Lara Muffley
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muffley.bsky.social
Lara Muffley
@muffley.bsky.social
430 followers 460 following 57 posts
Director of Program Operations (Variant Effects Portfolio) CMAP, CAVA and the Atlas of Variant Effects Alliance | she/her 🏳️‍🌈
https://fowlerlab.gs.washington.edu/people
https://brotmanbaty.org/research/atlas-of-variant-effects
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muffley.bsky.social
Lara Muffley @muffley.bsky.social · Nov 4
Looking for some heartwarming and interesting stories about early-career scientists making strides in genomics and precision medicine right here in Seattle? Check out the @brotmanbaty.bsky.social 's Promising Young Scientists Series! brotmanbaty.org/news/categor... @uwgenome.bsky.social
muffley.bsky.social
“THE ONLY THING MORE POWERFUL THAN HATE IS LOVE.”
February 9, 2026 at 1:39 AM
muffley.bsky.social
Let’s go Hawks!! 🏈
February 8, 2026 at 11:54 PM
muffley.bsky.social
Our @varianteffect.bsky.social annual reports summarize, celebrate and showcase our collective work.
Read the latest 🔖 zenodo.org/records/1833...
View them all 📖 www.varianteffect.org/annual-repor... #AnnualReport #GlobalAlliance
#FunctionalGenomics #Consortium
February 3, 2026 at 1:37 PM
Reposted by Lara Muffley
igvfconsortium.bsky.social
A recent preprint introduces MaveMD, a clinical interface for MaveDB that integrates MAVE data with ClinVar and ClinGen to support variant classification and reduce VUS uncertainty.

Uncover the science behind it:  www.medrxiv.org/content/10.1...
www.medrxiv.org
January 30, 2026 at 7:19 PM
Reposted by Lara Muffley
varianteffect.bsky.social
We’re happy to share our 2025 Annual Report!
A year of "momentum and connections"!
➡️ zenodo.org/records/1833...
#AnnualReport #GlobalAlliance #FunctionalGenomics #VariantEffect #Community
January 26, 2026 at 10:27 PM
muffley.bsky.social
Recommended reading!
January 16, 2026 at 1:17 PM
Reposted by Lara Muffley
varianteffect.bsky.social
The recording is now available www.youtube.com/watch?v=domr...
January 8, 2026 at 8:31 PM
Reposted by Lara Muffley
varianteffect.bsky.social
We have a special event coming up in early January.
Learn more and Save the Date!
ℹ️ www.varianteffect.org/event/firesi...
December 2, 2025 at 5:20 PM
muffley.bsky.social
Happening now!
Zoom link here: www.varianteffect.org/seminar-seri...
varianteffect.bsky.social Atlas of Variant Effects Alliance @varianteffect.bsky.social · Dec 2
Update for today's seminar: Presentation with @taylor-mighell.bsky.social (postdoc w/ @benlehner.bsky.social) on "Understanding GPCRs with massive mutagenesis"
(Thea will present with us at a later date)
Find the Zoom link on our website: www.varianteffect.org/seminar-seri...
December 2, 2025 at 5:08 PM
muffley.bsky.social
Today is the deadline to submit your abstract.
varianteffect.bsky.social Atlas of Variant Effects Alliance @varianteffect.bsky.social · Nov 27
Be sure to submit your abstract by December 1st! #VariantEffect26 #abstract #final #deadline
Please note that there will be no extensions ⌛
ℹ️ www.mss2026.org
December 1, 2025 at 6:40 PM
Reposted by Lara Muffley
varianteffect.bsky.social
Did you know that we have a Variant Effects Seminar Series playlist on YouTube? Tune in to watch previously recorded talks at your leisure 📺☕ www.youtube.com/playlist?lis... #FunctionalGenomics #Seminar
December 1, 2025 at 3:15 PM
Reposted by Lara Muffley
varianteffect.bsky.social
Tomorrow!
www.varianteffect.org/seminar-seri...
December 1, 2025 at 3:54 PM
Reposted by Lara Muffley
varianteffect.bsky.social
The FINAL Deadline to submit your #VariantEffect26
#abstract is ⏰🗓️🔜 December 1st, 2025!
ℹ️ www.mss2026.org
📝 docs.google.com/forms/d/e/1F...
MSS26 - Abstract submission
This form will enable you to submit an abstract for consideration for presentation at the 2026 Mutational Scanning Symposium & Workshop (MSS26). MSS26 will be held at the Aikenhead Centre for Medical ...
docs.google.com
November 27, 2025 at 1:39 PM
Reposted by Lara Muffley
varianteffect.bsky.social
Be sure to submit your abstract by December 1st! #VariantEffect26 #abstract #final #deadline
Please note that there will be no extensions ⌛
ℹ️ www.mss2026.org
November 27, 2025 at 1:44 PM
Reposted by Lara Muffley
amelierocks.bsky.social
So looking forward to this meeting!
muffley.bsky.social Lara Muffley @muffley.bsky.social · Nov 25
Also! We'd love your help in promoting this event in the #Australia #Australasia region! Topics and programming will be of interest to the #FunctionalGenomics #Genomics #Clinical #Research #Community ℹ️https://www.mss2026.org
November 25, 2025 at 7:29 PM
muffley.bsky.social
Also! We'd love your help in promoting this event in the #Australia #Australasia region! Topics and programming will be of interest to the #FunctionalGenomics #Genomics #Clinical #Research #Community ℹ️https://www.mss2026.org
November 25, 2025 at 7:17 PM
muffley.bsky.social
#VariantEffect26 will be in Melbourne Australia! 🐨
Note that there will be a computational modeling and a clinical variant interpretation workshop!!
