Mari Sepp
@marisepp.bsky.social
Evo-Devo neurobiologist | Associate Prof. at Institute of Genomics, University of Tartu | Cerebellum Development: from Evolution to Disorder
Pinned
Mari Sepp
@marisepp.bsky.social
· Mar 16
Wonderful to have the last (major) part of my postdoctoral work preprinted! Huge thanks to @ioansarr.bsky.social and @tyamadat.bsky.social—it's been a blast. Grateful to be part of the inspiring, collaborative and supportive team @kaessmannlab.bsky.social! #Cerebellum rocks! #EvoDevo #GeneRegulation
Reposted by Mari Sepp
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
November 13, 2025 at 8:34 PM
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Reposted by Mari Sepp
Interested in applying for our Fellows-to-Faculty Award? Watch the recording of our informational webinar for more details on the program: https://www.simonsfoundation.org/grant/fellows-to-faculty-award/#:~:text=Brain%20(SCPAB).-,Informational%20Webinar,-An%20informational%20webinar #science
Fellows-to-Faculty Award
The Fellows-to-Faculty Award is a new iteration of the previously offered Simons Foundation Independence Awards.
www.simonsfoundation.org
November 11, 2025 at 7:56 PM
Interested in applying for our Fellows-to-Faculty Award? Watch the recording of our informational webinar for more details on the program: https://www.simonsfoundation.org/grant/fellows-to-faculty-award/#:~:text=Brain%20(SCPAB).-,Informational%20Webinar,-An%20informational%20webinar #science
Reposted by Mari Sepp
Our intelligence and cognitive abilities are perhaps due to an expansion of our cerebral cortex. But surprisingly, compared to highly intelligent birds, primates have many more neurons in their cerebellum as compared to the cerebral cortex.
doi.org/10.1073/pnas...
doi.org/10.1073/pnas...
November 9, 2025 at 4:55 PM
Our intelligence and cognitive abilities are perhaps due to an expansion of our cerebral cortex. But surprisingly, compared to highly intelligent birds, primates have many more neurons in their cerebellum as compared to the cerebral cortex.
doi.org/10.1073/pnas...
doi.org/10.1073/pnas...
Reposted by Mari Sepp
Share this funding opportunity! We offer the Fellows-to-Faculty program to nurture new talent in the basic sciences and to broaden the community of scientists contributing to Simons Foundation Autism Research Initiative (SFARI) and Simons Collaboration on Plasticity and the Aging Brain (SCPAB).
Applications for our Fellows-to-Faculty Award are now open! This program supports early career scientists in #autism or #neuroscience research by facilitating their transition into tenure-track faculty positions. Apply by 1/14/2026: www.simonsfoundation.org/2025/10/31/a... #science
Applications for Fellows-to-Faculty Awards Now Open
Applications for Fellows-to-Faculty Awards Now Open on Simons Foundation
www.simonsfoundation.org
November 3, 2025 at 7:26 PM
Share this funding opportunity! We offer the Fellows-to-Faculty program to nurture new talent in the basic sciences and to broaden the community of scientists contributing to Simons Foundation Autism Research Initiative (SFARI) and Simons Collaboration on Plasticity and the Aging Brain (SCPAB).
Reposted by Mari Sepp
Stoked to share our latest work entitled: “Large-scale discovery of neural enhancers for cis-regulation therapies”
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
November 5, 2025 at 3:09 PM
Stoked to share our latest work entitled: “Large-scale discovery of neural enhancers for cis-regulation therapies”
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
Reposted by Mari Sepp
🚀 𝗣𝗼𝘀𝘁𝗱𝗼𝗰 𝗢𝗽𝗲𝗻𝗶𝗻𝗴
We’re recruiting an ERC-funded Postdoctoral Researcher to explore how 3D gene regulatory networks evolved during human and primate brain development, using cutting-edge single-cell multiomics, organoid models, and CRISPR screens.
👉 Apply by Nov 30 | www.bonevlab.com/join
We’re recruiting an ERC-funded Postdoctoral Researcher to explore how 3D gene regulatory networks evolved during human and primate brain development, using cutting-edge single-cell multiomics, organoid models, and CRISPR screens.
👉 Apply by Nov 30 | www.bonevlab.com/join
November 5, 2025 at 2:03 PM
🚀 𝗣𝗼𝘀𝘁𝗱𝗼𝗰 𝗢𝗽𝗲𝗻𝗶𝗻𝗴
We’re recruiting an ERC-funded Postdoctoral Researcher to explore how 3D gene regulatory networks evolved during human and primate brain development, using cutting-edge single-cell multiomics, organoid models, and CRISPR screens.
