Jonas Van lent
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jonasvanlent.bsky.social
Jonas Van lent
@jonasvanlent.bsky.social
390 followers 100 following 6 posts
Postdoctoral researcher at Institute of Oncology Research, Switzerland. Interested in hPSC-derived PNS neuronal models
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Reposted by Jonas Van lent
ariannabaggiolini.bsky.social
🚀 We’re growing! Are you passionate about human pluripotent stem cells? We are looking for 1 PhD student + 1 Lab technician to join us ☀️

ior.usi.ch/institute/jobs
September 30, 2025 at 7:18 PM
Reposted by Jonas Van lent
ardemp.bskyverified.social
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
PIEZO channels link mechanical forces to uterine contractions in parturition
Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...
www.biorxiv.org
September 18, 2025 at 3:23 PM
Reposted by Jonas Van lent
tedpricethepainguy.bsky.social
BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.
mheming.bsky.social mheming.bsky.social @mheming.bsky.social · Aug 24
Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
August 24, 2025 at 3:21 PM
Reposted by Jonas Van lent
tomgillingwater.bsky.social
New paper from the lab 🚨: Expansion microscopy reveals nano-scale insights into the human neuromuscular junction: Cell Reports Methods www.cell.com/cell-reports...
Expansion microscopy reveals nano-scale insights into the human neuromuscular junction
Ramadan et al. employ expansion microscopy to visualize neuromuscular junctions in human and mouse muscles. Their findings demonstrate expansion microscopy as an accessible and cost-effective approach...
www.cell.com
June 16, 2025 at 2:45 PM
jonasvanlent.bsky.social
🚨 Exciting opportunity to join us! 👇
iorbellinzona.bsky.social Institute of Oncology Research (IOR) @iorbellinzona.bsky.social · Jun 5
#IORjobs

Open PhD Position!
Join Arianna Baggiolini @ariannabaggiolini.bsky.social ’s Lab to work on human pluripotent stem cell (hPSC)-based models of the peripheral nervous system and disease.

Info and application: ior.usi.ch/events-news/...
June 11, 2025 at 5:27 AM
jonasvanlent.bsky.social
🚨 Exciting opportunity to join our lab 👇
ariannabaggiolini.bsky.social Arianna Baggiolini @ariannabaggiolini.bsky.social · May 29
📣 Join us! Were looking for a PhD student to join our lab and work on human pluripotent stem cell (hPSC)-based models of the peripheral nervous system and disease. Come be part of our supportive and dynamic lab family in the beautiful Bellinzona, Southern Switzerland 🇨🇭☀️⛰️ ior.usi.ch/events-news/...
PhD Student at the IOR - Institute of Oncology Research in Bellinzona, Switzerland
The Institute of Oncology Research (IOR) The IOR, affiliated with the Università della Svizzera italiana (USI), is located in a brand-new, high-tech research building that hosts more than 20 differ
ior.usi.ch
May 29, 2025 at 9:13 AM
Reposted by Jonas Van lent
ariannabaggiolini.bsky.social
Congrats to our brilliant postdoc🥳, @jonasvanlent.bsky.social, on receiving the Young Investigator Award from the Children’s Tumor Foundation! This recognition is a statement to the impact of your important research🌟!. We’re excited to follow your journey and see how you’ll advance science💪🌟
iorbellinzona.bsky.social Institute of Oncology Research (IOR) @iorbellinzona.bsky.social · May 23
#IORnews
Jonas Van Lent receives the Children's Tumor Foundation's Young Investigator Award. Congrats @jonasvanlent.bsky.social !

Read more: shorturl.at/ObLS5
May 23, 2025 at 9:57 PM
Reposted by Jonas Van lent
iorbellinzona.bsky.social
#IORnews
Jonas Van Lent receives the Children's Tumor Foundation's Young Investigator Award. Congrats @jonasvanlent.bsky.social !

Read more: shorturl.at/ObLS5
May 23, 2025 at 12:56 PM
Reposted by Jonas Van lent
dplamartin.bsky.social
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵

www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
www.science.org
April 4, 2025 at 6:42 PM
Reposted by Jonas Van lent
sergiuppasca.bsky.social
Check out this brief overview of human stem cell models and their promise in the @thetransmitter.org.web.brid.gy

#hipscells #stemcells #organoids #assembloids #braindisorders
thetransmitter.bsky.social The Transmitter @thetransmitter.bsky.social · Mar 31
Sophisticated 3D cultures reveal previously inaccessible stages of human brain development and enable the systematic study of disease genes, writes @sergiuppasca.bsky.social in the latest essay in our series “Frontiers in human neurotechnology.

www.thetransmitter.org/human-neurot...
Organoids and assembloids offer a new window into human brain
These sophisticated 3D cultures reveal previously inaccessible stages of human brain development and enable the systematic study of disease genes.
www.thetransmitter.org
March 31, 2025 at 1:46 PM
Reposted by Jonas Van lent
sergiuppasca.bsky.social
In this week’s @nature.com, we publish a group effort to outline a framework for studies with neural #organoids, #assembloids and transplantation. More details below 1/n
March 14, 2025 at 8:20 PM
jonasvanlent.bsky.social
Macrophages protect against sensory axon loss in peripheral neuropathy @Nature
www.nature.com/articles/s41...
Macrophages protect against sensory axon loss in peripheral neuropathy - Nature
A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.
www.nature.com
February 13, 2025 at 7:00 AM
Reposted by Jonas Van lent
jamessleigh.bsky.social
In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:

www.biorxiv.org/content/10.1...

Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.

@uclqsion.bsky.social #aging
February 2, 2025 at 8:47 AM
Reposted by Jonas Van lent
rituraman.bsky.social
So exciting to see our newest paper on muscle-nerve crosstalk featured in this @cellpress.bsky.social Device perspective - thanks to Claudia Loebel and team for highlighting our work! 💪🏽

www.cell.com/device/abstr...
An in vitro model for studying crosstalk between muscle cells and neurons
Muscle contraction and exercise are critical for peripheral nerve growth and innervation. Studying this interplay is challenging given the difficulty of decoupling mechanical from biochemical stimulat...
www.cell.com
January 22, 2025 at 2:03 PM
Reposted by Jonas Van lent
psalmotoxin.bsky.social
👏 to Tetsuo Hasegawa & others of Clatworthy lab
& beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch
www.nature.com/articles/s41...
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology
Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...
www.nature.com
November 26, 2024 at 1:19 PM