Lovasoa Randriantseheno
@lova14.bsky.social
PhD student studying the evolution of Yersinia pestis in Madagascar 🇲🇬 | Interested in all things bacteriology and genomics 👩🔬🧫🧬💻
Pinned
I had the great honor of representing Madagascar at the 15th International Symposium on Yersinia in Mongolia, where researchers working on the challenges posed by plague and other yersiniosis presented their work. I also presented some of the results of my PhD on the phylogeography of Y. pestis.
Reposted by Lovasoa Randriantseheno
New WHO report shows growing resistance to lifesaving malaria drugs:
🚩 Partial resistance to artemisinin confirmed or suspected in at least 8 African countries
🚩 Pyrethroid resistance in 48 countries
🚩 Anopheles stephensi 🦟 now detected in 9 African countries
🔗 bit.ly/3Y6IcXn #EndMalaria
🚩 Partial resistance to artemisinin confirmed or suspected in at least 8 African countries
🚩 Pyrethroid resistance in 48 countries
🚩 Anopheles stephensi 🦟 now detected in 9 African countries
🔗 bit.ly/3Y6IcXn #EndMalaria
December 5, 2025 at 7:45 AM
New WHO report shows growing resistance to lifesaving malaria drugs:
🚩 Partial resistance to artemisinin confirmed or suspected in at least 8 African countries
🚩 Pyrethroid resistance in 48 countries
🚩 Anopheles stephensi 🦟 now detected in 9 African countries
🔗 bit.ly/3Y6IcXn #EndMalaria
🚩 Partial resistance to artemisinin confirmed or suspected in at least 8 African countries
🚩 Pyrethroid resistance in 48 countries
🚩 Anopheles stephensi 🦟 now detected in 9 African countries
🔗 bit.ly/3Y6IcXn #EndMalaria
Reposted by Lovasoa Randriantseheno
www.biorxiv.org/content/10.1...
@soreklab.bsky.social Sorek lab does it again! Such a cool signal to specifically detect the event of genome degradation by a phage
@soreklab.bsky.social Sorek lab does it again! Such a cool signal to specifically detect the event of genome degradation by a phage
Bacteria sense virus-induced genome degradation via methylated mononucleotides
Phages often degrade the genome of their bacterial host to individual nucleotides and use these nucleotides to build their own genome. In this study, we describe a bacterial defense system that direct...
www.biorxiv.org
November 8, 2025 at 5:22 PM
www.biorxiv.org/content/10.1...
@soreklab.bsky.social Sorek lab does it again! Such a cool signal to specifically detect the event of genome degradation by a phage
@soreklab.bsky.social Sorek lab does it again! Such a cool signal to specifically detect the event of genome degradation by a phage
Reposted by Lovasoa Randriantseheno
💚 Last night, the Institut Pasteur lit up its historic building in green: the color of Phelan‑McDermid syndrome.
This rare genetic disorder is linked to developmental & language challenges and autism.
It was here that researchers identified SHANK3, the gene behind the syndrome 🧬✨
This rare genetic disorder is linked to developmental & language challenges and autism.
It was here that researchers identified SHANK3, the gene behind the syndrome 🧬✨
October 23, 2025 at 1:43 PM
💚 Last night, the Institut Pasteur lit up its historic building in green: the color of Phelan‑McDermid syndrome.
This rare genetic disorder is linked to developmental & language challenges and autism.
It was here that researchers identified SHANK3, the gene behind the syndrome 🧬✨
This rare genetic disorder is linked to developmental & language challenges and autism.
It was here that researchers identified SHANK3, the gene behind the syndrome 🧬✨
Reposted by Lovasoa Randriantseheno
Across Southeast Asia most newborn infections are now caused #AMR bugs, making standard treatments for neonatal sepsis ineffective. Without updated, locally informed treatment guidelines and new antibiotic development, infant mortality rates will rise.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Pathogen distribution and antimicrobial resistance among neonatal bloodstream infections in Southeast Asia: results from NeoSEAP, a multicentre retrospective study
Neonatal sepsis in tertiary hospitals in Southeast Asia is predominantly caused by
gram-negative bacteria, with high rates of non-susceptibility to commonly prescribed
antibiotics.
