Lotte Søgaard-Andersen
@lottesogaard.bsky.social
Ex-director at the Max Planck Institute for Terrestrial Microbiology, Marburg.
7/ For more condensates built from filaments. See also doi.org/10.1101/2024.12.27.630454 from kerenlasker.bsky.social
Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...
doi.org
January 3, 2025 at 10:32 AM
7/ For more condensates built from filaments. See also doi.org/10.1101/2024.12.27.630454 from kerenlasker.bsky.social
6/ Traditionally, the function of proteins depends on their assembly into complexes of well-defined stoichiometry & structure. The PomXYZ architecture illustrates how a co-condensate without a well-defined stoichiometry & structure spatiotemporally regulates cell division with exquisite precision.
January 3, 2025 at 10:32 AM
6/ Traditionally, the function of proteins depends on their assembly into complexes of well-defined stoichiometry & structure. The PomXYZ architecture illustrates how a co-condensate without a well-defined stoichiometry & structure spatiotemporally regulates cell division with exquisite precision.
5/ Because PomY biomolecular condensate formation is templated by & embedded within the PomX meshwork, precisely one PomXYZ co-condensate is formed per cell.
January 3, 2025 at 10:32 AM
5/ Because PomY biomolecular condensate formation is templated by & embedded within the PomX meshwork, precisely one PomXYZ co-condensate is formed per cell.
4/ PomY associates with the PomX meshwork and undergoes surface-assisted condensation on this meshwork, resulting in the formation of a highly selective PomXY co-condensate that is associated with the nucleoid by PomZ.
January 3, 2025 at 10:32 AM
4/ PomY associates with the PomX meshwork and undergoes surface-assisted condensation on this meshwork, resulting in the formation of a highly selective PomXY co-condensate that is associated with the nucleoid by PomZ.
3/ We show that PomX forms precisely one copy per cell of a highly variable, porous meshwork of randomly intertwined filaments akin to a tumbleweed architecture. The PomX meshwork contains large protein densities & ribosomes and is non-selective.
January 3, 2025 at 10:32 AM
3/ We show that PomX forms precisely one copy per cell of a highly variable, porous meshwork of randomly intertwined filaments akin to a tumbleweed architecture. The PomX meshwork contains large protein densities & ribosomes and is non-selective.
2/ Biomolecular condensates spatially organize cellular reactions in bacteria and eukaryotic cells. PomX, PomY & PomZ form precisely one MDa-sized, nonstoichiometric, nucleoid-associated co-condensate per cell that nucleates FtsZ polymerization to form the cytokinetic FtsZ-ring in Myxococcus.
January 3, 2025 at 10:32 AM
2/ Biomolecular condensates spatially organize cellular reactions in bacteria and eukaryotic cells. PomX, PomY & PomZ form precisely one MDa-sized, nonstoichiometric, nucleoid-associated co-condensate per cell that nucleates FtsZ polymerization to form the cytokinetic FtsZ-ring in Myxococcus.
Reposted by Lotte Søgaard-Andersen
Check out this new preprint on bioRxiv about a tyrosine pseudokinase involved in eps synthesis in Myxococcus xanthus by Bloecher et al., @lottesogaard.bsky.social
November 27, 2024 at 5:20 PM
Check out this new preprint on bioRxiv about a tyrosine pseudokinase involved in eps synthesis in Myxococcus xanthus by Bloecher et al., @lottesogaard.bsky.social