Reposted
This has now been published in print! Check it out:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase
Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...
www.science.org
November 28, 2025 at 10:53 AM
This has now been published in print! Check it out:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
The Brixen Summer School is back and is, as usual, building up a strong speaker list. Thank you @eupaproteomics.bsky.social @thermofishersci.bsky.social @biognosys.bsky.social @ionopticks.bsky.social @evosep.bsky.social for support!
November 21, 2025 at 9:54 AM
The Brixen Summer School is back and is, as usual, building up a strong speaker list. Thank you @eupaproteomics.bsky.social @thermofishersci.bsky.social @biognosys.bsky.social @ionopticks.bsky.social @evosep.bsky.social for support!
Reposted
My lab at the University of Birmingham have a fully funded 4 year PhD position available, focusing on the molecular mechanisms of the Alternative Lengthening of Telomeres (ALT).
Informal enquiries to r.a.broderick@bham.ac.uk
APPLICATION LINK:
sits.bham.ac.uk/urd/sits.urd...
Informal enquiries to r.a.broderick@bham.ac.uk
APPLICATION LINK:
sits.bham.ac.uk/urd/sits.urd...
IPP login screen
sits.bham.ac.uk
November 19, 2025 at 5:14 PM
My lab at the University of Birmingham have a fully funded 4 year PhD position available, focusing on the molecular mechanisms of the Alternative Lengthening of Telomeres (ALT).
Informal enquiries to r.a.broderick@bham.ac.uk
APPLICATION LINK:
sits.bham.ac.uk/urd/sits.urd...
Informal enquiries to r.a.broderick@bham.ac.uk
APPLICATION LINK:
sits.bham.ac.uk/urd/sits.urd...
Reposted
Hey @asms.org peeps. I’m running for VP for programs and I’d like your vote. Check out the asms web site for details and you will see an email with voting instructions in the near future. I approach this position with lots of experience organizing scientific conferences & I ❤️ asms. Please re-sky.
a spongebob squarepants scene with a mailbox and a flower
ALT: a spongebob squarepants scene with a mailbox and a flower
media.tenor.com
October 28, 2025 at 4:39 PM
Hey @asms.org peeps. I’m running for VP for programs and I’d like your vote. Check out the asms web site for details and you will see an email with voting instructions in the near future. I approach this position with lots of experience organizing scientific conferences & I ❤️ asms. Please re-sky.
Reposted
Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs
www.cell.com/cell-reports...
www.cell.com/cell-reports...
September 16, 2025 at 3:30 PM
Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted
Translon: a single term for translated regions. #Translation @natmethods.nature.com
September 4, 2025 at 9:15 AM
Translon: a single term for translated regions. #Translation @natmethods.nature.com
Reposted
Day 3 of the #GRC on #microproteins #darkproteome with a lively discussion on mega big data analyses for human #ncORFs #sORFs! What a great group!!
August 19, 2025 at 1:19 PM
Day 3 of the #GRC on #microproteins #darkproteome with a lively discussion on mega big data analyses for human #ncORFs #sORFs! What a great group!!
Reposted
Celebrating Al Burlingame's 41 years of the @asbmb.bsky.social Molecular and Cellular Proteomics meeting which he started before "proteomics" was a term. Congrats Al!
August 20, 2025 at 9:29 PM
Celebrating Al Burlingame's 41 years of the @asbmb.bsky.social Molecular and Cellular Proteomics meeting which he started before "proteomics" was a term. Congrats Al!
Reposted
Loving day 2 of the #GRC for microproteins with @rna-julie.bsky.social! Great talks this mornjng and now I can’t wait until the next one in 2027!
August 18, 2025 at 11:47 AM
Loving day 2 of the #GRC for microproteins with @rna-julie.bsky.social! Great talks this mornjng and now I can’t wait until the next one in 2027!
Reposted
An expanded reference catalog of translated open reading frames for biomedical research www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
July 7, 2025 at 4:40 PM
An expanded reference catalog of translated open reading frames for biomedical research www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
Reposted
🚨 Has PRIDE helped your research?
Take 15 mins to tell funders why open data matters!
📊 Fill out the EMBL-EBI 2025 survey 👉
www.surveymonkey.com/r/QGFMBH8?ch...