www.thelancet.com
October 12, 2025 at 11:29 AM
Across Southeast Asia most newborn infections are now caused #AMR bugs, making standard treatments for neonatal sepsis ineffective. Without updated, locally informed treatment guidelines and new antibiotic development, infant mortality rates will rise.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Lovasoa Randriantseheno
This is amazing! Researchers at McMaster University have discovered an antibiotic that could treat inflammatory bowel diseases, including Crohn’s Disease without killing beneficial gut bacteria
healthsci.mcmaster.ca/new-antibiot...
healthsci.mcmaster.ca/new-antibiot...
healthsci.mcmaster.ca
October 4, 2025 at 1:06 PM
This is amazing! Researchers at McMaster University have discovered an antibiotic that could treat inflammatory bowel diseases, including Crohn’s Disease without killing beneficial gut bacteria
healthsci.mcmaster.ca/new-antibiot...
healthsci.mcmaster.ca/new-antibiot...
I had the great honor of representing Madagascar at the 15th International Symposium on Yersinia in Mongolia, where researchers working on the challenges posed by plague and other yersiniosis presented their work. I also presented some of the results of my PhD on the phylogeography of Y. pestis.
September 22, 2025 at 5:27 AM
I had the great honor of representing Madagascar at the 15th International Symposium on Yersinia in Mongolia, where researchers working on the challenges posed by plague and other yersiniosis presented their work. I also presented some of the results of my PhD on the phylogeography of Y. pestis.
Reposted by Lovasoa Randriantseheno
💊 New antibiotic class
Scientists have developed Novltex, a new antibiotic with strong activity against multidrug-resistant bacteria like MRSA. It’s cheaper to make and highly effective in lab tests.
🔗 pubs.acs.org/doi/10.1021/...
#SciComm #Antibiotics #AMR 🧪
Scientists have developed Novltex, a new antibiotic with strong activity against multidrug-resistant bacteria like MRSA. It’s cheaper to make and highly effective in lab tests.
🔗 pubs.acs.org/doi/10.1021/...
#SciComm #Antibiotics #AMR 🧪
Novltex: A New Class of Antibiotics with Potent Activity against Multidrug-Resistant Bacterial Pathogens─Design, Synthesis, and Biological Evaluation
Increasing spread of multidrug-resistant (MDR) bacteria demands antibiotics that combine potent activity with scalable synthesis. Novo29 (clovibactin) is promising but suffers from low yield (1%), dep...
pubs.acs.org
September 20, 2025 at 6:21 PM
💊 New antibiotic class
Scientists have developed Novltex, a new antibiotic with strong activity against multidrug-resistant bacteria like MRSA. It’s cheaper to make and highly effective in lab tests.
🔗 pubs.acs.org/doi/10.1021/...
#SciComm #Antibiotics #AMR 🧪
Scientists have developed Novltex, a new antibiotic with strong activity against multidrug-resistant bacteria like MRSA. It’s cheaper to make and highly effective in lab tests.
🔗 pubs.acs.org/doi/10.1021/...
#SciComm #Antibiotics #AMR 🧪
Reposted by Lovasoa Randriantseheno
A new model sheds light on the seasonal dynamics of plague in Madagascar — a step toward better prevention through a One Health approach.
🔗 Read more: www.pasteur.fr/en/research-...
@scauchemez.bsky.social
@abrault.bsky.social
@fanohi.bsky.social
🔗 Read more: www.pasteur.fr/en/research-...
@scauchemez.bsky.social
@abrault.bsky.social
@fanohi.bsky.social
Plague in Madagascar: a new model sheds light on the seasonality of outbreaks
A new model has been developed to elucidate the seasonal dynamics of plague in Madagascar. In this country, where the disease remains endemic, and most often occurs between October and March. The asso...
www.pasteur.fr
September 12, 2025 at 9:32 AM
A new model sheds light on the seasonal dynamics of plague in Madagascar — a step toward better prevention through a One Health approach.
🔗 Read more: www.pasteur.fr/en/research-...
@scauchemez.bsky.social
@abrault.bsky.social
@fanohi.bsky.social
🔗 Read more: www.pasteur.fr/en/research-...
@scauchemez.bsky.social
@abrault.bsky.social
@fanohi.bsky.social
Reposted by Lovasoa Randriantseheno
🌡️ Heat is already hurting billions.
