Alex Whitworth lab
@labwhitworth.bsky.social
Research group at the MRC Mitochondrial Biology Unit, University of Cambridge. Interested in all things neurodegeneration, mitochondrial dysfunction, in vivo genetics, Drosophila, mitophagy, mtDNA, calcium, gut-brain axis etc
Reposted by Alex Whitworth lab
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
October 14, 2025 at 11:50 AM
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
Having fun enthusing young and old, expert and novice, about our mitochondria research at Cambridge’s Big Biology Day #PublicEngagement #Outreach @mrc-mbu.bsky.social
October 11, 2025 at 12:01 PM
Having fun enthusing young and old, expert and novice, about our mitochondria research at Cambridge’s Big Biology Day #PublicEngagement #Outreach @mrc-mbu.bsky.social
Amazing work @frisophagy.bsky.social and all the Chinnery lab team.
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 10, 2025 at 2:18 PM
Amazing work @frisophagy.bsky.social and all the Chinnery lab team.
Oh, this is sad. A great scientist and great (and modest) human being. I’m very proud that he once told me he liked my talk at the end. High praise indeed.
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
October 7, 2025 at 9:15 PM
Oh, this is sad. A great scientist and great (and modest) human being. I’m very proud that he once told me he liked my talk at the end. High praise indeed.
Reposted by Alex Whitworth lab
Applications now open for our work experience programme for year 12 students, run with @mrc-mbu.bsky.social & @stcatharines.bsky.social We give students a valuable insight into life as a research scientist and student in Cambridge. Details & application link here: www.cimr.cam.ac.uk/inspiring-sc...
October 7, 2025 at 12:43 PM
Applications now open for our work experience programme for year 12 students, run with @mrc-mbu.bsky.social & @stcatharines.bsky.social We give students a valuable insight into life as a research scientist and student in Cambridge. Details & application link here: www.cimr.cam.ac.uk/inspiring-sc...
Reposted by Alex Whitworth lab
🌟 We’re hiring a Postdoctoral Fellow! 🌟
Join my lab @sydney.edu.au and help drive cutting-edge research in axon degeneration as part of the Snow Vision Accelerator.
@snowmedical.bsky.social
usyd.wd105.myworkdayjobs.com/en-GB/USYD_E...
Join my lab @sydney.edu.au and help drive cutting-edge research in axon degeneration as part of the Snow Vision Accelerator.
@snowmedical.bsky.social
usyd.wd105.myworkdayjobs.com/en-GB/USYD_E...
Postdoctoral Research Associate - Neurodegeneration
An exciting opportunity to join the Snow Vision Accelerator Location: Loreto Group, Axon degeneration Lab, School of Medical Sciences, Charles Perkins Centre, Faculty of Medicine and Health Full time,...
usyd.wd105.myworkdayjobs.com
August 12, 2025 at 7:02 AM
🌟 We’re hiring a Postdoctoral Fellow! 🌟
Join my lab @sydney.edu.au and help drive cutting-edge research in axon degeneration as part of the Snow Vision Accelerator.
@snowmedical.bsky.social
usyd.wd105.myworkdayjobs.com/en-GB/USYD_E...
Join my lab @sydney.edu.au and help drive cutting-edge research in axon degeneration as part of the Snow Vision Accelerator.
@snowmedical.bsky.social
usyd.wd105.myworkdayjobs.com/en-GB/USYD_E...
Reposted by Alex Whitworth lab
Do you need help with mitochondrial image analysis? 🔬
Check out mitographica.com created by
Dane M Wolf
Find out more from his interview on MitoWorld
mitoworld.org/mitochondria...
Check out mitographica.com created by
Dane M Wolf
Find out more from his interview on MitoWorld
mitoworld.org/mitochondria...
mitographica.com
July 17, 2025 at 4:02 PM
Do you need help with mitochondrial image analysis? 🔬
Check out mitographica.com created by
Dane M Wolf
Find out more from his interview on MitoWorld
mitoworld.org/mitochondria...
