Florian Naudet
@floriannaudet.bsky.social
Meta-researcher, Clinician, Professor at Rennes University, Senior member at Institut Universitaire de France, affiliate at METRICStanford. ORCID: 0000-0003-3760-3801
Posts are my own.
Website: https://restores.univ-rennes.fr/
Posts are my own.
Website: https://restores.univ-rennes.fr/
Pinned
Florian Naudet
@floriannaudet.bsky.social
· Nov 24
It is good to see the move on Bluesky because, X was starting to be boring. Nice to e-meet so many new followers here. Here is a 🧶 that is introduces most of my research interests. It is about #metaresearch #openscience and #medicine.
Reposted by Florian Naudet
Happy 2026!
Well, I guess it will be more difficult for 2027, but in the meantime, Happy New Year 2026…
January 2, 2026 at 5:09 PM
Happy 2026!
Reposted by Florian Naudet
#OA articles are cited more, help citizen scientists learn more about the topic they've helped on, but there’s little strong evidence they have other long-lasting effects on research, or many economic and social benefits www.science.org/content/arti...
@jeffreybrainard.bsky.social @science.org
@jeffreybrainard.bsky.social @science.org
Is ‘open science’ delivering benefits? Major study finds proof is sparse
It’s hard to measure social and economic impacts of making papers and data free, researchers say
www.science.org
January 2, 2026 at 10:54 AM
#OA articles are cited more, help citizen scientists learn more about the topic they've helped on, but there’s little strong evidence they have other long-lasting effects on research, or many economic and social benefits www.science.org/content/arti...
@jeffreybrainard.bsky.social @science.org
@jeffreybrainard.bsky.social @science.org
Reposted by Florian Naudet
Happy New Year, y'all.
I don't do resolutions, but: my best wishes to my research integrity friends on this platform. May you persevere and find success on the road ahead. Thank all of you for your mentorship and support.
I don't do resolutions, but: my best wishes to my research integrity friends on this platform. May you persevere and find success on the road ahead. Thank all of you for your mentorship and support.
January 1, 2026 at 4:29 AM
Happy New Year, y'all.
I don't do resolutions, but: my best wishes to my research integrity friends on this platform. May you persevere and find success on the road ahead. Thank all of you for your mentorship and support.
I don't do resolutions, but: my best wishes to my research integrity friends on this platform. May you persevere and find success on the road ahead. Thank all of you for your mentorship and support.
Well, I guess it will be more difficult for 2027, but in the meantime, Happy New Year 2026…
January 1, 2026 at 9:22 AM
Well, I guess it will be more difficult for 2027, but in the meantime, Happy New Year 2026…
Reposted by Florian Naudet
This “stellar groups” has a North Star…@floriannaudet.bsky.social An honor to be helping shine some additional light!
A 🧵 : As 2025 comes to an end, it is time to look back at the work done this year with a stellar group of colleagues, including @ioanaacristea.bsky.social, @eturnermd1.bsky.social and many others. If I had to highlight 1 paper, it would be our BMC Medicine Registered Report 🥇...
Efficacy and safety of esketamine for “treatment resistant depression”: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-con...
Background In 2019, the FDA and EMA approved intranasal esketamine for treatment-resistant depression (TRD). The current study re-evaluated its efficacy and safety. Methods This registered report pres...
link.springer.com
December 31, 2025 at 3:44 PM
This “stellar groups” has a North Star…@floriannaudet.bsky.social An honor to be helping shine some additional light!
A 🧵 : As 2025 comes to an end, it is time to look back at the work done this year with a stellar group of colleagues, including @ioanaacristea.bsky.social, @eturnermd1.bsky.social and many others. If I had to highlight 1 paper, it would be our BMC Medicine Registered Report 🥇...
Efficacy and safety of esketamine for “treatment resistant depression”: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-con...
