Javi Martínez-López
@javiml221098.bsky.social
Biochemist and Immunology MsC🧪
PhD Student in FIBAO 🖥️🧬
Instituto de Parasitología y Biomedicina López-Neyra (CSIC) 📍
https://orcid.org/0000-0003-0184-9543
PhD Student in FIBAO 🖥️🧬
Instituto de Parasitología y Biomedicina López-Neyra (CSIC) 📍
https://orcid.org/0000-0003-0184-9543
Reposted by Javi Martínez-López
Identifican nuevas claves moleculares que podrían guiar el manejo clínico de la enfermedad de Erdheim–Chester
El @ipblncsic.bsky.social marca un punto de inflexión con su estudio de esta enfermedad, analizando y combinando por primera vez datos de metilación del ADN y expresión génica
t.ly/MCs11
El @ipblncsic.bsky.social marca un punto de inflexión con su estudio de esta enfermedad, analizando y combinando por primera vez datos de metilación del ADN y expresión génica
t.ly/MCs11
October 28, 2025 at 10:04 AM
Identifican nuevas claves moleculares que podrían guiar el manejo clínico de la enfermedad de Erdheim–Chester
El @ipblncsic.bsky.social marca un punto de inflexión con su estudio de esta enfermedad, analizando y combinando por primera vez datos de metilación del ADN y expresión génica
t.ly/MCs11
El @ipblncsic.bsky.social marca un punto de inflexión con su estudio de esta enfermedad, analizando y combinando por primera vez datos de metilación del ADN y expresión génica
t.ly/MCs11
Reposted by Javi Martínez-López
October 2, 2025 at 6:57 AM
Reposted by Javi Martínez-López
For the next three months I am doing a stay at the University of Manchester! Prof. Gisela Orozco's lab, in a project working on ATAC-seq and CUT&Tag data. Happy to be here!! 🌸
(also my first time in the UK! 😊)
@manchester.ac.uk
(also my first time in the UK! 😊)
@manchester.ac.uk
September 8, 2025 at 10:54 AM
For the next three months I am doing a stay at the University of Manchester! Prof. Gisela Orozco's lab, in a project working on ATAC-seq and CUT&Tag data. Happy to be here!! 🌸
(also my first time in the UK! 😊)
@manchester.ac.uk
(also my first time in the UK! 😊)
@manchester.ac.uk
Reposted by Javi Martínez-López
New paper just out (online first) in Arthritis & Rheumatology! 🎉
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
Genome‐wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients
Objectives Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by ...
doi.org
August 28, 2025 at 10:40 AM
New paper just out (online first) in Arthritis & Rheumatology! 🎉
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
To be part of the 19th SSc Workshop in Cambridge was an amazing experience! It was a privilege to have had the opportunity to give a talk about massively parallel reporter assays (MPRAs). And with that… it’s summer time! 🌞✨
¡DESPEDIMOS el curso con una gran felicitación a nuestros compañeros @javiml221098.bsky.social, Marialbert Acosta-Herrera, Carlos de la Rosa Báez e @inmaculadaroma.bsky.social del IPBLN por su notable presencia en el 19th International Workshop on Scleroderma Research! 👏🎊🥳🎉
August 8, 2025 at 10:38 AM
To be part of the 19th SSc Workshop in Cambridge was an amazing experience! It was a privilege to have had the opportunity to give a talk about massively parallel reporter assays (MPRAs). And with that… it’s summer time! 🌞✨
Reposted by Javi Martínez-López
These past days I had the amazing opportunity to attend the International Workshop on Scleroderma Research in Cambridge. Thanks to the SCTC for awarding me with a Workshop Travel Award 🙌🏻
July 31, 2025 at 8:41 PM
These past days I had the amazing opportunity to attend the International Workshop on Scleroderma Research in Cambridge. Thanks to the SCTC for awarding me with a Workshop Travel Award 🙌🏻
If you want some immune cells for your slides, here’s what you’re looking for🙌🏻
🎨🔬 I just released some simple immune cell illustrations I've made over time for my talks, for anyone to use in their talks, teaching, or outreach!
No attribution required, just not for commercial use.
You can download them from my github 👉 github.com/goboru/cell-...
#SciComm #Immunesky #sciart
No attribution required, just not for commercial use.
You can download them from my github 👉 github.com/goboru/cell-...
