Journal of Clinical Epidemiology
@jclinepi.bsky.social
Metascience and innovative methods to improve population health
Co-Editors-in-Chief: @andreatricco.bsky.social and @davidit.bsky.social
Jclinepi.com
Published by Elsevier
Co-Editors-in-Chief: @andreatricco.bsky.social and @davidit.bsky.social
Jclinepi.com
Published by Elsevier
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To connect our BlueSky community & promote the work of our authors, we started an #JClinEpi Authors Starter Pack.
If you've published with us and would like to be included, please reply with a short description of the paper and a link.
Toward transparent and accountable artificial intelligence in systematic review appraisal - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Toward transparent and accountable artificial intelligence in systematic review appraisal
We commend Marques-Cruz et al for their careful evaluation of large language models
(LLMs) in assessing the methodological quality of systematic reviews using the Reported
Methodological Quality (ReMa...
www.jclinepi.com
November 10, 2025 at 3:53 PM
Toward transparent and accountable artificial intelligence in systematic review appraisal - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
So where do we start? Prioritising clinical topics for the new Australian living guidelines for pregnancy and postnatal care - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
So where do we start? Prioritising clinical topics for the new Australian living guidelines for pregnancy and postnatal care
To undertake a formal process to identify and prioritise clinical topics for the updating
of the Australian Pregnancy Care Guidelines and development of new Australian Postnatal
Care Guidelines for th...
www.jclinepi.com
November 10, 2025 at 3:53 PM
So where do we start? Prioritising clinical topics for the new Australian living guidelines for pregnancy and postnatal care - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Framing Evidence Synthesis production with the lens of Sustainable Knowledge - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Framing Evidence Synthesis production with the lens of Sustainable Knowledge
Systematic reviews are widely recognized as the cornerstone of evidence-based health
decision-making. Individual studies are synthesized into coherent summaries, providing
clarity amid the complexity ...
www.jclinepi.com
November 10, 2025 at 3:52 PM
Framing Evidence Synthesis production with the lens of Sustainable Knowledge - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Most methodological characteristics do not exaggerate effect estimates in nutrition RCTs: findings from a meta-epidemiological study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Most methodological characteristics do not exaggerate effect estimates in nutrition RCTs: findings from a meta-epidemiological study
To evaluate the influence of bias from methodological characteristics on intervention
effect estimates in nutrition randomised controlled trials (RCTs) using the Cochrane
RoB2 tool.
www.jclinepi.com
November 10, 2025 at 3:51 PM
Most methodological characteristics do not exaggerate effect estimates in nutrition RCTs: findings from a meta-epidemiological study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Preference-based controlled design: toward increased patients’ engagement, efficiency and external validity of cardiovascular clinical trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Preference-based controlled design: toward increased patients’ engagement, efficiency and external validity of cardiovascular clinical trials
Randomized controlled trials (RCTs) are the gold standard for evaluating clinical
interventions, but their limitations—particularly in settings where strong patient
preferences exist—can impair recrui...
www.jclinepi.com
November 10, 2025 at 3:50 PM
Preference-based controlled design: toward increased patients’ engagement, efficiency and external validity of cardiovascular clinical trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Methodological review reveals essential gaps and inconsistencies in clinical claims, effects and outcomes in HTA reviews of diagnostic tests - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Methodological review reveals essential gaps and inconsistencies in clinical claims, effects and outcomes in HTA reviews of diagnostic tests
Essential first steps in performing a health technology assessment (HTA) for a diagnostic
test include: consideration of the clinical pathway in which the test will be used,
specifying the clinical cl...
www.jclinepi.com
November 10, 2025 at 3:50 PM
Methodological review reveals essential gaps and inconsistencies in clinical claims, effects and outcomes in HTA reviews of diagnostic tests - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
A qualitative study among guideline developers revealed challenges and strategies for rare disease guideline development - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
A qualitative study among guideline developers revealed challenges and strategies for rare disease guideline development
Clinical practice guideline (CPG) development for rare diseases is challenging due
to scarce evidence, small expert groups, limited resources, and heterogeneity and
complexity of conditions. Critical ...
www.jclinepi.com
November 10, 2025 at 3:45 PM
A qualitative study among guideline developers revealed challenges and strategies for rare disease guideline development - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Core GRADE unpacked: A summary of recent innovations in complementary GRADE Methodology - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Core GRADE unpacked: A summary of recent innovations in complementary GRADE Methodology
The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework
has become the global standard for rating evidence certainty and grading strength
of healthcare recommendations ...
www.jclinepi.com
November 10, 2025 at 3:44 PM
Core GRADE unpacked: A summary of recent innovations in complementary GRADE Methodology - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Editors' choice: The challenges and opportunities of artificial intelligence and their impact on the journal - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
The challenges and opportunities of artificial intelligence and their impact on the journal
As the keepers of the editorial “front door” of the journal, we are profoundly aware
of the myriad challenges and some opportunities that accompany the ubiquitous rise
of artificial intelligence (AI) ...
www.jclinepi.com
November 10, 2025 at 3:43 PM
Editors' choice: The challenges and opportunities of artificial intelligence and their impact on the journal - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Journal of Clinical Epidemiology
Glad to share our full paper on why deployed clinical prediction models should not discard predicted risks in favour of thresholds with @rexwp.bsky.social and @aidybarnett.bsky.social now up on @jclinepi.bsky.social. A brief explainer (1/4):
#statsky #rstats
authors.elsevier.com/a/1m1D83BcJQ...
