Sebastián Jara
@jsebajara.bsky.social
Neurobiólogo 🇨🇱 | postdoc @scrippsresearch| Sensory neurons-immune interaction | Axon plasticity
Reposted by Sebastián Jara
🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology!
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
biorxiv.org
November 7, 2025 at 4:43 AM
🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology!
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Reposted by Sebastián Jara
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
October 22, 2025 at 8:41 PM
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
Reposted by Sebastián Jara
Coming to SD 🌴 for #SfN25 🧠?! Join @storiesofwin.bsky.social for our first in-person event 🤩. We’ll have a keynote, panels, & time for networking! Won’t be in SD? You can still register to receive a recording! Speaker/panelist announcements coming soon 👀
Register by Nov 1: forms.gle/CJPcKZNZY7uU...
Register by Nov 1: forms.gle/CJPcKZNZY7uU...
October 9, 2025 at 11:57 PM
Coming to SD 🌴 for #SfN25 🧠?! Join @storiesofwin.bsky.social for our first in-person event 🤩. We’ll have a keynote, panels, & time for networking! Won’t be in SD? You can still register to receive a recording! Speaker/panelist announcements coming soon 👀
Register by Nov 1: forms.gle/CJPcKZNZY7uU...
Register by Nov 1: forms.gle/CJPcKZNZY7uU...
Reposted by Sebastián Jara
New preprint from the spinal cord group at Glasgow. Anatomical and functional characterisation of spinal circuits for cold, from sensory neurons to the brain…..https://www.biorxiv.org/content/10.1101/2025.10.03.680240v1
October 4, 2025 at 8:34 AM
New preprint from the spinal cord group at Glasgow. Anatomical and functional characterisation of spinal circuits for cold, from sensory neurons to the brain…..https://www.biorxiv.org/content/10.1101/2025.10.03.680240v1
Reposted by Sebastián Jara
We’re hiring!
My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease.
🔬 Apply here: myhr.northwestern.edu/psp/hrnu/EMP...
My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease.
🔬 Apply here: myhr.northwestern.edu/psp/hrnu/EMP...
Sign In
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myhr.northwestern.edu
September 30, 2025 at 10:32 PM
We’re hiring!
My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease.
🔬 Apply here: myhr.northwestern.edu/psp/hrnu/EMP...
My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease.
🔬 Apply here: myhr.northwestern.edu/psp/hrnu/EMP...
Reposted by Sebastián Jara
Great collaboration with Abel Torres Espín that arose from our work on SCI. Congrats to all involved, including @jsebajara.bsky.social , Amanda Bernstein, Marwa Soliman, and Yunuen Moreno López!
www.liebertpub.com/doi/abs/10.1...
www.liebertpub.com/doi/abs/10.1...
Development and Validation of a Machine Learning-Derived Kinematic Deviation Index for the Evaluation of Forelimb in Rodents | AI in Neuroscience
Background: Rodent models are widely used to study neurological conditions and assess forelimb movement to measure functional performance, deficit, recovery, and treatment effectiveness. Traditional a...
www.liebertpub.com
September 29, 2025 at 4:22 PM
Great collaboration with Abel Torres Espín that arose from our work on SCI. Congrats to all involved, including @jsebajara.bsky.social , Amanda Bernstein, Marwa Soliman, and Yunuen Moreno López!
www.liebertpub.com/doi/abs/10.1...
www.liebertpub.com/doi/abs/10.1...
Reposted by Sebastián Jara
Does anyone have favorite colors for color blind friendly fluorescence images on a black background where the overlap combinations of 3 colors are important?
Magenta/cyan/yellow overlaps are difficult to distinguish (lots of white)
Thank you!
Magenta/cyan/yellow overlaps are difficult to distinguish (lots of white)
Thank you!
September 11, 2025 at 5:11 PM
Does anyone have favorite colors for color blind friendly fluorescence images on a black background where the overlap combinations of 3 colors are important?
Magenta/cyan/yellow overlaps are difficult to distinguish (lots of white)
Thank you!
Magenta/cyan/yellow overlaps are difficult to distinguish (lots of white)
Thank you!