Check out mitographica.com created by
Dane M Wolf
Find out more from his interview on MitoWorld
mitoworld.org/mitochondria...
Proud that this being pioneered in the UK 💪
July 16, 2025 at 9:56 PM
Proud that this being pioneered in the UK 💪
Delighted to share our latest work looking at the role of the RNA-binding proteins Clu1 (yeast)/Clu (flies) in regulating the translation of #mitochondria proteins. Really interesting regulator of mito biology.
Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...
Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...
Clu1/Clu form mitochondria-associated granules upon metabolic transitions and regulate mitochondrial protein translation via ribosome interactions
Author summary Mitochondria are essential cellular organelles that perform many important roles in regulating metabolism. They are dynamic in form, function and composition which is crucial to maintai...
dx.plos.org
July 16, 2025 at 11:35 AM
Delighted to share our latest work looking at the role of the RNA-binding proteins Clu1 (yeast)/Clu (flies) in regulating the translation of #mitochondria proteins. Really interesting regulator of mito biology.
Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...
Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...
Ha. This is so accurate to how I’m spending my days.
Progress with my grant proposal:
July 10, 2025 at 9:34 PM
Ha. This is so accurate to how I’m spending my days.
Reposted by Alex Whitworth lab
We were shocked and disappointed to learn of the allegations made about Raynor and Moth Winn by The Observer. The article has taken everyone by surprise and has made people affected by CBD & PSP feel angry, let down and eager for clarity. Full statement: www.pspassociation.org.uk/news/pspas-r...
July 7, 2025 at 9:32 AM
We were shocked and disappointed to learn of the allegations made about Raynor and Moth Winn by The Observer. The article has taken everyone by surprise and has made people affected by CBD & PSP feel angry, let down and eager for clarity. Full statement: www.pspassociation.org.uk/news/pspas-r...
This is quite shocking and saddening if true.
I spent months on this investigation and gathered docs from the UK courts, Land Registry and a French local authority, to show that Raynor and Moth Winn's story is not as they claim. @tortoisemedia.bsky.social @observeruk.bsky.social
observer.co.uk/news/nationa...
observer.co.uk/news/nationa...
The real Salt Path: how the couple behind a bestseller le...
Penniless and homeless, the Winns found fame and fortune with the story of their 630-mile walk to salvation. We can reveal it was far from the truth
observer.co.uk
July 8, 2025 at 9:59 AM
This is quite shocking and saddening if true.
Reposted by Alex Whitworth lab
Reposted by Alex Whitworth lab
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
doi.org
June 27, 2025 at 11:21 AM
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
Reposted by Alex Whitworth lab
Check out the #LMSnews story on the @mrc-lms.bsky.social website about our latest study published in @natcomms.nature.com!
Illustrated by multi-talented first author #postdoc #painter @claudialennicke.bsky.social 💛 #redox #cysteine #sciart
Illustrated by multi-talented first author #postdoc #painter @claudialennicke.bsky.social 💛 #redox #cysteine #sciart
Researchers at the LMS have extended the lifespan of female fruit flies by boosting the levels of an enzyme which breaks down the reactive oxidant, hydrogen peroxide, inside cells. This highlights the role of hydrogen peroxide as an important cell signalling molecule.
‘Redox control’ of metabolism improves health and delays ageing in fruit flies
Researchers at the MRC Laboratory of Medical Sciences (LMS) have extended the lifespan of female fruit flies by boosting the levels of an enzyme which breaks down the reactive oxidant, hydrogen peroxi...
lms.mrc.ac.uk
June 27, 2025 at 11:32 AM
Check out the #LMSnews story on the @mrc-lms.bsky.social website about our latest study published in @natcomms.nature.com!
