Alexis A. Jourdain
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jourdainlab.bsky.social
Alexis A. Jourdain
@jourdainlab.bsky.social
1K followers 250 following 51 posts
Swiss-Belgian biologist, assistant professor @UNIL with interest in mitochondria, energy metabolism, innate immunity and systems biology.
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Reposted by Alexis A. Jourdain
frezzalab.bsky.social
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
November 16, 2025 at 7:04 AM
Reposted by Alexis A. Jourdain
fbm-unil.bsky.social
🔦 Flash #Recherche

🧬🦀 Des scientifiques @dib-unil.bsky.social @unil.bsky.social identifient un nouveau #mécanisme susceptible de faire dérailler certains #traitements du #cancer. En jeu ? La perte du gène 𝘕𝘜𝘋𝘛5.
🔗 www.unil.ch/news/fr/1762...

@jourdainlab.bsky.social
Ce gène qui sauve les chimiothérapies
Des scientifiques du Département d’immunobiologie de l’Unil mettent en évidence un nouveau mécanisme susceptible de faire dérailler certains traitements du cancer.
www.unil.ch
November 13, 2025 at 10:45 AM
jourdainlab.bsky.social
Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉

Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!

#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social

🔗 www.nature.com/articles/s42...
🧵1/17
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
www.nature.com
November 13, 2025 at 10:19 AM
Reposted by Alexis A. Jourdain
mellimittenblr.bsky.social
‼️ We're looking for a postdoc to join our team starting January 1st, 2026! ‼️
Are you curious about how exercise promotes positive changes at the molecular level in obesity and diabetes? If so, consider applying or reach out with any questions.

ddz.de/job/postdoct...

ddz.de/en/research/...
Postdoctoral Researcher (Ph.D./Dr. rer. nat., m/f/div., E13 TV-L, 100%) - Deutsches Diabetes-Zentrum (DDZ)
Institut für Klinische Biochemie und Pathobiochemie (Direktor: Univ.-Prof. Dr. rer. nat. Hadi Al-Hasani), Nachwuchsforschungsgruppe Crosstalk (Leiterin: Melanie Mittenbühler, Dr.) (25019)
ddz.de
July 30, 2025 at 10:53 AM
jourdainlab.bsky.social
Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉

🧫 New galactose #CRISPR screen
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂 Mito defects in #Menieres

www.cell.com/cell-reports...
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...
www.cell.com
July 28, 2025 at 5:40 AM
Reposted by Alexis A. Jourdain
cassiejclarke.bsky.social
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...
www.embopress.org
July 23, 2025 at 8:48 PM
Reposted by Alexis A. Jourdain
frezzalab.bsky.social
Uridine: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

a great not-to-miss piece from the @lyssiotislab.bsky.social
Uridine
Uridine is a pyrimidine nucleoside composed of an uracil base and a ribose sugar. In cells, uridine is predominantly present in RNA (as uridine monophosphate, UMP). Uridine can be produced through de ...
www.cell.com
June 15, 2025 at 6:43 AM
Reposted by Alexis A. Jourdain
fbm-unil.bsky.social
🌿 Bravo aux 12 laboratoires certifiés LEAF @fbm-unil.bsky.social

👏 Arber Lab, Bagni Lab, Chatton Lab, Du Pasquier Lab, Jourdain Lab, LPA, M-Lab, Martinon Lab, Rebsamen Lab, Suter Lab, Thome Lab, Widmann Lab.
➡️ www.unil.ch/news/1747834...

#LEAF #recherche #durable
Le programme LEAF reconduit pour une nouvelle année
12 Laboratoires ont reçu une certification LEAF (Laboratory Efficiency Assessment Framework) pour leur participation au programme de mai 2024 à mai 2025.
www.unil.ch
June 5, 2025 at 7:28 AM
jourdainlab.bsky.social
Powerful new method to diagnose mito disease!