Outdoor & manual workers in agriculture, construction & beyond face rising temperatures that slash productivity & threaten lives.
The new WHO / @wmo-global.bsky.social report shares practical, evidence-based solutions 👉 bit.ly/3JvqKI1 #ClimateAction
Outdoor & manual workers in agriculture, construction & beyond face rising temperatures that slash productivity & threaten lives.
The new WHO / @wmo-global.bsky.social report shares practical, evidence-based solutions 👉 bit.ly/3JvqKI1 #ClimateAction
August 22, 2025 at 6:44 AM
🌡️ Heat is already hurting billions.
Outdoor & manual workers in agriculture, construction & beyond face rising temperatures that slash productivity & threaten lives.
The new WHO / @wmo-global.bsky.social report shares practical, evidence-based solutions 👉 bit.ly/3JvqKI1 #ClimateAction
Outdoor & manual workers in agriculture, construction & beyond face rising temperatures that slash productivity & threaten lives.
The new WHO / @wmo-global.bsky.social report shares practical, evidence-based solutions 👉 bit.ly/3JvqKI1 #ClimateAction
Plague is not a disease of the past
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
California resident tests positive for the plague after camping, officials say
South Lake Tahoe resident was probably bitten by infected flea while camping in the area, local health authorities say
www.theguardian.com
August 22, 2025 at 1:52 AM
Plague is not a disease of the past
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
Reposted by Lovasoa Randriantseheno
An exciting negative result!
At the same time, we made thousands of synonymous mutations in endogenous yeast genes and measured their growth. We used careful statistics and controls. Only 3%, 204 of 6874, had a fitness effect! This goes against a controversial recent result that most synonymous mutations had fitness effects.
August 8, 2025 at 9:23 PM
An exciting negative result!
Reposted by Lovasoa Randriantseheno
“In a paper published in Nature Communications, the researchers have shown for the 1st time that mRNA can be delivered into the cells where HIV is hiding, by encasing it in a tiny, specially formulated fat bubble. The mRNA then instructs the cells to reveal the virus.”
The virus can no longer hide!
The virus can no longer hide!
June 5, 2025 at 9:12 AM
“In a paper published in Nature Communications, the researchers have shown for the 1st time that mRNA can be delivered into the cells where HIV is hiding, by encasing it in a tiny, specially formulated fat bubble. The mRNA then instructs the cells to reveal the virus.”
The virus can no longer hide!
The virus can no longer hide!
Reposted by Lovasoa Randriantseheno
New research from LSTM shows E. coli can evolve drug resistance mid-treatment by amplifying an existing gene, not gaining a new one.
A striking reminder of how quickly resistance can emerge.
🔗
A striking reminder of how quickly resistance can emerge.
🔗
New study shows that E. coli can evolve antibiotic resistance during treatment
This new study, led by Liverpool School of Tropical Medicine (LSTM) and published in the Journal of Medical Microbiology, details the rapid evolution of resistance in an E.
lstm.ac
August 5, 2025 at 2:28 PM
New research from LSTM shows E. coli can evolve drug resistance mid-treatment by amplifying an existing gene, not gaining a new one.
A striking reminder of how quickly resistance can emerge.
🔗
A striking reminder of how quickly resistance can emerge.
🔗
Reposted by Lovasoa Randriantseheno
In our latest blog post, our Data Scientist Osheen MacOscar shares a great overview of how to use {ggplot2} and {gganimate}, when dealing with spatial data.
#rstats #datavis #spatialdata #maps
#rstats #datavis #spatialdata #maps
Animated Maps with {ggplot2} and {gganimate}
In this blog we are creating an animated map of the gapminder data using {ggplot2} and {gganimate}. In the process we will cover some of the common pitfalls when working with spatial data and how to get round them!
www.jumpingrivers.com
July 31, 2025 at 10:41 AM
In our latest blog post, our Data Scientist Osheen MacOscar shares a great overview of how to use {ggplot2} and {gganimate}, when dealing with spatial data.
#rstats #datavis #spatialdata #maps
#rstats #datavis #spatialdata #maps
Reposted by Lovasoa Randriantseheno
Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi
diversity & conservation among Lyme spirochetes, including the curious DNA chunk that is sometimes on the chromosome, other times a separate linear plasmid
#MicroSky
www.biorxiv.org/content/10.1...
diversity & conservation among Lyme spirochetes, including the curious DNA chunk that is sometimes on the chromosome, other times a separate linear plasmid
#MicroSky
www.biorxiv.org/content/10.1...
