Matteo Fiorenza
@matteo-fiorenza.bsky.social
Assistant Professor in Clinical Translational Metabolism at the University of Copenhagen | #Physiology #Metabolism #Mitochondria #Diabetes #Obesity #Exercise #Muscle
Pinned
Hello @bsky.app #science community!
I'll be sharing papers on #physiology, #metabolism, #diabetes, #obesity, #mitochondria, #muscle, and #exercise.
If you are working in these areas, reach out and connect.
I'll be sharing papers on #physiology, #metabolism, #diabetes, #obesity, #mitochondria, #muscle, and #exercise.
If you are working in these areas, reach out and connect.
✨Proud moment at #EASD2025
Tue L. Nielsen presented our MITO-DYS-IR study results in the plenary hall, uncovering the causal role of #muscle #mitochondrial defects in #diabetes pathophysiology
Grateful to our collaborators and @easdnews.bsky.social Early Career Academy for the Best Abstract Award
Tue L. Nielsen presented our MITO-DYS-IR study results in the plenary hall, uncovering the causal role of #muscle #mitochondrial defects in #diabetes pathophysiology
Grateful to our collaborators and @easdnews.bsky.social Early Career Academy for the Best Abstract Award
September 19, 2025 at 4:20 PM
✨Proud moment at #EASD2025
Tue L. Nielsen presented our MITO-DYS-IR study results in the plenary hall, uncovering the causal role of #muscle #mitochondrial defects in #diabetes pathophysiology
Grateful to our collaborators and @easdnews.bsky.social Early Career Academy for the Best Abstract Award
Tue L. Nielsen presented our MITO-DYS-IR study results in the plenary hall, uncovering the causal role of #muscle #mitochondrial defects in #diabetes pathophysiology
Grateful to our collaborators and @easdnews.bsky.social Early Career Academy for the Best Abstract Award
If you’re at #EASD2025 and interested in potential mechanisms that protect against obesity, don’t miss:
“LBA SO 02 – Thinking Big About Treating Obesity”
📍 Short Oral Station 23 (Hall C)
📅 Tuesday, 16 Sept
⏰ 13:15
@easdnews.bsky.social
“LBA SO 02 – Thinking Big About Treating Obesity”
📍 Short Oral Station 23 (Hall C)
📅 Tuesday, 16 Sept
⏰ 13:15
@easdnews.bsky.social
September 16, 2025 at 9:48 AM
If you’re at #EASD2025 and interested in potential mechanisms that protect against obesity, don’t miss:
“LBA SO 02 – Thinking Big About Treating Obesity”
📍 Short Oral Station 23 (Hall C)
📅 Tuesday, 16 Sept
⏰ 13:15
@easdnews.bsky.social
“LBA SO 02 – Thinking Big About Treating Obesity”
📍 Short Oral Station 23 (Hall C)
📅 Tuesday, 16 Sept
⏰ 13:15
@easdnews.bsky.social
Reposted by Matteo Fiorenza
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
July 17, 2025 at 1:25 AM
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Matteo Fiorenza
Here it is proposed that halofuginone, a FDA–approved anti-scleroderma and antiprotozoal drug, is a promising anti-#obesity agent acting via FGF-21 and GDF-15 in preclinical mouse and pig models www.science.org/doi/10.1126/...
The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21
Halofuginone curbs weight gain in mice and pigs.
www.science.org
March 26, 2025 at 7:44 PM
Here it is proposed that halofuginone, a FDA–approved anti-scleroderma and antiprotozoal drug, is a promising anti-#obesity agent acting via FGF-21 and GDF-15 in preclinical mouse and pig models www.science.org/doi/10.1126/...
Reposted by Matteo Fiorenza
Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans
Selective targeting of mitochondrial oxidative stress mitigates lipid-induced insulin resistance in humans.
science.org
November 20, 2024 at 3:42 PM
Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
Kicking off 2025 with a highlight from our 2024 study in #CellReportsMedicine @cellpress.bsky.social
We uncovered the potential role of a metabokine-sphingolipid axis in sustaining weight loss in humans with #obesity.
