Ruth Amy Purcell
@ruthamypurcell.bsky.social
Postdoc @scripps.edu || PhD @thedohertyinst.bsky.social || 🧬 🦠 🧫 🇿🇦 🇦🇺
Our paper exploring the effects of solid tumor malignancy-associated inflammation upon COVID-19 vaccine-induced antibodies is finally live!
We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust.
www.nature.com/articles/s41...
We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust.
www.nature.com/articles/s41...
Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination - npj Vaccines
npj Vaccines - Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination
www.nature.com
October 15, 2025 at 10:18 PM
Our paper exploring the effects of solid tumor malignancy-associated inflammation upon COVID-19 vaccine-induced antibodies is finally live!
We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust.
www.nature.com/articles/s41...
We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust.
www.nature.com/articles/s41...
Happy to have the latest @amywchung.bsky.social lab preprint online! 🦠 Here we demonstrated that systemic inflammation in solid tumor malignancy patients was associated with impaired SARS-CoV-2 neutralizing antibody functions while non-neutralizing functions remained robust (yay Fc functions!) 🦠
Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination https://www.medrxiv.org/content/10.1101/2025.05.09.25327344v1
May 12, 2025 at 10:08 AM
Happy to have the latest @amywchung.bsky.social lab preprint online! 🦠 Here we demonstrated that systemic inflammation in solid tumor malignancy patients was associated with impaired SARS-CoV-2 neutralizing antibody functions while non-neutralizing functions remained robust (yay Fc functions!) 🦠
Reposted by Ruth Amy Purcell
Happy #DayofImmunology! Congrats @ramadhenni.bsky.social & Alexandra Carey Hoppé it's out (finally!) @cp-cell.bsky.social! Incredibly grateful to co-leads @mlmunier.bsky.social, Vanessa Venturi & Tony Kelleher & all brilliant folks @garvaninstitute.bsky.social & Kirby Inst. for fantastic collab! 🧵
Macrophages direct location-dependent recall of B cell memory to vaccination
Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell…
www.sciencedirect.com
April 29, 2025 at 1:20 PM
Happy #DayofImmunology! Congrats @ramadhenni.bsky.social & Alexandra Carey Hoppé it's out (finally!) @cp-cell.bsky.social! Incredibly grateful to co-leads @mlmunier.bsky.social, Vanessa Venturi & Tony Kelleher & all brilliant folks @garvaninstitute.bsky.social & Kirby Inst. for fantastic collab! 🧵
Reposted by Ruth Amy Purcell
Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS
The lungs are constantly exposed to the external environment and a myriad of antigenic
challenges within the air. Chronic exposure to allergens and...
doi.org
April 3, 2025 at 3:03 AM
Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
Reposted by Ruth Amy Purcell
1/ Hot off the press in @jimmunol.bsky.social. We investigated how same side (ipsilateral) vs alternate side (contralateral) prime-boost vaccination impacts germinal center (GC) dynamics & antibody responses against SARS-CoV-2 spike in mice.💉🦠#immunology #vaccines @thedohertyinst.bsky.social
March 11, 2025 at 5:59 AM
1/ Hot off the press in @jimmunol.bsky.social. We investigated how same side (ipsilateral) vs alternate side (contralateral) prime-boost vaccination impacts germinal center (GC) dynamics & antibody responses against SARS-CoV-2 spike in mice.💉🦠#immunology #vaccines @thedohertyinst.bsky.social
Fantastic to have our study out describing the nuances of increased SARS-CoV-2 IgG4 following repeated mRNA vaccination 💉💉💉 @amywchung.bsky.social @kev-in-science.bsky.social @viralvaxlab.bsky.social
And great discussion started below!
And great discussion started below!
#immunosky #IDsky #medsky 🧪
I know everyone missed thinking about IgG4, but we have a new study that finds some very interesting properties of anti-spike IgG4 elicited by mRNA vaccines
tl;dr- IgG4 seems to buffer inflammation but enhances the function of other antibodies when titers are lower
🧵
I know everyone missed thinking about IgG4, but we have a new study that finds some very interesting properties of anti-spike IgG4 elicited by mRNA vaccines
tl;dr- IgG4 seems to buffer inflammation but enhances the function of other antibodies when titers are lower
🧵
Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant
Elevated SARS-CoV-2–specific IgG4 titers decrease ADCC but can increase ADCP when spike-specific antibody titers are low.
www.science.org
March 1, 2025 at 1:27 PM
Fantastic to have our study out describing the nuances of increased SARS-CoV-2 IgG4 following repeated mRNA vaccination 💉💉💉 @amywchung.bsky.social @kev-in-science.bsky.social @viralvaxlab.bsky.social
And great discussion started below!
And great discussion started below!