👉 Apply by Nov 30 | www.bonevlab.com/join
We’re recruiting an ERC-funded Postdoctoral Researcher to explore how 3D gene regulatory networks evolved during human and primate brain development, using cutting-edge single-cell multiomics, organoid models, and CRISPR screens.
👉 Apply by Nov 30 | www.bonevlab.com/join
Happy to have contributed to this work on how transposable elements shape the regulatory landscape of cerebellar cells - together with @tyamadat.bsky.social , @ioansarr.bsky.social and @kaessmannlab.bsky.social. Tetsuya's scientific journey is just taking off - definitely one to watch!
So excited to see this out on bioRxiv! Huge thanks to @kaessmannlab.bsky.social and the amazing cerebellum team (@marisepp.bsky.social and @ioansarr.bsky.social) for all the support and insightful discussions that made this work possible!!
Did transposable elements shape brain evolution — and if so, which ones, and in which cell states and lineages? Led by @tyamadat.bsky.social, we explored this question in cerebellum development using sequence-based deep learning models!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 17, 2025 at 7:25 AM
Happy to have contributed to this work on how transposable elements shape the regulatory landscape of cerebellar cells - together with @tyamadat.bsky.social , @ioansarr.bsky.social and @kaessmannlab.bsky.social. Tetsuya's scientific journey is just taking off - definitely one to watch!
Reposted by Mari Sepp
Excited to share the preprint from my main postdoc project! It’s been a long journey—huge thanks to everyone who made it possible, especially @leticiarm1618.bsky.social for being the best collaborator one could ask for, and the amazing @kaessmannlab.bsky.social lab for the invaluable support!
We are thrilled to share our new preprint entitled “The origin and molecular evolution of the mammalian liver cell architecture” www.biorxiv.org/content/10.1...
October 15, 2025 at 1:39 PM
Excited to share the preprint from my main postdoc project! It’s been a long journey—huge thanks to everyone who made it possible, especially @leticiarm1618.bsky.social for being the best collaborator one could ask for, and the amazing @kaessmannlab.bsky.social lab for the invaluable support!
Reposted by Mari Sepp
We are thrilled to share our new preprint entitled “The origin and molecular evolution of the mammalian liver cell architecture” www.biorxiv.org/content/10.1...
October 15, 2025 at 12:51 PM
We are thrilled to share our new preprint entitled “The origin and molecular evolution of the mammalian liver cell architecture” www.biorxiv.org/content/10.1...
Reposted by Mari Sepp
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
October 3, 2025 at 7:14 AM
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
Reposted by Mari Sepp
Announcing our 9 new Fellows-to-Faculty Fellows! These awards help senior postdoctoral researchers with fresh perspectives on autism & neuroscience transition to tenure-track faculty positions: https://www.simonsfoundation.org/simons-foundation-announces-recipients-of-2025-fellows-to-faculty-awards/
Simons Foundation Announces Recipients of 2025 Fellows-to-Faculty Awards
The Simons Foundation is pleased to announce the 2025 class of Fellows-to-Faculty Fellows.
www.simonsfoundation.org
September 16, 2025 at 7:26 PM
Announcing our 9 new Fellows-to-Faculty Fellows! These awards help senior postdoctoral researchers with fresh perspectives on autism & neuroscience transition to tenure-track faculty positions: https://www.simonsfoundation.org/simons-foundation-announces-recipients-of-2025-fellows-to-faculty-awards/
Reposted by Mari Sepp
👇 !!!
Register to attend the #LouisJeantetSymposium on vertebrate genome #evolution. Organised by Svante Pääbo and
@kaessmannlab.bsky.social . Free event, full line up of speakers 👉 www.jeantet.ch/en/
📆Tuesday 14 October, 08h15
📍CMU - Auditoire Alex-F. Müller (A250)
@genevunige.bsky.social
@kaessmannlab.bsky.social . Free event, full line up of speakers 👉 www.jeantet.ch/en/
📆Tuesday 14 October, 08h15
📍CMU - Auditoire Alex-F. Müller (A250)
@genevunige.bsky.social
September 11, 2025 at 1:09 PM
👇 !!!
Reposted by Mari Sepp
Huge congrats @klehto.bsky.social on this achievement!! Her work has already enriched the @estbiobank.bsky.social and will continue to do so! 💙🖤🤍
Are adult attention deficit hyperactivity disorder (ADHD) features truly the same as childhood ADHD?
