Jorge Lozano-Juste
@jorgetwe.bsky.social
Chemical Biology - Plant hormone signaling - Drug Discovery - Targeted Protein Degradation
Reposted by Jorge Lozano-Juste
New Article: "A combined biochemical and computational approach provides evidence for membrane remodelling by the structural scaffold of the endocytic TPLATE complex" rdcu.be/eP4fX
... to generate a comprehensive structure of the multisubunit endocytic TPLATE complex.
... to generate a comprehensive structure of the multisubunit endocytic TPLATE complex.
November 15, 2025 at 12:03 PM
New Article: "A combined biochemical and computational approach provides evidence for membrane remodelling by the structural scaffold of the endocytic TPLATE complex" rdcu.be/eP4fX
... to generate a comprehensive structure of the multisubunit endocytic TPLATE complex.
... to generate a comprehensive structure of the multisubunit endocytic TPLATE complex.
Reposted by Jorge Lozano-Juste
Version 2 is out! More comprehensive text plus new tissue- and pathway-specific analysis revealing how different viruses trigger systemic aging through diverse mechanisms.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 16, 2025 at 12:44 AM
Version 2 is out! More comprehensive text plus new tissue- and pathway-specific analysis revealing how different viruses trigger systemic aging through diverse mechanisms.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jorge Lozano-Juste
Our new review is out @theplantjournal.bsky.social! Christian (@unil.bsky.social) and I dive into brassinosteroid perception specificity and the importance of BRs in shaping vascular development. @ibmcp.bsky.social @upv.es @csic.es onlinelibrary.wiley.com/doi/10.1111/...
November 15, 2025 at 7:38 PM
Our new review is out @theplantjournal.bsky.social! Christian (@unil.bsky.social) and I dive into brassinosteroid perception specificity and the importance of BRs in shaping vascular development. @ibmcp.bsky.social @upv.es @csic.es onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Jorge Lozano-Juste
🌱🧬The #SeminarSeriesCBGP continues!
📅 Friday, November 14th – 12:30 PM
📺 Zoom: shorturl.at/BB2CU (🗝️627464)
🗣️Miguel Ángel Blázquez (@ibmcp.bsky.social)
“Why do plants stop growing under stress?”
#SeminarSeriesCBGP #ScienceTalks #PlantBiology #Research #PlantScience
📅 Friday, November 14th – 12:30 PM
📺 Zoom: shorturl.at/BB2CU (🗝️627464)
🗣️Miguel Ángel Blázquez (@ibmcp.bsky.social)
“Why do plants stop growing under stress?”
#SeminarSeriesCBGP #ScienceTalks #PlantBiology #Research #PlantScience
November 12, 2025 at 8:54 AM
🌱🧬The #SeminarSeriesCBGP continues!
📅 Friday, November 14th – 12:30 PM
📺 Zoom: shorturl.at/BB2CU (🗝️627464)
🗣️Miguel Ángel Blázquez (@ibmcp.bsky.social)
“Why do plants stop growing under stress?”
#SeminarSeriesCBGP #ScienceTalks #PlantBiology #Research #PlantScience
📅 Friday, November 14th – 12:30 PM
📺 Zoom: shorturl.at/BB2CU (🗝️627464)
🗣️Miguel Ángel Blázquez (@ibmcp.bsky.social)
“Why do plants stop growing under stress?”
#SeminarSeriesCBGP #ScienceTalks #PlantBiology #Research #PlantScience
Reposted by Jorge Lozano-Juste
Such a cool pre-print on making sentinel plants - so much potential!
Bioluminescent sentinel plants enable autonomous diagnostics of viral infections
www.biorxiv.org/content/10.1...
Bioluminescent sentinel plants enable autonomous diagnostics of viral infections
www.biorxiv.org/content/10.1...
Bioluminescent sentinel plants enable autonomous diagnostics of viral infections
Plants engineered with synthetic genetic programs can transform how we monitor and manage the extension of crop pests and diseases. Here, we establish a bioluminescent platform in Nicotiana benthamian...
www.biorxiv.org
November 12, 2025 at 3:55 AM
Such a cool pre-print on making sentinel plants - so much potential!
Bioluminescent sentinel plants enable autonomous diagnostics of viral infections
www.biorxiv.org/content/10.1...
Bioluminescent sentinel plants enable autonomous diagnostics of viral infections
www.biorxiv.org/content/10.1...
Reposted by Jorge Lozano-Juste
Academic tip: sometimes you have to write "Importantly," to get a sentence started and then you can go back and delete it.
November 6, 2025 at 9:16 PM
Academic tip: sometimes you have to write "Importantly," to get a sentence started and then you can go back and delete it.
