laggyy
@laggyy.bsky.social
Chromosomal biology / Structure / Obsidianmd / ...
Reposted by laggyy
Nature research paper: Holliday junction–ZMM protein feedback enables meiotic crossover assurance
go.nature.com/42JHXnV
go.nature.com/42JHXnV
Holliday junction–ZMM protein feedback enables meiotic crossover assurance - Nature
Holliday junctions maintain chromosome synapsis to enable crossover assurance in budding yeast.
go.nature.com
September 30, 2025 at 7:47 AM
Nature research paper: Holliday junction–ZMM protein feedback enables meiotic crossover assurance
go.nature.com/42JHXnV
go.nature.com/42JHXnV
Reposted by laggyy
作品における描写が明確ではなく曖昧なとき（たとえばAは死んだのか？生き延びたのか？）、それが"曖昧である"ということ自体が「曖昧にしよう」という作者の意図を明快に伝えているのだけど、流行としての「考察」的な態度は、その観点を無視しているように思える。
September 21, 2025 at 12:12 PM
作品における描写が明確ではなく曖昧なとき（たとえばAは死んだのか？生き延びたのか？）、それが"曖昧である"ということ自体が「曖昧にしよう」という作者の意図を明快に伝えているのだけど、流行としての「考察」的な態度は、その観点を無視しているように思える。
Reposted by laggyy
In families with several children of the same sex, the odds of having another baby of that sex are higher than of having one of the opposite sex
go.nature.com/45caBj4
go.nature.com/45caBj4
Sex at birth is not always random — mum’s age and genetics can play a part
Families with three or more boys, for example, are more likely to have another boy than a girl as the next child.
go.nature.com
July 21, 2025 at 7:58 AM
In families with several children of the same sex, the odds of having another baby of that sex are higher than of having one of the opposite sex
go.nature.com/45caBj4
go.nature.com/45caBj4
Reposted by laggyy
Implantable soft bioelectronics track neural activity in the developing vertebrate brain. www.nature.com/articles/s41... #NBThighlight
Brain implantation of soft bioelectronics via embryonic development - Nature
A soft mesh microelectrode array can seamlessly integrate in developing brains, enabling long-term, stable mapping of how single-neuron activity and population dynamics emerge and evolve during brain ...
www.nature.com
June 12, 2025 at 2:24 PM
Implantable soft bioelectronics track neural activity in the developing vertebrate brain. www.nature.com/articles/s41... #NBThighlight
Reposted by laggyy
with Obsidian Bases you can create embedded views that reference the current file — for example if I put my "Places" base inside Taipei I get only places I saved in Taipei
May 27, 2025 at 1:28 AM
with Obsidian Bases you can create embedded views that reference the current file — for example if I put my "Places" base inside Taipei I get only places I saved in Taipei
Reposted by laggyy
Nature research paper: The origin of vertebrate teeth and evolution of sensory exoskeletons
https://go.nature.com/4jduyKk
https://go.nature.com/4jduyKk
The origin of vertebrate teeth and evolution of sensory exoskeletons - Nature
Re-examination of the presumed Cambrian fossil fish Anatolepis reveals previous misidentification of aglaspidid sensory structures as dentine, a vertebrate sensory tissue, showing it to be an arthropod, and shifting the origin of vertebrate hard tissues to the Middle Ordovician.
go.nature.com
May 27, 2025 at 10:31 AM
Nature research paper: The origin of vertebrate teeth and evolution of sensory exoskeletons
https://go.nature.com/4jduyKk
https://go.nature.com/4jduyKk
Reposted by laggyy
Introducing Bases, a new core plugin that lets you turn any set of notes into a powerful database. With Bases you can organize everything from projects to travel plans, reading lists, and more.
Bases are now available in Obsidian 1.9.0 for early access users.
Bases are now available in Obsidian 1.9.0 for early access users.
May 21, 2025 at 3:29 PM
Introducing Bases, a new core plugin that lets you turn any set of notes into a powerful database. With Bases you can organize everything from projects to travel plans, reading lists, and more.
Bases are now available in Obsidian 1.9.0 for early access users.
Bases are now available in Obsidian 1.9.0 for early access users.
