The ESPOD fellowship builds on the collaborative relationship between EMBL-EBI and the Wellcome Sanger Institute, offering projects that combine experimental (wet-lab) and computational (dry-lab) appr...

Variant effect prediction remains a key challenge to resolve in precision medicine. Sophisticated computational models that exploit sequence conservation and structure are increasingly successful in t...

Lambourne, Mattioli, Santoso, et al. compare protein isoforms of the same transcription factor genes through high-throughput profiling of DNA-binding, protein-binding, activation, localization, and condensate formation. Differences between isoforms are widespread, often unpredictable from sequence differences, and inform a disease-associated categorization of alternative isoforms into rewirers or negative regulators.

Lambourne, Mattioli, Santoso, et al. compare protein isoforms of the same transcription factor genes through high-throughput profiling of DNA-binding, protein-binding, activation, localization, and condensate formation. Differences between isoforms are widespread, often unpredictable from sequence differences, and inform a disease-associated categorization of alternative isoforms into rewirers or negative regulators.