Jeff Freiberg
@jefffreiberg.bsky.social
ID physician scientist studying S. aureus and antibiotic treatment failure. Views my own.
Reposted by Jeff Freiberg
Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...
A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics - Nature Microbiology
The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.
www.nature.com
October 10, 2025 at 1:24 PM
Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...
I feel seen
It’s a cruel irony that the specialty attracting the most neurotic, detail-oriented clinicians also forces them to manually italicize every microorganism they mention in their notes.
#idsky
#idsky
May 17, 2025 at 2:09 PM
I feel seen
Can’t wait to see the discoveries that are going to come out of the Reyes Ruiz Lab! Such a great scientist and mentor!
1/3 It’s official 🙌🏽
The Reyes Ruiz Lab is opening in 2026 at the University of Wisconsin, Madison in the Department of Pathobiological Sciences. My lab will focus on host antibacterial effectors and adaptation of bacteria to host-imposed stress during S. aureus infections.
The Reyes Ruiz Lab is opening in 2026 at the University of Wisconsin, Madison in the Department of Pathobiological Sciences. My lab will focus on host antibacterial effectors and adaptation of bacteria to host-imposed stress during S. aureus infections.
May 14, 2025 at 12:41 PM
Can’t wait to see the discoveries that are going to come out of the Reyes Ruiz Lab! Such a great scientist and mentor!
Reposted by Jeff Freiberg
New review article on management of S. aureus bacteraemia: jamanetwork.com/journals/jam...
@jama.com @vancefowler.bsky.social #IDSky
Check out the gorgeous Figure which brings together elements of pathogenesis and management: (thread)
@jama.com @vancefowler.bsky.social #IDSky
Check out the gorgeous Figure which brings together elements of pathogenesis and management: (thread)
Staphylococcus aureus Bacteremia: A Review
This narrative review summarizes current evidence on the epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment of Staphylococcus aureus bacteremia.
jamanetwork.com
April 7, 2025 at 3:52 PM
New review article on management of S. aureus bacteraemia: jamanetwork.com/journals/jam...
@jama.com @vancefowler.bsky.social #IDSky
Check out the gorgeous Figure which brings together elements of pathogenesis and management: (thread)
@jama.com @vancefowler.bsky.social #IDSky
Check out the gorgeous Figure which brings together elements of pathogenesis and management: (thread)
Such a wonderful day celebrating all that has been accomplished by the Skaar lab over the last 20 years! I feel very lucky and proud to be a part of such an incredible group of scientists!
20 years of the Skaar lab!
April 6, 2025 at 12:20 PM
Such a wonderful day celebrating all that has been accomplished by the Skaar lab over the last 20 years! I feel very lucky and proud to be a part of such an incredible group of scientists!
Thanks @contagionlive.bsky.social for the opportunity to highlight some of the hot ID topics from 2024 that we covered in our recent review:
doi.org/10.1093/cid/...
Always great to be able to talk about all that is going on in ID!
doi.org/10.1093/cid/...
Always great to be able to talk about all that is going on in ID!
February 25, 2025 at 10:19 PM
Thanks @contagionlive.bsky.social for the opportunity to highlight some of the hot ID topics from 2024 that we covered in our recent review:
doi.org/10.1093/cid/...
Always great to be able to talk about all that is going on in ID!
doi.org/10.1093/cid/...
Always great to be able to talk about all that is going on in ID!
Reposted by Jeff Freiberg
Part 3 w/ Dr. @jefffreiberg.bsky.social takeaways:
-SABATO Trial shows oral antibiotics can replace IV for certain S aureus cases.
-Mupirocin still tops iodine for MRSA decolonization, but rising resistance is a concern.
#IDsky #MEDsky
Listen here: www.contagionlive.com/view/2024-s-...
-SABATO Trial shows oral antibiotics can replace IV for certain S aureus cases.
-Mupirocin still tops iodine for MRSA decolonization, but rising resistance is a concern.
#IDsky #MEDsky
Listen here: www.contagionlive.com/view/2024-s-...
2024 S aureus and MRSA Trials: Key Takeaways
Jeffrey Freiberg, MD, PhD review of the SABATO trial on oral antibiotics for S aureus bacteremia and a comparison of mupirocin and iodine treatments for MRSA decolonization.
www.contagionlive.com
February 25, 2025 at 2:23 PM
Part 3 w/ Dr. @jefffreiberg.bsky.social takeaways:
-SABATO Trial shows oral antibiotics can replace IV for certain S aureus cases.
-Mupirocin still tops iodine for MRSA decolonization, but rising resistance is a concern.
#IDsky #MEDsky
Listen here: www.contagionlive.com/view/2024-s-...
-SABATO Trial shows oral antibiotics can replace IV for certain S aureus cases.
-Mupirocin still tops iodine for MRSA decolonization, but rising resistance is a concern.
#IDsky #MEDsky
Listen here: www.contagionlive.com/view/2024-s-...
Reposted by Jeff Freiberg
Part 2 w/ Dr. @jefffreiberg.bsky.social, he discussed some findings from 2024 on the rise of AMR in #UTIs. From trials of cefepime-taniborbactam to the potential of gepotidacin, some of the challenges and future of #UTI treatment. #IDsky #MEDsky
Listen here: www.contagionlive.com/view/antibio...
Listen here: www.contagionlive.com/view/antibio...
