Juan C. Landoni 🔬
@jclandoni.bsky.social
Mitochondriac 🔬 Postdoc @EPFL Manley lab of Experimental Biophysics 🧪 Ph.D. @HelsinkiUni 🇦🇷🇫🇮🇪🇺🇨🇭🏳️🌈 (he/él)
linktr.ee/jclandoni
linktr.ee/jclandoni
Pinned
Juan C. Landoni 🔬
@jclandoni.bsky.social
· Dec 23
Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
Smartest booth luring strategy I've seen: a pro barista on site 🤯
Drop the free pens. Science runs on espresso ☕️
Drop the free pens. Science runs on espresso ☕️
November 6, 2025 at 12:24 PM
Smartest booth luring strategy I've seen: a pro barista on site 🤯
Drop the free pens. Science runs on espresso ☕️
Drop the free pens. Science runs on espresso ☕️
That's a wrap on a much-needed family vacay, thank you Costa Rica for your incredible nature 🌋🦥🏞️🐠🐡🐒🦈, now back to our regularly scheduled programming 🔬
October 27, 2025 at 3:31 PM
That's a wrap on a much-needed family vacay, thank you Costa Rica for your incredible nature 🌋🦥🏞️🐠🐡🐒🦈, now back to our regularly scheduled programming 🔬
Reposted by Juan C. Landoni 🔬
#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added!
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
November 12, 2024 at 6:35 PM
#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added!
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
Reposted by Juan C. Landoni 🔬
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
October 14, 2025 at 11:50 AM
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
Reposted by Juan C. Landoni 🔬
What complex are you if you have a very versatile company in close proximity? The MICOS Complex.
We present the MINDNet: Proximity Proteomics revealing the nanodomain interactome in the mitochondrial inner membrane, done by the talented Yulia and team.
We present the MINDNet: Proximity Proteomics revealing the nanodomain interactome in the mitochondrial inner membrane, done by the talented Yulia and team.
MINDNet: Proximity interactome of the MICOS complex revealing a multifaceted network orchestrating mitochondrial biogenesis https://www.biorxiv.org/content/10.1101/2025.05.20.655052v1
May 21, 2025 at 6:29 PM
What complex are you if you have a very versatile company in close proximity? The MICOS Complex.
We present the MINDNet: Proximity Proteomics revealing the nanodomain interactome in the mitochondrial inner membrane, done by the talented Yulia and team.
We present the MINDNet: Proximity Proteomics revealing the nanodomain interactome in the mitochondrial inner membrane, done by the talented Yulia and team.
Still buzzing from the incomparable @embl.org #SeeingisBelieving conference! 🔬
Great science and truly amazing people, thanks everyone!
#EESImaging
Great science and truly amazing people, thanks everyone!
#EESImaging
October 14, 2025 at 7:32 PM
Still buzzing from the incomparable @embl.org #SeeingisBelieving conference! 🔬
Great science and truly amazing people, thanks everyone!
#EESImaging
Great science and truly amazing people, thanks everyone!
#EESImaging
📣 Do you want to be part of #EESImaging, the exciting symposium that brings together leading innovators in imaging technologies and biological applications?
Then hurry up and submit your abstract! The deadline is tomorrow ⏰ https://s.embl.org/ees25-09-bl
Then hurry up and submit your abstract! The deadline is tomorrow ⏰ https://s.embl.org/ees25-09-bl
October 4, 2025 at 10:01 AM
Reposted by Juan C. Landoni 🔬
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Juan C. Landoni 🔬
From MBoC: Wallace F. Marshall (UCSF) and team profile the giant ciliate Stentor pyriformis—symbiotic algae in microtubule baskets, symbiont-dependent phototaxis, and a standard genetic code. Paper: www.molbiolcell.org/doi/10.1091/... #CellBiology
September 19, 2025 at 12:02 PM
From MBoC: Wallace F. Marshall (UCSF) and team profile the giant ciliate Stentor pyriformis—symbiotic algae in microtubule baskets, symbiont-dependent phototaxis, and a standard genetic code. Paper: www.molbiolcell.org/doi/10.1091/... #CellBiology
"Who needs a 30x zoom anyway?"
I just found out the answer 🌙🤩
I just found out the answer 🌙🤩
September 7, 2025 at 7:15 PM
"Who needs a 30x zoom anyway?"
I just found out the answer 🌙🤩
I just found out the answer 🌙🤩
August 26, 2025 at 3:04 PM
Trying my hand at HTML/CSS using @github.com hosting for a new personal website 💻 Highly recommend!
jclandoni.github.io
Comments/tips welcome (should look nicer on desktop but mobile should work too).
jclandoni.github.io
Comments/tips welcome (should look nicer on desktop but mobile should work too).
August 25, 2025 at 11:52 AM
Trying my hand at HTML/CSS using @github.com hosting for a new personal website 💻 Highly recommend!
jclandoni.github.io
Comments/tips welcome (should look nicer on desktop but mobile should work too).
jclandoni.github.io
Comments/tips welcome (should look nicer on desktop but mobile should work too).
August 22, 2025 at 10:57 AM
So excited to follow the opening symposium of #SWAN 🦢[Sustainable Wellbeing Across Lifespan] at @helsinki.fi today! Congrats to @awartiovaara.bsky.social and all members for the exciting ongoing and future reseach!
#mitochondria #metabolism #aging #health
#mitochondria #metabolism #aging #health
August 20, 2025 at 12:43 PM
So excited to follow the opening symposium of #SWAN 🦢[Sustainable Wellbeing Across Lifespan] at @helsinki.fi today! Congrats to @awartiovaara.bsky.social and all members for the exciting ongoing and future reseach!