(and not only because in my heart proteomics>>>sequencing)
May 23, 2025 at 11:50 AM
Reposted by Alexis A. Jourdain
apatgiri.bsky.social
Job alert: My lab at Emory University in vibrant Atlanta is recruiting a postdoc to study #mitochondrialbiology and #metabolism! Please help spread the word!
(1/3) @cp-cellmetabolism.bsky.social @natmetabolism.nature.com
May 6, 2025 at 2:12 PM
Reposted by Alexis A. Jourdain
euromit-2026.bsky.social
🚀 Boost your brand at EUROMIT 2026!
🎯 Sponsorship opportunities open in May 2025, but you can express your interest now by dropping us a line at 👉 euromit2026@univ-angers.fr
Don't miss this unique opportunity for your business! 💼✨
#euromit2026 #mitochondria #sponsorship #businessopportunity
April 18, 2025 at 9:24 AM
Reposted by Alexis A. Jourdain
euromit-2026.bsky.social
Exciting News: Learn about the Speakers of Euromit 2026!
We are happy to announce the amazing speakers for Euromit 2026, the leading congress on mitochondrial pathology.🌍✨
📢 See the full list ! 👇
#euromit2026 #mitochondria #science #innovation #angers
March 20, 2025 at 2:26 PM
Reposted by Alexis A. Jourdain
rebsamenlab.bsky.social
Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later!
More info: wp.unil.ch/immunobiolog...

#ImmunoSky
May 1, 2025 at 11:22 AM
jourdainlab.bsky.social
🚨 New preprint available! Third and final in the #CRISPR screen series!🚨

👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis

www.biorxiv.org/content/10.1...

By A. Strefeler in collaboration with Dave Pagliarini and team.

@DIB_UNIL @FBM_UNIL

🧵 1/9
www.biorxiv.org
March 14, 2025 at 8:14 AM
Reposted by Alexis A. Jourdain
rebsamenlab.bsky.social
🚨Registrations are open🚨

Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.

Attendance is limited to 150 participants!
March 2, 2025 at 3:52 PM
Reposted by Alexis A. Jourdain
apatgiri.bsky.social
My lab at #EmoryUniversity is seeking a #Postdoc candidate with expertise in #proteinbiochemistry to continue our exciting work on engineered protein therapies for #MitochondrialDiseases and #MetabolicDiseases. Email me to discuss this further. Please repost! #Proteinengineering #proteintherapy
apatgiri.bsky.social Anupam Patgiri @apatgiri.bsky.social · Dec 11
My lab at Emory University in vibrant Atlanta is looking for a postdoc candidate in #mitochondrialbiology and #metabolism! This position offers training opportunities in #metabolomics using our in-house Agilent 6546 QTOF LCMS. Please spread the word! (1/3)
February 12, 2025 at 4:05 PM
jourdainlab.bsky.social
New preprint from the lab! 🚨

🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease

by @marcellharhai.bsky.social @fbm-unil.bsky.social

A short thread 1/5

www.biorxiv.org/content/10.1...
January 30, 2025 at 7:58 AM
Reposted by Alexis A. Jourdain
jobrxiv.org
▶️ Postdoctoral position in Metabolism
University of Lausanne @jourdainlab

jobrxiv.org/job/univ...

▶️ Postdoctoral Fellow in Metabolites and Host Antimicrobial Defense
Washington University School of Medicine

jobrxiv.org/job/wash...
3/4
Postdoctoral position in Metabolism
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
January 29, 2025 at 10:00 PM
Reposted by Alexis A. Jourdain
rebsamenlab.bsky.social
We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.

Registrations open March 1 - Attendance limited to 150 participants.

More info: wp.unil.ch/immunobiolog...

#ImmunoSky
Symposium immunobiology
wp.unil.ch
January 28, 2025 at 2:33 PM
jourdainlab.bsky.social
Celebrating the New Year in style! Best wishes from the Jourdain Lab 🥌🫕🇨🇭
January 18, 2025 at 11:48 AM
jourdainlab.bsky.social
📢We're recruiting📢

Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!

Please share

#uridine #cancermetabolism #immunometabolism

@unil.bsky.social

🔗(PDF): www.jourdainlab.org/wp-content/u...
January 8, 2025 at 8:37 AM
Reposted by Alexis A. Jourdain
jclandoni.bsky.social
Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
December 23, 2024 at 4:37 PM
jourdainlab.bsky.social
📢We're recruiting📢

Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!

Please share

#uridine #cancermetabolism #immunometabolism

@unil.bsky.social

🔗(PDF): www.jourdainlab.org/wp-content/u...
December 16, 2024 at 11:13 AM
Reposted by Alexis A. Jourdain
apatgiri.bsky.social
My lab at Emory University in vibrant Atlanta is looking for a postdoc candidate in #mitochondrialbiology and #metabolism! This position offers training opportunities in #metabolomics using our in-house Agilent 6546 QTOF LCMS. Please spread the word! (1/3)
December 11, 2024 at 1:24 PM
Reposted by Alexis A. Jourdain
frezzalab.bsky.social
"Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer"

Congrats to @gjpattij.bsky.social & team

www.nature.com/articles/s41...
Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer - Nature
Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.
www.nature.com
December 4, 2024 at 4:33 PM