Max Hockenberry
@maxhock.bsky.social
PhD Candidate @ UNC Chapel Hill @ Bear and Legant labs
Thinks mechanobiology, cellular forces, and cell migration are kinda neat.
Thinks mechanobiology, cellular forces, and cell migration are kinda neat.
Reposted by Max Hockenberry
🔔🧪 Super interesting paper from the Sanz-Moreno group showing that the #ECMatrix influences #tumour #dissemination, with distinct #structure in different tumour regions that then affect #invasion patterns.
#cancer #metastasis #mechanosensing
#mechanoregulation
www.nature.com/articles/s41...
#cancer #metastasis #mechanosensing
#mechanoregulation
www.nature.com/articles/s41...
Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis - Nature Communications
Interactions with the extracellular matrix (ECM) control tumor proliferation, invasion and metastasis. Here, authors provide spatial information on ECM organization and how it influences tumor cell in...
www.nature.com
February 14, 2025 at 5:45 PM
🔔🧪 Super interesting paper from the Sanz-Moreno group showing that the #ECMatrix influences #tumour #dissemination, with distinct #structure in different tumour regions that then affect #invasion patterns.
#cancer #metastasis #mechanosensing
#mechanoregulation
www.nature.com/articles/s41...
#cancer #metastasis #mechanosensing
#mechanoregulation
www.nature.com/articles/s41...
Reposted by Max Hockenberry
NIH-funded research is at risk. Cuts to federal funding could harm science and the economy. Contact Congress now to protect research. Every call matters. Find your reps at govtrack.us and speak up today. #FundScience
www.ascb.org/science-poli...
www.ascb.org/science-poli...
February 13, 2025 at 3:30 PM
NIH-funded research is at risk. Cuts to federal funding could harm science and the economy. Contact Congress now to protect research. Every call matters. Find your reps at govtrack.us and speak up today. #FundScience
www.ascb.org/science-poli...
www.ascb.org/science-poli...
Reposted by Max Hockenberry
Two great talks today from Chris Ho @chrisho.bsky.social and Julio Belmonte at the UNC MathBio seminar series. Interesting discussions on the role of Coronin 1a and Trim67 interactions in neuron growth cone guidance and the connectivity requirements of local and global cytoskeleton contraction.
December 4, 2024 at 7:46 PM
Two great talks today from Chris Ho @chrisho.bsky.social and Julio Belmonte at the UNC MathBio seminar series. Interesting discussions on the role of Coronin 1a and Trim67 interactions in neuron growth cone guidance and the connectivity requirements of local and global cytoskeleton contraction.
Reposted by Max Hockenberry
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
December 3, 2024 at 9:18 AM
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
Reposted by Max Hockenberry
🕵🏼1 month ago we published in NatComm new insights on how #CCM vascular lesions are formed by mutated AND healthy ECs.
Mutated "convince" healthy to join a lesion via:
💪🏼Forces
🛤️Paths in ECM
🧬Reprogramming
#mechanobiology #TFM
👀 See Shapeti et al. here 👇🏼📰
www.nature.com/articles/s41...
Mutated "convince" healthy to join a lesion via:
💪🏼Forces
🛤️Paths in ECM
🧬Reprogramming
#mechanobiology #TFM
👀 See Shapeti et al. here 👇🏼📰
www.nature.com/articles/s41...
Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth - Nature Communications
In cerebral cavernous malformations, mutant cells recruit healthy endothelial cells to form mosaic lesions. Here, the authors show that mutant cells can hijack and reprogram neighboring wildtype cells...
www.nature.com
November 18, 2024 at 8:09 AM
🕵🏼1 month ago we published in NatComm new insights on how #CCM vascular lesions are formed by mutated AND healthy ECs.
Mutated "convince" healthy to join a lesion via:
💪🏼Forces
🛤️Paths in ECM
🧬Reprogramming
#mechanobiology #TFM
👀 See Shapeti et al. here 👇🏼📰
www.nature.com/articles/s41...
Mutated "convince" healthy to join a lesion via:
💪🏼Forces
🛤️Paths in ECM
🧬Reprogramming
#mechanobiology #TFM
👀 See Shapeti et al. here 👇🏼📰
www.nature.com/articles/s41...
Reposted by Max Hockenberry
Just out! Exploring the Impact of Variability in Cell Segmentation and Tracking Approaches. Published in Microscopy Research and Technique. Thanks #BBSRC for funding.
see: doi.org/10.1002/jemt...
@laurawiggins13.bsky.social @globias.bsky.social @eurobioimaging.bsky.social
see: doi.org/10.1002/jemt...
@laurawiggins13.bsky.social @globias.bsky.social @eurobioimaging.bsky.social
Exploring the Impact of Variability in Cell Segmentation and Tracking Approaches
While manual segmentation and tracking of cells from microscopy images remain common practices in biological studies, our work demonstrates the inter- and intra-user variability that can arise from t...
doi.org
November 21, 2024 at 3:10 PM
Just out! Exploring the Impact of Variability in Cell Segmentation and Tracking Approaches. Published in Microscopy Research and Technique. Thanks #BBSRC for funding.
see: doi.org/10.1002/jemt...
@laurawiggins13.bsky.social @globias.bsky.social @eurobioimaging.bsky.social
see: doi.org/10.1002/jemt...
@laurawiggins13.bsky.social @globias.bsky.social @eurobioimaging.bsky.social
Reposted by Max Hockenberry
Total articles have grown exponentially in the last few years. Academics know this, cause they're sick and tired of requests to review, or submit their 'preeminent paper' to journal "justmadeup" - for a fee of course.