Background In 2019, the FDA and EMA approved intranasal esketamine for treatment-resistant depression (TRD). The current study re-evaluated its efficacy and safety. Methods This registered report pres...
link.springer.com
December 31, 2025 at 2:29 PM
A 🧵 : As 2025 comes to an end, it is time to look back at the work done this year with a stellar group of colleagues, including @ioanaacristea.bsky.social, @eturnermd1.bsky.social and many others. If I had to highlight 1 paper, it would be our BMC Medicine Registered Report 🥇...
@richarddriley.bsky.social fantastic talk is now online. Thank you Richard and Merry Xmaths!
restores.univ-rennes.fr/highlights/1...
restores.univ-rennes.fr/highlights/1...
December 12, 2025 at 6:21 PM
@richarddriley.bsky.social fantastic talk is now online. Thank you Richard and Merry Xmaths!
restores.univ-rennes.fr/highlights/1...
restores.univ-rennes.fr/highlights/1...
Hello, new paper in @thelancetpsych.bsky.social : « Comparison of antidepressant deprescribing strategies in individuals with clinically remitted depression: a systematic review and network meta-analysis »
authors.elsevier.com/c/1mFU8_oNJN...
authors.elsevier.com/c/1mFU8_oNJN...
authors.elsevier.com
December 11, 2025 at 6:14 AM
Hello, new paper in @thelancetpsych.bsky.social : « Comparison of antidepressant deprescribing strategies in individuals with clinically remitted depression: a systematic review and network meta-analysis »
authors.elsevier.com/c/1mFU8_oNJN...
authors.elsevier.com/c/1mFU8_oNJN...
Reposted by Florian Naudet
Thank you @rachpips.bsky.social and @suziecro.bsky.social - this is great!! 🤣
December 10, 2025 at 9:25 PM
Thank you @rachpips.bsky.social and @suziecro.bsky.social - this is great!! 🤣
New post on ResToRes's website :
"When regulators find problems but papers stay silent"
The very first RestoRes study shows that concerns raised during EMA Good Clinical Practice inspections almost never appear in the medical literature.
restores.univ-rennes.fr/highlights/w...
"When regulators find problems but papers stay silent"
The very first RestoRes study shows that concerns raised during EMA Good Clinical Practice inspections almost never appear in the medical literature.
restores.univ-rennes.fr/highlights/w...
December 6, 2025 at 9:23 AM
New post on ResToRes's website :
"When regulators find problems but papers stay silent"
The very first RestoRes study shows that concerns raised during EMA Good Clinical Practice inspections almost never appear in the medical literature.
restores.univ-rennes.fr/highlights/w...
"When regulators find problems but papers stay silent"
The very first RestoRes study shows that concerns raised during EMA Good Clinical Practice inspections almost never appear in the medical literature.
restores.univ-rennes.fr/highlights/w...
Reposted by Florian Naudet
1/ Disclosure: No conflict of interest 👇
😜 Disclosure: the I am not the NAUDET selling Xmas trees 🌲 and this person is not from my family. I have no COI with the Xmas 🎄 business regarding our @plosbiology.org paper about meringue Xmas trees. 😅https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002953
December 25, 2024 at 3:52 PM
1/ Disclosure: No conflict of interest 👇
Reposted by Florian Naudet
Meta-🧵 (🧵 made of 🧵) on our last paper in @plosbiology.org with @constantvinatier.bsky.social, @ingestegeman.bsky.social, @hynekczu.bsky.social, L. Caquelin, @veerlevde.bsky.social & M. Kozula about meta-research. Please repost if you find it meta-enough or just in case you like Xmas spirit.
Public engagement with research reproducibility
Public engagement with reproducibility is crucial for fostering trust in science. This Community Page describes how, by using relatable analogies and hands-on activities, participants explored the cha...
journals.plos.org
December 25, 2024 at 3:52 PM
Meta-🧵 (🧵 made of 🧵) on our last paper in @plosbiology.org with @constantvinatier.bsky.social, @ingestegeman.bsky.social, @hynekczu.bsky.social, L. Caquelin, @veerlevde.bsky.social & M. Kozula about meta-research. Please repost if you find it meta-enough or just in case you like Xmas spirit.