1/10 🧵👇
We uncovered the potential role of a metabokine-sphingolipid axis in sustaining weight loss in humans with #obesity.
1/10 🧵👇
Weight-loss maintenance is accompanied by interconnected alterations in circulating FGF21-adiponectin-leptin and bioactive sphingolipids
Fiorenza et al. reveal selective and dynamic alterations in energy-balance-regulating metabokines and sphingolipids throughout weight loss, weight-loss maintenance, and weight regain in adults with obesity. Weight-loss maintenance elicits distinct remodeling patterns within the FGF21-adiponectin-leptin-sphingolipid axis as compared with weight regain, and these changes are associated with cardiometabolic health outcomes.
www.cell.com
January 6, 2025 at 4:07 PM
Kicking off 2025 with a highlight from our 2024 study in #CellReportsMedicine @cellpress.bsky.social
We uncovered the potential role of a metabokine-sphingolipid axis in sustaining weight loss in humans with #obesity.
1/10 🧵👇
We uncovered the potential role of a metabokine-sphingolipid axis in sustaining weight loss in humans with #obesity.
1/10 🧵👇
Reposted by Matteo Fiorenza
Views about the causes of obesity have polarised. Characterised by low carb and energy balance models. Last year NovoNordisk invited the protagonists of these models to Copenhagen to discuss commonalities and differences. The resultant paper has now been published in Nature Metabolism rdcu.be/dZryb
On the pathogenesis of obesity: causal models and missing pieces of the puzzle
Nature Metabolism - This authoritative Perspective lays a foundation for the field of obesity research by comparing commonalities and differences between competing models of obesity pathogenesis...
rdcu.be
November 21, 2024 at 1:23 PM
Views about the causes of obesity have polarised. Characterised by low carb and energy balance models. Last year NovoNordisk invited the protagonists of these models to Copenhagen to discuss commonalities and differences. The resultant paper has now been published in Nature Metabolism rdcu.be/dZryb
Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans
Selective targeting of mitochondrial oxidative stress mitigates lipid-induced insulin resistance in humans.
science.org
November 20, 2024 at 3:42 PM
Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
Reposted by Matteo Fiorenza
A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 18, 2024 at 4:36 PM
A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hello @bsky.app #science community!
I'll be sharing papers on #physiology, #metabolism, #diabetes, #obesity, #mitochondria, #muscle, and #exercise.
If you are working in these areas, reach out and connect.
I'll be sharing papers on #physiology, #metabolism, #diabetes, #obesity, #mitochondria, #muscle, and #exercise.
If you are working in these areas, reach out and connect.
November 18, 2024 at 4:13 PM
Hello @bsky.app #science community!
I'll be sharing papers on #physiology, #metabolism, #diabetes, #obesity, #mitochondria, #muscle, and #exercise.
If you are working in these areas, reach out and connect.
I'll be sharing papers on #physiology, #metabolism, #diabetes, #obesity, #mitochondria, #muscle, and #exercise.
If you are working in these areas, reach out and connect.
Reposted by Matteo Fiorenza
New preprint! We show that GLP1RA semaglutide increases skeletal muscle OXPHOS efficiency in mice. Improved energy efficiency would be predicted to lower energy expenditure and may contribute to propensity for weight regain. www.biorxiv.org/content/10.1...
Semaglutide-induced weight loss improves mitochondrial energy efficiency in skeletal muscle
Objective: Glucagon-like peptide 1 receptor agonists (e.g. semaglutide) potently induce weight loss and thereby reducing obesity-related complications. However, weight regain occurs when treatment is ...
www.biorxiv.org
November 16, 2024 at 3:22 AM
New preprint! We show that GLP1RA semaglutide increases skeletal muscle OXPHOS efficiency in mice. Improved energy efficiency would be predicted to lower energy expenditure and may contribute to propensity for weight regain. www.biorxiv.org/content/10.1...
Reposted by Matteo Fiorenza
People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.
a bald man in a blue suit is making a funny face and pointing at something .
ALT: a bald man in a blue suit is making a funny face and pointing at something .
media.tenor.com
November 13, 2024 at 7:24 PM
People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.