Jaime de Juan-Sanz
@jdejuan-sanz.bsky.social
Neuroscientist at the Paris Brain Institute / www.dejuansanzlab.org / ERC / FENS-Kavli Scholar / Young Academy of Spain / CNRS
Reposted by Jaime de Juan-Sanz
Call for junior or mid-career group leaders in neuroscience! Apply by 30 Jan to join the FENS-Kavli Network. We are looking for excellent and engaged future scholars who are committed to exchanging scientific ideas & improve neuroscience in Europe. fenskavlinetwork.org/who-we-are/a...
November 17, 2025 at 11:21 AM
Call for junior or mid-career group leaders in neuroscience! Apply by 30 Jan to join the FENS-Kavli Network. We are looking for excellent and engaged future scholars who are committed to exchanging scientific ideas & improve neuroscience in Europe. fenskavlinetwork.org/who-we-are/a...
Reposted by Jaime de Juan-Sanz
⚠️ Half of commercial antibodies miss their target!
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
OGA - Only Good Antibodies Community
onlygoodantibodies.co.uk
September 29, 2025 at 6:34 PM
⚠️ Half of commercial antibodies miss their target!
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
Reposted by Jaime de Juan-Sanz
What do we know about the causes of #autism? @kingscollegelondon.bsky.social Professor Laura Andreae speaks with BBC Radio 4's Inside Science about the genetic factors behind autism, particularly around twin studies.
🔊 Listen now: www.bbc.co.uk/sounds/play/...
🔊 Listen now: www.bbc.co.uk/sounds/play/...
BBC Inside Science - The science behind autism - BBC Sounds
What do we know about the causes of autism?
www.bbc.co.uk
September 26, 2025 at 10:49 AM
What do we know about the causes of #autism? @kingscollegelondon.bsky.social Professor Laura Andreae speaks with BBC Radio 4's Inside Science about the genetic factors behind autism, particularly around twin studies.
🔊 Listen now: www.bbc.co.uk/sounds/play/...
🔊 Listen now: www.bbc.co.uk/sounds/play/...
Reposted by Jaime de Juan-Sanz
Latest from the lab, the beautiful work of Iryna Mohylyak and colleagues describing a temporal developmental transcriptional program for mitochondrial quality control and synaptic connectivity, with @jdejuan-sanz.bsky.social, Olga Corti and @steinaerts.bsky.social
labs
www.nature.com/articles/s41...
labs
www.nature.com/articles/s41...
Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity - Nature Communications
This study investigates the developmental transcriptional regulation of mitochondrial quality control. Authors identify the Drosophila factor Mirana, homologous to mammalian TZAP, as a key temporal re...
www.nature.com
September 1, 2025 at 8:50 PM
Latest from the lab, the beautiful work of Iryna Mohylyak and colleagues describing a temporal developmental transcriptional program for mitochondrial quality control and synaptic connectivity, with @jdejuan-sanz.bsky.social, Olga Corti and @steinaerts.bsky.social
labs
www.nature.com/articles/s41...
labs
www.nature.com/articles/s41...
Reposted by Jaime de Juan-Sanz
Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience
The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...
www.nature.com
August 22, 2025 at 10:15 PM
Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Reposted by Jaime de Juan-Sanz
ER_2025 #endoplasmicreticulum #ER #conference Paris October 8-10 2025 Register! itbcrde.inserm.fr/index.php?page…
July 24, 2025 at 11:40 AM
ER_2025 #endoplasmicreticulum #ER #conference Paris October 8-10 2025 Register! itbcrde.inserm.fr/index.php?page…
Another example! 🚲🚲🚲
July 10, 2025 at 6:57 AM
Another example! 🚲🚲🚲
Always faster to 🚲 in Paris!
July 2, 2025 at 12:09 PM
Always faster to 🚲 in Paris!
Reposted by Jaime de Juan-Sanz
Nicer pics from the @academiesciences.bsky.social ceremony - a great occasion to celebrate our recent work together with @stefvass.bsky.social @florianwerner.bsky.social and @moparthisk.bsky.social!
Photos © Académie des sciences – Mathieu Baumer.
Photos © Académie des sciences – Mathieu Baumer.
July 1, 2025 at 11:02 AM
Nicer pics from the @academiesciences.bsky.social ceremony - a great occasion to celebrate our recent work together with @stefvass.bsky.social @florianwerner.bsky.social and @moparthisk.bsky.social!
Photos © Académie des sciences – Mathieu Baumer.
Photos © Académie des sciences – Mathieu Baumer.
Had a blast in the SynAnb/generate symposium in Tutzing! Lots to learn about the relationship between the immune system and the brain (and how things can go south). Thanks for the invite!
June 24, 2025 at 7:13 PM
Had a blast in the SynAnb/generate symposium in Tutzing! Lots to learn about the relationship between the immune system and the brain (and how things can go south). Thanks for the invite!
20 days waiting for an editorial decision on whether our paper will be sent for review at @elife.bsky.social — did others have a similar experience? I wonder if these long timelines will make it somewhat hard to support the new model
June 17, 2025 at 9:08 AM
20 days waiting for an editorial decision on whether our paper will be sent for review at @elife.bsky.social — did others have a similar experience? I wonder if these long timelines will make it somewhat hard to support the new model
Real fun hosting @chaichinta.bsky.social to discuss how to merge theory and experiments in ATP diffusion in axons. Thanks to @kavlifoundation.org for funding these exchanges!
June 11, 2025 at 10:16 AM
Real fun hosting @chaichinta.bsky.social to discuss how to merge theory and experiments in ATP diffusion in axons. Thanks to @kavlifoundation.org for funding these exchanges!
