The amazing @jmacuada.bsky.social found that cristae architecture plays a dual role: cristae density regulates pearling frequency/reversibility and maintains nucleoid spacing🧩 Without either, nucleoids form long clusters—or “nucleotes”!

Lo and behold, #pearling “forces” nucleoids into specific spots, and they typically stay there after #mito recovery. It even splits large nucleoid clusters, mediating their segregation! 🎥 by STED wizard @lycasworks.bsky.social 🔬 biorxiv.org/content/10.1...

Solution? Mitochondrial #pearling!📿Long mitos can spontaneously, frequently, and reversibly form “beads-on-a-string” structures, seen across evolution (Check your movies—you’ll spot it! And the regular wavelength of pearling is suspiciously similar to nucleoid positioning 👀