Juan Martinez Hernández
@juanmartinez5.bsky.social
Postdoc in Ciudad de Mexico #StructuralBiology #XRay
Reposted by Juan Martinez Hernández
Registration for the EMBO workshop ‘Plant evolution: from origins to diversification on land’ closes on 25th August. Don’t miss it! More details can be found here: meetings.embo.org/event/25-pla... 🌱 😀
Plant evolution: from origins to diversification on land
The evolution of plants – photosynthetic eukaryotes resulting from the endosymbiosis of a cyanobacterium and a non-photosynthetic host cell – transformed the earth system by reducing the amount of CO…
meetings.embo.org
August 12, 2025 at 5:54 AM
Registration for the EMBO workshop ‘Plant evolution: from origins to diversification on land’ closes on 25th August. Don’t miss it! More details can be found here: meetings.embo.org/event/25-pla... 🌱 😀
Reposted by Juan Martinez Hernández
Excited / nervous to share the “magnum opus” of my postdoc in Andreas Wagner’s lab!
"De-novo promoters emerge more readily from random DNA than from genomic DNA"
This project is the accumulation of 4 years of work, and lays the foundation for my future group. In short, we… (1/4)
"De-novo promoters emerge more readily from random DNA than from genomic DNA"
This project is the accumulation of 4 years of work, and lays the foundation for my future group. In short, we… (1/4)
De-novo promoters emerge more readily from random DNA than from genomic DNA
Promoters are DNA sequences that help to initiate transcription. Point mutations can create de-novo promoters, which can consequently transcribe inactive genes or create novel transcripts. We know lit...
www.biorxiv.org
August 28, 2025 at 6:37 AM
Excited / nervous to share the “magnum opus” of my postdoc in Andreas Wagner’s lab!
"De-novo promoters emerge more readily from random DNA than from genomic DNA"
This project is the accumulation of 4 years of work, and lays the foundation for my future group. In short, we… (1/4)
"De-novo promoters emerge more readily from random DNA than from genomic DNA"
This project is the accumulation of 4 years of work, and lays the foundation for my future group. In short, we… (1/4)
Reposted by Juan Martinez Hernández
Amazing work by the Santiago lab @unil.bsky.social. The malectin-LRR receptor kinase IGP1 senses cello-oligomers to alert the plant immune system & enhance disease resistance. Very nice discovery & mechanism.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 30, 2025 at 2:18 PM
Amazing work by the Santiago lab @unil.bsky.social. The malectin-LRR receptor kinase IGP1 senses cello-oligomers to alert the plant immune system & enhance disease resistance. Very nice discovery & mechanism.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Juan Martinez Hernández
Today, @rcsbpdb.bsky.social introduces Q-score in EM validation reports. Q-score assesses model-map fit. A new percentile slider will compare an entry’s average Q-score to the full archive and a resolution-matched subset. This would help judge whether the fit is typical for the reported resolution.
Introducing the first 3DEM Model-Map percentile slider to the wwPDB validation report
Introducing the latest wwPDB Percentile slider based on the Q-score model-map validation metric
www.rcsb.org
October 1, 2025 at 12:25 AM
Today, @rcsbpdb.bsky.social introduces Q-score in EM validation reports. Q-score assesses model-map fit. A new percentile slider will compare an entry’s average Q-score to the full archive and a resolution-matched subset. This would help judge whether the fit is typical for the reported resolution.
Reposted by Juan Martinez Hernández
Protein–protein interactomes incorporating structural data predict the functional consequences of disease mutations go.nature.com/3BYJBrg
rdcu.be/eILA1
rdcu.be/eILA1
A structurally informed human protein–protein interactome reveals proteome-wide perturbations caused by disease mutations - Nature Biotechnology
Protein–protein interactomes incorporating structural data predict the functional consequences of disease mutations.