#SciComm #Immunesky #sciart
July 29, 2025 at 10:12 AM
If you want some immune cells for your slides, here’s what you’re looking for🙌🏻
Reposted by Javi Martínez-López
SOOOO MANY GENOMICS MODELSSSS! 😱 Often unclear which is best since they benchmark differently! In this preprint, we introduce GAME, a new framework that utilizes APIs to enable sustainable, uniform model evaluation so we can see which is actually best for each task. doi.org/10.1101/2025...
July 11, 2025 at 7:34 AM
SOOOO MANY GENOMICS MODELSSSS! 😱 Often unclear which is best since they benchmark differently! In this preprint, we introduce GAME, a new framework that utilizes APIs to enable sustainable, uniform model evaluation so we can see which is actually best for each task. doi.org/10.1101/2025...
Reposted by Javi Martínez-López
Methods and applications for single-cell and spatial multi-omics go.nature.com/3GkzmzZ #Review by Katy Vandereyken, Alejandro Sifrim, @bernthie.bsky.social & Thierry Voet
Free to read here: rdcu.be/c6JjL
Free to read here: rdcu.be/c6JjL
Methods and applications for single-cell and spatial multi-omics
Nature Reviews Genetics - In this Review, the authors discuss the latest advances in profiling multiple molecular modalities from single cells, including genomic, transcriptomic, epigenomic and...
rdcu.be
June 27, 2025 at 8:30 AM
Methods and applications for single-cell and spatial multi-omics go.nature.com/3GkzmzZ #Review by Katy Vandereyken, Alejandro Sifrim, @bernthie.bsky.social & Thierry Voet
Free to read here: rdcu.be/c6JjL
Free to read here: rdcu.be/c6JjL
EULAR2025 has come to an end! I learned a lot, met amazing people, and had a great time with @goboru.bsky.social and @lauramg22.bsky.social. Really enjoyed it! ✨✨
June 16, 2025 at 10:24 AM
EULAR2025 has come to an end! I learned a lot, met amazing people, and had a great time with @goboru.bsky.social and @lauramg22.bsky.social. Really enjoyed it! ✨✨
Reposted by Javi Martínez-López
Last day of EULAR! Here's a thread 🧵 of my (very personal) takeaways from #EULAR2025 on giant cell arteritis (GCA)! Keep in mind that as someone focused on basic research, my EULAR schedule was definitely biased in that direction #GCA #rheumsky
June 14, 2025 at 7:37 AM
Last day of EULAR! Here's a thread 🧵 of my (very personal) takeaways from #EULAR2025 on giant cell arteritis (GCA)! Keep in mind that as someone focused on basic research, my EULAR schedule was definitely biased in that direction #GCA #rheumsky
Great presentation by my lab mate @inmaculadaroma.bsky.social ✨
Sex-aware science is something to stand strong for ✊
Sex-aware science is something to stand strong for ✊
🎓 En el #WIPSeminar de hoy, Inma ha explicado los resultados preliminares de su investigación acerca del perfil genético con enfoque de sexo que revela la relevancia de IL12RB2 como un locus específico en mujeres en la #EsclerosisSistemica 🧬
June 10, 2025 at 10:07 AM
Great presentation by my lab mate @inmaculadaroma.bsky.social ✨
Sex-aware science is something to stand strong for ✊
Sex-aware science is something to stand strong for ✊
Reposted by Javi Martínez-López
🎓 En el #WIPSeminar de hoy, Inma ha explicado los resultados preliminares de su investigación acerca del perfil genético con enfoque de sexo que revela la relevancia de IL12RB2 como un locus específico en mujeres en la #EsclerosisSistemica 🧬
June 10, 2025 at 9:35 AM
🎓 En el #WIPSeminar de hoy, Inma ha explicado los resultados preliminares de su investigación acerca del perfil genético con enfoque de sexo que revela la relevancia de IL12RB2 como un locus específico en mujeres en la #EsclerosisSistemica 🧬
Reposted by Javi Martínez-López
One thing still missing in many GWAS pipelines: chrX analysis... In this study from @ajhgnews.bsky.social, Mefford et al. explore X-GWAS across 48 UKBB traits and as expected, ~3% of trait heritability comes from chrX.
Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...
Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...