Discounted tickets available for participants from LMICs.
More info and to register www.mss2026.org
varianteffect.bsky.social Atlas of Variant Effects Alliance @varianteffect.bsky.social · Nov 24
If you are planning to attend the Mutational Scanning Symposium (and companion workshops!) we recommend that you register as soon as possible to secure your spot!
ℹ️ www.mss2026.org
Keynotes! @mehurles.bsky.social @maitreya.bsky.social
#VariantEffect26 #Symposium #Workshop #RegisterNow
November 24, 2025 at 3:12 PM
Reposted by Lara Muffley
chaiannng.bsky.social
Thank you @amglazer.bsky.social for the exciting opportunity to collaborate! Since then, we've provided functional evidence supporting the VUS reclassification in children with abnormal sodium #ionchannel function at Sydney Children’s Hospital.
amglazer.bsky.social Andrew Glazer @amglazer.bsky.social · Nov 20
📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]
November 21, 2025 at 12:14 AM
Reposted by Lara Muffley
varianteffect.bsky.social
🧬 #SponsorshipOpportunity #VariantEffect26
For more info reach out directly to @muffley.bsky.social
or inquire here 📧 www.mss2026.org
We'd love to have your support!
November 18, 2025 at 12:47 PM
muffley.bsky.social
Join us for a special @varianteffect.bsky.social Fireside Chat on Jan 6th, 2026 (9-10am Pacific) w/ @maitreya.bsky.social (@uwgenome.bsky.social) & @mehurles.bsky.social (@sangerinstitute.bsky.social)

Visit www.varianteffect.org/event/firesi...
for more info and to add this event to your calendar
The image is a promotional graphic for a "Fireside Chat" event organized by the Variant Effects Seminar Series and the AVE Alliance. The background is light gray, and the text is in dark gray and green. At the top, there is a stylized image of a fireplace with flames. Below, bold text reads "Fireside Chat," with an invitation to join on January 6th, 2026, featuring Dr. Maitreya Dunham and Dr. Matthew Hurles discussing MAVEs in clinical space and model organism systems. The date and time are highlighted in dark and light green ovals: "01.06.26" and "9:00AM (Pacific)." To the right, the Atlas of Variant Effects logo is displayed featuring stylized DNA strands formed by interwoven lines. At the bottom, there are two photos: on the left is Dr. Maitreya Dunham, with the text "Maitreya Dunham, University of Washington," and on the right is Dr. Matthew Hurles, with the text "Matthew Hurles, Wellcome Sanger Institute."
November 10, 2025 at 2:30 PM
muffley.bsky.social
Looking for some heartwarming and interesting stories about early-career scientists making strides in genomics and precision medicine right here in Seattle? Check out the @brotmanbaty.bsky.social 's Promising Young Scientists Series! brotmanbaty.org/news/categor... @uwgenome.bsky.social
November 4, 2025 at 6:48 PM
muffley.bsky.social
🦕🦖🦕🦖🦕🦖 Conference dinner at Melbourne Museum ! Yes please.
varianteffect.bsky.social Atlas of Variant Effects Alliance @varianteffect.bsky.social · Nov 4
2026 Mutational Scanning Symposium & Workshop will be here before you know it! Register now to secure your spot and get a ticket 🎟️ for the conference dinner at Melbourne Museum! 🦕 tinyurl.com/MSS26Registr... #VariantEffect26 #Dinosaurs #RegisterNow
November 4, 2025 at 3:13 PM
Reposted by Lara Muffley
varianteffect.bsky.social
🗓️Abstract Deadline Extended
to December 1st, 2025!
#VariantEffect26
ℹ️https://www.mss2026.org
November 3, 2025 at 2:30 PM
Reposted by Lara Muffley
varianteffect.bsky.social
We have an incredible speaker line-up for next years Mutational Scanning Symposium 🤩. Register now and submit your abstract before the deadline next week!
ℹ️ www.mss2026.org
#VariantEffect26 #FOMO #Functional #Genomics #Symposium #Abstract #Deadline
October 31, 2025 at 2:11 PM
Reposted by Lara Muffley
varianteffect.bsky.social
brotmanbaty.org/news/q-and-a... @brotmanbaty.bsky.social Q&A with #VariantEffect26 co-organizer Rehan Villani.
October 17, 2025 at 6:10 PM