Marcus Goncalves
@marcusgon.bsky.social
endocrinologist, scientist, Cancer metabolism, cachexia, insulin, PI3K, diabetes, obesity. GI Villi lover. Metabolic Consulting. NYJ/NYY/NYCFC fan.
Interested in doing clinical science in the best city in the world? Clinician-Investigator job with NYU Grossman School of Medicine www.nejmcareercenter.org/job/938583/c...
Clinician-Investigator - New York City, New York job with NYU Grossman School of Medicine | 938583
The Holman Division of Endocrinology, Diabetes & Metabolism at NYU Langone Health is seeking an academically oriented physician
www.nejmcareercenter.org
November 13, 2025 at 11:42 AM
Interested in doing clinical science in the best city in the world? Clinician-Investigator job with NYU Grossman School of Medicine www.nejmcareercenter.org/job/938583/c...
The largest description of cancer #cachexia to date across all tumor types and over time using data from 60,000 people. @edreznik.bsky.social redefines what we know about human cachexia integrating genetics, lab values, and treatment lines. www.medrxiv.org/content/10.1...
A health-system-scale, episode-resolved multimodal atlas of cancer cachexia
Cancer cachexia is a wasting syndrome with outsized impact on morbidity and mortality. Neither the etiology of cachexia, nor its consequences on patient physiology and outcomes, are well-understood. H...
www.medrxiv.org
September 30, 2025 at 10:22 PM
The largest description of cancer #cachexia to date across all tumor types and over time using data from 60,000 people. @edreznik.bsky.social redefines what we know about human cachexia integrating genetics, lab values, and treatment lines. www.medrxiv.org/content/10.1...
I’m proud to share that diabetes & endocrinology at @nyulangone has been ranked #4 in the U.S. by @usnews!
July 29, 2025 at 1:20 PM
I’m proud to share that diabetes & endocrinology at @nyulangone has been ranked #4 in the U.S. by @usnews!
Not to miss this week: Beyond Mammals: Exploring Cancer Models Webinar Series. Thursday, May 22, from 1:00 – 2:15 PM ET events.cancer.gov/dcb/beyond-m...
Beyond Mammals: Exploring Cancer Models Webinar Series (Overview) | Events Registration
Overview The Beyond Mammals: Exploring Cancer Models series will feature three webinars, each focused on one non-mammalian animal model and its applicability to cancer research. Each webinar will high...
events.cancer.gov
May 19, 2025 at 8:45 PM
Not to miss this week: Beyond Mammals: Exploring Cancer Models Webinar Series. Thursday, May 22, from 1:00 – 2:15 PM ET events.cancer.gov/dcb/beyond-m...
Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models www.nature.com/articles/s41...
Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models - British Journal of Cancer
British Journal of Cancer - Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models
www.nature.com
May 15, 2025 at 9:56 AM
Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models www.nature.com/articles/s41...
Reposted by Marcus Goncalves
This Review from Phillip J. White, Nicolai J. Wewer Albrechtsen & Jonathan E. Campbell explores islet hormones at the intersection of glucose and amino acid metabolism (£) go.nature.com/3S26jDE
#EndoSky #WorldHormoneDay #BecauseHormonesMatter
#EndoSky #WorldHormoneDay #BecauseHormonesMatter
April 24, 2025 at 3:20 PM
This Review from Phillip J. White, Nicolai J. Wewer Albrechtsen & Jonathan E. Campbell explores islet hormones at the intersection of glucose and amino acid metabolism (£) go.nature.com/3S26jDE
#EndoSky #WorldHormoneDay #BecauseHormonesMatter
#EndoSky #WorldHormoneDay #BecauseHormonesMatter
Reposted by Marcus Goncalves
The 24/25 edition of @cancergrand.bsky.social progress magazine is now live!
Including:
👉key advances from our funded teams
👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease
👉our 7 new challenges
features.cancerresearchuk.org/cancergrandc...
Including:
👉key advances from our funded teams
👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease
👉our 7 new challenges
features.cancerresearchuk.org/cancergrandc...
DFS 0161 CGC Discover mag 2024
A year of scientific creativity
features.cancerresearchuk.org
April 24, 2025 at 12:25 PM
The 24/25 edition of @cancergrand.bsky.social progress magazine is now live!
Including:
👉key advances from our funded teams
👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease
👉our 7 new challenges
features.cancerresearchuk.org/cancergrandc...
Including:
👉key advances from our funded teams
👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease
👉our 7 new challenges
features.cancerresearchuk.org/cancergrandc...
IL-6 regulates fat and muscle lipid metabolism in humans www.cell.com/cell-reports...
Inhibition of basal IL-6 activity promotes subcutaneous fat retention in humans during fasting and postprandial states
Trinh et al. demonstrate that basal IL-6 activity regulates fat uptake and storage.