Reposted by Jorge Lozano-Juste
My main work as postdoc @plantophagy.bsky.social lab in @gmivienna.bsky.social is out in @natplants.nature.com 🌱🎉
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape - Nature Plants
The evolutionary diversification of an exocyst subunit was enabled by electrostatic shifts leading to its dissociation from the ancestral complex.
www.nature.com
October 31, 2025 at 1:57 PM
My main work as postdoc @plantophagy.bsky.social lab in @gmivienna.bsky.social is out in @natplants.nature.com 🌱🎉
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
Reposted by Jorge Lozano-Juste
If this being (a human can’t be this cruel) is not a war criminal, who is?!! www.bbc.com/news/live/c8...
Israeli PM Netanyahu orders military to immediately strike Gaza - live updates
It comes as Israel says a coffin handed over by Hamas on Monday did not contain the body of another deceased hostage.
www.bbc.com
October 28, 2025 at 5:14 PM
If this being (a human can’t be this cruel) is not a war criminal, who is?!! www.bbc.com/news/live/c8...
Reposted by Jorge Lozano-Juste
El evento “Ultrasonidos de plantas: inteligencia vegetal e IA” nos invita a escuchar las voces del mundo vegetal y su interpretación mediante inteligencia artificial
27 Nov en @casaencendida.bsky.social
www.lacasaencendida.es/encuentros/u...
27 Nov en @casaencendida.bsky.social
www.lacasaencendida.es/encuentros/u...
October 27, 2025 at 4:30 PM
El evento “Ultrasonidos de plantas: inteligencia vegetal e IA” nos invita a escuchar las voces del mundo vegetal y su interpretación mediante inteligencia artificial
27 Nov en @casaencendida.bsky.social
www.lacasaencendida.es/encuentros/u...
27 Nov en @casaencendida.bsky.social
www.lacasaencendida.es/encuentros/u...
Had an awesome time at the Medicinal and Crop Protection Chemistry Meeting in Como, Italy 🇮🇹! Great to share our work at this unique event bridging pharma and agro drug discovery. Huge thanks to the organizers for an amazing lineup of speakers from academia and industry! 👏🌿💊
October 19, 2025 at 8:58 AM
Had an awesome time at the Medicinal and Crop Protection Chemistry Meeting in Como, Italy 🇮🇹! Great to share our work at this unique event bridging pharma and agro drug discovery. Huge thanks to the organizers for an amazing lineup of speakers from academia and industry! 👏🌿💊
Reposted by Jorge Lozano-Juste
Algal pyrenoids—condensates that mediate ~1/3 of Earth’s CO2 fixation—change size and number as cells divide. Our data suggest a simple control mechanism: a kinase that continuously ejects material from the condensate! ☀️🌍🔬💧 #Biophysics #Photosynthesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 12, 2025 at 1:22 PM
Algal pyrenoids—condensates that mediate ~1/3 of Earth’s CO2 fixation—change size and number as cells divide. Our data suggest a simple control mechanism: a kinase that continuously ejects material from the condensate! ☀️🌍🔬💧 #Biophysics #Photosynthesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jorge Lozano-Juste
📢 Don’t miss the upcoming seminar: ‘Drug discovery for thirsty plants’🌱, given by Dr Jorge Lozano Juste, Instituto de Biología Molecular y Celular de Plantas (@ibmcp.bsky.social ). Valencia.
🗓️26 September
🕛12:00h
📍CNB Lecture Hall
🗓️26 September
🕛12:00h
📍CNB Lecture Hall
September 25, 2025 at 5:03 PM
📢 Don’t miss the upcoming seminar: ‘Drug discovery for thirsty plants’🌱, given by Dr Jorge Lozano Juste, Instituto de Biología Molecular y Celular de Plantas (@ibmcp.bsky.social ). Valencia.
🗓️26 September
🕛12:00h
📍CNB Lecture Hall
🗓️26 September
🕛12:00h
📍CNB Lecture Hall
Reposted by Jorge Lozano-Juste
Very nice new review on roles for translational control in plant cell signalling by @maureynoso.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Update on translational control modes in plant cell signaling
Protein synthesis can contribute to plant cell signaling at multiple regulatory levels. Recent studies have expanded the conditions that are directly …
www.sciencedirect.com
October 5, 2025 at 9:22 AM
Very nice new review on roles for translational control in plant cell signalling by @maureynoso.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jorge Lozano-Juste
«Entre las demandas principales destacan la aprobación de un Estatuto del Personal de Investigación, la simplificación de trámites administrativos y el incremento de la inversión pública en I+D+i hasta alcanzar el 3% del PIB.»
www.larazon.es/ciencia/cien... vía @larazonlr.bsky.social
www.larazon.es/ciencia/cien... vía @larazonlr.bsky.social
Científicos exigen este domingo el cumplimiento del Pacto por la Ciencia firmado en 2023
Varias plataformas convocan concentraciones en Madrid, Barcelona y Valencia para exigir que el Pacto por la Ciencia "no sea papel mojado"
www.larazon.es
September 29, 2025 at 8:09 AM
«Entre las demandas principales destacan la aprobación de un Estatuto del Personal de Investigación, la simplificación de trámites administrativos y el incremento de la inversión pública en I+D+i hasta alcanzar el 3% del PIB.»
www.larazon.es/ciencia/cien... vía @larazonlr.bsky.social
www.larazon.es/ciencia/cien... vía @larazonlr.bsky.social
Reposted by Jorge Lozano-Juste
'The rise of Chinese pharmaceutical innovation is reflected in the number of new drugs that were approved in China before being approved in any other country, which increased from 9 in 2018 to 45 — not including 3 traditional Chinese medicines — in 2024' www.nejm.org/doi/full/10....
