Lotte Søgaard-Andersen
@lottesogaard.bsky.social
Ex-director at the Max Planck Institute for Terrestrial Microbiology, Marburg.
Reposted by Lotte Søgaard-Andersen
Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation https://www.biorxiv.org/content/10.1101/2025.03.14.642875v1
March 15, 2025 at 2:17 AM
Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation https://www.biorxiv.org/content/10.1101/2025.03.14.642875v1
Reposted by Lotte Søgaard-Andersen
DdiA, an XRE family transcriptional regulator, regulates a LexA-independent DNA damage response in Myxococcus xanthus https://www.biorxiv.org/content/10.1101/2025.02.19.639066v1
February 20, 2025 at 2:20 AM
DdiA, an XRE family transcriptional regulator, regulates a LexA-independent DNA damage response in Myxococcus xanthus https://www.biorxiv.org/content/10.1101/2025.02.19.639066v1
Reposted by Lotte Søgaard-Andersen
Would you expect that Bacteria use an archaellum for swimming? We didn't, but we found that some Chloroflexota do! Find the story here: www.biorxiv.org/content/10.1...
A little thread below 1/n
A little thread below 1/n
Horizontal gene transfer of the functional archaellum machinery to Bacteria
Motility in Archaea is driven by a nanomachinery called the archaellum. So far, archaella have been exclusively described for the archaeal domain; however, a recent study reported the presence of arch...
www.biorxiv.org
February 3, 2025 at 10:09 AM
Would you expect that Bacteria use an archaellum for swimming? We didn't, but we found that some Chloroflexota do! Find the story here: www.biorxiv.org/content/10.1...
A little thread below 1/n
A little thread below 1/n
Reposted by Lotte Søgaard-Andersen
#MicroSky
CTPases, the new kids on the block
CTPases, the new kids on the block
OUT NOW: KorB is a DNA clamp which slides along DNA to mediate long-range gene silencing upon interaction with the clamp-locking KorA protein
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid - Nature Microbiology
Structural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...
www.nature.com
January 23, 2025 at 4:37 PM
#MicroSky
CTPases, the new kids on the block
CTPases, the new kids on the block
Reposted by Lotte Søgaard-Andersen
Indeed - thank you David Goodsell for bringing science to life with art! Seeing the pilus motor featured is still my favourite grad school memory
doi.org/10.2210/rcsb...
doi.org/10.2210/rcsb...
January 7, 2025 at 5:02 PM
Indeed - thank you David Goodsell for bringing science to life with art! Seeing the pilus motor featured is still my favourite grad school memory
doi.org/10.2210/rcsb...
doi.org/10.2210/rcsb...
and here the direct link
doi.org/10.1073/pnas...
doi.org/10.1073/pnas...
January 3, 2025 at 10:38 AM
and here the direct link
doi.org/10.1073/pnas...
doi.org/10.1073/pnas...
1/Interested in biomolecular condensates? If yes, check 10.1073/pnas.2419610121 where we describe the in situ architecture of the PomXYZ co-condensate using cryo-correlative light and electron microscopy & in situ cryo-ET
Wonderful coll/w Baumeister lab @madic.bsky.social
#teamtomo #cryoET #cryoEM
Wonderful coll/w Baumeister lab @madic.bsky.social
#teamtomo #cryoET #cryoEM
January 3, 2025 at 10:32 AM
1/Interested in biomolecular condensates? If yes, check 10.1073/pnas.2419610121 where we describe the in situ architecture of the PomXYZ co-condensate using cryo-correlative light and electron microscopy & in situ cryo-ET
Wonderful coll/w Baumeister lab @madic.bsky.social
#teamtomo #cryoET #cryoEM
Wonderful coll/w Baumeister lab @madic.bsky.social
#teamtomo #cryoET #cryoEM
Reposted by Lotte Søgaard-Andersen
Reposted by Lotte Søgaard-Andersen
Latest from Baumeister & @lottesogaard.bsky.social labs:
The PomXYZ complex and its role in bacterial cell division.
www.pnas.org/doi/10.1073/...
#teamtomo #cryoET #cryoEM
The PomXYZ complex and its role in bacterial cell division.
www.pnas.org/doi/10.1073/...
#teamtomo #cryoET #cryoEM
In situ architecture of a nucleoid-associated biomolecular co-condensate that regulates bacterial cell division | PNAS
In most bacteria, cell division depends on the tubulin-homolog FtsZ that polymerizes
in a GTP-dependent manner to form the cytokinetic Z-ring at th...
www.pnas.org
January 1, 2025 at 8:52 AM
Latest from Baumeister & @lottesogaard.bsky.social labs:
The PomXYZ complex and its role in bacterial cell division.
www.pnas.org/doi/10.1073/...
#teamtomo #cryoET #cryoEM
The PomXYZ complex and its role in bacterial cell division.
www.pnas.org/doi/10.1073/...