IL-6 enhances skeletal muscle fat uptake, promotes fat release from subcutaneous adipose
tissue during fasting, and ...
www.cell.com
March 27, 2025 at 11:42 PM
IL-6 regulates fat and muscle lipid metabolism in humans www.cell.com/cell-reports...
Changes in neurotensin signalling drive hedonic devaluation in obesity www.nature.com/articles/s41...
Changes in neurotensin signalling drive hedonic devaluation in obesity - Nature
In mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding behaviour linke...
www.nature.com
March 27, 2025 at 11:40 PM
Changes in neurotensin signalling drive hedonic devaluation in obesity www.nature.com/articles/s41...
Reposted by Marcus Goncalves
We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for:
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
March 20, 2025 at 3:23 AM
We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for:
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
Reposted by Marcus Goncalves
We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
February 5, 2025 at 3:35 PM
We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Reposted by Marcus Goncalves
A 38-year-old woman with a history of disordered eating was found to have ground-glass opacities on a chest CT. Cytologic examination of bronchoalveolar-lavage fluid showed lipid-laden macrophages and droplets of oil. Full case details: nej.md/428CqI5
#MedSky #PulmSky
#MedSky #PulmSky
January 22, 2025 at 3:32 PM
A 38-year-old woman with a history of disordered eating was found to have ground-glass opacities on a chest CT. Cytologic examination of bronchoalveolar-lavage fluid showed lipid-laden macrophages and droplets of oil. Full case details: nej.md/428CqI5
#MedSky #PulmSky
#MedSky #PulmSky
Cachexia is rarely diagnosed and coded, which undermines clinical care. Today, we release a Call to Improve Coding of Cancer-Associated Cachexia ascopubs.org/doi/10.1200/...
Call to Improve Coding of Cancer-Associated Cachexia | JCO Oncology Practice
Cachexia is a systemic wasting syndrome prevalent in patients with cancer that significantly
affects quality of life, health care costs, and therapeutic outcomes. Despite its
clinical importance, cach...
ascopubs.org
January 14, 2025 at 3:16 AM
Cachexia is rarely diagnosed and coded, which undermines clinical care. Today, we release a Call to Improve Coding of Cancer-Associated Cachexia ascopubs.org/doi/10.1200/...
The Cancer Metabolism and Signaling in the Tumor Microenvironment *Abstract Deadline* is rapidly approaching 2/4/25. Don't miss this star-studded event!
@nyasciences.bsky.social @nyulangonepccsm.bsky.social events.nyas.org/event/16a78a...
@nyasciences.bsky.social @nyulangonepccsm.bsky.social events.nyas.org/event/16a78a...
Cancer Metabolism and Signaling 2025
events.nyas.org
January 8, 2025 at 9:35 PM
The Cancer Metabolism and Signaling in the Tumor Microenvironment *Abstract Deadline* is rapidly approaching 2/4/25. Don't miss this star-studded event!
@nyasciences.bsky.social @nyulangonepccsm.bsky.social events.nyas.org/event/16a78a...
@nyasciences.bsky.social @nyulangonepccsm.bsky.social events.nyas.org/event/16a78a...
This is very cool. Brain circuit that regulates chewing www.nature.com/articles/d41...
A brain circuit that links hunger signals with the jaw movements of eating
In mice, silencing a set of neurons in the brain’s hypothalamus leads to chewing behaviours, even when food is unavailable.
www.nature.com
December 7, 2024 at 9:27 PM
This is very cool. Brain circuit that regulates chewing www.nature.com/articles/d41...
Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer www.nature.com/articles/s41...
Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer - Nature
Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.
www.nature.com
December 5, 2024 at 11:34 AM
Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer www.nature.com/articles/s41...
GLP-1/leptin dual agonist
Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist
Orthogonal murine models demonstrate the bioactivity and neuronal targets of a GLP-1/leptin coagonist in relation to food intake and body weight.
www.science.org
December 5, 2024 at 11:33 AM
GLP-1/leptin dual agonist
Reposted by Marcus Goncalves
The 8th Cancer Cachexia Conference will be hosted in Turin Italy, Sept 25-27, 2025
November 18, 2024 at 8:48 PM
The 8th Cancer Cachexia Conference will be hosted in Turin Italy, Sept 25-27, 2025
Loving this jam packed AACR tumor body interactions meeting!
November 18, 2024 at 1:55 AM
Loving this jam packed AACR tumor body interactions meeting!
Let’s support Bipartisan calls for better diet research
FDA commissioner: We need action and higher-quality research on ultra-processed foods
“Researchers, public health and health care groups, advocates, industry, and the public must put tackling diet-related disease at the top of their priority list.”
www.statnews.com
November 18, 2024 at 1:55 AM
Let’s support Bipartisan calls for better diet research