UniTmp
@unitmporg.bsky.social
New membrane proteins every week. Structure, topology and more. #MembraneProteins #PDB #cryoEM #transporter #ionchannel #GPCR #ABC #carriers
The completely redesigned TmDet algorithm by @ProtBioinfRG has just been accepted in the Nucleic Acids Research! Simple, double, curved membrane or even erroneously modeled tm proteins are no problem! Check it here: https://tmdet.unitmp.org.
April 13, 2025 at 12:31 PM
The completely redesigned TmDet algorithm by @ProtBioinfRG has just been accepted in the Nucleic Acids Research! Simple, double, curved membrane or even erroneously modeled tm proteins are no problem! Check it here: https://tmdet.unitmp.org.
Structural insights into the agonist selectivity of the adenosine A3 receptor. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8yh0
March 10, 2025 at 8:00 AM
Structural insights into the agonist selectivity of the adenosine A3 receptor. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8yh0
60 new transmembrane protein structures in this week! Check them out here: https://pdbtm.unitmp.org/browse/releases/2025/2025-02-21
March 2, 2025 at 9:37 AM
60 new transmembrane protein structures in this week! Check them out here: https://pdbtm.unitmp.org/browse/releases/2025/2025-02-21
Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects. @biorxivpreprint Check this #membrane #protein in UniTmp: https://pdbtm.unitmp.org/entry/9mqh
February 16, 2025 at 7:56 PM
Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects. @biorxivpreprint Check this #membrane #protein in UniTmp: https://pdbtm.unitmp.org/entry/9mqh
Mechanism of NACHO-mediated assembly of pentameric ligand-gated ion channels. @biorxivpreprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9h9e
December 10, 2024 at 7:59 AM
Mechanism of NACHO-mediated assembly of pentameric ligand-gated ion channels. @biorxivpreprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9h9e
#CryoEM #structure of the zinc-activated channel (ZAC) in the Cys-loop receptor superfamily. @PNASNews Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zts
December 2, 2024 at 8:00 PM
#CryoEM #structure of the zinc-activated channel (ZAC) in the Cys-loop receptor superfamily. @PNASNews Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zts
Structural basis for hepatitis B virus restriction by a viral receptor homologue. @NatureComms. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8xcd
November 19, 2024 at 8:02 PM
Structural basis for hepatitis B virus restriction by a viral receptor homologue. @NatureComms. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8xcd
TRPML1 gating modulation by allosteric mutations and lipids. @biorxivpreprint. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9cbz
October 15, 2024 at 8:59 AM
TRPML1 gating modulation by allosteric mutations and lipids. @biorxivpreprint. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9cbz
Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/
October 7, 2024 at 8:59 PM
Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/
Am I the only one who sees the similarity?
September 19, 2024 at 8:17 AM
Am I the only one who sees the similarity?
Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface. @NatureComms 15, 2502. Check the #cryoEM #structure of this #ABC #transporter in the UniTmp database: https://pdbtm.unitmp.org/entry/8ti1
May 17, 2024 at 8:58 AM
Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface. @NatureComms 15, 2502. Check the #cryoEM #structure of this #ABC #transporter in the UniTmp database: https://pdbtm.unitmp.org/entry/8ti1
Cryo-EM structures of adenosine receptor A3AR bound to selective agonists. @NatureComms 15, 3252. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8x16
May 3, 2024 at 8:58 AM
Cryo-EM structures of adenosine receptor A3AR bound to selective agonists. @NatureComms 15, 3252. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8x16
Cryo-EM structure of cannabinoid receptor CB1-β-arrestin complex. Protein & Cell 15, 230. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8wrz
March 27, 2024 at 3:29 AM
Cryo-EM structure of cannabinoid receptor CB1-β-arrestin complex. Protein & Cell 15, 230. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8wrz
Structure and mechanism of a membrane-bound phosphoribosyltransferase central to Mtb cell wall biosynthesis. Check it in the UniTmp database: https://pdbtm.unitmp.org/entry/8j8j
March 23, 2024 at 3:29 PM
Structure and mechanism of a membrane-bound phosphoribosyltransferase central to Mtb cell wall biosynthesis. Check it in the UniTmp database: https://pdbtm.unitmp.org/entry/8j8j
Cryo-EM structure of cell-free synthesized human histamine 2 receptor/Gs complex in nanodisc environment. Nat Comm 15, 1831.
Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8pok
Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8pok
March 21, 2024 at 7:29 AM
Cryo-EM structure of cell-free synthesized human histamine 2 receptor/Gs complex in nanodisc environment. Nat Comm 15, 1831.
Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8pok
Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8pok
More than 10 thousand membrane proteins in the UniTmp database (pdbtm.unitmp.org)! And their number is growing exponentially thanks to the great effort of many structure biologist researchers.
March 8, 2024 at 6:32 PM
More than 10 thousand membrane proteins in the UniTmp database (pdbtm.unitmp.org)! And their number is growing exponentially thanks to the great effort of many structure biologist researchers.
There are almost 10.000 transmembrane proteins in the UniTmp database. Next week the counter will turn over. Stay tuned.
March 5, 2024 at 7:17 PM
There are almost 10.000 transmembrane proteins in the UniTmp database. Next week the counter will turn over. Stay tuned.
Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell 186, 4956. www.cell.com/cell/fulltex.... See in UniTmp: pdbtm.unitmp.org/entry/8hpt.
January 14, 2024 at 5:13 PM
Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell 186, 4956. www.cell.com/cell/fulltex.... See in UniTmp: pdbtm.unitmp.org/entry/8hpt.
Reanalysis of a μ opioid receptor crystal structure reveals a covalent adduct with BU72. BMC Biol 21, 213. bmcbiol.biomedcentral.com/articles/10....
See in UniTmp: pdbtm.unitmp.org/entry/8e0g
See in UniTmp: pdbtm.unitmp.org/entry/8e0g
January 14, 2024 at 5:08 PM
Reanalysis of a μ opioid receptor crystal structure reveals a covalent adduct with BU72. BMC Biol 21, 213. bmcbiol.biomedcentral.com/articles/10....
See in UniTmp: pdbtm.unitmp.org/entry/8e0g
See in UniTmp: pdbtm.unitmp.org/entry/8e0g
Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Comm 14, 4874. www.nature.com/articles/s41.... See in UniTmp: pdbtm.unitmp.org/entry/8sun.
January 13, 2024 at 3:20 PM
Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Comm 14, 4874. www.nature.com/articles/s41.... See in UniTmp: pdbtm.unitmp.org/entry/8sun.
Structure of the bc1–cbb3 respiratory supercomplex from Pseudomonas aeruginosa. PNAS 120 e2307093120. www.pnas.org/doi/10.1073/.... See in UniTmp: pdbtm.unitmp.org/entry/8smr.
January 13, 2024 at 3:16 PM
Structure of the bc1–cbb3 respiratory supercomplex from Pseudomonas aeruginosa. PNAS 120 e2307093120. www.pnas.org/doi/10.1073/.... See in UniTmp: pdbtm.unitmp.org/entry/8smr.
Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling. Nat Comm 14, 5901. www.nature.com/articles/s41.... See in UniTmp: pdbtm.unitmp.org/entry/8kgk.
January 13, 2024 at 3:09 PM
Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling. Nat Comm 14, 5901. www.nature.com/articles/s41.... See in UniTmp: pdbtm.unitmp.org/entry/8kgk.
Superiority of the Triple-Acting 5-HT6R/5-HT3R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT6R Antagonist Intepirdine .... J. Med. Chem. 2023, 66, 21, 14928–14947. pubs.acs.org/doi/10.1021/.... See in UniTmp: pdbtm.unitmp.org/entry/8cc6
January 13, 2024 at 2:36 PM
Superiority of the Triple-Acting 5-HT6R/5-HT3R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT6R Antagonist Intepirdine .... J. Med. Chem. 2023, 66, 21, 14928–14947. pubs.acs.org/doi/10.1021/.... See in UniTmp: pdbtm.unitmp.org/entry/8cc6
W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state. Comm Biol 6, 960. www.nature.com/articles/s42.... See in UniTmp: pdbtm.unitmp.org/entry/8k7b
January 12, 2024 at 4:18 PM
W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state. Comm Biol 6, 960. www.nature.com/articles/s42.... See in UniTmp: pdbtm.unitmp.org/entry/8k7b
Structure of a fungal 1,3-β-glucan synthase. Sci Adv 9, 3. www.science.org/doi/10.1126/.... See in UniTmp: pdbtm.unitmp.org/entry/8jzn.
January 12, 2024 at 4:11 PM
Structure of a fungal 1,3-β-glucan synthase. Sci Adv 9, 3. www.science.org/doi/10.1126/.... See in UniTmp: pdbtm.unitmp.org/entry/8jzn.