Reposted
The deck of cards that is frailty
Looking at frailty is a question of perspective, obviously, doh
open.substack.com
September 3, 2025 at 8:34 AM
Reposted
A blood-based #epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and #lifestyle factors
"...a validated tool bridging molecular readouts of #aging and clinical assessments of #IC..."
#IntrinsicCapacity #Frailty
www.nature.com/articles/s43...
"...a validated tool bridging molecular readouts of #aging and clinical assessments of #IC..."
#IntrinsicCapacity #Frailty
www.nature.com/articles/s43...
A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors - Nature Aging
Fuentealba and colleagues build and validate a DNA methylation clock of intrinsic capacity (IC) to bridge resource-intensive clinical assessments of IC with molecular readouts of aging, highlighting s...
www.nature.com
June 10, 2025 at 5:29 AM
A blood-based #epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and #lifestyle factors
"...a validated tool bridging molecular readouts of #aging and clinical assessments of #IC..."
#IntrinsicCapacity #Frailty
www.nature.com/articles/s43...
"...a validated tool bridging molecular readouts of #aging and clinical assessments of #IC..."
#IntrinsicCapacity #Frailty
www.nature.com/articles/s43...
Reposted
A short 🧵
In a remote corner of Arctic Alaska, archaeologists have unearthed blue glass beads at sites like Punyik Point.
1/5
In a remote corner of Arctic Alaska, archaeologists have unearthed blue glass beads at sites like Punyik Point.
1/5
May 21, 2025 at 5:43 PM
A short 🧵
In a remote corner of Arctic Alaska, archaeologists have unearthed blue glass beads at sites like Punyik Point.
1/5
In a remote corner of Arctic Alaska, archaeologists have unearthed blue glass beads at sites like Punyik Point.
1/5
Reposted
Sir Edward Grey, 1916:
"If the world cannot organise against war, if war must go on, then nations can protect themselves henceforth only by using whatever destructive agencies they can invent, till the resources and inventions of science end by destroying the humanity that they were meant to serve"
"If the world cannot organise against war, if war must go on, then nations can protect themselves henceforth only by using whatever destructive agencies they can invent, till the resources and inventions of science end by destroying the humanity that they were meant to serve"
May 17, 2025 at 2:24 PM
Sir Edward Grey, 1916:
"If the world cannot organise against war, if war must go on, then nations can protect themselves henceforth only by using whatever destructive agencies they can invent, till the resources and inventions of science end by destroying the humanity that they were meant to serve"
"If the world cannot organise against war, if war must go on, then nations can protect themselves henceforth only by using whatever destructive agencies they can invent, till the resources and inventions of science end by destroying the humanity that they were meant to serve"
Reposted
NEW 🧵 Is human intelligence starting to decline?
Recent results from major international tests show that the average person’s capacity to process information, use reasoning and solve novel problems has been falling since around the mid 2010s
What should we make of this?
www.ft.com/content/a801...
Recent results from major international tests show that the average person’s capacity to process information, use reasoning and solve novel problems has been falling since around the mid 2010s
What should we make of this?
www.ft.com/content/a801...
March 14, 2025 at 1:18 PM
NEW 🧵 Is human intelligence starting to decline?
Recent results from major international tests show that the average person’s capacity to process information, use reasoning and solve novel problems has been falling since around the mid 2010s
What should we make of this?
www.ft.com/content/a801...
Recent results from major international tests show that the average person’s capacity to process information, use reasoning and solve novel problems has been falling since around the mid 2010s
What should we make of this?
www.ft.com/content/a801...
Reposted
Okay, so.
I don’t know how much of a heads up this is when it’s just a notice about these 2 mutations. Do they really raise serious concerns about “increased transmission?”
Sort of. It’s more complex than D701N & E626K, omg pandemic bird flu.
What do these mutations do in H5N1?
I don’t know how much of a heads up this is when it’s just a notice about these 2 mutations. Do they really raise serious concerns about “increased transmission?”
Sort of. It’s more complex than D701N & E626K, omg pandemic bird flu.
What do these mutations do in H5N1?
February 27, 2025 at 12:36 PM
Okay, so.
I don’t know how much of a heads up this is when it’s just a notice about these 2 mutations. Do they really raise serious concerns about “increased transmission?”
Sort of. It’s more complex than D701N & E626K, omg pandemic bird flu.
What do these mutations do in H5N1?
I don’t know how much of a heads up this is when it’s just a notice about these 2 mutations. Do they really raise serious concerns about “increased transmission?”
Sort of. It’s more complex than D701N & E626K, omg pandemic bird flu.
What do these mutations do in H5N1?
Reposted
One glance at a book and you hear the voice of another person, perhaps someone dead for 1,000 years. To read is to voyage through time.
February 24, 2025 at 1:19 PM
One glance at a book and you hear the voice of another person, perhaps someone dead for 1,000 years. To read is to voyage through time.
