Karim Majzoub
@karimaj.bsky.social
Group leader @igmm-montpel.bsky.social studying viruses - ERC Stg- Amateur athlete and musician- Husband and father- Europtimist @biolum-montpellier.bsky.social
https://www.igmm.cnrs.fr/en/team/rna-viruses-and-host-factors/
https://www.igmm.cnrs.fr/en/team/rna-viruses-and-host-factors/
Pinned
Karim Majzoub
@karimaj.bsky.social
· Oct 9
Great crowd and attendance for our France-Japan Virology workshop we kicked off this morning !
My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...
November 14, 2025 at 2:27 PM
My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...
Bravo @mkrupovic.bsky.social and team !
November 13, 2025 at 11:04 AM
Bravo @mkrupovic.bsky.social and team !
P-bodies , microRNAs and cell fate ! Not everything is transcription in cell fate decisions ;)
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 29, 2025 at 8:06 PM
P-bodies , microRNAs and cell fate ! Not everything is transcription in cell fate decisions ;)
Reposted by Karim Majzoub
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by Karim Majzoub
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 7:37 PM
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Shout out for @johanneszuber.bsky.social and team ! Beautiful work with new biology !
Acidosis orchestrates adaptations of energy metabolism in tumors
Malignant tumors are characterized by diverse metabolic stresses, including nutrient shortages, hypoxia, and buildup of metabolic by-products. To understand how cancer cells adapt to such challenges, ...
www.science.org
October 20, 2025 at 7:07 PM
Shout out for @johanneszuber.bsky.social and team ! Beautiful work with new biology !
Reposted by Karim Majzoub
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
Reposted by Karim Majzoub
@viroscope.bsky.social (@karimaj.bsky.social team) partage dans The Scientist ses travaux sur les deltavirus et l’imagerie de cellules, des cellules humaines aux cellules de boa constrictor 🐍.
👉 Lire l’article : “Boa Constrictor Brain Cells Slither into Focus”
www.the-scientist.com/boa-constric...
👉 Lire l’article : “Boa Constrictor Brain Cells Slither into Focus”
www.the-scientist.com/boa-constric...
Boa Constrictor Brain Cells Slither into Focus
From reptiles and Tasmanian devils to humans, one researcher zooms in on unseen features of the brain and liver cells, like the cytoskeleton.
www.the-scientist.com
October 13, 2025 at 11:13 AM
@viroscope.bsky.social (@karimaj.bsky.social team) partage dans The Scientist ses travaux sur les deltavirus et l’imagerie de cellules, des cellules humaines aux cellules de boa constrictor 🐍.
👉 Lire l’article : “Boa Constrictor Brain Cells Slither into Focus”
www.the-scientist.com/boa-constric...
👉 Lire l’article : “Boa Constrictor Brain Cells Slither into Focus”
www.the-scientist.com/boa-constric...
Reposted by Karim Majzoub
September 23, 2025 at 7:21 AM
Great crowd and attendance for our France-Japan Virology workshop we kicked off this morning !
October 9, 2025 at 11:35 AM
Great crowd and attendance for our France-Japan Virology workshop we kicked off this morning !
Reposted by Karim Majzoub
Thank you to @viroscope.bsky.social and @carogoujon.bsky.social for nicely answering the very important question I’ve been receiving after more than a decade of seminars.
And the mechanism…
Quelle surprise!!! 😮 🤩
And the mechanism…
Quelle surprise!!! 😮 🤩
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS
Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza
A virus (IAV) transcription/replication process. Herein,...
www.pnas.org
October 7, 2025 at 9:15 PM
Thank you to @viroscope.bsky.social and @carogoujon.bsky.social for nicely answering the very important question I’ve been receiving after more than a decade of seminars.
And the mechanism…
Quelle surprise!!! 😮 🤩
And the mechanism…
Quelle surprise!!! 😮 🤩
Meet us in 2 days in Montpellier for the French-Japan Virology symposium!
Meet us at Genopolys , Montpellier for a France-Japan virology workshop ! 9-10 october 2025 ! 2 exciting days with many viruses! Co-organized with @systemsvirology.bsky.social Kei Sato and Monsef Benkirane @igmm-montpel.bsky.social @cnrsbiologie.bsky.social @umontpellier.bsky.social
October 7, 2025 at 5:37 PM
Meet us in 2 days in Montpellier for the French-Japan Virology symposium!
Reposted by Karim Majzoub
Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
October 6, 2025 at 1:36 PM
Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
New paper (micro) from our lab : “No evidence for human or rodent deltavirus replication in yeast”. A collaboration with Dom helmlinger’s lab .
No evidence for human or rodent deltavirus replication in yeast | microPublication
doi.org
October 4, 2025 at 6:55 AM
New paper (micro) from our lab : “No evidence for human or rodent deltavirus replication in yeast”. A collaboration with Dom helmlinger’s lab .
Our @viroscope.bsky.social Joe McKellar interviewed by The-Scientist Magazine ! Look at all these beautiful cells we have in the lab :)
Boa Constrictor Brain Cells Slither into Focus
From reptiles and Tasmanian devils to humans, one researcher zooms in on unseen features of the brain and liver cells, like the cytoskeleton.
www.the-scientist.com
October 3, 2025 at 8:13 PM
Our @viroscope.bsky.social Joe McKellar interviewed by The-Scientist Magazine ! Look at all these beautiful cells we have in the lab :)
Reposted by Karim Majzoub
🧬 𝐋’𝐚𝐫𝐭 𝐝𝐞́𝐥𝐢𝐜𝐚𝐭 𝐝𝐞 𝐟𝐚𝐢𝐫𝐞 𝐭𝐚𝐢𝐫𝐞 𝐥𝐞𝐬 𝐠𝐞̀𝐧𝐞𝐬
Des scientifiques de l'IGMM utilisent l’embryon de drosophile pour démontrer que la répression de l’expression des gènes est un mécanisme beaucoup plus complexe qu’attendu.