Illustrated by multi-talented first author #postdoc #painter @claudialennicke.bsky.social 💛 #redox #cysteine #sciart
Illustrated by multi-talented first author #postdoc #painter @claudialennicke.bsky.social 💛 #redox #cysteine #sciart
Reposted by Alex Whitworth lab
Delighted to announce Prof Miratul Muqit as Centre Director of our groundbreaking new Parkinson's Research Centre, a partnership with @parkinsons.org.uk!🎉👏
Prof Muqit is a world leader in Parkinson’s research, having made major contributions to understanding genetic risk👉 buff.ly/etNUa4b
Prof Muqit is a world leader in Parkinson’s research, having made major contributions to understanding genetic risk👉 buff.ly/etNUa4b
June 25, 2025 at 8:13 AM
Delighted to announce Prof Miratul Muqit as Centre Director of our groundbreaking new Parkinson's Research Centre, a partnership with @parkinsons.org.uk!🎉👏
Prof Muqit is a world leader in Parkinson’s research, having made major contributions to understanding genetic risk👉 buff.ly/etNUa4b
Prof Muqit is a world leader in Parkinson’s research, having made major contributions to understanding genetic risk👉 buff.ly/etNUa4b
Very useful overview, especially for the Drosophila-curious.
It’s easy to bring the power of fly genetics to your neurobiology questions.
It’s easy to bring the power of fly genetics to your neurobiology questions.
"The Drosophila adult brain: short overview of structure, function, and resources Graphical Review Paper": www.sciencedirect.com/science/arti...
@arielframe.bsky.social
@ibangs.bsky.social
@brentsinclair.bsky.social
@westernu.bsky.social
@arielframe.bsky.social
@ibangs.bsky.social
@brentsinclair.bsky.social
@westernu.bsky.social
The Drosophila adult brain: short overview of structure, function, and resources Graphical Review Paper
This short review is targeted at researchers new to the Drosophila model (thereafter: a Drosophilist) in the field of neuroscience. We aim to provide …
www.sciencedirect.com
June 25, 2025 at 6:16 AM
Very useful overview, especially for the Drosophila-curious.
It’s easy to bring the power of fly genetics to your neurobiology questions.
It’s easy to bring the power of fly genetics to your neurobiology questions.
Reposted by Alex Whitworth lab
Reposted by Alex Whitworth lab
This week I will be finally presenting my postdoc data in an exciting webinar on #ubiquitin biology, together with an old classmate of mine.
If your interested, follow the link below
If your interested, follow the link below
Interested in ubiquitin? Register for our latest ECR #webinar to uncover the surprising role of TRIM proteins in disease and discover how mtDNA mutations evade QC systems & lead to mitochondrial diseases affecting 1 in 8,000 people. Secure your place today 🧪: register.gotowebinar.com/register/821...
June 15, 2025 at 11:42 AM
This week I will be finally presenting my postdoc data in an exciting webinar on #ubiquitin biology, together with an old classmate of mine.
If your interested, follow the link below
If your interested, follow the link below
Great post doc opportunity 👇
✨️ Come join my lab! ✨️ I have an ARUK funded post doc position available for a talented ECR to work with Drosophila and human iPSC derived neurons.
krb-sjobs.brassring.com/TGnewUI/Sear...
krb-sjobs.brassring.com/TGnewUI/Sear...
Job Search | Cardiff University
Search for Internet job results.
krb-sjobs.brassring.com
June 11, 2025 at 11:05 AM
Great post doc opportunity 👇
Thank you @crisprflydesign.bsky.social for continuing to develop cutting edge tools that help maintain #Drosophila as still the best animal model for genetic manipulation
Why use #CRISPR in #Drosophila when RNAi works so well? Because for some genes well is not good enough.
Check out new preprint from the lab demonstrating a role for Vps15 in Wingless trafficking. Something that was missed in several RNAi screens.
www.biorxiv.org/content/10.1...
Check out new preprint from the lab demonstrating a role for Vps15 in Wingless trafficking. Something that was missed in several RNAi screens.
www.biorxiv.org/content/10.1...
May 26, 2025 at 7:41 AM
Thank you @crisprflydesign.bsky.social for continuing to develop cutting edge tools that help maintain #Drosophila as still the best animal model for genetic manipulation
Yes! Join the network, folk. It’s fun
Welcome to the new serie of Cambridge Fly Club meetings. We organise several events every year to foster collaboration and maintain a positive dynamic between Drosophila groups in Cambridge.
