Kang Jin
@kang-jin-1997.bsky.social
Postdoc with Xiaowei Zhuang; spatial transcriptomics and computational biology
Reposted by Kang Jin
One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...
May 21, 2025 at 4:50 PM
One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...
Reposted by Kang Jin
Nature research paper: Chromatin loops are an ancestral hallmark of the animal regulatory genome
https://go.nature.com/4kcNObU
https://go.nature.com/4kcNObU
Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature
The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of genome architecture and spatial genome regulation emerged early in animal evolution.
go.nature.com
May 7, 2025 at 5:33 PM
Nature research paper: Chromatin loops are an ancestral hallmark of the animal regulatory genome
https://go.nature.com/4kcNObU
https://go.nature.com/4kcNObU
Reposted by Kang Jin
Benchmarking of tumor subclonal reconstruction algorithms finds that interalgorithm variability overwhelms intertumor variability and identifies key quality metrics go.nature.com/4aSNXfv
rdcu.be/ejMjs
rdcu.be/ejMjs
Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction - Nature Biotechnology
Benchmarking of tumor subclonal reconstruction algorithms finds that interalgorithm variability overwhelms intertumor variability and identifies key quality metrics.
go.nature.com
April 30, 2025 at 4:08 AM
Benchmarking of tumor subclonal reconstruction algorithms finds that interalgorithm variability overwhelms intertumor variability and identifies key quality metrics go.nature.com/4aSNXfv
rdcu.be/ejMjs
rdcu.be/ejMjs
Reposted by Kang Jin
New online! TACIT and CoTACIT for histone modification profiling in single cells and lineage tracing
TACIT and CoTACIT for histone modification profiling in single cells and lineage tracing
Nature Reviews Genetics, Published online: 30 April 2025; doi:10.1038/s41576-025-00844-zIn this Tools of the Trade article, Min Liu and Aibin He describe TACIT, a single-cell method that maps histone modifications at near genome-wide coverage, and its extension CoTACIT, which simultaneously maps up to six histone modifications in the same cell.
www.nature.com
April 30, 2025 at 1:00 PM
New online! TACIT and CoTACIT for histone modification profiling in single cells and lineage tracing
Reposted by Kang Jin
It’s out! The evolutionary origins of yeast point centromeres uncovered!
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
Ancient co-option of LTR retrotransposons as yeast centromeres
The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...
www.biorxiv.org
April 25, 2025 at 1:59 PM
It’s out! The evolutionary origins of yeast point centromeres uncovered!
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...