go.nature.com
October 1, 2025 at 1:53 AM
Protein–protein interactomes incorporating structural data predict the functional consequences of disease mutations go.nature.com/3BYJBrg
rdcu.be/eILA1
rdcu.be/eILA1
Reposted by Juan Martinez Hernández
Kim-Kristine Mueller from the Classen lab in Kiel shares new insights into bryophyte arabinogalactan-proteins from a hornwort and a moss model organism #MAdLand2025
October 1, 2025 at 7:40 AM
Kim-Kristine Mueller from the Classen lab in Kiel shares new insights into bryophyte arabinogalactan-proteins from a hornwort and a moss model organism #MAdLand2025
Reposted by Juan Martinez Hernández
Cryo-EM structure of plant urea transporter DUR3 reveals essential role of C-terminal domain in tetramer assembly and insights into proton-coupled transport https://www.biorxiv.org/content/10.1101/2025.05.20.653754v1
May 23, 2025 at 12:05 PM
Cryo-EM structure of plant urea transporter DUR3 reveals essential role of C-terminal domain in tetramer assembly and insights into proton-coupled transport https://www.biorxiv.org/content/10.1101/2025.05.20.653754v1
Reposted by Juan Martinez Hernández
Cryo-EM structures of the Plant Augmin reveal its intertwined coiled-coil assembly, antiparallel dimerization and NEDD1 binding mechanisms https://www.biorxiv.org/content/10.1101/2025.02.25.640204v1
February 27, 2025 at 10:46 AM
Cryo-EM structures of the Plant Augmin reveal its intertwined coiled-coil assembly, antiparallel dimerization and NEDD1 binding mechanisms https://www.biorxiv.org/content/10.1101/2025.02.25.640204v1
Reposted by Juan Martinez Hernández
Cryo-EM structures of the plant #anion #channel SLAC1 from Arabidopsis thaliana. @NatureComms 14, 7345. Check #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8gw6
www.nature.com
April 3, 2024 at 8:59 AM
Cryo-EM structures of the plant #anion #channel SLAC1 from Arabidopsis thaliana. @NatureComms 14, 7345. Check #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8gw6
Reposted by Juan Martinez Hernández
Revealing the structure of land plant photosystem II: the journey from negative-stain EM to cryo-EM pubmed.ncbi.nlm.nih.gov/40994146/
September 26, 2025 at 6:46 PM
Revealing the structure of land plant photosystem II: the journey from negative-stain EM to cryo-EM pubmed.ncbi.nlm.nih.gov/40994146/
Reposted by Juan Martinez Hernández
🚨New Article Out!!
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
April 15, 2025 at 11:24 PM
🚨New Article Out!!
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
Reposted by Juan Martinez Hernández
Cryo-EM structure of plant urea transporter DUR3 reveals essential role of C-terminal domain in tetramer assembly and insights into proton-coupled transport https://www.biorxiv.org/content/10.1101/2025.05.20.653754v1
May 23, 2025 at 12:06 PM
Cryo-EM structure of plant urea transporter DUR3 reveals essential role of C-terminal domain in tetramer assembly and insights into proton-coupled transport https://www.biorxiv.org/content/10.1101/2025.05.20.653754v1
Reposted by Juan Martinez Hernández
Cryo-EM structures of the plant plastid-encoded RNA polymerase
Cryo-EM structures of the plant plastid-encoded RNA polymerase
The cryo-EM structures of Nicotiana tabacum (tobacco) chloroplast RNA polymerase apoenzyme and transcription elongation complexes reveal the composition, assembly, function, and evolution of the chloroplast transcription apparatus.
www.cell.com
February 29, 2024 at 3:45 PM
Cryo-EM structures of the plant plastid-encoded RNA polymerase
Reposted by Juan Martinez Hernández
📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉
👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️
www.cell.com/trends/cell-...
👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️
www.cell.com/trends/cell-...
January 23, 2025 at 10:09 PM
📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉
👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️
www.cell.com/trends/cell-...
👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️
www.cell.com/trends/cell-...
Reposted by Juan Martinez Hernández
Check out our new preprint on plant🌱mitoribosome!
We captured it in action, translating mRNA, and combining cryo-EM 🔬 and Nanopore sequencing 🧬, identified key rRNA modifications. Plus we delve into a late-stage maturation step of the small subunit.
📖: www.biorxiv.org/content/10.1...
#CryoEM
We captured it in action, translating mRNA, and combining cryo-EM 🔬 and Nanopore sequencing 🧬, identified key rRNA modifications. Plus we delve into a late-stage maturation step of the small subunit.
📖: www.biorxiv.org/content/10.1...
#CryoEM
October 30, 2024 at 7:54 PM
Check out our new preprint on plant🌱mitoribosome!
We captured it in action, translating mRNA, and combining cryo-EM 🔬 and Nanopore sequencing 🧬, identified key rRNA modifications. Plus we delve into a late-stage maturation step of the small subunit.
📖: www.biorxiv.org/content/10.1...
#CryoEM
We captured it in action, translating mRNA, and combining cryo-EM 🔬 and Nanopore sequencing 🧬, identified key rRNA modifications. Plus we delve into a late-stage maturation step of the small subunit.
📖: www.biorxiv.org/content/10.1...