Your feedback helps keep PRIDE open, FAIR & impactful.
🙏 Please share!
#FAIR #OpenData #Proteomics #MassSpectrometry #PRIDE
Take 15 mins to tell funders why open data matters!
📊 Fill out the EMBL-EBI 2025 survey 👉
www.surveymonkey.com/r/QGFMBH8?ch...
Your feedback helps keep PRIDE open, FAIR & impactful.
🙏 Please share!
#FAIR #OpenData #Proteomics #MassSpectrometry #PRIDE
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
June 18, 2025 at 6:02 AM
🚨 Has PRIDE helped your research?
Take 15 mins to tell funders why open data matters!
📊 Fill out the EMBL-EBI 2025 survey 👉
www.surveymonkey.com/r/QGFMBH8?ch...
Your feedback helps keep PRIDE open, FAIR & impactful.
🙏 Please share!
#FAIR #OpenData #Proteomics #MassSpectrometry #PRIDE
Take 15 mins to tell funders why open data matters!
📊 Fill out the EMBL-EBI 2025 survey 👉
www.surveymonkey.com/r/QGFMBH8?ch...
Your feedback helps keep PRIDE open, FAIR & impactful.
🙏 Please share!
#FAIR #OpenData #Proteomics #MassSpectrometry #PRIDE
Reposted
I am really pleased we managed to squeeze this story out during #ASMS2025. This is our contribution relating to the fantastic Omnitrap/Orbitrap. What we thought would be a straightforward conversation of our exploris-omnitrap turned into quite a journey. (1/n)
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Integrating Alternative Fragmentation Techniques into Standard LC-MS Workflows Using a Single Deep Learning Model Enhances Proteome Coverage
We built and characterised a mass spectrometer capable of performing CID (both beam type and resonant type), UVPD, EID and ECD in an automated fashion during an LCMS type experiment. We exploited this...
www.biorxiv.org
June 1, 2025 at 5:17 PM
I am really pleased we managed to squeeze this story out during #ASMS2025. This is our contribution relating to the fantastic Omnitrap/Orbitrap. What we thought would be a straightforward conversation of our exploris-omnitrap turned into quite a journey. (1/n)
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted
Here's an LC story from our lab. Unlike a lot of stories with titles phrased as questions, it's a maybe/ yes! Interesting for those high throughput proteome people!
Are Solid Particles Ready for Prime-Time Proteomics? https://www.biorxiv.org/content/10.1101/2025.05.22.655475v1
May 27, 2025 at 3:10 PM
Here's an LC story from our lab. Unlike a lot of stories with titles phrased as questions, it's a maybe/ yes! Interesting for those high throughput proteome people!
Reposted
New preprint from the lab on ARID1A, G quadruplexes, and repair:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. It is challenging to predict how ARID1A loss impacts cancer therapy response because it participates ...
www.biorxiv.org
May 27, 2025 at 5:32 PM
New preprint from the lab on ARID1A, G quadruplexes, and repair:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Calling data scientists: we have opening in our Data Science core @icr.ac.uk to lead work around cancer spatial biology and single cell analysis. These are staff scientist type positions, ideal for someone who wants to help drive computational research. Apply here: jobs.icr.ac.uk/vacancies/12...
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton.
Salary : Salary range £39,805 to £49,023 (depending on the experience)
Reporting to: Professor Trevor Graham
...
jobs.icr.ac.uk
May 22, 2025 at 10:25 AM
Calling data scientists: we have opening in our Data Science core @icr.ac.uk to lead work around cancer spatial biology and single cell analysis. These are staff scientist type positions, ideal for someone who wants to help drive computational research. Apply here: jobs.icr.ac.uk/vacancies/12...
Reposted
Now is the time to reserve your spot for the 2025 Gordon Research Conference on #microproteins. Come join us in beautiful Barcelona in August!
www.grc.org/decoding-mic...
www.grc.org/decoding-mic...
2025 Decoding Microproteins Across Evolution and Disease Conference GRC
The 2025 Gordon Research Conference on Decoding Microproteins Across Evolution and Disease will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
www.grc.org
April 8, 2025 at 5:40 PM
Now is the time to reserve your spot for the 2025 Gordon Research Conference on #microproteins. Come join us in beautiful Barcelona in August!
www.grc.org/decoding-mic...
www.grc.org/decoding-mic...