Big congrats to Alejandra @thepenkpanther.bsky.social on her new SI paper! Kicking off the Mendoza Lab’s work on sensory neuron-immune interactions. Glad to see our image highlighted on their website too!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
www.science.org
September 9, 2025 at 5:27 PM
Big congrats to Alejandra @thepenkpanther.bsky.social on her new SI paper! Kicking off the Mendoza Lab’s work on sensory neuron-immune interactions. Glad to see our image highlighted on their website too!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Sebastián Jara
Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
September 8, 2025 at 4:25 PM
Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Reposted by Sebastián Jara
After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻♀️
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
www.science.org
September 5, 2025 at 6:53 PM
After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻♀️
Reposted by Sebastián Jara
Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
August 24, 2025 at 1:08 PM
Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
Reposted by Sebastián Jara
This work is finally online as in-press preview!
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI -
Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy
www.jci.org
August 19, 2025 at 4:55 PM
This work is finally online as in-press preview!
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
Reposted by Sebastián Jara
In this month’s “Liftoff,” @janetsong.bsky.social shares how she plans to expose trainees to new ideas during lab meetings and Rachel Parkinson emphasizes the importance of taking a step back and reminding yourself about the joys of science.
By @franciscorr25.bsky.social
bit.ly/4mFNGCQ
By @franciscorr25.bsky.social
bit.ly/4mFNGCQ
Liftoff: New lab alerts
Learn about early-career scientists starting their own labs.
https://bit.ly/4mFNGCQ"
August 13, 2025 at 3:23 PM
In this month’s “Liftoff,” @janetsong.bsky.social shares how she plans to expose trainees to new ideas during lab meetings and Rachel Parkinson emphasizes the importance of taking a step back and reminding yourself about the joys of science.
By @franciscorr25.bsky.social
bit.ly/4mFNGCQ
By @franciscorr25.bsky.social
bit.ly/4mFNGCQ
Reposted by Sebastián Jara
As Requested - A Starter Pack of PIs in Biology (or adjacent) fields who are recruiting POSTDOCS! Please don't hesitate to reach out if you wish to be added! go.bsky.app/4gbXXR3
July 18, 2025 at 6:33 PM
As Requested - A Starter Pack of PIs in Biology (or adjacent) fields who are recruiting POSTDOCS! Please don't hesitate to reach out if you wish to be added! go.bsky.app/4gbXXR3
Reposted by Sebastián Jara
The Salk Institute seeks a Full Professor in Neuroimmunology to lead innovative research on nervous and immune system interactions within a collaborative, world-class setting. Closing date: 7th September
www.dementiaresearcher.nihr.ac.uk/job/professo...
www.dementiaresearcher.nihr.ac.uk/job/professo...
Professor in Neuroimmunology - DEMENTIA RESEARCHER
The Salk Institute seeks a Professor in Neuroimmunology to lead innovative research on nervous and immune system interactions within a world-class setting
www.dementiaresearcher.nihr.ac.uk
July 10, 2025 at 12:39 PM
The Salk Institute seeks a Full Professor in Neuroimmunology to lead innovative research on nervous and immune system interactions within a collaborative, world-class setting. Closing date: 7th September
www.dementiaresearcher.nihr.ac.uk/job/professo...
www.dementiaresearcher.nihr.ac.uk/job/professo...
Reposted by Sebastián Jara
Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in @nature.com today! Congrats to Brian Andersen and Camilo Faust Akl!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Barcoded viral tracing identifies immunosuppressive astrocyte–glioma interactions - Nature
Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity ...
www.nature.com
June 25, 2025 at 8:44 PM
Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in @nature.com today! Congrats to Brian Andersen and Camilo Faust Akl!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sebastián Jara
New paper from the lab 🚨: Expansion microscopy reveals nano-scale insights into the human neuromuscular junction: Cell Reports Methods www.cell.com/cell-reports...
Expansion microscopy reveals nano-scale insights into the human neuromuscular junction
Ramadan et al. employ expansion microscopy to visualize neuromuscular junctions in
human and mouse muscles. Their findings demonstrate expansion microscopy as an accessible
and cost-effective approach...
www.cell.com
June 16, 2025 at 2:45 PM
New paper from the lab 🚨: Expansion microscopy reveals nano-scale insights into the human neuromuscular junction: Cell Reports Methods www.cell.com/cell-reports...
Reposted by Sebastián Jara
Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_...
#Neuroscience #Postdoc #ResearchOpportunity
#Neuroscience #Postdoc #ResearchOpportunity
June 15, 2025 at 4:20 PM
Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_...
#Neuroscience #Postdoc #ResearchOpportunity
#Neuroscience #Postdoc #ResearchOpportunity
Reposted by Sebastián Jara
🧠🐁
Interested in a quick / reliable / reproducible tool to quantify your fluoresently-tagged axons ?
