Neil O’Connell
@neiloconnell.bsky.social
Physio, Professor, BBQer. Editor @cochrane. Views are my own and don’t necessarily reflect those of Brunel University/ Cochrane
Interested in trustworthy evidence: https://entrust-pe.org/
Interested in trustworthy evidence: https://entrust-pe.org/
Pinned
IASP Formally Endorses the ENhancing TRUST in Pain Evidence (ENTRUST-PE) Framework - International Association for the Study of Pain (IASP)
The ENTRUST-PE project Recognizing multiple important and systematic challenges to the trustworthiness of research, the ENTRUST-PE project convened an international, interdisciplinary network of lead...
www.iasp-pain.org
The International Association for the Study of Pain have chosen to formally endorse the ENTRUST-PE framework (www.iasp-pain.org/publications...
).
This is an excellent step in mobilising the global pain research community towards more trustworthy evidence.
Why?: www.jpain.org/article/S152...
New systematic review focused on amputation for complex regional pain syndrome and briliantly led by @yannickgilanyi.bsky.social from UNSW and Neura
sciencedirect.com/science/arti...
HT @iasp.bsky.social @iasp-mesisig.bsky.social @britishpainsoc.bsky.social @efic.bsky.social @usasp.bsky.social
sciencedirect.com/science/arti...
HT @iasp.bsky.social @iasp-mesisig.bsky.social @britishpainsoc.bsky.social @efic.bsky.social @usasp.bsky.social
Amputation for complex regional pain syndrome: a systematic review
Complex regional pain syndrome (CRPS) is a disabling pain condition, usually confined to a single limb. Amputation of the affected limb is sometimes p…
sciencedirect.com
October 24, 2025 at 1:57 PM
New systematic review focused on amputation for complex regional pain syndrome and briliantly led by @yannickgilanyi.bsky.social from UNSW and Neura
sciencedirect.com/science/arti...
HT @iasp.bsky.social @iasp-mesisig.bsky.social @britishpainsoc.bsky.social @efic.bsky.social @usasp.bsky.social
sciencedirect.com/science/arti...
HT @iasp.bsky.social @iasp-mesisig.bsky.social @britishpainsoc.bsky.social @efic.bsky.social @usasp.bsky.social
Reposted by Neil O’Connell
🚨 BPS Endorses the ENTRUST-PE Framework
The British Pain Society is proud to endorse ENTRUST-PE – a framework boosting the trustworthiness, transparency, and rigor of pain research.
🔗Read more: m.entrust-pe.org
The British Pain Society is proud to endorse ENTRUST-PE – a framework boosting the trustworthiness, transparency, and rigor of pain research.
🔗Read more: m.entrust-pe.org
October 13, 2025 at 10:15 AM
🚨 BPS Endorses the ENTRUST-PE Framework
The British Pain Society is proud to endorse ENTRUST-PE – a framework boosting the trustworthiness, transparency, and rigor of pain research.
🔗Read more: m.entrust-pe.org
The British Pain Society is proud to endorse ENTRUST-PE – a framework boosting the trustworthiness, transparency, and rigor of pain research.
🔗Read more: m.entrust-pe.org
Reposted by Neil O’Connell
Great to see the OPTIMETH framework for optimising clinical trials in CRPS, brilliantly led by Keith Smart from @ucddublin.bsky.social now out in @painreports.bsky.social
journals.lww.com/painrpts/ful...
@britishpainsoc.bsky.social @efic.bsky.social @iasp.bsky.social @iasp-mesisig.bsky.social
journals.lww.com/painrpts/ful...
@britishpainsoc.bsky.social @efic.bsky.social @iasp.bsky.social @iasp-mesisig.bsky.social
journals.lww.com
October 9, 2025 at 8:01 AM
Great to see the OPTIMETH framework for optimising clinical trials in CRPS, brilliantly led by Keith Smart from @ucddublin.bsky.social now out in @painreports.bsky.social
journals.lww.com/painrpts/ful...
@britishpainsoc.bsky.social @efic.bsky.social @iasp.bsky.social @iasp-mesisig.bsky.social
journals.lww.com/painrpts/ful...
@britishpainsoc.bsky.social @efic.bsky.social @iasp.bsky.social @iasp-mesisig.bsky.social
Reposted by Neil O’Connell
MESISIG is now on BlueSky. We've migrated who we follow 9as far as possible) from X but do please follow us back. We promise all things methodology and pain research!
October 7, 2025 at 12:13 PM
MESISIG is now on BlueSky. We've migrated who we follow 9as far as possible) from X but do please follow us back. We promise all things methodology and pain research!