Reposted by Jaime de Juan-Sanz
"Tanner, a chemist at the Univ. of Mississippi working to develop a novel approach for treating glioblastoma, was notified in April that the grant was terminated.
“I would like to cure brain cancer,” Dr. Tanner said. “I think that's not particularly controversial.”
www.nytimes.com/interactive/...
“I would like to cure brain cancer,” Dr. Tanner said. “I think that's not particularly controversial.”
www.nytimes.com/interactive/...
The Gutting of America’s Medical Research: Here Is Every Canceled or Delayed N.I.H. Grant
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
www.nytimes.com
June 8, 2025 at 6:12 PM
"Tanner, a chemist at the Univ. of Mississippi working to develop a novel approach for treating glioblastoma, was notified in April that the grant was terminated.
“I would like to cure brain cancer,” Dr. Tanner said. “I think that's not particularly controversial.”
www.nytimes.com/interactive/...
“I would like to cure brain cancer,” Dr. Tanner said. “I think that's not particularly controversial.”
www.nytimes.com/interactive/...
Reposted by Jaime de Juan-Sanz
A really important skill for trainees to learn is to be a “closer” of a project-that is to take it over the finish line for publication. This means doing the experiments, getting the figures/text ready for submission and being prepared to do review corrections 😀
September 8, 2023 at 9:59 PM
A really important skill for trainees to learn is to be a “closer” of a project-that is to take it over the finish line for publication. This means doing the experiments, getting the figures/text ready for submission and being prepared to do review corrections 😀
Reposted by Jaime de Juan-Sanz
This is a summary of our recent @jcellsci.bsky.social paper.
If you've ever wondered why ATG9A has many and varied roles, we think it's because it is trafficked by a subset of a large, diverse family of vesicles - intracellular nanovesicles.
doi.org/10.1242/jcs....
If you've ever wondered why ATG9A has many and varied roles, we think it's because it is trafficked by a subset of a large, diverse family of vesicles - intracellular nanovesicles.
doi.org/10.1242/jcs....
ATG9A vesicles are a subtype of intracellular nanovesicle
Highlighted Article: Presentation of the first intracellular nanovesicle (INV) proteome, showing that a subset of INVs are ATG9A vesicles. This places ATG9A vesicles in a broader superfamily of traffi...
doi.org
June 5, 2025 at 7:41 AM
This is a summary of our recent @jcellsci.bsky.social paper.
If you've ever wondered why ATG9A has many and varied roles, we think it's because it is trafficked by a subset of a large, diverse family of vesicles - intracellular nanovesicles.
doi.org/10.1242/jcs....
If you've ever wondered why ATG9A has many and varied roles, we think it's because it is trafficked by a subset of a large, diverse family of vesicles - intracellular nanovesicles.
doi.org/10.1242/jcs....
Reposted by Jaime de Juan-Sanz
Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...
In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors
Dopamine (DA) plays a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex netwo...
www.science.org
June 6, 2025 at 5:20 AM
Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...
Reposted by Jaime de Juan-Sanz
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
June 3, 2025 at 9:17 PM
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
Reposted by Jaime de Juan-Sanz
We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...
Memory by a thousand rules: Automated discovery of functional multi-type plasticity rules reveals variety & degeneracy at the heart of learning
Synaptic plasticity is the basis of learning and memory, but the link between synaptic changes and neural function remains elusive. Here, we used automated search algorithms to obtain thousands of str...
www.biorxiv.org
June 2, 2025 at 6:50 PM
We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...
Great visit today of @hoppam.bsky.social at the Paris Brain Institute. We learned a lot about K+ channels and the unexpected stuff they do at the presynapse!
June 2, 2025 at 3:16 PM
Great visit today of @hoppam.bsky.social at the Paris Brain Institute. We learned a lot about K+ channels and the unexpected stuff they do at the presynapse!
Congrats to PSG and all parisians on the big win tonight! Celebrations on the streets of the 11eme district starting! Great to watch with @hoppam.bsky.social
May 31, 2025 at 9:15 PM
Congrats to PSG and all parisians on the big win tonight! Celebrations on the streets of the 11eme district starting! Great to watch with @hoppam.bsky.social
Reposted by Jaime de Juan-Sanz
There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd.
It's not just budgets but research, institutions, expertise, and training the next generation.
It's not just budgets but research, institutions, expertise, and training the next generation.
May 31, 2025 at 4:43 AM
There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd.
It's not just budgets but research, institutions, expertise, and training the next generation.
It's not just budgets but research, institutions, expertise, and training the next generation.
Reposted by Jaime de Juan-Sanz
A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious 🐁🍄
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
A multi-institutional investigation of psilocybin's effects on mouse behavior
Studies reporting novel therapeutic effects of psychedelic drugs are rapidly emerging. However, the reproducibility and reliability of these findings could remain uncertain for years. Here, we impleme...
www.biorxiv.org
April 9, 2025 at 7:11 PM
A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious 🐁🍄
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
Reposted by Jaime de Juan-Sanz
Friends! Late to the party but finally made the change to bsky! Happy to reconnect with everyone - and just in case this is us! www.dejuansanzlab.org
May 21, 2025 at 8:33 PM
Friends! Late to the party but finally made the change to bsky! Happy to reconnect with everyone - and just in case this is us! www.dejuansanzlab.org
Friends! Late to the party but finally made the change to bsky! Happy to reconnect with everyone - and just in case this is us! www.dejuansanzlab.org
May 21, 2025 at 8:33 PM
Friends! Late to the party but finally made the change to bsky! Happy to reconnect with everyone - and just in case this is us! www.dejuansanzlab.org