Reposted
#USDA posted an analysis of the D1.1 #H5N1 #birdflu viruses that infected Nevada cows — the new spillover event. They spotted a mutation in the PB2 gene that is associated with mammalian adaptation. What's this mean? Dunno. But 2 spillovers means more could come. www.aphis.usda.gov/sites/defaul...
February 7, 2025 at 11:09 PM
#USDA posted an analysis of the D1.1 #H5N1 #birdflu viruses that infected Nevada cows — the new spillover event. They spotted a mutation in the PB2 gene that is associated with mammalian adaptation. What's this mean? Dunno. But 2 spillovers means more could come. www.aphis.usda.gov/sites/defaul...
Reposted
“Facing death differently: revolutionising our approach to death and grief”.
A really important piece here from @lucyselman.bsky.social in the @bmj.com.
I’ll try to pick out some highlights in a🧵, but actually I’d recommend reading the whole article.
Link here:
www.bmj.com/content/387/...
A really important piece here from @lucyselman.bsky.social in the @bmj.com.
I’ll try to pick out some highlights in a🧵, but actually I’d recommend reading the whole article.
Link here:
www.bmj.com/content/387/...
January 4, 2025 at 10:02 AM
“Facing death differently: revolutionising our approach to death and grief”.
A really important piece here from @lucyselman.bsky.social in the @bmj.com.
I’ll try to pick out some highlights in a🧵, but actually I’d recommend reading the whole article.
Link here:
www.bmj.com/content/387/...
A really important piece here from @lucyselman.bsky.social in the @bmj.com.
I’ll try to pick out some highlights in a🧵, but actually I’d recommend reading the whole article.
Link here:
www.bmj.com/content/387/...
Reposted
Elizabeth Garrett Anderson (1836-1917), 1st female dean of a British med school, and 1st female mayor in Britain, pretended to be rich during med school (in Paris, 1870) so admin would think she'd be able to sue if they suddenly said women couldn't be doctors 1/10
December 17, 2024 at 11:10 PM
Elizabeth Garrett Anderson (1836-1917), 1st female dean of a British med school, and 1st female mayor in Britain, pretended to be rich during med school (in Paris, 1870) so admin would think she'd be able to sue if they suddenly said women couldn't be doctors 1/10
Reposted
If an #H5N1 pandemic starts tomorrow or in three months, there will be little mystery as to how it happened. The conditions are all there. They have been for a while.
So in some ways the more interesting question to me at the moment is: Why aren’t we in a pandemic yet?
Story here, 🧵 to come:
🧪#IDSky
So in some ways the more interesting question to me at the moment is: Why aren’t we in a pandemic yet?
Story here, 🧵 to come:
🧪#IDSky
Why hasn’t the bird flu pandemic started?
Some scientists examining mutations found in H5N1 viruses fear major outbreak is imminent but others says pathogen remains unpredictable
www.science.org
December 6, 2024 at 12:54 PM
If an #H5N1 pandemic starts tomorrow or in three months, there will be little mystery as to how it happened. The conditions are all there. They have been for a while.
So in some ways the more interesting question to me at the moment is: Why aren’t we in a pandemic yet?
Story here, 🧵 to come:
🧪#IDSky
So in some ways the more interesting question to me at the moment is: Why aren’t we in a pandemic yet?
Story here, 🧵 to come:
🧪#IDSky
Reposted
So much work done by GP practices is unseen
The media focus purely on appointments - 30 million a month & up 5 million since 2019
Imagine if appts are up 20% what is going on behind the scenes
All this with 20% £/patient since 2016 in real terms cuts
#MedSky #RCGP #GeneralPractice #NHS #TeamGP
The media focus purely on appointments - 30 million a month & up 5 million since 2019
Imagine if appts are up 20% what is going on behind the scenes
All this with 20% £/patient since 2016 in real terms cuts
#MedSky #RCGP #GeneralPractice #NHS #TeamGP
November 23, 2024 at 11:29 AM
So much work done by GP practices is unseen
The media focus purely on appointments - 30 million a month & up 5 million since 2019
Imagine if appts are up 20% what is going on behind the scenes
All this with 20% £/patient since 2016 in real terms cuts
#MedSky #RCGP #GeneralPractice #NHS #TeamGP
The media focus purely on appointments - 30 million a month & up 5 million since 2019
Imagine if appts are up 20% what is going on behind the scenes
All this with 20% £/patient since 2016 in real terms cuts
#MedSky #RCGP #GeneralPractice #NHS #TeamGP
Reposted
Oldest-surviving anatomical theatre, located in Padua and built in 1594. Over the entrance is the Latin inscription: “hic est locus ubi mors gaudet succurrere vitam.” Roughly: “this is the place where death delights to help life (or the living).”
Photo: Rolando Paolo Guerzoni. #histmed #skystorians
Photo: Rolando Paolo Guerzoni. #histmed #skystorians
November 23, 2024 at 11:13 AM
Oldest-surviving anatomical theatre, located in Padua and built in 1594. Over the entrance is the Latin inscription: “hic est locus ubi mors gaudet succurrere vitam.” Roughly: “this is the place where death delights to help life (or the living).”