📖 👉 lnkd.in/dPqUREuf
📷 © Mounia Lagha et Virginia Pimmett
Des scientifiques de l'IGMM utilisent l’embryon de drosophile pour démontrer que la répression de l’expression des gènes est un mécanisme beaucoup plus complexe qu’attendu.
📖 👉 lnkd.in/dPqUREuf
📷 © Mounia Lagha et Virginia Pimmett
September 30, 2025 at 6:35 AM
🧬 𝐋’𝐚𝐫𝐭 𝐝𝐞́𝐥𝐢𝐜𝐚𝐭 𝐝𝐞 𝐟𝐚𝐢𝐫𝐞 𝐭𝐚𝐢𝐫𝐞 𝐥𝐞𝐬 𝐠𝐞̀𝐧𝐞𝐬
Des scientifiques de l'IGMM utilisent l’embryon de drosophile pour démontrer que la répression de l’expression des gènes est un mécanisme beaucoup plus complexe qu’attendu.
📖 👉 lnkd.in/dPqUREuf
📷 © Mounia Lagha et Virginia Pimmett
Des scientifiques de l'IGMM utilisent l’embryon de drosophile pour démontrer que la répression de l’expression des gènes est un mécanisme beaucoup plus complexe qu’attendu.
📖 👉 lnkd.in/dPqUREuf
📷 © Mounia Lagha et Virginia Pimmett
Reposted by Karim Majzoub
Meet us at Genopolys , Montpellier for a France-Japan virology workshop ! 9-10 october 2025 ! 2 exciting days with many viruses! Co-organized with @systemsvirology.bsky.social Kei Sato and Monsef Benkirane @igmm-montpel.bsky.social @cnrsbiologie.bsky.social @umontpellier.bsky.social
September 17, 2025 at 8:56 AM
Meet us at Genopolys , Montpellier for a France-Japan virology workshop ! 9-10 october 2025 ! 2 exciting days with many viruses! Co-organized with @systemsvirology.bsky.social Kei Sato and Monsef Benkirane @igmm-montpel.bsky.social @cnrsbiologie.bsky.social @umontpellier.bsky.social
Reposted by Karim Majzoub
Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail
nature.com/articles/s41467-025-63463-6
nature.com/articles/s41467-025-63463-6
Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail - Nature Communications
Rodrigues and Queiroz et al. report the discovery of Naiavirus, the largest enveloped virus, isolated from a Brazil biome. With an oval capsid and flexible tail, its giant genome holds many novel gene...
nature.com
September 17, 2025 at 3:36 PM
Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail
nature.com/articles/s41467-025-63463-6
nature.com/articles/s41467-025-63463-6
Meet us at Genopolys , Montpellier for a France-Japan virology workshop ! 9-10 october 2025 ! 2 exciting days with many viruses! Co-organized with @systemsvirology.bsky.social Kei Sato and Monsef Benkirane @igmm-montpel.bsky.social @cnrsbiologie.bsky.social @umontpellier.bsky.social
September 17, 2025 at 8:56 AM
Meet us at Genopolys , Montpellier for a France-Japan virology workshop ! 9-10 october 2025 ! 2 exciting days with many viruses! Co-organized with @systemsvirology.bsky.social Kei Sato and Monsef Benkirane @igmm-montpel.bsky.social @cnrsbiologie.bsky.social @umontpellier.bsky.social
Reposted by Karim Majzoub
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
September 15, 2025 at 5:26 PM
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
Endogenous Deltaviruses (EVEs) in termite genomes !
Endogenous viral elements in termite genomes reveal extensive diversity of deltaviruses and provide insights into their origins
Deltaviruses are subviral agents of animals, which, in humans, require a hepadnavirus helper for transmission. The absence of deltavirus-like endogeno…
www.sciencedirect.com
September 14, 2025 at 5:09 AM
Endogenous Deltaviruses (EVEs) in termite genomes !
RIP
A giant in molecular biology and virology has passed. RIP David Baltimore.
www.nytimes.com/2025/09/07/s...
www.nytimes.com/2025/09/07/s...
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
www.nytimes.com
September 8, 2025 at 2:06 AM
RIP
Reposted by Karim Majzoub
Get fucked, textbooks.
Seriously breaking my PhD in ecology and evolutionary biology brain that this happened.
www.nature.com/articles/s41...
Seriously breaking my PhD in ecology and evolutionary biology brain that this happened.
www.nature.com/articles/s41...
September 6, 2025 at 3:08 AM
Get fucked, textbooks.
Seriously breaking my PhD in ecology and evolutionary biology brain that this happened.
www.nature.com/articles/s41...
Seriously breaking my PhD in ecology and evolutionary biology brain that this happened.
www.nature.com/articles/s41...
Reposted by Karim Majzoub
New pre-print from Doudna lab members @erinedoherty.bsky.social & @jnoms.bsky.social ✨
Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.
Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.
Excited to share our new preprint co-led by @jnoms.bsky.social!
Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
Divergent viral phosphodiesterases for immune signaling evasion
Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...
www.biorxiv.org
August 22, 2025 at 7:36 PM
New pre-print from Doudna lab members @erinedoherty.bsky.social & @jnoms.bsky.social ✨
Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.
Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.