In the current issue of the American Journal of Hypertension, Zhang and colleagues report that higher levels of mean systolic blood pressure (SBP) and seve

Childhood hypertension affects a substantial and growing proportion of the global paediatric population, with prevalence varying considerably by diagnostic approach. These findings underscore the need...

Background Few studies are available on changes in maintenance immunosuppression after pediatric kidney transplantation (KT). This is a retrospective registry analysis of the long-term medication…

Abstract Rare monogenic diseases are increasingly identified in children with chronic kidney disease. We describe a consanguineous preterm male infant with a clinical picture of advanced kidney dysfunction and severe renal salt-wasting, highly suggestive of prenatal onset Bartter syndrome. Patient’s follow-up was characterized by severe polyuria; episodes of hyponatremia, hypokalemia, and hypochloremia; and metabolic alkalosis and hyperuricemia. We found a homozygous pathogenic variant in the TFCP2L1 gene, a transcription factor required for normal kidney development, that regulates acid–base and salt–water homeostasis. To our knowledge, there is only one published case of a child with TFCP2L1 gene pathogenic variants with a similar phenotype. This report adds evidence to TFCP2L1 as a cause of monogenic kidney disorders. Rare kidney dysplasias may manifest as phenocopies of primary tubulopathies. Genetic diagnosis plays a major role and should be carefully considered in patients with refractory course to standard treatment to facilitate management and family counselling.

In a groundbreaking longitudinal study published in JAMA Cardiology, researchers have unveiled compelling evidence that maintaining an optimal cardiovascular health profile between the ages of 30 and

Pediatric hypertension is associated with a significantly increased long-term risk of kidney-related morbidity and mortality.

The rapidly advancing field of neonatal nephrology has reached a pivotal moment, as highlighted in the comprehensive report from the First International Neonatal Nephrology Symposium published recently in Pediatric Research. This landmark gathering of leading experts and researchers has cast a visionary spotlight on the complexities and urgent needs within the care and study of kidney function and disorders in newborns, an area historically underrepresented despite its critical significance.