Markus Elsner
@markuselsner.bsky.social
Deputy Director of the Institute for Intelligent Biotechnologies at HelmholtzMunich, former editor @naturebiotech.bsky.social, all views expressed here are my own
Reposted by Markus Elsner
The November issue is live nature.com/nbt/volumes/...
On the cover, lipid nanoparticles targeting the lung, designed using neural networks. A method developed by Witten et al. identified two structures that efficiently delivered mRNA to ferret lungs go.nature.com/4fbj0VU
On the cover, lipid nanoparticles targeting the lung, designed using neural networks. A method developed by Witten et al. identified two structures that efficiently delivered mRNA to ferret lungs go.nature.com/4fbj0VU
November 12, 2025 at 7:03 PM
The November issue is live nature.com/nbt/volumes/...
On the cover, lipid nanoparticles targeting the lung, designed using neural networks. A method developed by Witten et al. identified two structures that efficiently delivered mRNA to ferret lungs go.nature.com/4fbj0VU
On the cover, lipid nanoparticles targeting the lung, designed using neural networks. A method developed by Witten et al. identified two structures that efficiently delivered mRNA to ferret lungs go.nature.com/4fbj0VU
I just watched House of Dynamite on Netflix. Insanely good and more scary than any horror movie.
November 12, 2025 at 10:01 PM
I just watched House of Dynamite on Netflix. Insanely good and more scary than any horror movie.
Reposted by Markus Elsner
It's been nearly two years since the first gene-editing therapy, Casgevy, was approved for sickle cell disease. Just 39 patients worldwide have received it in that time. This is from a Nov. 10 update from manufacturer Vertex:
November 12, 2025 at 4:58 PM
It's been nearly two years since the first gene-editing therapy, Casgevy, was approved for sickle cell disease. Just 39 patients worldwide have received it in that time. This is from a Nov. 10 update from manufacturer Vertex:
Flu and Corona shot for this year ✅️
November 11, 2025 at 10:45 AM
Flu and Corona shot for this year ✅️
Reposted by Markus Elsner
Big pharma shares its machine learning models with biotechs, but awaits definitive data on success of artificial intelligence-generated drugs www.nature.com/articles/s41...
Drugmakers share data to feed voracious foundation models - Nature Biotechnology
Big pharma shares its machine learning models with biotechs, but awaits definitive data on success of artificial intelligence-generated drugs.
www.nature.com
November 10, 2025 at 9:09 PM
Big pharma shares its machine learning models with biotechs, but awaits definitive data on success of artificial intelligence-generated drugs www.nature.com/articles/s41...
😮
The protein concentration in the cytoplasm is so high that the average protein has a water hydration shell with a thickness of only ≈ 10 water molecules separating it from the adjacent protein hydration shell.
1/2
1/2
November 10, 2025 at 1:39 PM
😮
We went to see the fantastic exhibition on Marcus Aurelius in Trier today. Really worth a visit (ends in two weeks, though)
November 8, 2025 at 10:39 PM
We went to see the fantastic exhibition on Marcus Aurelius in Trier today. Really worth a visit (ends in two weeks, though)
💯
![Comic. [Person sitting at desk with laptop with machine labeled E-21 making “click click” noises on the floor behind] VOICE FROM LAPTOP: Hey all! Does your E-21 humidifier make an annoying clicking noise? Mine did, but I finally figured out that there’s an easy fix, so I made this video in case anyone else… PERSON AT DESK: Oh my god. Yes. *Yes.* [caption] I know there’s more important work in the world, but I feel like these people deserve, at minimum a statue.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreifdjde6wgflkeil7kf4kdh3zqk32k55rkljlwu6arzbw557ogbulu@jpeg)
November 6, 2025 at 7:03 AM
💯
Took a while, but here is the skeetorial for the latest reprint from our lab. Let us know what you think!
We are introducing LipiGo 🤗
A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...
A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...
November 4, 2025 at 4:09 PM
Took a while, but here is the skeetorial for the latest reprint from our lab. Let us know what you think!
🤣
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
November 3, 2025 at 9:38 PM
🤣
Reposted by Markus Elsner
Wer unsere Arbeit unterstützen möchte, kann das über Patreon tun - oder ganz einfach hier entlang 👇
😊
sicherheitspod.de/spenden/
😊
sicherheitspod.de/spenden/
Spenden - Sicherheitspod
Sicherheitshalber ist eine Privatinitiative von Ulrike Franke, Carlo Masala, Frank Sauer und Thomas Wiegold. Wir freuen uns über Unterstützung für den Betrieb des Podcasts und dieser Webseite – das ge...
sicherheitspod.de
November 3, 2025 at 12:37 PM
Wer unsere Arbeit unterstützen möchte, kann das über Patreon tun - oder ganz einfach hier entlang 👇
😊
sicherheitspod.de/spenden/
😊
sicherheitspod.de/spenden/
And Germany?
November 3, 2025 at 8:30 PM
And Germany?