Photo: Rolando Paolo Guerzoni. #histmed #skystorians
Photo: Rolando Paolo Guerzoni. #histmed #skystorians
Reposted
Today in relatable science: Gulls making a mysterious daily trip that turned out to be to a potato chip factory
November 15, 2024 at 8:15 PM
Today in relatable science: Gulls making a mysterious daily trip that turned out to be to a potato chip factory
Reposted
I’m not going to leave X just yet - I hate that sense of being driven away from a place I used to love. But after one day on here, I already know how much prefer it.
So if you see this and would be kind enough to share it to let people find me, that would be hugely appreciated. Thank you.
So if you see this and would be kind enough to share it to let people find me, that would be hugely appreciated. Thank you.
November 15, 2024 at 7:21 PM
I’m not going to leave X just yet - I hate that sense of being driven away from a place I used to love. But after one day on here, I already know how much prefer it.
So if you see this and would be kind enough to share it to let people find me, that would be hugely appreciated. Thank you.
So if you see this and would be kind enough to share it to let people find me, that would be hugely appreciated. Thank you.
Reposted
Word of the Day, should you need it, is ‘latibulate’, a 17th-century verb meaning to find a corner somewhere and hide in it.
November 15, 2024 at 8:16 AM
Word of the Day, should you need it, is ‘latibulate’, a 17th-century verb meaning to find a corner somewhere and hide in it.
Reposted
Reposted
TORC HAS CROSSED THE SAHARA
(Torc is a cuckoo)
(Torc is a cuckoo)
November 8, 2024 at 4:41 PM
TORC HAS CROSSED THE SAHARA
(Torc is a cuckoo)
(Torc is a cuckoo)
Reposted
'Britain has increased the risk level of bird flu to medium after the virus was detected in a number of wild birds in the country this autumn. Bird flu [avian influenza] has increasingly spread to mammals, raising concern of human transmission.' @Reuters
www.reuters.com/world/uk/bri...
www.reuters.com/world/uk/bri...
Britain raises risk level of bird flu to medium
Britain has increased on Thursday the risk level of bird flu to medium from low after the virus was detected in a number of wild birds in the country over the autumn, the government said in an update posted on its website.
www.reuters.com
October 19, 2024 at 9:38 AM
'Britain has increased the risk level of bird flu to medium after the virus was detected in a number of wild birds in the country this autumn. Bird flu [avian influenza] has increasingly spread to mammals, raising concern of human transmission.' @Reuters
www.reuters.com/world/uk/bri...
www.reuters.com/world/uk/bri...
Reposted
This is extraordinarily good news: 43 of the people who were infected with #Marburg in Rwanda's outbreak have recovered; only 4 people remain in isolation & treatment. No new cases (62 in total), no new deaths (15 in total).
Things are looking very hopeful.
Things are looking very hopeful.
October 17, 2024 at 7:20 PM
This is extraordinarily good news: 43 of the people who were infected with #Marburg in Rwanda's outbreak have recovered; only 4 people remain in isolation & treatment. No new cases (62 in total), no new deaths (15 in total).
Things are looking very hopeful.
Things are looking very hopeful.
Reposted
Hungary and Italy report outbreaks of H5N1 bird flu on farms, WOAH says - via Reuters
www.reuters.com/business/hea...
www.reuters.com/business/hea...
Hungary and Italy report outbreaks of H5N1 bird flu, WOAH says
Hungary and Italy have both reported an outbreak of the severe H5N1 avian influenza virus in the first such cases in the countries for several months, the World Organisation for Animal Health (WOAH) said, as the disease spreads again in Europe.
www.reuters.com
October 2, 2024 at 7:50 PM
Hungary and Italy report outbreaks of H5N1 bird flu on farms, WOAH says - via Reuters
www.reuters.com/business/hea...
www.reuters.com/business/hea...
Reposted
Just to make things clear, this might be the best-timed shot in science TV history. In the BBC series "Connections", James Burke points to a rocket just as it launches. It was filmed on August 20, 1977, during the launch of Voyager 2 spacecraft. 🧪🚀
September 11, 2024 at 7:35 PM
Just to make things clear, this might be the best-timed shot in science TV history. In the BBC series "Connections", James Burke points to a rocket just as it launches. It was filmed on August 20, 1977, during the launch of Voyager 2 spacecraft. 🧪🚀
Reposted
Seeing a few people posting about swallows gathering – always a time of year I’m not quite ready for. They’re about to undertake a frankly ridiculous journey – tiny slips of things flying to Africa.
Africa. Southern Africa, at that. I mean, come on.
Africa. Southern Africa, at that. I mean, come on.
September 6, 2024 at 6:38 PM
Seeing a few people posting about swallows gathering – always a time of year I’m not quite ready for. They’re about to undertake a frankly ridiculous journey – tiny slips of things flying to Africa.
Africa. Southern Africa, at that. I mean, come on.
Africa. Southern Africa, at that. I mean, come on.