May 23, 2025 at 5:28 PM
Yes! Join the network, folk. It’s fun
Want to understand how mitochondrial disruptions lead to neurodenegeneration?
We have an ideal opening for a new graduate or experienced research assistant.
Looking for skills in molecular and cell biology, microscopy, and experience with #Drosophila would be a plus.
Just a few days left to 👇👇
We have an ideal opening for a new graduate or experienced research assistant.
Looking for skills in molecular and cell biology, microscopy, and experience with #Drosophila would be a plus.
Just a few days left to 👇👇
📣Job alert🎉
Want to join a dynamic team investigating mitochondria in neurodegeneration in Cambridge @mrc-mbu.bsky.social? Keen to use the power of fly genetics?
We’re recruiting a Research Assistant from July. Perfect for a finishing under/postgrad.
Get in touch!
www.jobs.cam.ac.uk/job/50944/
Want to join a dynamic team investigating mitochondria in neurodegeneration in Cambridge @mrc-mbu.bsky.social? Keen to use the power of fly genetics?
We’re recruiting a Research Assistant from July. Perfect for a finishing under/postgrad.
Get in touch!
www.jobs.cam.ac.uk/job/50944/
Research Assistant (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant (Fixed Term) in the MRC Mitochondrial Biology Unit at the University of Cambridge.
www.jobs.cam.ac.uk
May 2, 2025 at 4:04 PM
Want to understand how mitochondrial disruptions lead to neurodenegeneration?
We have an ideal opening for a new graduate or experienced research assistant.
Looking for skills in molecular and cell biology, microscopy, and experience with #Drosophila would be a plus.
Just a few days left to 👇👇
We have an ideal opening for a new graduate or experienced research assistant.
Looking for skills in molecular and cell biology, microscopy, and experience with #Drosophila would be a plus.
Just a few days left to 👇👇
Reposted by Alex Whitworth lab
Fly journal is now on BlueSky! The world’s only academic journal dedicated to research on Drosophila & cognate insects. A fully open-access journal that combines rapid publication with high standards of peer-review. For further info and how to submit your work, see the link.
Fly
Open access research on Drosophila developmental/evolutionary biology, organogenesis, neurobiology, circadian rhythms, learning & memory, sex determination
www.tandfonline.com
April 17, 2025 at 9:39 AM
Fly journal is now on BlueSky! The world’s only academic journal dedicated to research on Drosophila & cognate insects. A fully open-access journal that combines rapid publication with high standards of peer-review. For further info and how to submit your work, see the link.
📣Job alert🎉
Want to join a dynamic team investigating mitochondria in neurodegeneration in Cambridge @mrc-mbu.bsky.social? Keen to use the power of fly genetics?
We’re recruiting a Research Assistant from July. Perfect for a finishing under/postgrad.
Get in touch!
www.jobs.cam.ac.uk/job/50944/
Want to join a dynamic team investigating mitochondria in neurodegeneration in Cambridge @mrc-mbu.bsky.social? Keen to use the power of fly genetics?
We’re recruiting a Research Assistant from July. Perfect for a finishing under/postgrad.
Get in touch!
www.jobs.cam.ac.uk/job/50944/
Research Assistant (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant (Fixed Term) in the MRC Mitochondrial Biology Unit at the University of Cambridge.
www.jobs.cam.ac.uk
April 4, 2025 at 3:38 PM
📣Job alert🎉
Want to join a dynamic team investigating mitochondria in neurodegeneration in Cambridge @mrc-mbu.bsky.social? Keen to use the power of fly genetics?
We’re recruiting a Research Assistant from July. Perfect for a finishing under/postgrad.
Get in touch!
www.jobs.cam.ac.uk/job/50944/
Want to join a dynamic team investigating mitochondria in neurodegeneration in Cambridge @mrc-mbu.bsky.social? Keen to use the power of fly genetics?
We’re recruiting a Research Assistant from July. Perfect for a finishing under/postgrad.
Get in touch!
www.jobs.cam.ac.uk/job/50944/