Reposted by Florian Naudet
The abstract’s is a nice appetizer to taste ;) looking forward to read the piece ! Thanks for this
December 5, 2025 at 7:29 AM
The abstract’s is a nice appetizer to taste ;) looking forward to read the piece ! Thanks for this
New paper published in BMC Medicine led by the super cool Alexandre Terre Becker. This is part of the ResToRes project.
"Concordance between European medicine agency good clinical practice inspections and medical literature: a meta-research survey"
link.springer.com/article/10.1...
"Concordance between European medicine agency good clinical practice inspections and medical literature: a meta-research survey"
link.springer.com/article/10.1...
Concordance between European medicine agency good clinical practice inspections and medical literature: a meta-research survey - BMC Medicine
Background Health authorities, such as the European Medicines Agency (EMA), inspect clinical sites performing clinical trials and occasionally find evidence of substantial departures from Good Clinica...
link.springer.com
December 4, 2025 at 9:56 PM
New paper published in BMC Medicine led by the super cool Alexandre Terre Becker. This is part of the ResToRes project.
"Concordance between European medicine agency good clinical practice inspections and medical literature: a meta-research survey"
link.springer.com/article/10.1...
"Concordance between European medicine agency good clinical practice inspections and medical literature: a meta-research survey"
link.springer.com/article/10.1...
Reposted by Florian Naudet
Haha, this is brilliant 😂
December 4, 2025 at 7:21 PM
Haha, this is brilliant 😂
Reposted by Florian Naudet
A short preprint describing our adoption of more consistent and precise use of terminology related to reproducibility, robustness, replicability, repeatability, and credibility.
osf.io/preprints/me...
osf.io/preprints/me...
December 3, 2025 at 6:51 PM
A short preprint describing our adoption of more consistent and precise use of terminology related to reproducibility, robustness, replicability, repeatability, and credibility.
osf.io/preprints/me...
osf.io/preprints/me...
Reposted by Florian Naudet
We might be at a stage where systematic reviews without checks of trustworthiness become a problem in itself - even a danger to patients, as these reviews are considered as highest level of evidence and the foundation of guidelines and clinical practice
Currently busy with updating a systematic review and have the impression that the flood of "clinical studies" from certain countries is intensifying - results too good to be true: enduring effects (usually uncommon), no drop-out, perfectly balanced sample sizes etc.
December 3, 2025 at 8:35 PM
We might be at a stage where systematic reviews without checks of trustworthiness become a problem in itself - even a danger to patients, as these reviews are considered as highest level of evidence and the foundation of guidelines and clinical practice
New paper just out with @constantvinatier.bsky.social and al. in Research Integrity and Peer Review.
"Using reporting guidelines to improve the reproducibility of cooking Christmas tree meringues: the “People tasting trees” cluster-randomised controlled trial"
link.springer.com/article/10.1...
"Using reporting guidelines to improve the reproducibility of cooking Christmas tree meringues: the “People tasting trees” cluster-randomised controlled trial"
link.springer.com/article/10.1...
Using reporting guidelines to improve the reproducibility of cooking Christmas tree meringues: the “People tasting trees” cluster-randomised controlled trial - Research Integrity and Peer Review
Objectives To test whether improving a Christmas tree meringue recipe using reporting guidelines yields more appealing and sweeter meringues. Design A prospective, superiority, single-blind, cluster-r...
link.springer.com
December 3, 2025 at 8:55 AM
New paper just out with @constantvinatier.bsky.social and al. in Research Integrity and Peer Review.
"Using reporting guidelines to improve the reproducibility of cooking Christmas tree meringues: the “People tasting trees” cluster-randomised controlled trial"
link.springer.com/article/10.1...
"Using reporting guidelines to improve the reproducibility of cooking Christmas tree meringues: the “People tasting trees” cluster-randomised controlled trial"
link.springer.com/article/10.1...
Reposted by Florian Naudet
🚨 Our team has just published a Registered Report in BMC Medicine, one of the very few medical journals that offers this format (if we want better science, we should not follow journal impact factors, we should support journals with the best policies).
Efficacy and safety of esketamine for “treatment resistant depression”: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-con...