Reposted
Reposted
Had a pretty profound and revitalizing moment in life today. Stood up for science with my father (and lots of other scientists, and non-scientists too). Like my father’s father before us, we Maniatii don’t sit around when fascism is on the move.
March 8, 2025 at 12:34 AM
Had a pretty profound and revitalizing moment in life today. Stood up for science with my father (and lots of other scientists, and non-scientists too). Like my father’s father before us, we Maniatii don’t sit around when fascism is on the move.
Reposted
Please share. 🙏🏻
March 2, 2025 at 10:06 AM
Please share. 🙏🏻
Reposted
Looking forward to welcoming the proteomics community to Liverpool this July!
We are delighted to tell you that the registration for BSPR2025 is now live.
We have great science, lots of exciting proteomics and amazing speakers lined up, so make sure not to miss out!
Plenary speakers:
@slavov-n.bsky.social @epetsalaki.bsky.social @vadim-demichev.bsky.social
We have great science, lots of exciting proteomics and amazing speakers lined up, so make sure not to miss out!
Plenary speakers:
@slavov-n.bsky.social @epetsalaki.bsky.social @vadim-demichev.bsky.social
British Society for Proteome Research Annual Scientific Conference 2025 | University of Liverpool
We are delighted to invite you to attend the BSPR Annual Scientific Meeting in the historic and exciting city of Liverpool on 7-9th July 2025. We
payments.liv.ac.uk
February 28, 2025 at 9:46 PM
Looking forward to welcoming the proteomics community to Liverpool this July!
Reposted
Check out our paper here to find out more about PBRM1’s role in protecting centromere integrity: www.nature.com/articles/s41... I’ve loved working with @kezlane.bsky.social, @thedownslab.bsky.social, @lillianwu.bsky.social and everyone else involved on this project over the last several years!
PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications
Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...
www.nature.com
February 28, 2025 at 10:31 PM
Check out our paper here to find out more about PBRM1’s role in protecting centromere integrity: www.nature.com/articles/s41... I’ve loved working with @kezlane.bsky.social, @thedownslab.bsky.social, @lillianwu.bsky.social and everyone else involved on this project over the last several years!
Reposted
Sometimes the #microprotein field needs to police itself.
I rarely see the point in sharing disapproval for published papers. Let bygones be bygones, I suppose.
Several days ago, however, a new paper came out. My assessment is that it is bogus.
#genomics
🧬 💻
1/
www.nature.com/articles/s41...
I rarely see the point in sharing disapproval for published papers. Let bygones be bygones, I suppose.
Several days ago, however, a new paper came out. My assessment is that it is bogus.
#genomics
🧬 💻
1/
www.nature.com/articles/s41...
Comprehensive discovery and functional characterization of the noncanonical proteome - Cell Research
Cell Research - Comprehensive discovery and functional characterization of the noncanonical proteome
www.nature.com
January 16, 2025 at 12:32 PM
Sometimes the #microprotein field needs to police itself.
I rarely see the point in sharing disapproval for published papers. Let bygones be bygones, I suppose.
Several days ago, however, a new paper came out. My assessment is that it is bogus.
#genomics
🧬 💻
1/
www.nature.com/articles/s41...
I rarely see the point in sharing disapproval for published papers. Let bygones be bygones, I suppose.
Several days ago, however, a new paper came out. My assessment is that it is bogus.
#genomics
🧬 💻
1/
www.nature.com/articles/s41...
Reposted
The board of USHUPO has set up a GoFundMe site to support USHUPO members in the LA area. In particular these kinds of tragedies can impact graduate students and postdoctoral fellows hard. Here's the link. gofund.me/d73ac63a
Donate to Support LA Proteomics Families, organized by USHUPO org
USHUPO is raising funds for our LA Proteomics family who have been devastated by the recent … USHUPO org needs your support for Support LA Proteomics Families
gofund.me
January 13, 2025 at 3:17 PM
The board of USHUPO has set up a GoFundMe site to support USHUPO members in the LA area. In particular these kinds of tragedies can impact graduate students and postdoctoral fellows hard. Here's the link. gofund.me/d73ac63a