#statsky #rstats
authors.elsevier.com/a/1m1D83BcJQ...
authors.elsevier.com
October 31, 2025 at 10:49 AM
Glad to share our full paper on why deployed clinical prediction models should not discard predicted risks in favour of thresholds with @rexwp.bsky.social and @aidybarnett.bsky.social now up on @jclinepi.bsky.social. A brief explainer (1/4):
#statsky #rstats
authors.elsevier.com/a/1m1D83BcJQ...
#statsky #rstats
authors.elsevier.com/a/1m1D83BcJQ...
Jurisdictional scans: methodological considerations for systematically analysing and comparing policy approaches across different jurisdictions - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Jurisdictional scans: methodological considerations for systematically analysing and comparing policy approaches across different jurisdictions
Jurisdictional scans are used to inform policy by systematically comparing how different
jurisdictions define problems, design policies, and implement strategies. They provide
insights into policy opt...
www.jclinepi.com
October 26, 2025 at 7:23 PM
Jurisdictional scans: methodological considerations for systematically analysing and comparing policy approaches across different jurisdictions - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Applying the GREET checklist for assessing reporting of evidence-based practice educational interventions and teaching showed inter-rater discrepancies and item-level challenges - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Applying the GREET checklist for assessing reporting of evidence-based practice educational interventions and teaching showed inter-rater discrepancies and item-level challenges
This study aimed to analyze in-depth inter-rater discrepancies in GREET (Guideline
for Reporting Evidence-Based Practice Educational Interventions and Teaching) item
ratings between two GREET-naïve da...
www.jclinepi.com
October 26, 2025 at 7:18 PM
Applying the GREET checklist for assessing reporting of evidence-based practice educational interventions and teaching showed inter-rater discrepancies and item-level challenges - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Identifying potentially inappropriate prescribing in entire populations: Coding the STOPP-START and Beers criteria for use with large, routinely collected population health datasets - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Identifying potentially inappropriate prescribing in entire populations: Coding the STOPP-START and Beers criteria for use with large, routinely collected population health datasets
Plain Language Summary: Older adults often take multiple medications, increasing the
risk of harmful drug interactions or unnecessary treatments. STOPP-START and Beers
criteria help doctors identify i...
www.jclinepi.com
October 26, 2025 at 7:18 PM
Identifying potentially inappropriate prescribing in entire populations: Coding the STOPP-START and Beers criteria for use with large, routinely collected population health datasets - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
So where do we start? Prioritising clinical topics for the new Australian living guidelines for pregnancy and postnatal care - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
So where do we start? Prioritising clinical topics for the new Australian living guidelines for pregnancy and postnatal care
To undertake a formal process to identify and prioritise clinical topics for the updating
of the Australian Pregnancy Care Guidelines and development of new Australian Postnatal
Care Guidelines for th...
www.jclinepi.com
October 26, 2025 at 7:17 PM
So where do we start? Prioritising clinical topics for the new Australian living guidelines for pregnancy and postnatal care - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reporting guidelines can be used to foster reporting of evidence-based research principles: A cross-sectional study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reporting guidelines can be used to foster reporting of evidence-based research principles: A cross-sectional study
The purpose of our study was to examine the presence and the extent of items related
to an evidence-based research (EBR) approach in reporting guidelines, as well as their
features and how these items...
www.jclinepi.com
October 19, 2025 at 2:40 PM
Reporting guidelines can be used to foster reporting of evidence-based research principles: A cross-sectional study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Network meta-analysis of prediction models using aggregate or individual participant data - A scoping review and recommendations for reporting and conduct - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Network meta-analysis of prediction models using aggregate or individual participant data - A scoping review and recommendations for reporting and conduct
Prediction models are essential in clinical decision-making for estimating the probability
of current (diagnosis, screening) or future (prognosis) outcomes. Network meta-analysis
(NMA) serves as a pow...
www.jclinepi.com
October 19, 2025 at 2:40 PM
Network meta-analysis of prediction models using aggregate or individual participant data - A scoping review and recommendations for reporting and conduct - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Continuous predicted risks should be retained when deploying clinical prediction models - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Continuous predicted risks should be retained when deploying clinical prediction models
Clinical prediction models are used to obtain predicted risks of a diagnosis or future
event. While models can produce continuous predicted probabilities, these are often
dichotomised or categorised i...