#CryoEM
Reposted by Juan Martinez Hernández
Reposted by Juan Martinez Hernández
Revealing the structure of land plant photosystem II: the journey from negative-stain EM to cryo-EM pubmed.ncbi.nlm.nih.gov/40994146/ #cryoem
September 27, 2025 at 3:52 AM
Revealing the structure of land plant photosystem II: the journey from negative-stain EM to cryo-EM pubmed.ncbi.nlm.nih.gov/40994146/ #cryoem
Reposted by Juan Martinez Hernández
🚨 New strategy against colorectal cancer!
Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪
➡️Read more: www.nature.com/articles/s41...
Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪
➡️Read more: www.nature.com/articles/s41...
GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells - Oncogenesis
Oncogenesis - GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells
www.nature.com
July 15, 2025 at 9:39 AM
🚨 New strategy against colorectal cancer!
Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪
➡️Read more: www.nature.com/articles/s41...
Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪
➡️Read more: www.nature.com/articles/s41...
Reposted by Juan Martinez Hernández
📄NEW PUBLICATION: A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity (2024)
@amiralito.bsky.social @adnroide.bsky.social @kamounlab.bsky.social @mauriciocontreras @JMadhuprakash
www.science.org/doi/10.1126/...
@amiralito.bsky.social @adnroide.bsky.social @kamounlab.bsky.social @mauriciocontreras @JMadhuprakash
www.science.org/doi/10.1126/...
A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity
Cryo-EM analysis revealed the homohexameric resistosome structure of NbNRC2 activated with Rx and Potato virus X coat protein.
www.science.org
November 18, 2024 at 10:52 PM
📄NEW PUBLICATION: A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity (2024)
@amiralito.bsky.social @adnroide.bsky.social @kamounlab.bsky.social @mauriciocontreras @JMadhuprakash
www.science.org/doi/10.1126/...
@amiralito.bsky.social @adnroide.bsky.social @kamounlab.bsky.social @mauriciocontreras @JMadhuprakash
www.science.org/doi/10.1126/...
Reposted by Juan Martinez Hernández
What’s this intriguing complex? Together with Ben, we purified the AVRcap1b-SlNRC3 complex from our favourite plant—the Aussie wonder Nicotiana benthamiana aka benthi—and resolved this beautiful cryo-EM structure and see how AVRcap1b wraps around three SlNRC3 protomers!
4/10
4/10
July 16, 2025 at 12:27 PM
What’s this intriguing complex? Together with Ben, we purified the AVRcap1b-SlNRC3 complex from our favourite plant—the Aussie wonder Nicotiana benthamiana aka benthi—and resolved this beautiful cryo-EM structure and see how AVRcap1b wraps around three SlNRC3 protomers!
4/10
4/10
Reposted by Juan Martinez Hernández
Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model. Nat Comm 14, 7345. Check it in the UniTmp database: https://pdbtm.unitmp.org/entry/8gw6
www.nature.com
March 7, 2024 at 7:29 PM
Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model. Nat Comm 14, 7345. Check it in the UniTmp database: https://pdbtm.unitmp.org/entry/8gw6
Reposted by Juan Martinez Hernández
SRBD1, a highly conserved gene required for chromosome individualization
SRBD1, a highly conserved gene required for chromosome individualization
Raaijmakers et al. study S1 domain containing protein 1 (SRBD1), a previously uncharacterized essential protein. The loss of SRBD1 results in a complete failure in anaphase chromosome segregation due to defects established in prophase. The phenotype…
dlvr.it
March 19, 2025 at 11:23 PM
SRBD1, a highly conserved gene required for chromosome individualization
Reposted by Juan Martinez Hernández
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression
Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...
www.science.org
July 4, 2025 at 11:00 AM
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
Reposted by Juan Martinez Hernández
In plant immunity, activated sensor NLRs generate second messengers, which in turn activate helper NLRs such as NRG1. Two studies @nature use cryo-EM to provide mechanistic insights into NRG1 activation and inhibition.
www.nature.com/articles/s41...
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www.nature.com/articles/s41...
www.nature.com/articles/s41...
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www.nature.com/articles/s41...
Balanced plant helper NLR activation by a modified host protein complex - Nature
In Arabidopsis, mechanisms for NRG1A activation by recognition of a modified host EDS1–SAG101 complex, and NRG1A inhibition by NRG1C through sequestration of activated EDS1–SAG101, show activation and...
www.nature.com
February 12, 2025 at 10:53 PM
In plant immunity, activated sensor NLRs generate second messengers, which in turn activate helper NLRs such as NRG1. Two studies @nature use cryo-EM to provide mechanistic insights into NRG1 activation and inhibition.
www.nature.com/articles/s41...
&
www.nature.com/articles/s41...
www.nature.com/articles/s41...
&
www.nature.com/articles/s41...
Reposted by Juan Martinez Hernández
👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
July 15, 2025 at 10:50 PM
👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...