redirecting
doi.org
July 14, 2025 at 12:31 PM
Editorial: The editors-in-chief from @thejournalofpain.bsky.social & other pain/anesthesia journals come together to align and strengthen initiatives to enhance research integrity, trust, and impact across our field.
Full: doi.org/10.1016/j.jp...
Full: doi.org/10.1016/j.jp...
Reposted by Michael Ferraro
Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research journals.lww.com/pain/fulltex...
Editorial commitment to trust and integrity in science:... : PAIN
An abstract is unavailable.
journals.lww.com
July 8, 2025 at 5:30 PM
Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research journals.lww.com/pain/fulltex...
Reposted by Michael Ferraro
Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project
The aim of the INSPECT-SR project is to develop a tool to identify problematic RCTs
in systematic reviews. In Stage 1 of the project, a list of potential trustworthiness
checks was created. The checks...
www.jclinepi.com
May 17, 2025 at 7:24 PM
Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Michael Ferraro
International #ResearchIntegrity conference taking place in beautiful Sydney Australia on 16-18 November 2025 🐨 🌏
Great speakers including @elisabethbik.bsky.social @jdwilko.bsky.social @jasonchin.bsky.social
For more info contact
@simongandevia.bsky.social 🧪
Great speakers including @elisabethbik.bsky.social @jdwilko.bsky.social @jasonchin.bsky.social
For more info contact
@simongandevia.bsky.social 🧪
International Research Integrity Conference. I am arranging this in Sydney in November 16-18th 2025. researchintegrityconf.com Note the excellent speaker list. Contact me!
International Research Integrity Conference | 17-18 November 2025, Sydney, Australia
researchintegrityconf.com
May 15, 2025 at 9:39 AM
International #ResearchIntegrity conference taking place in beautiful Sydney Australia on 16-18 November 2025 🐨 🌏
Great speakers including @elisabethbik.bsky.social @jdwilko.bsky.social @jasonchin.bsky.social
For more info contact
@simongandevia.bsky.social 🧪
Great speakers including @elisabethbik.bsky.social @jdwilko.bsky.social @jasonchin.bsky.social
For more info contact
@simongandevia.bsky.social 🧪
Reposted by Michael Ferraro
International Research Integrity Conference. I am arranging this in Sydney in November 16-18th 2025. researchintegrityconf.com Note the excellent speaker list. Contact me!
International Research Integrity Conference | 17-18 November 2025, Sydney, Australia
researchintegrityconf.com
May 14, 2025 at 3:00 AM
International Research Integrity Conference. I am arranging this in Sydney in November 16-18th 2025. researchintegrityconf.com Note the excellent speaker list. Contact me!
Reposted by Michael Ferraro
www.bmj.com/content/389/...
"Evidence from 68 systematic reviews with conclusions distorted by retracted trials was used in 157 guideline documents."
"Evidence from 68 systematic reviews with conclusions distorted by retracted trials was used in 157 guideline documents."
Investigating the impact of trial retractions on the healthcare evidence ecosystem (VITALITY Study I): retrospective cohort study
Objective To investigate the impact of retracted trials on the production and use of healthcare evidence in the evidence ecosystem.
Design Retrospective cohort study based on forward citation searchi...
www.bmj.com
April 24, 2025 at 9:46 AM
www.bmj.com/content/389/...
"Evidence from 68 systematic reviews with conclusions distorted by retracted trials was used in 157 guideline documents."
"Evidence from 68 systematic reviews with conclusions distorted by retracted trials was used in 157 guideline documents."
Updated @iasp.bsky.social NeuPSIG systematic review & guideline for treatment of neuropathic pain now published in @thelancetneuro.bsky.social. A privilege to contribute to this project, brilliantly led by @nadiasoliman.bsky.social
doi.org/10.1016/S147...
doi.org/10.1016/S147...
Redirecting
doi.org
April 22, 2025 at 7:17 AM
Updated @iasp.bsky.social NeuPSIG systematic review & guideline for treatment of neuropathic pain now published in @thelancetneuro.bsky.social. A privilege to contribute to this project, brilliantly led by @nadiasoliman.bsky.social
doi.org/10.1016/S147...
doi.org/10.1016/S147...
Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions
This systematic review and meta-analysis identifies reports of systematic reviews that included retracted studies in their meta-analyses, and assesses the impact of these retracted studies on the resu...
jamanetwork.com
March 31, 2025 at 10:51 PM
Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Michael Ferraro
File under “Never take the company’s word for it” www.thelancet.com/journals/lan...
Misleading marketing claims fuel tapentadol prescriptions
German drugmaker Grünenthal pushed its latest opioid as a safer option. People around
the world got hooked. Madlen Davies, Hristio Boytchev, and Rafael Cabrera report.
www.thelancet.com
March 24, 2025 at 9:08 AM
File under “Never take the company’s word for it” www.thelancet.com/journals/lan...
Reposted by Michael Ferraro
What are the benefits and harms of antidepressants for low back pain and spine‐related leg pain?
Find out in our Cochrane review, published today: doi.org/10.1002/1465...
Find out in our Cochrane review, published today: doi.org/10.1002/1465...
Antidepressants for low back pain and spine‐related leg pain - Ferraro, MC - 2025 | Cochrane Library
Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.
doi.org
March 11, 2025 at 7:47 PM
What are the benefits and harms of antidepressants for low back pain and spine‐related leg pain?
Find out in our Cochrane review, published today: doi.org/10.1002/1465...
Find out in our Cochrane review, published today: doi.org/10.1002/1465...
Antidepressants for low back pain and spine‐related leg pain - Ferraro, MC - 2025 | Cochrane Library
Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.
doi.org
March 11, 2025 at 5:59 AM
What are the benefits and harms of antidepressants for low back pain and spine‐related leg pain?
Find out in our Cochrane review, published today: doi.org/10.1002/1465...
Find out in our Cochrane review, published today: doi.org/10.1002/1465...
Reposted by Michael Ferraro
Fantastic to make the front cover of @journalofpain with the featured article “Enhancing the trustworthiness of pain research: A call to action” www.jpain.org/article/S152...
It’s open access so get downloading!
It’s open access so get downloading!
March 8, 2025 at 5:08 PM
Fantastic to make the front cover of @journalofpain with the featured article “Enhancing the trustworthiness of pain research: A call to action” www.jpain.org/article/S152...
It’s open access so get downloading!
It’s open access so get downloading!