www.jclinepi.com
October 19, 2025 at 2:39 PM
Continuous predicted risks should be retained when deploying clinical prediction models - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Development and Validation of Case-Ascertainment Algorithms for Hypertensive Disorders of Pregnancy Using Longitudinal Electronic Health Records Data - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Development and Validation of Case-Ascertainment Algorithms for Hypertensive Disorders of Pregnancy Using Longitudinal Electronic Health Records Data
Hypertensive disorders of pregnancy (HDP), including chronic hypertension, gestational
hypertension, and preeclampsia/eclampsia, is a leading cause of maternal and perinatal
morbidity. Accurate identi...
www.jclinepi.com
October 19, 2025 at 2:34 PM
Development and Validation of Case-Ascertainment Algorithms for Hypertensive Disorders of Pregnancy Using Longitudinal Electronic Health Records Data - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
In humble defence of unexplainable black box prediction models in healthcare - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
In humble defence of unexplainable black box prediction models in healthcare
The increasing complexity of prediction models for healthcare purposes – whether developed
with or without artificial intelligence (AI) techniques – drives the urge to open
complex ‘black box’ models ...
www.jclinepi.com
October 19, 2025 at 2:33 PM
In humble defence of unexplainable black box prediction models in healthcare - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
A scoping review identified additional considerations for defining estimands in cluster randomised trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
A scoping review identified additional considerations for defining estimands in cluster randomised trials
An estimand is a clear description of the treatment effect a study aims to quantify.
The ICH E9(R1) addendum lists five attributes that should be described when defining
an estimand. However, the adde...
www.jclinepi.com
October 19, 2025 at 2:33 PM
A scoping review identified additional considerations for defining estimands in cluster randomised trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Methodological and Reporting Rigor in Non-Inferiority and Equivalence Trials for Multimodality Cancer Treatment: Lessons from Breast Cancer Radiotherapy - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Methodological and Reporting Rigor in Non-Inferiority and Equivalence Trials for Multimodality Cancer Treatment: Lessons from Breast Cancer Radiotherapy
To investigate the methodological and reporting quality of non-inferiority (NI) or
equivalence trials in breast cancer radiotherapy, providing suggestions for future
NI/equivalence trials.
www.jclinepi.com
October 19, 2025 at 2:31 PM
Methodological and Reporting Rigor in Non-Inferiority and Equivalence Trials for Multimodality Cancer Treatment: Lessons from Breast Cancer Radiotherapy - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Assessing the Impact of Unpublished Data on Network Meta-Analysis Outcomes in Outpatient Adults with Acute Migraine: A Study within a Review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Assessing the Impact of Unpublished Data on Network Meta-Analysis Outcomes in Outpatient Adults with Acute Migraine: A Study within a Review
Methodological guidance recommends including both published and unpublished data in
systematic reviews to enhance reliability and reduce potential bias.
www.jclinepi.com
October 19, 2025 at 2:30 PM
Assessing the Impact of Unpublished Data on Network Meta-Analysis Outcomes in Outpatient Adults with Acute Migraine: A Study within a Review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Systematic reviews on the same topic are common but often fail to meet key methodological standards: a research-on-research study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Systematic reviews on the same topic are common but often fail to meet key methodological standards: a research-on-research study
To assess 1)the frequency of overlapping systematic reviews (SRs) on the same topic
including overlap in outcomes, 2)whether SRs meet key methodological characteristics
and 3)to describe discrepancies...
www.jclinepi.com
October 19, 2025 at 2:27 PM
Systematic reviews on the same topic are common but often fail to meet key methodological standards: a research-on-research study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Jurisdictional scans: methodological considerations for systematically analysing and comparing policy approaches across different jurisdictions - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Jurisdictional scans: methodological considerations for systematically analysing and comparing policy approaches across different jurisdictions
Jurisdictional scans are used to inform policy by systematically comparing how different
jurisdictions define problems, design policies, and implement strategies. They provide
insights into policy opt...
www.jclinepi.com
October 19, 2025 at 2:26 PM
Jurisdictional scans: methodological considerations for systematically analysing and comparing policy approaches across different jurisdictions - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Statistical model assessment in published dose-response meta-analyses is suboptimal: Evidence from a methodological review and re-analysis of 242 datasets - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Statistical model assessment in published dose-response meta-analyses is suboptimal: Evidence from a methodological review and re-analysis of 242 datasets
Dose-response meta-analysis (DRMA) is a crucial clinical and epidemiological research
tool for synthesizing exposure-risk relationships. Despite its growing use, facilitated
by the availability of sta...
www.jclinepi.com
October 10, 2025 at 1:33 PM
Statistical model assessment in published dose-response meta-analyses is suboptimal: Evidence from a methodological review and re-analysis of 242 datasets - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...