Juan F. De la Hoz
@juandelahoz.bsky.social
precision psychiatry & psychiatric genetics
postdoc @ massgen | harvard med | broad institute
postdoc @ massgen | harvard med | broad institute
Reposted by Juan F. De la Hoz
📣New from @bpasaniuc.bsky.social & co
📄Exploring #depression treatment response by using #polygenic risk scoring across diverse populations
📄Exploring #depression treatment response by using #polygenic risk scoring across diverse populations
Exploring depression treatment response by using polygenic risk scoring across diverse populations
Ancestrally diverse biobanks where medication, disease, and genetics are linked provide
an opportunity to understand treatment response to major depressive disorder (MDD).
We developed polygenic risk ...
www.cell.com
June 30, 2025 at 3:48 PM
📣New from @bpasaniuc.bsky.social & co
📄Exploring #depression treatment response by using #polygenic risk scoring across diverse populations
📄Exploring #depression treatment response by using #polygenic risk scoring across diverse populations
Reposted by Juan F. De la Hoz
Interesting to see two new papers reporting variable accuracy of polygenic scores across non-genetic (or at least non-PRS) backgrounds.
Cudic et al considers intersections of age, sex, smoking, alcohol, income, and deprivation.
www.medrxiv.org/content/10.1...
Cudic et al considers intersections of age, sex, smoking, alcohol, income, and deprivation.
www.medrxiv.org/content/10.1...
June 8, 2025 at 9:21 AM
Interesting to see two new papers reporting variable accuracy of polygenic scores across non-genetic (or at least non-PRS) backgrounds.
Cudic et al considers intersections of age, sex, smoking, alcohol, income, and deprivation.
www.medrxiv.org/content/10.1...
Cudic et al considers intersections of age, sex, smoking, alcohol, income, and deprivation.
www.medrxiv.org/content/10.1...
Exciting work by the great @ruthiejohnson.bsky.social !! 👏
Interesting work! By mapping many medical ontologies to the same embedding space we can go beyond the need of time-consuming data mapping and harmonization.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Unified Clinical Vocabulary Embeddings for Advancing Precision Medicine
Integrating clinical knowledge into AI remains challenging despite numerous medical guidelines and vocabularies. Medical codes, central to healthcare systems, often reflect operational patterns shaped...
www.medrxiv.org
December 11, 2024 at 10:08 PM
Exciting work by the great @ruthiejohnson.bsky.social !! 👏
Reposted by Juan F. De la Hoz
Dear statgen friends at #ASHG2023 #ASHG23, my lab is #hiring #phds #postdocs to work on heterogeneity and trajectories of psychiatric disorders using EHR/cohorts across US/Europe/Asia (incl. data from PGC), lots of cool stuff to be done!
Please reach out by email!
Ad link: tinyurl.com/7tae8k
Please reach out by email!
Ad link: tinyurl.com/7tae8k
Postdoctoral Fellow in Statistical Genetics (f/m/x)
tinyurl.com
November 4, 2023 at 11:40 AM
Reposted by Juan F. De la Hoz
NIMH has a list of genes with strong statistical support for association with mental health phenotypes, and they are interested in supporting researchers want to investigate a particular gene
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-MH-24-370: Notice of Information: NIMH List of Human Genes Having Rare Variants with Strong Statistical Support for Association to Mental Health Traits
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Information: NIMH List of Human Genes Having Rare Variants with Strong Statistical Support for Association t...
grants.nih.gov
November 15, 2024 at 2:45 PM
NIMH has a list of genes with strong statistical support for association with mental health phenotypes, and they are interested in supporting researchers want to investigate a particular gene
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...