Kevin John
@kev-in-science.bsky.social
Virologist / Immunologist 🧑🏾🔬🇸🇬
Researching down under 🇦🇺
Mucosal Humoral 🐜 Covid Pundit 😷 Salival Archival 🤤 Nasal Appraisal 🤧 Semen Demon 😈 Research fellow in Amy Chung lab at the Doherty Institute
Researching down under 🇦🇺
Mucosal Humoral 🐜 Covid Pundit 😷 Salival Archival 🤤 Nasal Appraisal 🤧 Semen Demon 😈 Research fellow in Amy Chung lab at the Doherty Institute
Reposted by Kevin John
Our paper exploring the effects of solid tumor malignancy-associated inflammation upon COVID-19 vaccine-induced antibodies is finally live!
We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust.
www.nature.com/articles/s41...
We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust.
www.nature.com/articles/s41...
Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination - npj Vaccines
npj Vaccines - Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination
www.nature.com
October 15, 2025 at 10:18 PM
Our paper exploring the effects of solid tumor malignancy-associated inflammation upon COVID-19 vaccine-induced antibodies is finally live!
We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust.
www.nature.com/articles/s41...
We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust.
www.nature.com/articles/s41...
Reposted by Kevin John
In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
September 24, 2025 at 3:07 PM
In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Reposted by Kevin John
In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025
The hemagglutinin of human influenza virus evolves rapidly to erode neutralizing antibody immunity. Twice per year, new vaccine strains are selected with the goal of providing maximum protection again...
www.biorxiv.org
September 8, 2025 at 9:48 PM
In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Reposted by Kevin John
🎉 Thrilled to share our newest paper and my first one in the Valkenburg lab @thedohertyinst.bsky.social published in @natcomms.nature.com:
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults
doi.org/10.1038/s414...
👇1/5
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults
doi.org/10.1038/s414...
👇1/5
https://doi.org/10.1038/s41467-025-63263-y
t.co
September 8, 2025 at 1:34 AM
🎉 Thrilled to share our newest paper and my first one in the Valkenburg lab @thedohertyinst.bsky.social published in @natcomms.nature.com:
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults
doi.org/10.1038/s414...
👇1/5
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults
doi.org/10.1038/s414...
👇1/5
Reposted by Kevin John
The labs of Krammer, @wchnicholas.bsky.social, Ellebedy et al. identify a neuraminidase-targeting human monoclonal antibody (mAb-297) induced by seasonal #influenza vaccination that broadly protects against multiple influenza A & B strains, incl. avian #H5N1. rupress.org/jem/article/...
April 3, 2025 at 4:18 PM
The labs of Krammer, @wchnicholas.bsky.social, Ellebedy et al. identify a neuraminidase-targeting human monoclonal antibody (mAb-297) induced by seasonal #influenza vaccination that broadly protects against multiple influenza A & B strains, incl. avian #H5N1. rupress.org/jem/article/...
Nice summary and discussion about our recent IgG4 publication that just came out on #scienceadvances from @amywchung.bsky.social lab (kudos to our PhD candidate Carissa Aurelia 👩🔬🎉)
Glad it has answered some technical questions and raised more for future work/discussion 🧐🔬🧪
Glad it has answered some technical questions and raised more for future work/discussion 🧐🔬🧪
#immunosky #IDsky #medsky 🧪
I know everyone missed thinking about IgG4, but we have a new study that finds some very interesting properties of anti-spike IgG4 elicited by mRNA vaccines
tl;dr- IgG4 seems to buffer inflammation but enhances the function of other antibodies when titers are lower
🧵
I know everyone missed thinking about IgG4, but we have a new study that finds some very interesting properties of anti-spike IgG4 elicited by mRNA vaccines
tl;dr- IgG4 seems to buffer inflammation but enhances the function of other antibodies when titers are lower
🧵
Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant
Elevated SARS-CoV-2–specific IgG4 titers decrease ADCC but can increase ADCP when spike-specific antibody titers are low.
www.science.org
March 1, 2025 at 8:38 AM
Nice summary and discussion about our recent IgG4 publication that just came out on #scienceadvances from @amywchung.bsky.social lab (kudos to our PhD candidate Carissa Aurelia 👩🔬🎉)
Glad it has answered some technical questions and raised more for future work/discussion 🧐🔬🧪
Glad it has answered some technical questions and raised more for future work/discussion 🧐🔬🧪