Antibiotic Resistance in the Context of UTI Treatment Developments
Jeff Freiberg, MD, PhD review on key trials and challenges from 2024 in the fight against antibiotic resistance in complicated and uncomplictaed UTIs, including cefepime-taniborbactam and gepotidacin.
www.contagionlive.com
February 24, 2025 at 2:25 PM
Part 2 w/ Dr. @jefffreiberg.bsky.social, he discussed some findings from 2024 on the rise of AMR in #UTIs. From trials of cefepime-taniborbactam to the potential of gepotidacin, some of the challenges and future of #UTI treatment. #IDsky #MEDsky
Listen here: www.contagionlive.com/view/antibio...
Listen here: www.contagionlive.com/view/antibio...
Reposted by Jeff Freiberg
In Part 1 of our conversation with Dr. Jeffrey Freiberg from Vanderbilt University Medical Center, we dive into the rising concerns of emerging infections, including #dengue, #mpox, #measles, and #H5N1 influenza. #IDsky #MEDsky
Stay tuned for Part 2 next week: www.contagionlive.com/view/emergin...
Stay tuned for Part 2 next week: www.contagionlive.com/view/emergin...
Emerging Threats and Key Knowledge From 2024 Trending Into 2025
Jeff Freiberg, MD, PhD, on the rising emerging infection concerns of dengue, mpox, measles, and H5N1 influenza in clinical practice.
www.contagionlive.com
February 21, 2025 at 5:34 PM
Another year of incredible advances in ID! Our review hardly does justice to everything accomplished last year. Fortunate to have had the opportunity to write this review, but even more fortunate to be part of a field working so hard for the good of so many. ID is needed now as much as ever! #IDSky
2024 was a 🔥 year in ID
🆕💫 @cidjournal.bsky.social
What’s Hot This Year in ID Clinical Science
The review highlights some of the most important trials and clinical trends in infectious diseases over the past year #idsky
academic.oup.com/cid/advance-...
🆕💫 @cidjournal.bsky.social
What’s Hot This Year in ID Clinical Science
The review highlights some of the most important trials and clinical trends in infectious diseases over the past year #idsky
academic.oup.com/cid/advance-...
What’s Hot This Year in ID Clinical Science
This review covers important public health notices and clinical trials covering a broad range of infectious diseases topics from October 2023 to September
academic.oup.com
February 1, 2025 at 11:56 PM
Another year of incredible advances in ID! Our review hardly does justice to everything accomplished last year. Fortunate to have had the opportunity to write this review, but even more fortunate to be part of a field working so hard for the good of so many. ID is needed now as much as ever! #IDSky
The study protocol for STOP-Vanc, our RCT looking at the use of MRSA nares PCR testing in an ICU, is finally published!
We are hoping to be done with enrollment soon and excited to see what we learn from this study! #IDSky #MedSky
trialsjournal.biomedcentral.com/articles/10....
We are hoping to be done with enrollment soon and excited to see what we learn from this study! #IDSky #MedSky
trialsjournal.biomedcentral.com/articles/10....
Swab Testing to Optimize Pneumonia treatment with empiric Vancomycin (STOP-Vanc): study protocol for a randomized controlled trial - Trials
Background Vancomycin, an antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA), is frequently included in empiric treatment for community-acquired pneumonia (CAP) despit...
trialsjournal.biomedcentral.com
December 29, 2024 at 4:02 PM
The study protocol for STOP-Vanc, our RCT looking at the use of MRSA nares PCR testing in an ICU, is finally published!
We are hoping to be done with enrollment soon and excited to see what we learn from this study! #IDSky #MedSky
trialsjournal.biomedcentral.com/articles/10....
We are hoping to be done with enrollment soon and excited to see what we learn from this study! #IDSky #MedSky
trialsjournal.biomedcentral.com/articles/10....
Very interesting analysis of the opportunity cost of doing an MD-PhD.
At the end of the day the choice should be about the type of career you want to have. I have not regretted my choice to get an MD-PhD one bit because it has set me on the perfect path for what I want my career to be!
At the end of the day the choice should be about the type of career you want to have. I have not regretted my choice to get an MD-PhD one bit because it has set me on the perfect path for what I want my career to be!
Eva Catenaccio, et al. demonstrate prolonged physician-scientist training postpones full salary earnings compared with MD physicians & MD-PhD physicians have a lower lifetime earning potential than MD physicians in their same specialties... https://insight.jci.org/articles/view/183476
December 26, 2024 at 9:50 AM
Very interesting analysis of the opportunity cost of doing an MD-PhD.
At the end of the day the choice should be about the type of career you want to have. I have not regretted my choice to get an MD-PhD one bit because it has set me on the perfect path for what I want my career to be!
At the end of the day the choice should be about the type of career you want to have. I have not regretted my choice to get an MD-PhD one bit because it has set me on the perfect path for what I want my career to be!
Reposted by Jeff Freiberg
Bactericidal antibiotics release bacterial DNA that activates TLR9, while static antibiotics do not. This can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics to prescribe?
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk
Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA
Nature Communications - The immunologic differences induced by bactericidal versus bacteriostatic antibiotics remain unclear. Gross et al. show that, in contrast to static antibiotics, cidal...
rdcu.be
December 2, 2024 at 2:17 PM
Bactericidal antibiotics release bacterial DNA that activates TLR9, while static antibiotics do not. This can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics to prescribe?
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk
Staph papers @staph-papers.bsky.social is now on Bluesky!
November 14, 2024 at 12:35 PM
Staph papers @staph-papers.bsky.social is now on Bluesky!