UniTmp
@unitmporg.bsky.social
New membrane proteins every week. Structure, topology and more. #MembraneProteins #PDB #cryoEM #transporter #ionchannel #GPCR #ABC #carriers
I am thrilled to announce that the completely redesigned TmDet algorithm by @ProtBioinfRG has just been published in the Nucleic Acids Research! Simple, double, curved membrane or even erroneously modeled tm proteins are no problem!
doi.org
April 25, 2025 at 11:31 AM
I am thrilled to announce that the completely redesigned TmDet algorithm by @ProtBioinfRG has just been published in the Nucleic Acids Research! Simple, double, curved membrane or even erroneously modeled tm proteins are no problem!
Structural basis of oligomerization-modulated activation and autoinhibition of orphan receptor GPR3. @CellReports Check this #membrane #protein in UniTmp: https://pdbtm.unitmp.org/entry/9lyb
www.cell.com
April 20, 2025 at 9:00 AM
Structural basis of oligomerization-modulated activation and autoinhibition of orphan receptor GPR3. @CellReports Check this #membrane #protein in UniTmp: https://pdbtm.unitmp.org/entry/9lyb
#CryoEM #Structure of the Flagellar Motor Complex from Paenibacillus sp. TCA20. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9lu9
www.mdpi.com
April 19, 2025 at 9:00 PM
#CryoEM #Structure of the Flagellar Motor Complex from Paenibacillus sp. TCA20. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9lu9
Structural insights into the selective recognition of RF-amide peptides by neuropeptide FF receptor 2. @EMBOReports. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jfy
www.embopress.org
April 19, 2025 at 9:00 AM
Structural insights into the selective recognition of RF-amide peptides by neuropeptide FF receptor 2. @EMBOReports. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jfy
Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9ee8
www.nature.com
April 18, 2025 at 9:00 PM
Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9ee8
Structural basis for the reversal of human MRP4-mediated multidrug resistance by lapatinib. @CellReports Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zbs
www.cell.com
April 18, 2025 at 9:00 AM
Structural basis for the reversal of human MRP4-mediated multidrug resistance by lapatinib. @CellReports Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zbs
Mycobacterium tuberculosis CrgA Forms a Dimeric Structure with Its Transmembrane Domain Sandwiched between Cytoplasmic and Periplasmic β-Sheets... https://pdbtm.unitmp.org/entry/9nm2
pubs.acs.org
April 16, 2025 at 9:00 PM
Mycobacterium tuberculosis CrgA Forms a Dimeric Structure with Its Transmembrane Domain Sandwiched between Cytoplasmic and Periplasmic β-Sheets... https://pdbtm.unitmp.org/entry/9nm2
Structural basis for catalytic mechanism of human phosphatidylserine synthase 1. @CellDiscovery Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kqf
www.nature.com
April 16, 2025 at 9:00 AM
Structural basis for catalytic mechanism of human phosphatidylserine synthase 1. @CellDiscovery Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kqf
Structural basis for cholesterol sensing of LYCHOS and its interaction with indoxyl sulfate. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9j3x
www.nature.com
April 15, 2025 at 9:00 PM
Structural basis for cholesterol sensing of LYCHOS and its interaction with indoxyl sulfate. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9j3x
A structural and mechanistic model for BSEP dysfunction in PFIC2 cholestatic disease. @biorxiv_preprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/
www.biorxiv.org
April 15, 2025 at 9:00 AM
A structural and mechanistic model for BSEP dysfunction in PFIC2 cholestatic disease. @biorxiv_preprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/
#CryoEM #structure of a phosphotransferase system glucose transporter stalled in an intermediate conformation. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9hnp
www.sciencedirect.com
April 14, 2025 at 9:00 PM
#CryoEM #structure of a phosphotransferase system glucose transporter stalled in an intermediate conformation. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9hnp
Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P2. @biorxiv_preprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9do0
www.biorxiv.org
April 14, 2025 at 9:00 AM
Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P2. @biorxiv_preprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9do0
The completely redesigned TmDet algorithm by @ProtBioinfRG has just been accepted in the Nucleic Acids Research! Simple, double, curved membrane or even erroneously modeled tm proteins are no problem! Check it here: https://tmdet.unitmp.org.
April 13, 2025 at 12:31 PM
The completely redesigned TmDet algorithm by @ProtBioinfRG has just been accepted in the Nucleic Acids Research! Simple, double, curved membrane or even erroneously modeled tm proteins are no problem! Check it here: https://tmdet.unitmp.org.
The structural diversity of psychedelic drug actions revealed. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9arx
www.nature.com
April 12, 2025 at 9:00 AM
The structural diversity of psychedelic drug actions revealed. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9arx
Mechanistic insights into proton-coupled substrate translocation of nucleoside proton symporters. @JBiolChem Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zoj
www.jbc.org
April 11, 2025 at 8:55 PM
Mechanistic insights into proton-coupled substrate translocation of nucleoside proton symporters. @JBiolChem Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zoj
Structural basis for the substrate recognition and transport mechanism of the human y+LAT1-4F2hc transporter complex. @ScienceAdvances Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kh5
www.science.org
April 11, 2025 at 9:00 AM
Structural basis for the substrate recognition and transport mechanism of the human y+LAT1-4F2hc transporter complex. @ScienceAdvances Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kh5
Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jdm
www.nature.com
April 7, 2025 at 9:00 AM
Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jdm
#CryoEM #structure of the human monocarboxylate transporter 10. @Structure Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9hhq
www.sciencedirect.com
April 6, 2025 at 9:00 PM
#CryoEM #structure of the human monocarboxylate transporter 10. @Structure Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9hhq
Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel. @BJP Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9ex6
bpspubs.onlinelibrary.wiley.com
April 6, 2025 at 9:00 AM
Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel. @BJP Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9ex6
#CryoEM #structure of the brine shrimp mitochondrial ATP synthase suggests an inactivation mechanism for the ATP synthase leak channel. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9b3j
www.nature.com
April 5, 2025 at 9:00 PM
#CryoEM #structure of the brine shrimp mitochondrial ATP synthase suggests an inactivation mechanism for the ATP synthase leak channel. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9b3j
Glutamate gating of AMPA-subtype iGluRs at physiological temperatures. @Nature Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9dhp
www.nature.com
April 5, 2025 at 9:00 AM
Glutamate gating of AMPA-subtype iGluRs at physiological temperatures. @Nature Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9dhp
Structure of the CD33 Receptor and Implications for the Siglec Family. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9bet
pubs.acs.org
April 4, 2025 at 9:00 PM
Structure of the CD33 Receptor and Implications for the Siglec Family. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9bet
Architecture and rearrangements of a sperm-specific Na+/H+ exchanger. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8u6z
www.researchsquare.com
April 4, 2025 at 9:00 AM
Architecture and rearrangements of a sperm-specific Na+/H+ exchanger. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8u6z
#CryoEM #structures of mouse bestrophin 1 channel in closed and partially open conformations. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kc9
www.sciencedirect.com
April 3, 2025 at 8:55 AM
#CryoEM #structures of mouse bestrophin 1 channel in closed and partially open conformations. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kc9
Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. @Science Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jhj
www.science.org
April 2, 2025 at 9:00 PM
Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. @Science Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jhj