Reposted by laggyy
Nature research paper: Solid phase transitions as a solution to the genome folding paradox
https://go.nature.com/3S8gJSq
https://go.nature.com/3S8gJSq
Solid phase transitions as a solution to the genome folding paradox - Nature
In vitro reconstitution and in vivo live-cell imaging of LHX2–EBF1–LDB1 enhancer hubs in olfactory sensory neurons reveals that these transcription factors form condensates with solid, rather than liquid, phase properties.
go.nature.com
May 15, 2025 at 5:48 PM
Nature research paper: Solid phase transitions as a solution to the genome folding paradox
https://go.nature.com/3S8gJSq
https://go.nature.com/3S8gJSq
Reposted by laggyy
Autonomous locomotion simply with tubes as limbs, and no brain? 🎈🤖
Yes, through physical synchronization! Our article is out today in Science (@science.org)
Article: www.science.org/doi/10.1126/...
Authors: @albertocomoretto.bsky.social, H.A.H. Schomaker, J.T.B. Overvelde
More below 🧪 ⚛️
(1/6)
Yes, through physical synchronization! Our article is out today in Science (@science.org)
Article: www.science.org/doi/10.1126/...
Authors: @albertocomoretto.bsky.social, H.A.H. Schomaker, J.T.B. Overvelde
More below 🧪 ⚛️
(1/6)
May 8, 2025 at 6:15 PM
Autonomous locomotion simply with tubes as limbs, and no brain? 🎈🤖
Yes, through physical synchronization! Our article is out today in Science (@science.org)
Article: www.science.org/doi/10.1126/...
Authors: @albertocomoretto.bsky.social, H.A.H. Schomaker, J.T.B. Overvelde
More below 🧪 ⚛️
(1/6)
Yes, through physical synchronization! Our article is out today in Science (@science.org)
Article: www.science.org/doi/10.1126/...
Authors: @albertocomoretto.bsky.social, H.A.H. Schomaker, J.T.B. Overvelde
More below 🧪 ⚛️
(1/6)
Reposted by laggyy
Nature research paper: Chromatin loops are an ancestral hallmark of the animal regulatory genome
https://go.nature.com/4kcNObU
https://go.nature.com/4kcNObU
Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature
The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of genome architecture and spatial genome regulation emerged early in animal evolution.
go.nature.com
May 7, 2025 at 5:33 PM
Nature research paper: Chromatin loops are an ancestral hallmark of the animal regulatory genome
https://go.nature.com/4kcNObU
https://go.nature.com/4kcNObU
Reposted by laggyy
A method to generate large mitochondrial DNA deletions in human cells enables the study of their pathogenicity, which could inform future treatment strategies. www.cell.com/cell/fulltex... #NBTHighlight
Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Combined expression of a mitochondrially targeted endonuclease and end-joining machinery
enables formation of mtDNA deletions with a broad range of heteroplasmy.
www.cell.com
March 12, 2025 at 9:25 AM
A method to generate large mitochondrial DNA deletions in human cells enables the study of their pathogenicity, which could inform future treatment strategies. www.cell.com/cell/fulltex... #NBTHighlight
Reposted by laggyy
Virtual cells for predictive immunotherapy - @fertiglab.bsky.social @genomescience.bsky.social go.nature.com/4jfqM3Y
April 16, 2025 at 3:27 PM
Virtual cells for predictive immunotherapy - @fertiglab.bsky.social @genomescience.bsky.social go.nature.com/4jfqM3Y
Reposted by laggyy
Excited to share that our protein editing method from the Muir Lab is now published in @science.org
We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules
www.science.org/doi/10.1126/...
We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules
www.science.org/doi/10.1126/...
Protein editing using a coordinated transposition reaction
Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step...
www.science.org
April 4, 2025 at 12:35 AM
Excited to share that our protein editing method from the Muir Lab is now published in @science.org
We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules
www.science.org/doi/10.1126/...
We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules
www.science.org/doi/10.1126/...