July 31, 2025 at 3:16 PM
Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi
diversity & conservation among Lyme spirochetes, including the curious DNA chunk that is sometimes on the chromosome, other times a separate linear plasmid
#MicroSky
www.biorxiv.org/content/10.1...
diversity & conservation among Lyme spirochetes, including the curious DNA chunk that is sometimes on the chromosome, other times a separate linear plasmid
#MicroSky
www.biorxiv.org/content/10.1...
Reposted by Lovasoa Randriantseheno
New pre-print from my lab!
Plasmids link antibiotic resistance and phage defense.
E.coli plasmids are hotspots for both antibiotic resistance and phage defense. Phage therapy has the potential to accidentally select for antibiotic resistance!!!
#microsky#AMR#phage
www.biorxiv.org/content/10.1....
Plasmids link antibiotic resistance and phage defense.
E.coli plasmids are hotspots for both antibiotic resistance and phage defense. Phage therapy has the potential to accidentally select for antibiotic resistance!!!
#microsky#AMR#phage
www.biorxiv.org/content/10.1....
Plasmids link antibiotic resistance genes and phage defense systems in E. coli
Phage therapy has been proposed as an alternative to antibiotics to treat resistant infections. However, we have a limited understanding of how antibiotic resistance genes (ARGs) associate with bacter...
www.biorxiv.org
July 29, 2025 at 1:28 PM
New pre-print from my lab!
Plasmids link antibiotic resistance and phage defense.
E.coli plasmids are hotspots for both antibiotic resistance and phage defense. Phage therapy has the potential to accidentally select for antibiotic resistance!!!
#microsky#AMR#phage
www.biorxiv.org/content/10.1....
Plasmids link antibiotic resistance and phage defense.
E.coli plasmids are hotspots for both antibiotic resistance and phage defense. Phage therapy has the potential to accidentally select for antibiotic resistance!!!
#microsky#AMR#phage
www.biorxiv.org/content/10.1....
Reposted by Lovasoa Randriantseheno
📣 I'm recruiting a postdoc researcher to join my team for a project on mosquito-specific viruses and host interactions. Peep the job description & how to apply below. Perfect for soon-to-be or recent PhD graduates in mosquito vector biology 🦟 or arbovirology 🦠
🗓️ Application deadline 31 August 2025
🗓️ Application deadline 31 August 2025
July 28, 2025 at 9:25 AM
📣 I'm recruiting a postdoc researcher to join my team for a project on mosquito-specific viruses and host interactions. Peep the job description & how to apply below. Perfect for soon-to-be or recent PhD graduates in mosquito vector biology 🦟 or arbovirology 🦠
🗓️ Application deadline 31 August 2025
🗓️ Application deadline 31 August 2025
Reposted by Lovasoa Randriantseheno
🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
www.science.org
July 24, 2025 at 6:23 PM
🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
Reposted by Lovasoa Randriantseheno
“just 68% of the 7,057 researchers whose work had produced null results had shared them in some form, and just 30% had tried to publish them in a journal.”
What a joke.
#NullEffectsMatter
www.nature.com/articles/d41...
What a joke.
#NullEffectsMatter
www.nature.com/articles/d41...
Researchers value null results, but struggle to publish them
Survey finds that fear of reputational harm and a lack of support and publication platforms are among respondents’ key concerns.
www.nature.com
July 24, 2025 at 12:33 AM
“just 68% of the 7,057 researchers whose work had produced null results had shared them in some form, and just 30% had tried to publish them in a journal.”
What a joke.
#NullEffectsMatter
www.nature.com/articles/d41...
What a joke.
#NullEffectsMatter
www.nature.com/articles/d41...
The plague, always... 😊
youtu.be/eBdwcqa39rc?...
youtu.be/eBdwcqa39rc?...
Les leçons de la peste
YouTube video by Institut Pasteur
youtu.be
July 22, 2025 at 1:39 PM
The plague, always... 😊
youtu.be/eBdwcqa39rc?...
youtu.be/eBdwcqa39rc?...
Reposted by Lovasoa Randriantseheno
Introducing my new #rstats package {kitchensink}
Not sure what the right model to fit is? Should you allow random intercepts, slopes, both? What do Bayesian methods say?