What's striking is how this has grown disproportionate to no. of scientists 🧵 2/n
What's striking is how this has grown disproportionate to no. of scientists 🧵 2/n
November 19, 2024 at 12:27 PM
Total articles have grown exponentially in the last few years. Academics know this, cause they're sick and tired of requests to review, or submit their 'preeminent paper' to journal "justmadeup" - for a fee of course.
What's striking is how this has grown disproportionate to no. of scientists 🧵 2/n
What's striking is how this has grown disproportionate to no. of scientists 🧵 2/n
Reposted by Max Hockenberry
Traction force microscopy is important tool for #mechanobiology!
Check our thread for some of the historic papers moving the technique forward!
Check our thread for some of the historic papers moving the technique forward!
Cells are strong & generate forces while interacting with their environment.
Traction Force Microscopy has been instrumental in measuring these forces, revealing the underlying mechanics. Let's explore pioneering papers in this 🧵by @onenimesa.bsky.social & @juliaeckert.bsky.social
Traction Force Microscopy has been instrumental in measuring these forces, revealing the underlying mechanics. Let's explore pioneering papers in this 🧵by @onenimesa.bsky.social & @juliaeckert.bsky.social
November 17, 2024 at 3:03 PM
Traction force microscopy is important tool for #mechanobiology!
Check our thread for some of the historic papers moving the technique forward!
Check our thread for some of the historic papers moving the technique forward!
Reposted by Max Hockenberry
Q: What's wrong with these plots?
A: Pooling cell-level measurements across multiple runs conceals experimental reproducibility.
Read more in JCB (with @fritzlaylin.bsky.social @katrinavelle.bsky.social & Dyche Mullins): rupress.org/jcb/article/...
A: Pooling cell-level measurements across multiple runs conceals experimental reproducibility.
Read more in JCB (with @fritzlaylin.bsky.social @katrinavelle.bsky.social & Dyche Mullins): rupress.org/jcb/article/...
November 18, 2024 at 7:02 PM
Q: What's wrong with these plots?
A: Pooling cell-level measurements across multiple runs conceals experimental reproducibility.
Read more in JCB (with @fritzlaylin.bsky.social @katrinavelle.bsky.social & Dyche Mullins): rupress.org/jcb/article/...
A: Pooling cell-level measurements across multiple runs conceals experimental reproducibility.
Read more in JCB (with @fritzlaylin.bsky.social @katrinavelle.bsky.social & Dyche Mullins): rupress.org/jcb/article/...
Reposted by Max Hockenberry
Hi #cancer, #ECMatrix, #biomaterials and #mechanobiology folks:
Below a Nat Cell Biol paper from the Chen and Weaver groups, of interest to many of us 🧪👇:
www.nature.com/articles/s41...
Below a Nat Cell Biol paper from the Chen and Weaver groups, of interest to many of us 🧪👇:
www.nature.com/articles/s41...
Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option - Nature Cell Biology
Uroz et al. report that the distinct mechanical properties of brain vasculature versus parenchyma drive cancer cell migration through a talin-dependent mechanism, enabling vessel co-option and metasta...
www.nature.com
November 18, 2024 at 10:14 AM
Hi #cancer, #ECMatrix, #biomaterials and #mechanobiology folks:
Below a Nat Cell Biol paper from the Chen and Weaver groups, of interest to many of us 🧪👇:
www.nature.com/articles/s41...
Below a Nat Cell Biol paper from the Chen and Weaver groups, of interest to many of us 🧪👇:
www.nature.com/articles/s41...
Reposted by Max Hockenberry
Chromatin compaction during confined cell migration induces and reshapes nuclear condensates.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Chromatin compaction during confined cell migration induces and reshapes nuclear condensates - Nature Communications
Cell migration through narrow constrictions during cancer metastasis significantly deforms the nucleus, creating mechanical stress on chromatin. Here, the authors reveal that such chromatin deformatio...
doi.org
November 18, 2024 at 1:58 PM
Chromatin compaction during confined cell migration induces and reshapes nuclear condensates.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Max Hockenberry
Reposted by Max Hockenberry
Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing www.science.org/doi/10.1126/...
Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing
Viscosity blunts cell response to stiff matrices in agreement with a pull-and-hold model of molecular clutch-based mechanosensing.
www.science.org
November 16, 2024 at 9:46 AM
Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing www.science.org/doi/10.1126/...
Something we’ve been working on recently: soft PDMS micropatterned channels for traction force microscopy during confined migration. If you’re interested in seeing cells crawl through them while we measure traction forces take a look at our recent preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 16, 2024 at 12:36 AM
Something we’ve been working on recently: soft PDMS micropatterned channels for traction force microscopy during confined migration. If you’re interested in seeing cells crawl through them while we measure traction forces take a look at our recent preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Max Hockenberry
Thought this would be a great opportunity to gather the #mechanobiology community. Please feel free to spread the word.
go.bsky.app/G5cQqYT
go.bsky.app/G5cQqYT
November 11, 2024 at 3:09 PM
Thought this would be a great opportunity to gather the #mechanobiology community. Please feel free to spread the word.
go.bsky.app/G5cQqYT
go.bsky.app/G5cQqYT
Reposted by Max Hockenberry
Introducing "3D Micropatterned Traction Force Microscopy", our new joint work with Pere Roca-Cusach's lab, led by amazing Laura Faure and Manu Gómez. Hope you find it useful!👇
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
November 15, 2024 at 1:37 PM
Introducing "3D Micropatterned Traction Force Microscopy", our new joint work with Pere Roca-Cusach's lab, led by amazing Laura Faure and Manu Gómez. Hope you find it useful!👇
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....