Reposted by Markus Elsner
Europa ist viel sicherer als die USA
November 2, 2025 at 7:22 PM
Europa ist viel sicherer als die USA
Reposted by Markus Elsner
#MosaicMonday - Central medallion of the Polydus Mosaic depicting a popular charioteer for the red faction (factio russata) and his lead horse Compressor. From a Roman villa in Augusta Treverorum, dated to the 3rd century AD.
Rheinisches Landesmuseum Trier, Germany.
Rheinisches Landesmuseum Trier, Germany.
November 3, 2025 at 4:55 PM
#MosaicMonday - Central medallion of the Polydus Mosaic depicting a popular charioteer for the red faction (factio russata) and his lead horse Compressor. From a Roman villa in Augusta Treverorum, dated to the 3rd century AD.
Rheinisches Landesmuseum Trier, Germany.
Rheinisches Landesmuseum Trier, Germany.
Reposted by Markus Elsner
Spend a day with me on the campaign trail in Virginia.
November 2, 2025 at 2:18 PM
Spend a day with me on the campaign trail in Virginia.
Reposted by Markus Elsner
An iPSC heart muscle cell forming sarcomeres videoed through a microscope by Emma Koory for 20 h before it dies most dramatically. This was our first try on a new microscope, and Emma now has the imaging parameters dialed in so her cells do not go POP! Alpha-actinin-2 is shown. #CellBiology
October 31, 2025 at 2:46 PM
An iPSC heart muscle cell forming sarcomeres videoed through a microscope by Emma Koory for 20 h before it dies most dramatically. This was our first try on a new microscope, and Emma now has the imaging parameters dialed in so her cells do not go POP! Alpha-actinin-2 is shown. #CellBiology
Having worked with AI-based image generation for the last day, I think human graphics designers will have a job for a very long time.
🤯
🤯
October 31, 2025 at 11:11 AM
Having worked with AI-based image generation for the last day, I think human graphics designers will have a job for a very long time.
🤯
🤯
Reposted by Markus Elsner
Nascent proteins may be phosphorylated during translation & the phosphosite buried in the protein’s inner core
Such buried phosphosite are found in ~ 1/3 of the phosphorylated human proteins.
They can influence protein abundance (👇), providing another example for proteoform specific regulation.
Such buried phosphosite are found in ~ 1/3 of the phosphorylated human proteins.
They can influence protein abundance (👇), providing another example for proteoform specific regulation.
October 31, 2025 at 10:31 AM
Nascent proteins may be phosphorylated during translation & the phosphosite buried in the protein’s inner core
Such buried phosphosite are found in ~ 1/3 of the phosphorylated human proteins.
They can influence protein abundance (👇), providing another example for proteoform specific regulation.
Such buried phosphosite are found in ~ 1/3 of the phosphorylated human proteins.
They can influence protein abundance (👇), providing another example for proteoform specific regulation.
Our turtoise is now in hibernation. How envy him, no fall grant deadlines in reptile world.
October 29, 2025 at 5:39 PM
Our turtoise is now in hibernation. How envy him, no fall grant deadlines in reptile world.
Reposted by Markus Elsner
A protein platform rapidly develops peptide-focused major histocompatibility complex class I binders with high specificity go.nature.com/4gcLzn5
rdcu.be/eNagQ
rdcu.be/eNagQ
Targeting peptide antigens using a multiallelic MHC I-binding system - Nature Biotechnology
A protein platform rapidly develops peptide-focused major histocompatibility complex class I binders with high specificity.
go.nature.com
October 29, 2025 at 1:04 AM
A protein platform rapidly develops peptide-focused major histocompatibility complex class I binders with high specificity go.nature.com/4gcLzn5
rdcu.be/eNagQ
rdcu.be/eNagQ
😂
![Comic. [diploma from East State University for Doctor of Philosophy in Document Forgery] [caption] If you put one of these up in your office, and no one notices, you’ve earned it.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreif2hl6u2eqv7rmq27tenpy5s5d7egkhwzvfw4ohpskh67ibuw52ym@jpeg)
October 28, 2025 at 9:29 PM
😂
Reposted by Markus Elsner
October 26, 2025 at 9:25 AM
Reposted by Markus Elsner
'In this manuscript, we show that tag fusions often change protein expression to a degree that is highly dependent on cell and tissue context. We characterise two underlying mechanisms, providing information that should help others to design more effective transgenic strategies'
Tissue-specific consequences of tag fusions on protein expression in transgenic mice
Author summary To better understand the function of specific proteins, researchers need ways to quantify their abundance, to visualise their movements, to understand what other molecules they interact...
journals.plos.org
October 26, 2025 at 6:18 PM
'In this manuscript, we show that tag fusions often change protein expression to a degree that is highly dependent on cell and tissue context. We characterise two underlying mechanisms, providing information that should help others to design more effective transgenic strategies'
So the US Army now depends on the personal generosity of an individual close to the president for their livelihood. What could possibly go wrong?
October 26, 2025 at 12:35 PM
So the US Army now depends on the personal generosity of an individual close to the president for their livelihood. What could possibly go wrong?