Background In 2019, the FDA and EMA approved intranasal esketamine for treatment-resistant depression (TRD). The current study re-evaluated its efficacy and safety. Methods This registered report pres...
link.springer.com
November 29, 2025 at 1:06 PM
🚨 Our team has just published a Registered Report in BMC Medicine, one of the very few medical journals that offers this format (if we want better science, we should not follow journal impact factors, we should support journals with the best policies).
Reposted by Florian Naudet
Proud to have been a member of @floriannaudet.bsky.social's team. Great to see this out!
A Registered Report is a publishing format in which the study question, hypotheses, and full methodology are peer-reviewed and accepted before the results are known.
November 29, 2025 at 7:26 PM
Proud to have been a member of @floriannaudet.bsky.social's team. Great to see this out!
🚨 Our team has just published a Registered Report in BMC Medicine, one of the very few medical journals that offers this format (if we want better science, we should not follow journal impact factors, we should support journals with the best policies).
Efficacy and safety of esketamine for “treatment resistant depression”: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-con...
Background In 2019, the FDA and EMA approved intranasal esketamine for treatment-resistant depression (TRD). The current study re-evaluated its efficacy and safety. Methods This registered report pres...
link.springer.com
November 29, 2025 at 1:06 PM
🚨 Our team has just published a Registered Report in BMC Medicine, one of the very few medical journals that offers this format (if we want better science, we should not follow journal impact factors, we should support journals with the best policies).
t is out in BMC Medicine with Ioana A. Cristea and others.
REGISTERED REPORT ON ESKETAMINE IN "TREATMENT RESISTANT" DEPRESSION. IPD META-ANALYSIS.
A more detailed post soon.
link.springer.com/article/10.1...
REGISTERED REPORT ON ESKETAMINE IN "TREATMENT RESISTANT" DEPRESSION. IPD META-ANALYSIS.
A more detailed post soon.
link.springer.com/article/10.1...
Efficacy and safety of esketamine for “treatment resistant depression”: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-con...
Background In 2019, the FDA and EMA approved intranasal esketamine for treatment-resistant depression (TRD). The current study re-evaluated its efficacy and safety. Methods This registered report pres...
link.springer.com
November 29, 2025 at 9:37 AM
t is out in BMC Medicine with Ioana A. Cristea and others.
REGISTERED REPORT ON ESKETAMINE IN "TREATMENT RESISTANT" DEPRESSION. IPD META-ANALYSIS.
A more detailed post soon.
link.springer.com/article/10.1...
REGISTERED REPORT ON ESKETAMINE IN "TREATMENT RESISTANT" DEPRESSION. IPD META-ANALYSIS.
A more detailed post soon.
link.springer.com/article/10.1...
Reposted by Florian Naudet
New preprint retracted randomized trials attributed to super-retractors and top-cited scientists with multiple retractions: secondary analysis of the VITALITY retrospective cohort
www.medrxiv.org/content/10.1...
Led by PhD students, C Lyu & M Matbouriahi, w/ @floriannaudet.bsky.social, J Ioannidis
www.medrxiv.org/content/10.1...
Led by PhD students, C Lyu & M Matbouriahi, w/ @floriannaudet.bsky.social, J Ioannidis
Retracted randomized trials attributed to super-retractors and top-cited scientists with multiple retractions: secondary analysis of the VITALITY retrospective cohort
Importance Multiple retractions from the same author often uncover issues affecting their entire work, such as having systematically altered or fabricated data.
Objectives Evaluate the contribution o...
www.medrxiv.org
November 27, 2025 at 3:34 PM
New preprint retracted randomized trials attributed to super-retractors and top-cited scientists with multiple retractions: secondary analysis of the VITALITY retrospective cohort
www.medrxiv.org/content/10.1...
Led by PhD students, C Lyu & M Matbouriahi, w/ @floriannaudet.bsky.social, J Ioannidis
www.medrxiv.org/content/10.1...
Led by PhD students, C Lyu & M Matbouriahi, w/ @floriannaudet.bsky.social, J Ioannidis