#teamtomo #cryoET #cryoEM
Reposted by Lotte Søgaard-Andersen
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...
www.biorxiv.org
December 30, 2024 at 9:01 PM
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Reposted by Lotte Søgaard-Andersen
Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus
Finally out in PLOS Pathogens. Congrats Hannah Ochner and co-authors. @mrclmb.bsky.social
journals.plos.org/plospathogen...
Finally out in PLOS Pathogens. Congrats Hannah Ochner and co-authors. @mrclmb.bsky.social
journals.plos.org/plospathogen...
December 16, 2024 at 3:53 PM
Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus
Finally out in PLOS Pathogens. Congrats Hannah Ochner and co-authors. @mrclmb.bsky.social
journals.plos.org/plospathogen...
Finally out in PLOS Pathogens. Congrats Hannah Ochner and co-authors. @mrclmb.bsky.social
journals.plos.org/plospathogen...
Reposted by Lotte Søgaard-Andersen
Today is @vestager.bsky.social last day as commissioner. She has certainly left many footprints. Just take the DSA. But also literally. The protocol in the Berlaymont has been changed so that sneakers are now also part of the dress-code. Tak!
November 30, 2024 at 12:07 PM
Today is @vestager.bsky.social last day as commissioner. She has certainly left many footprints. Just take the DSA. But also literally. The protocol in the Berlaymont has been changed so that sneakers are now also part of the dress-code. Tak!
Reposted by Lotte Søgaard-Andersen
Check out this new preprint on bioRxiv about a tyrosine pseudokinase involved in eps synthesis in Myxococcus xanthus by Bloecher et al., @lottesogaard.bsky.social
November 27, 2024 at 5:20 PM
Check out this new preprint on bioRxiv about a tyrosine pseudokinase involved in eps synthesis in Myxococcus xanthus by Bloecher et al., @lottesogaard.bsky.social
Once again, Akos is quicker than I am.
To polysaccharide afficionados: EcpK, a BY pseudokinase facilitates exopolysaccharide synthesis by direct interaction with its PCP partner. We speculate that EcpK stimulates PCP by binding/unbinding cycles rather than phosphorylation/dephosphorylation cycles.
To polysaccharide afficionados: EcpK, a BY pseudokinase facilitates exopolysaccharide synthesis by direct interaction with its PCP partner. We speculate that EcpK stimulates PCP by binding/unbinding cycles rather than phosphorylation/dephosphorylation cycles.
bioRxiv on EPS synthesis in Mycococcus - from Lotte Sogaard-Andersen at @maxplanck.bsky.social Marburg
Identification of EcpK, a bacterial tyrosine pseudokinase important for exopolysaccharide biosynthesis in Myxococcus xanthus https://www.biorxiv.org/content/10.1101/2024.11.26.625375v1
November 27, 2024 at 8:09 AM
Once again, Akos is quicker than I am.
To polysaccharide afficionados: EcpK, a BY pseudokinase facilitates exopolysaccharide synthesis by direct interaction with its PCP partner. We speculate that EcpK stimulates PCP by binding/unbinding cycles rather than phosphorylation/dephosphorylation cycles.
To polysaccharide afficionados: EcpK, a BY pseudokinase facilitates exopolysaccharide synthesis by direct interaction with its PCP partner. We speculate that EcpK stimulates PCP by binding/unbinding cycles rather than phosphorylation/dephosphorylation cycles.
Reposted by Lotte Søgaard-Andersen
Super nice work from Simon Schäper showing that septal peptidoglycan synthases in S. aureus are not driven by FtsZ treadmilling. Instead they follow a one track model and their processive movement is dependent on peptidoglycan synthesis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cell constriction requires processive septal peptidoglycan synthase movement independent of FtsZ treadmilling in Staphylococcus aureus - Nature Microbiology
Single-molecule imaging reveals that peptidoglycan synthesis and synthase activity, rather than FtsZ treadmilling, are rate limiting and drive septum constriction in Staphylococcus aureus.
www.nature.com
March 13, 2024 at 11:47 AM
Super nice work from Simon Schäper showing that septal peptidoglycan synthases in S. aureus are not driven by FtsZ treadmilling. Instead they follow a one track model and their processive movement is dependent on peptidoglycan synthesis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lotte Søgaard-Andersen
Great review by @pinholab.bsky.social and Simon Foster on the current knowledge regarding growth, elongation and division of Staphylococcus aureus www.annualreviews.org/content/jour...
November 21, 2024 at 5:42 PM
Great review by @pinholab.bsky.social and Simon Foster on the current knowledge regarding growth, elongation and division of Staphylococcus aureus www.annualreviews.org/content/jour...
Reposted by Lotte Søgaard-Andersen
Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
🦠🧪🧫🧬
🦠🧪🧫🧬
November 10, 2024 at 1:13 PM
Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
🦠🧪🧫🧬
🦠🧪🧫🧬