Just call {kitchensink::throw} to fit every possible model and see how your results differ!
Not sure what the right model to fit is? Should you allow random intercepts, slopes, both? What do Bayesian methods say?
Just call {kitchensink::throw} to fit every possible model and see how your results differ!
July 16, 2025 at 7:01 AM
Introducing my new #rstats package {kitchensink}
Not sure what the right model to fit is? Should you allow random intercepts, slopes, both? What do Bayesian methods say?
Just call {kitchensink::throw} to fit every possible model and see how your results differ!
Not sure what the right model to fit is? Should you allow random intercepts, slopes, both? What do Bayesian methods say?
Just call {kitchensink::throw} to fit every possible model and see how your results differ!
Reposted by Lovasoa Randriantseheno
Our Hybrid Gar (Alligator Gar x Spotted Gar) was also popular in the fish world…
She was “the face” of recent gar evolutionary rates/living fossils research led by @chasedbrownstein.bsky.social & @dmacguig.bsky.social: www.science.org/content/arti...
She was “the face” of recent gar evolutionary rates/living fossils research led by @chasedbrownstein.bsky.social & @dmacguig.bsky.social: www.science.org/content/arti...
These gars are the ultimate ‘living fossils’
Fish’s genomes are so static that groups whose last common ancestor lived during the time of the dinosaurs can produce fertile hybrids today
www.science.org
May 9, 2025 at 7:33 PM
Our Hybrid Gar (Alligator Gar x Spotted Gar) was also popular in the fish world…
She was “the face” of recent gar evolutionary rates/living fossils research led by @chasedbrownstein.bsky.social & @dmacguig.bsky.social: www.science.org/content/arti...
She was “the face” of recent gar evolutionary rates/living fossils research led by @chasedbrownstein.bsky.social & @dmacguig.bsky.social: www.science.org/content/arti...
Reposted by Lovasoa Randriantseheno
New paper with @rwheatley8.bsky.social and Cedric Lood
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...
Chromosomal capture of beneficial genes drives plasmids toward ecological redundancy
Abstract. Plasmids are a ubiquitous feature of bacterial genomes, but the forces driving genes and phenotypes to become associated with plasmids are poorly
academic.oup.com
July 16, 2025 at 9:17 AM
New paper with @rwheatley8.bsky.social and Cedric Lood
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...
Actual title: Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy.
Sensationalist title: Plasmids carry useless genes
academic.oup.com/ismej/articl...
Reposted by Lovasoa Randriantseheno
#Multiomics approaches are enabling the decoding of the impact of non-coding variants and of disease-associated molecular dysregulation. Hear from @saobettencourt.bsky.social and Andrew Stergachis TODAY in Webinar 1 of the Multi-Omics Online series. Register now: hubs.la/Q03wC2FL0
July 15, 2025 at 8:26 AM
#Multiomics approaches are enabling the decoding of the impact of non-coding variants and of disease-associated molecular dysregulation. Hear from @saobettencourt.bsky.social and Andrew Stergachis TODAY in Webinar 1 of the Multi-Omics Online series. Register now: hubs.la/Q03wC2FL0
Reposted by Lovasoa Randriantseheno
My colleague Pilar Domingo-Calap @pilardomingoc.bsky.social successfully treated a patient with prosthetic joint infection by her phage therapy 👏👏🏆🦠🧪🧫 #microsky #viruses #phages @uv.es @csic.es @ucciuv.bsky.social
Phage therapy in a patient with prosthetic join infection in Spain! Another sucessful treatment from the #EnBiVir #VLCphagehunters @i2sysbio.es and #EvolvingTherapeutics in collaboration with Dr. de la Villa #GregorioMarañon
@uv.es
@csic.es
www.sciencedirect.com/science/arti...
@uv.es
@csic.es
www.sciencedirect.com/science/arti...
Successful phage therapy in a patient with prosthetic joint infection
www.sciencedirect.com
July 12, 2025 at 9:52 PM
My colleague Pilar Domingo-Calap @pilardomingoc.bsky.social successfully treated a patient with prosthetic joint infection by her phage therapy 👏👏🏆🦠🧪🧫 #microsky #viruses #phages @uv.es @csic.es @ucciuv.bsky.social