Reposted by Neil O’Connell
Registration and reporting will become mandatory for all clinical trials next year. It's good to see many trial sponsors already delivering on this, but with clear @hralatest.bsky.social guidance, no excuse for anyone not to be transparent about results #AllTrials
www.hra.nhs.uk/planning-and...
www.hra.nhs.uk/planning-and...
Guidance on changes to the clinical trials regulations
www.hra.nhs.uk
October 1, 2025 at 3:10 PM
Registration and reporting will become mandatory for all clinical trials next year. It's good to see many trial sponsors already delivering on this, but with clear @hralatest.bsky.social guidance, no excuse for anyone not to be transparent about results #AllTrials
www.hra.nhs.uk/planning-and...
www.hra.nhs.uk/planning-and...
Reposted by Neil O’Connell
To do no harm, we must first “know harms”
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
To do no harm, we must first “know harms”. The challenge of ... : PAIN
An abstract is unavailable.
dx.doi.org
September 3, 2025 at 6:50 AM
To do no harm, we must first “know harms”
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
Reposted by Neil O’Connell
www.medrxiv.org/content/10.1...
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
INSPECT-SR: a tool for assessing trustworthiness of randomised controlled trials
The integrity of evidence synthesis is threatened by problematic randomised controlled trials (RCTs). These are RCTs where there are serious concerns about the trustworthiness of the data or findings....
www.medrxiv.org
September 5, 2025 at 6:11 PM
www.medrxiv.org/content/10.1...
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.
To do no harm, we must first “know harms”
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
To do no harm, we must first “know harms”. The challenge of ... : PAIN
An abstract is unavailable.
dx.doi.org
September 3, 2025 at 6:50 AM
To do no harm, we must first “know harms”
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social
Reposted by Neil O’Connell
📣 Save the date for the 12th PCI webinar on September 18, 2025, at 4 PM CET!! Dorothy Bishop (@deevybee.bsky.social) will present "Editors matter: How negligent publishers subvert quality control in scientific publishing ". For more details and registration, visit:
PCI Webinar Series - Peer Community In
The PCI webinar series is a series of seminars on research practices, publication practices, evaluation, scientific integrity, meta-research, organised by Peer Community In
peercommunityin.org
August 22, 2025 at 11:00 AM
📣 Save the date for the 12th PCI webinar on September 18, 2025, at 4 PM CET!! Dorothy Bishop (@deevybee.bsky.social) will present "Editors matter: How negligent publishers subvert quality control in scientific publishing ". For more details and registration, visit:
Out today 🚨 Our Cochrane review of 67 RCTs finds no clear evidence of benefit for ketamine or other NMDA antagonists for chronic pain. IV ketamine associated with risk of psychotomimetic effects, nausea, and vomiting. doi.org/10.1002/1465...
Ketamine and other NMDA receptor antagonists for chronic pain - Ferraro, MC - 2025 | Cochrane Library
Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.
doi.org
August 18, 2025 at 6:12 AM
Reposted by Neil O’Connell
Out today 🚨 Our Cochrane review of 67 RCTs finds no clear evidence of benefit for ketamine or other NMDA antagonists for chronic pain. IV ketamine associated with risk of psychotomimetic effects, nausea, and vomiting. doi.org/10.1002/1465...
Ketamine and other NMDA receptor antagonists for chronic pain - Ferraro, MC - 2025 | Cochrane Library
Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.
doi.org
August 18, 2025 at 2:39 AM
Out today 🚨 Our Cochrane review of 67 RCTs finds no clear evidence of benefit for ketamine or other NMDA antagonists for chronic pain. IV ketamine associated with risk of psychotomimetic effects, nausea, and vomiting. doi.org/10.1002/1465...
Reposted by Neil O’Connell
The ENTRUST-Pain Evidence (Entrust-PE) is an important initiative to ensure that pain science is of high quality.
Framework published in J Pain.
Endorsed by @iasp.bsky.social & @efic.bsky.social.
More here: m.entrust-pe.org
#pain
Framework published in J Pain.
Endorsed by @iasp.bsky.social & @efic.bsky.social.
More here: m.entrust-pe.org
#pain
May 3, 2025 at 2:01 PM
The ENTRUST-Pain Evidence (Entrust-PE) is an important initiative to ensure that pain science is of high quality.
Framework published in J Pain.
Endorsed by @iasp.bsky.social & @efic.bsky.social.
More here: m.entrust-pe.org
#pain
Framework published in J Pain.