Reposted by laggyy
Reposted by laggyy
Reposted by laggyy
Nature research paper: Reconstitution of SPO11-dependent double-strand break formation
https://go.nature.com/4kdj0bt
https://go.nature.com/4kdj0bt
Reconstitution of SPO11-dependent double-strand break formation - Nature
Reconstitution of recombinantly expressed SPO11–TOP6BL complex recapitulates its DNA cleavage function and together with structural modelling and biochemical experiments, provides insights into the regulation and mechanism of SPO11 activity.
go.nature.com
February 25, 2025 at 8:49 PM
Nature research paper: Reconstitution of SPO11-dependent double-strand break formation
https://go.nature.com/4kdj0bt
https://go.nature.com/4kdj0bt
Fred again...とFour Tetのこの曲、途中のノイズ入った様にズレる部分がとても気持ちいい
open.spotify.com/track/3i9QKR...
open.spotify.com/track/3i9QKR...
glow
Fred again.., Duskus, Four Tet, Joy Anonymous, Skrillex · ten days · Song · 2024
open.spotify.com
February 25, 2025 at 1:13 PM
Fred again...とFour Tetのこの曲、途中のノイズ入った様にズレる部分がとても気持ちいい
open.spotify.com/track/3i9QKR...
open.spotify.com/track/3i9QKR...
Reposted by laggyy
NYタイムズのエズラ・クラインが、トランプの就任直後の（度を越して最悪な）挙動を冷静に分析。ギフトにしとく
「トランプは自分の進路が分岐点を迎えることを知らないのかもしれない。彼は自分が主張するほどの権力を持っていると信じているのかもしれない。それは彼の間違いであり、大統領としての彼の運命を破滅に導く自己欺瞞である。しかし本当の脅威は、彼が私たちに、自分にはない権力を持っていると信じ込ませることだ。」
目と耳を疑うような暴挙によって、自分が強いと信じ込ませようとする態度は、実は弱さの裏返しでもある。必要なのは「信じない」こと。
www.nytimes.com/2025/02/02/o...
「トランプは自分の進路が分岐点を迎えることを知らないのかもしれない。彼は自分が主張するほどの権力を持っていると信じているのかもしれない。それは彼の間違いであり、大統領としての彼の運命を破滅に導く自己欺瞞である。しかし本当の脅威は、彼が私たちに、自分にはない権力を持っていると信じ込ませることだ。」
目と耳を疑うような暴挙によって、自分が強いと信じ込ませようとする態度は、実は弱さの裏返しでもある。必要なのは「信じない」こと。
www.nytimes.com/2025/02/02/o...
Opinion | Don’t Believe Him (Gift Article)
Look closely at the first two weeks of Donald Trump’s second term and you’ll see something very different than what he wants you to see.
www.nytimes.com
February 2, 2025 at 12:00 PM
NYタイムズのエズラ・クラインが、トランプの就任直後の（度を越して最悪な）挙動を冷静に分析。ギフトにしとく
「トランプは自分の進路が分岐点を迎えることを知らないのかもしれない。彼は自分が主張するほどの権力を持っていると信じているのかもしれない。それは彼の間違いであり、大統領としての彼の運命を破滅に導く自己欺瞞である。しかし本当の脅威は、彼が私たちに、自分にはない権力を持っていると信じ込ませることだ。」
目と耳を疑うような暴挙によって、自分が強いと信じ込ませようとする態度は、実は弱さの裏返しでもある。必要なのは「信じない」こと。
www.nytimes.com/2025/02/02/o...
「トランプは自分の進路が分岐点を迎えることを知らないのかもしれない。彼は自分が主張するほどの権力を持っていると信じているのかもしれない。それは彼の間違いであり、大統領としての彼の運命を破滅に導く自己欺瞞である。しかし本当の脅威は、彼が私たちに、自分にはない権力を持っていると信じ込ませることだ。」
目と耳を疑うような暴挙によって、自分が強いと信じ込ませようとする態度は、実は弱さの裏返しでもある。必要なのは「信じない」こと。
www.nytimes.com/2025/02/02/o...
Reposted by laggyy
Reposted by laggyy
How can stress-response machinery eliminate chemically damaged proteins to ensure continued cell function and survival?
https://go.nature.com/3WECgVv
https://go.nature.com/3WECgVv
Signs of damage that drive protein degradation
How the stress-response machinery eliminates damaged proteins.
go.nature.com
January 29, 2025 at 6:44 PM
How can stress-response machinery eliminate chemically damaged proteins to ensure continued cell function and survival?
https://go.nature.com/3WECgVv
https://go.nature.com/3WECgVv
Reposted by laggyy
Munch mode activated
November 28, 2024 at 5:05 PM
Munch mode activated