September 7, 2025 at 9:10 AM
'The rise of Chinese pharmaceutical innovation is reflected in the number of new drugs that were approved in China before being approved in any other country, which increased from 9 in 2018 to 45 — not including 3 traditional Chinese medicines — in 2024' www.nejm.org/doi/full/10....
Reposted by Jorge Lozano-Juste
S4.1. Molecular genetic mechanisms of plant development, evolution and adaptation
📢 Multisensory integration during plant terrestrialization - Miguel Blazquez @IBMCP
#47congresosebbm
📢 Multisensory integration during plant terrestrialization - Miguel Blazquez @IBMCP
#47congresosebbm
September 3, 2025 at 8:09 AM
S4.1. Molecular genetic mechanisms of plant development, evolution and adaptation
📢 Multisensory integration during plant terrestrialization - Miguel Blazquez @IBMCP
#47congresosebbm
📢 Multisensory integration during plant terrestrialization - Miguel Blazquez @IBMCP
#47congresosebbm
Reposted by Jorge Lozano-Juste
Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk
rdcu.be/eDzPk
Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...
rdcu.be
September 2, 2025 at 11:55 AM
Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk
rdcu.be/eDzPk
Reposted by Jorge Lozano-Juste
Reposted by Jorge Lozano-Juste
We are hiring the second cohort of EvoReSt PhD students. If you are interested in deep evolutionary questions, checkout:
www.uni-goettingen.de/de/687607.html
Apply here:
obp.uni-goettingen.de/de-de/OBF/In...
www.uni-goettingen.de/de/687607.html
Apply here:
obp.uni-goettingen.de/de-de/OBF/In...
August 25, 2025 at 6:22 PM
We are hiring the second cohort of EvoReSt PhD students. If you are interested in deep evolutionary questions, checkout:
www.uni-goettingen.de/de/687607.html
Apply here:
obp.uni-goettingen.de/de-de/OBF/In...
www.uni-goettingen.de/de/687607.html
Apply here:
obp.uni-goettingen.de/de-de/OBF/In...
Reposted by Jorge Lozano-Juste
In the new book Labwork to Leadership, chemist Jen Heemstra offers actionable leadership advice to principal investigators.
Read the #ScienceBooks Review: https://scim.ag/4mljVr1
Read the #ScienceBooks Review: https://scim.ag/4mljVr1
August 19, 2025 at 6:49 PM
In the new book Labwork to Leadership, chemist Jen Heemstra offers actionable leadership advice to principal investigators.
Read the #ScienceBooks Review: https://scim.ag/4mljVr1
Read the #ScienceBooks Review: https://scim.ag/4mljVr1
Reposted by Jorge Lozano-Juste
Introducing the 1,000 Flower Collection 🧬🌹
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
August 11, 2025 at 6:54 PM
Introducing the 1,000 Flower Collection 🧬🌹
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
Reposted by Jorge Lozano-Juste
(1/7)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Accelerating Biomolecular Modeling with AtomWorks and RF3
Deep learning methods trained on protein structure databases have revolutionized biomolecular structure prediction, but developing and training new models remains a considerable challenge. To facilita...
www.biorxiv.org
August 15, 2025 at 5:17 PM
(1/7)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Reposted by Jorge Lozano-Juste
This review summarizes advancements in solubility and controllable aggregation tags for recombinant protein purification, highlighting design strategies, on-demand cleavage, and emerging production challenges.
#HM #protein #purification #tags #proteases
www.sciltp.com/journals/hm/...
#HM #protein #purification #tags #proteases
www.sciltp.com/journals/hm/...
August 15, 2025 at 7:45 AM
This review summarizes advancements in solubility and controllable aggregation tags for recombinant protein purification, highlighting design strategies, on-demand cleavage, and emerging production challenges.
#HM #protein #purification #tags #proteases
www.sciltp.com/journals/hm/...
#HM #protein #purification #tags #proteases
www.sciltp.com/journals/hm/...
Reposted by Jorge Lozano-Juste
RosettaFold 3 is here! 🧬🚀
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
August 15, 2025 at 1:26 PM
RosettaFold 3 is here! 🧬🚀
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
Reposted by Jorge Lozano-Juste
How a Ph.D. is like riding a bike www.science.org/content/arti... --- also true (long) after the PhD (and I don't even mention bike lanes)
How a Ph.D. is like riding a bike
This researcher struggled in grad school—until he embraced it as a time for learning
www.science.org
August 15, 2025 at 4:24 PM
How a Ph.D. is like riding a bike www.science.org/content/arti... --- also true (long) after the PhD (and I don't even mention bike lanes)