Endorsed by @iasp.bsky.social & @efic.bsky.social.
More here: m.entrust-pe.org
#pain
Reposted by Neil O’Connell
Editorial: The editors-in-chief from @thejournalofpain.bsky.social & other pain/anesthesia journals come together to align and strengthen initiatives to enhance research integrity, trust, and impact across our field.
Full: www.jpain.org/article/S152...
Full: www.jpain.org/article/S152...
July 28, 2025 at 12:30 PM
Editorial: The editors-in-chief from @thejournalofpain.bsky.social & other pain/anesthesia journals come together to align and strengthen initiatives to enhance research integrity, trust, and impact across our field.
Full: www.jpain.org/article/S152...
Full: www.jpain.org/article/S152...
Reposted by Neil O’Connell
Led by Prof. Neil O’Connell and funded by ERA-Net NEURON, ENTRUST-PE brought together an international network to co-create a new framework for trustworthy pain research.
Learn more: entrust-pe.org
#ENTRUSTPE #ChronicPain #ResearchIntegrity #EquityInResearch #PainResearch #NEURON #SuccessStory #RRI
Learn more: entrust-pe.org
#ENTRUSTPE #ChronicPain #ResearchIntegrity #EquityInResearch #PainResearch #NEURON #SuccessStory #RRI
ENTRUST-PE: A New Framework for Trustworthy Pain Research - ERA-NET NEURON
NEURON’s Role and Reflections from the First Networking Call The success of ENTRUST-PE also reflects the value of ERA-Net NEURON’s strategic focus on networking and community building. The Networking ...
www.neuron-eranet.eu
July 31, 2025 at 6:18 AM
Led by Prof. Neil O’Connell and funded by ERA-Net NEURON, ENTRUST-PE brought together an international network to co-create a new framework for trustworthy pain research.
Learn more: entrust-pe.org
#ENTRUSTPE #ChronicPain #ResearchIntegrity #EquityInResearch #PainResearch #NEURON #SuccessStory #RRI
Learn more: entrust-pe.org
#ENTRUSTPE #ChronicPain #ResearchIntegrity #EquityInResearch #PainResearch #NEURON #SuccessStory #RRI
Reposted by Neil O’Connell
📌 The SPIRIT 2025 statement updates the guidelines for randomized trial protocols to enhance their completeness, transparency, and consistency, benefiting stakeholders involved in clinical research.
ja.ma/4fzMVZS
ja.ma/4fzMVZS
August 10, 2025 at 4:00 PM
📌 The SPIRIT 2025 statement updates the guidelines for randomized trial protocols to enhance their completeness, transparency, and consistency, benefiting stakeholders involved in clinical research.
ja.ma/4fzMVZS
ja.ma/4fzMVZS
Reposted by Neil O’Connell
Excellent, insightful conversation on the What the REF podcast between @simonhettrick.bsky.social and Marcus Munafo (@ukrepro.bsky.social) covering REF, open and transparent research and research culture (also rowing) youtu.be/uHRQjNqY6CY
Ep3. What the REF are our research incentives?
YouTube video by Hidden REF
youtu.be
August 6, 2025 at 11:29 AM
Excellent, insightful conversation on the What the REF podcast between @simonhettrick.bsky.social and Marcus Munafo (@ukrepro.bsky.social) covering REF, open and transparent research and research culture (also rowing) youtu.be/uHRQjNqY6CY
An expression of concern for an RCT 2 years after we raised concerns around the trustworthiness of the data. pubmed.ncbi.nlm.nih.gov/40709807/ this trial influences guidelines www.sciencedirect.com/science/arti...
EXPRESSION OF CONCERN: Group-Based Task-Oriented Exercises Aimed at Managing Kinesiophobia Improved Disability in Chronic Low Back Pain - PubMed
EXPRESSION OF CONCERN: Group-Based Task-Oriented Exercises Aimed at Managing Kinesiophobia Improved Disability in Chronic Low Back Pain
pubmed.ncbi.nlm.nih.gov
July 29, 2025 at 8:29 PM
An expression of concern for an RCT 2 years after we raised concerns around the trustworthiness of the data. pubmed.ncbi.nlm.nih.gov/40709807/ this trial influences guidelines www.sciencedirect.com/science/arti...