Kelli Letho, a new ERC Starting Grantee at the University of Tartu will dissect the causal mechanisms of adult ADHD features
More 👉 buff.ly/nci5eve
#ERCStG #FontierResearch @klehto.bsky.social
Kelli Letho, a new ERC Starting Grantee at the University of Tartu will dissect the causal mechanisms of adult ADHD features
More 👉 buff.ly/nci5eve
#ERCStG #FontierResearch @klehto.bsky.social
September 4, 2025 at 11:44 AM
Huge congrats @klehto.bsky.social on this achievement!! Her work has already enriched the @estbiobank.bsky.social and will continue to do so! 💙🖤🤍
Reposted by Mari Sepp
🧠 Opportunity for a post-doctoral position on human neurobiology, funded by the @erc.europa.eu!
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - Postdoctoral researcher in human neurobiology (M/F)
emploi.cnrs.fr
July 30, 2025 at 8:26 AM
🧠 Opportunity for a post-doctoral position on human neurobiology, funded by the @erc.europa.eu!
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...
Reposted by Mari Sepp
🔬 New preprint out!
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
Just a moment...
Verifying you are human. This may take a few seconds.
https://biorxiv.org/content/10.110…
July 29, 2025 at 7:05 AM
🔬 New preprint out!
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
Reposted by Mari Sepp
The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to west@neuro.duke.edu.
July 27, 2025 at 8:27 PM
The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to west@neuro.duke.edu.
Reposted by Mari Sepp
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
July 27, 2025 at 5:26 PM
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
Reposted by Mari Sepp
Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...
Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs
Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show
rapid progression of transcriptional programs in specific tissues relative to morphological
landmarks. This shift in...
www.cell.com
July 24, 2025 at 5:07 PM
Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...
Reposted by Mari Sepp
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature
Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...
www.nature.com
July 16, 2025 at 3:23 PM
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
Reposted by Mari Sepp
Human de novo mutation rates from a four-generation pedigree reference www.nature.com/articles/s41... - amazingly comprehensive study from Evan Eichler and colleagues
Human de novo mutation rates from a four-generation pedigree reference - Nature
Analysis of more than 95% of each diploid human genome of a four-generation, twenty-eight-member family using five complementary short-read and long-read sequencing technologies provides a truth set t...
www.nature.com
July 14, 2025 at 9:52 AM
Human de novo mutation rates from a four-generation pedigree reference www.nature.com/articles/s41... - amazingly comprehensive study from Evan Eichler and colleagues
Reposted by Mari Sepp
Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
www.nature.com/articles/s41...
1/n
Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience
Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...
www.nature.com
July 8, 2025 at 12:04 PM
Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
www.nature.com/articles/s41...
1/n
🤩 Happy to see my PhD mentor Tõnis Timmusk elected as a Member of the European Molecular Biology Organization @embo.org. So well-deserved!
An inspiring scientist, supportive mentor, and generous friend!
@taltech.bsky.social
An inspiring scientist, supportive mentor, and generous friend!
@taltech.bsky.social
Welcome and congratulations to the 60 new members and 9 associate members who have been elected to the EMBO Membership! This honour celebrates #research excellence and outstanding achievements in the #LifeSciences. 🧪
Learn more here:
www.embo.org/press-releas... #EMBOMembers2025
Learn more here:
www.embo.org/press-releas... #EMBOMembers2025
Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO
Sixty-nine new members join the community of leading life scientists in Europe and beyond
www.embo.org
July 1, 2025 at 4:48 PM
🤩 Happy to see my PhD mentor Tõnis Timmusk elected as a Member of the European Molecular Biology Organization @embo.org. So well-deserved!
An inspiring scientist, supportive mentor, and generous friend!
@taltech.bsky.social
An inspiring scientist, supportive mentor, and generous friend!
@taltech.bsky.social
Reposted by Mari Sepp
Did the miss the Cerebellum Development and Disease conference last year? Never fear, as we wrote up a conference report! link.springer.com/article/10.1...
Conference Report: Cerebellar Development and Disease at Single-Cell Resolution - The Cerebellum
The Cerebellum -
link.springer.com
June 29, 2025 at 9:00 AM
Did the miss the Cerebellum Development and Disease conference last year? Never fear, as we wrote up a conference report! link.springer.com/article/10.1...
Reposted by Mari Sepp
Excited to share the first 2(!) preprints from the Kebschull Lab. The amazing @hyopilkim.bsky.social developed MAPseq2 & POINTseq and used them to map the dopaminergic cells of VTA and SNc. tl;dr MAPseq2=10x cheaper, 4x better; POINTseq=easy cell type specific barcoding; DA neurons=very cool.
June 26, 2025 at 4:24 PM
Excited to share the first 2(!) preprints from the Kebschull Lab. The amazing @hyopilkim.bsky.social developed MAPseq2 & POINTseq and used them to map the dopaminergic cells of VTA and SNc. tl;dr MAPseq2=10x cheaper, 4x better; POINTseq=easy cell type specific barcoding; DA neurons=very cool.