Check out AxoDen, a no-coding-needed web app and downloadable GUI ...
Designed + developed entriely by the amazing Raquel Adaia Sandoval Ortega
www.eneuro.org/content/12/6...
Interested in a quick / reliable / reproducible tool to quantify your fluoresently-tagged axons ?
Check out AxoDen, a no-coding-needed web app and downloadable GUI ...
Designed + developed entriely by the amazing Raquel Adaia Sandoval Ortega
www.eneuro.org/content/12/6...
AxoDen: An Algorithm for the Automated Quantification of Axonal Density in Defined Brain Regions
The rodent brain contains 70,000,000+ neurons interconnected via complex axonal circuits with varying architectures. Neural pathologies are often associated with anatomical changes in these axonal pro...
www.eneuro.org
June 14, 2025 at 1:02 PM
🧠🐁
Interested in a quick / reliable / reproducible tool to quantify your fluoresently-tagged axons ?
Check out AxoDen, a no-coding-needed web app and downloadable GUI ...
Designed + developed entriely by the amazing Raquel Adaia Sandoval Ortega
www.eneuro.org/content/12/6...
Interested in a quick / reliable / reproducible tool to quantify your fluoresently-tagged axons ?
Check out AxoDen, a no-coding-needed web app and downloadable GUI ...
Designed + developed entriely by the amazing Raquel Adaia Sandoval Ortega
www.eneuro.org/content/12/6...
Reposted by Sebastián Jara
Happy to share my first publication with @patrikernfors.bsky.social Lab - all about the DRG: Chromatin accessibility, single cell and spatial RNA sequencing - a great source for everyone interested in sensory neurons and non-neuronal cell of the DRG 😊
A read only for the DRG nerd: "Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons". www.nature.com/articles/s42...
Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons - Communications Biology
Single cell RNA-sequencing, spatial transcriptomics and chromatin analyses of sensory neurons provide insights into cell type organization of the dorsal root ganglion and the enhancer-driven co-regula...
www.nature.com
June 13, 2025 at 3:01 PM
Happy to share my first publication with @patrikernfors.bsky.social Lab - all about the DRG: Chromatin accessibility, single cell and spatial RNA sequencing - a great source for everyone interested in sensory neurons and non-neuronal cell of the DRG 😊
Reposted by Sebastián Jara
Led by @scienceyael.bsky.social & out today in @natneuro.nature.com: the brain's fluid-secreting organ — the choroid plexus — can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. 🧠👇 A thread
rdcu.be/eoaSY
rdcu.be/eoaSY
Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development
Nature Neuroscience - The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism...
rdcu.be
May 28, 2025 at 12:56 PM
Led by @scienceyael.bsky.social & out today in @natneuro.nature.com: the brain's fluid-secreting organ — the choroid plexus — can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. 🧠👇 A thread
rdcu.be/eoaSY
rdcu.be/eoaSY
Reposted by Sebastián Jara
We set out to map a detailed proteome of the human DRG and nerve using DIA-MS as a reference to the field, and I think we've succeeded! Lots of proteins (& lots of ion channels), with the data is fully searchable. It's also available on @sparc.science
sensoryomics.shinyapps.io/Proteomics/
sensoryomics.shinyapps.io/Proteomics/
May 20, 2025 at 5:58 AM
We set out to map a detailed proteome of the human DRG and nerve using DIA-MS as a reference to the field, and I think we've succeeded! Lots of proteins (& lots of ion channels), with the data is fully searchable. It's also available on @sparc.science
sensoryomics.shinyapps.io/Proteomics/
sensoryomics.shinyapps.io/Proteomics/
Reposted by Sebastián Jara
Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.
Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.
dlvr.it
April 30, 2025 at 9:20 PM
Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.
Reposted by Sebastián Jara
Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Interoceptive processing in the nucleus of the solitary tract
The interoceptive nervous system continuously monitors the status of visceral organs to synthesize internal perceptions and regulate behavioral and ph…
www.sciencedirect.com
April 16, 2025 at 4:02 AM
Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Sebastián Jara
SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web.
chemsymposia.com
chemsymposia.com
Join Chemsymposia 2026: Research & Innovation | ChemSymposia 2026
Join us at Chemsymposia 2026 to discover groundbreaking research in physics applications. Connect with experts, engage in insightful discussions, and explore our venue, registration details, and speak...
chemsymposia.com
April 11, 2025 at 4:35 PM
SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web.
chemsymposia.com
chemsymposia.com