Be angry
A major NIH grant to study ways to restore hearing was terminated by the Trump administration bc it was awarded through a DEI initiative—to a researcher who qualified bc of his own hearing loss www.cnn.com/2025/07/29/h... @manorlaboratory.bsky.social
July 29, 2025 at 8:20 PM
Be angry
Reposted by Neil O’Connell
👉Predatory Conference Check List 👈
...based on my experience in detecting difficult cases, I did my own list for our group, as I was missing some points in those available... anyway, I'm happy to get suggestions etc.
#researchintegrity #PredatoryConference
download: www.uv.es/jogiers/pdf/...
...based on my experience in detecting difficult cases, I did my own list for our group, as I was missing some points in those available... anyway, I'm happy to get suggestions etc.
#researchintegrity #PredatoryConference
download: www.uv.es/jogiers/pdf/...
July 22, 2025 at 11:58 AM
👉Predatory Conference Check List 👈
...based on my experience in detecting difficult cases, I did my own list for our group, as I was missing some points in those available... anyway, I'm happy to get suggestions etc.
#researchintegrity #PredatoryConference
download: www.uv.es/jogiers/pdf/...
...based on my experience in detecting difficult cases, I did my own list for our group, as I was missing some points in those available... anyway, I'm happy to get suggestions etc.
#researchintegrity #PredatoryConference
download: www.uv.es/jogiers/pdf/...
Reposted by Neil O’Connell
Have you wanted to understand what is meant by “trustworthy” research? Attend this #webinar TODAY to hear from @davidhosch.bsky.social, @neiloconnell.bsky.social, @jdwilko.bsky.social, @nadiasoliman.bsky.social, @lesleyuttley.bsky.social bit.ly/4kSQjjy
July 21, 2025 at 12:00 PM
Have you wanted to understand what is meant by “trustworthy” research? Attend this #webinar TODAY to hear from @davidhosch.bsky.social, @neiloconnell.bsky.social, @jdwilko.bsky.social, @nadiasoliman.bsky.social, @lesleyuttley.bsky.social bit.ly/4kSQjjy
Nice piece from Nadia Soliman and Michael Ferraro in MJA Insight on the state of the evidence for the management of neuropathic pain: insightplus.mja.com.au/2025/28/neur...
Neuropathic pain: our best treatments still fall short - InSight+
Despite a large body of new evidence, our best treatments for neuropathic pain continue to provide only modest benefits. Neuropathic pain is a common and disabling condition caused by injury or diseas...
insightplus.mja.com.au
July 21, 2025 at 9:13 AM
Nice piece from Nadia Soliman and Michael Ferraro in MJA Insight on the state of the evidence for the management of neuropathic pain: insightplus.mja.com.au/2025/28/neur...
A Call for Reckoning and Reform in Interventional Pain Medicine and Neuromodulation Research
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
A Call for Reckoning and Reform in Interventional Pain Medicine and Neuromodulation Research
Published in Journal of Pain Research (Vol. 18, No. , 2025)
www.tandfonline.com
July 18, 2025 at 7:46 AM
A Call for Reckoning and Reform in Interventional Pain Medicine and Neuromodulation Research
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Delighted that the editors of 15 Pain and Anaesthesiology have chosen to endorse and amplify the ENTRUST-PE framework. More info here: www.linkedin.com/pulse/entrus...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social @ukrio.bsky.social @coarassessment.bsky.social
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social @ukrio.bsky.social @coarassessment.bsky.social
ENTRUST-PE: endorsement by senior editors of 15 Pain and Anaesthesiology Journals
We are beyond delighted that the ENTRUST-PE framework has been endorsed by the Editors in Chief of 15 International Pain and Anaesthesiology journals. Those editors are copublishing, across the journa...
www.linkedin.com
July 16, 2025 at 3:00 PM
Delighted that the editors of 15 Pain and Anaesthesiology have chosen to endorse and amplify the ENTRUST-PE framework. More info here: www.linkedin.com/pulse/entrus...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social @ukrio.bsky.social @coarassessment.bsky.social
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social @ukrio.bsky.social @coarassessment.bsky.social
Reposted by Neil O’Connell
Editorial: The editors-in-chief from @thejournalofpain.bsky.social & other pain/anesthesia journals come together to align and strengthen initiatives to enhance research integrity, trust, and impact across our field.
Full: doi.org/10.1016/j.jp...
Full: doi.org/10.1016/j.jp...
Redirecting
doi.org
July 14, 2025 at 12:31 PM
Editorial: The editors-in-chief from @thejournalofpain.bsky.social & other pain/anesthesia journals come together to align and strengthen initiatives to enhance research integrity, trust, and impact across our field.
Full: doi.org/10.1016/j.jp...
Full: doi.org/10.1016/j.jp...