#mitochondria #metabolism #aging #health
#mitochondria #metabolism #aging #health
August 19, 2025 at 2:42 PM
Reposted by Juan C. Landoni 🔬
🐟 Zebrafish (Danio rerio): Clear as glass, zebrafish embryos let you watch organs form in real time. A powerhouse for studying organogenesis and regeneration, they’re also champions of transgenic expression of fluorescent proteins 🌈 image from Gopi Shah 🧪 #ModelMonday #DevBio
August 18, 2025 at 5:07 PM
🐟 Zebrafish (Danio rerio): Clear as glass, zebrafish embryos let you watch organs form in real time. A powerhouse for studying organogenesis and regeneration, they’re also champions of transgenic expression of fluorescent proteins 🌈 image from Gopi Shah 🧪 #ModelMonday #DevBio
In case you haven't heard, #Argentinian scientists are live-streaming their deep-sea mission with real-time interactive commentary.
It's genius, mesmerising, and triggering huge public interest and support for #science funding 🐙🧪 And the memes are great! #CONICET #MarDelPlataCanyon
It's genius, mesmerising, and triggering huge public interest and support for #science funding 🐙🧪 And the memes are great! #CONICET #MarDelPlataCanyon
August 6, 2025 at 8:32 AM
In case you haven't heard, #Argentinian scientists are live-streaming their deep-sea mission with real-time interactive commentary.
It's genius, mesmerising, and triggering huge public interest and support for #science funding 🐙🧪 And the memes are great! #CONICET #MarDelPlataCanyon
It's genius, mesmerising, and triggering huge public interest and support for #science funding 🐙🧪 And the memes are great! #CONICET #MarDelPlataCanyon
Reposted by Juan C. Landoni 🔬
Here it is❗️Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports by Cell Press! 🎉
Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫
www.cell.com/cell-reports...
Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫
www.cell.com/cell-reports...
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation
and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial
contribution to...
www.cell.com
July 28, 2025 at 7:17 AM
Here it is❗️Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports by Cell Press! 🎉
Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫
www.cell.com/cell-reports...
Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫
www.cell.com/cell-reports...
Reposted by Juan C. Landoni 🔬
Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉
🧫 New galactose #CRISPR screen
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂 Mito defects in #Menieres
www.cell.com/cell-reports...
🧫 New galactose #CRISPR screen
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂 Mito defects in #Menieres
www.cell.com/cell-reports...
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation
and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial
contribution to...
www.cell.com
July 28, 2025 at 5:40 AM
Reposted by Juan C. Landoni 🔬
Congrats to PhD student @marcellharhai.bsky.social , who joined the lab 2y ago (!) and led this work, to second author M. Foged, and to all our collaborators!
We are thankful to our funding sources including the @FSRMM, Novartis and @snsf.ch.
@dib-unil.bsky.social @fbm-unil.bsky.social
We are thankful to our funding sources including the @FSRMM, Novartis and @snsf.ch.
@dib-unil.bsky.social @fbm-unil.bsky.social
July 28, 2025 at 5:40 AM
Congrats to PhD student @marcellharhai.bsky.social , who joined the lab 2y ago (!) and led this work, to second author M. Foged, and to all our collaborators!
We are thankful to our funding sources including the @FSRMM, Novartis and @snsf.ch.
@dib-unil.bsky.social @fbm-unil.bsky.social
We are thankful to our funding sources including the @FSRMM, Novartis and @snsf.ch.
@dib-unil.bsky.social @fbm-unil.bsky.social
Reposted by Juan C. Landoni 🔬
Join us in Engelberg for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys. Great speaker line up and opportunities for short talks from early career scientists!
Submit your abstract until May 30st!
meetings.embo.org/event/25-mit...
Submit your abstract until May 30st!
meetings.embo.org/event/25-mit...
April 14, 2025 at 8:48 AM
Join us in Engelberg for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys. Great speaker line up and opportunities for short talks from early career scientists!
Submit your abstract until May 30st!
meetings.embo.org/event/25-mit...
Submit your abstract until May 30st!
meetings.embo.org/event/25-mit...
Is there still a reason for dumping figures at the end of manuscripts instead of in-text, even for #BioRxiv preprints? My scroll-finger is exhausted... 🙏🧪📜
May 1, 2025 at 7:59 AM
Is there still a reason for dumping figures at the end of manuscripts instead of in-text, even for #BioRxiv preprints? My scroll-finger is exhausted... 🙏🧪📜
Reposted by Juan C. Landoni 🔬
🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪
www.annualreviews.org/content/jour...
#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
www.annualreviews.org/content/jour...
#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
November 17, 2024 at 4:46 PM
🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪
www.annualreviews.org/content/jour...
#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
www.annualreviews.org/content/jour...
#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
Want to capture elusive events without stressing out your cells? Check out @wl-stepp.bsky.social hybrid-EDA! A smart microscopy approach to detect events in phase, and only image when it matters! 🔬🧫🧪
www.biorxiv.org/content/10.1...
@sulianamanley.bsky.social @maweigert.bsky.social
www.biorxiv.org/content/10.1...
@sulianamanley.bsky.social @maweigert.bsky.social
Smart hybrid microscopy for cell-friendly detection of rare events
Fluorescence microscopy offers unparalleled access to the spatial organization and dynamics of biological events in living samples, yet capturing rare processes over extended durations remains challen...
www.biorxiv.org
April 7, 2025 at 7:18 AM
Want to capture elusive events without stressing out your cells? Check out @wl-stepp.bsky.social hybrid-EDA! A smart microscopy approach to detect events in phase, and only image when it matters! 🔬🧫🧪
www.biorxiv.org/content/10.1...
@sulianamanley.bsky.social @maweigert.bsky.social
www.biorxiv.org/content/10.1...
@sulianamanley.bsky.social @maweigert.bsky.social