Role of X chromosome and dosage-compensation mechanisms in complex trait genetics
We show that the X chromosome, understudied in genome-wide association studies, contributes
to complex traits in a manner shaped by dosage-compensation mechanisms. We find near-full
X inactivation bal...
www.cell.com
June 6, 2025 at 9:32 AM
One thing still missing in many GWAS pipelines: chrX analysis... In this study from @ajhgnews.bsky.social, Mefford et al. explore X-GWAS across 48 UKBB traits and as expected, ~3% of trait heritability comes from chrX.
Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...
Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...
Congratulations!!! ✨
Excited to share that our abstract for #EULAR was selected as one of the Top 10 Abstracts at EULAR 2025 by EMEUNET! 🙌🥰
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
May 28, 2025 at 3:22 PM
Congratulations!!! ✨
Reposted by Javi Martínez-López
Excited to share that our abstract for #EULAR was selected as one of the Top 10 Abstracts at EULAR 2025 by EMEUNET! 🙌🥰
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
May 28, 2025 at 3:13 PM
Excited to share that our abstract for #EULAR was selected as one of the Top 10 Abstracts at EULAR 2025 by EMEUNET! 🙌🥰
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
Reposted by Javi Martínez-López
Today marks #WorldImmunologyDay 2025: The immune system and your brain. Multiple system atrophy is a rare synucleinopathy that affects the nigrostriatal system, pons, cerebellum, inferior olives, brainstem and spinal cord. Learn more: https://www.nature.c...
April 30, 2025 at 7:01 AM
Today marks #WorldImmunologyDay 2025: The immune system and your brain. Multiple system atrophy is a rare synucleinopathy that affects the nigrostriatal system, pons, cerebellum, inferior olives, brainstem and spinal cord. Learn more: https://www.nature.c...
Reposted by Javi Martínez-López
Happy to see our paper on "The Spanish Polygenic Score reference distribution: a resource for personalized medicine" out nature.com/articles/s41... this is a collaborative effort of the CIBERER, Navarrabiomed and other groups across Spain @ibis-investigacion.bsky.social
The Spanish Polygenic Score reference distribution: a resource for personalized medicine - European Journal of Human Genetics
European Journal of Human Genetics - The Spanish Polygenic Score reference distribution: a resource for personalized medicine
nature.com
April 25, 2025 at 8:59 AM
Happy to see our paper on "The Spanish Polygenic Score reference distribution: a resource for personalized medicine" out nature.com/articles/s41... this is a collaborative effort of the CIBERER, Navarrabiomed and other groups across Spain @ibis-investigacion.bsky.social
Reposted by Javi Martínez-López
¿Conoces #HuMicA! 🌟 Investiga el papel de la microglía en enfermedades neurodegenerativas y su potencial terapéutico. Te lo cuentan sus autores en #RevistaSEBBM
https://f.mtr.cool/stowmipiea
https://f.mtr.cool/stowmipiea
April 24, 2025 at 7:56 AM
¿Conoces #HuMicA! 🌟 Investiga el papel de la microglía en enfermedades neurodegenerativas y su potencial terapéutico. Te lo cuentan sus autores en #RevistaSEBBM
https://f.mtr.cool/stowmipiea
https://f.mtr.cool/stowmipiea
Reposted by Javi Martínez-López
In This Issue:
•Epigenetic myeloid dysregulation in SSc
•Incidence of JIA increases with latitude in Norway cohort
•FoxO1 deficiency in M-MDSCs exacerbates B cell dysfunction in SLE
•Journal Club: Body pain diagram to describe nonarticular pain evolution in 1st year of RA dx
acr.tw/4hLtPzi
#Medsky
•Epigenetic myeloid dysregulation in SSc
•Incidence of JIA increases with latitude in Norway cohort
•FoxO1 deficiency in M-MDSCs exacerbates B cell dysfunction in SLE
•Journal Club: Body pain diagram to describe nonarticular pain evolution in 1st year of RA dx
acr.tw/4hLtPzi
#Medsky
April 1, 2025 at 12:31 PM
In This Issue:
•Epigenetic myeloid dysregulation in SSc
•Incidence of JIA increases with latitude in Norway cohort
•FoxO1 deficiency in M-MDSCs exacerbates B cell dysfunction in SLE
•Journal Club: Body pain diagram to describe nonarticular pain evolution in 1st year of RA dx
acr.tw/4hLtPzi
#Medsky
•Epigenetic myeloid dysregulation in SSc
•Incidence of JIA increases with latitude in Norway cohort
•FoxO1 deficiency in M-MDSCs exacerbates B cell dysfunction in SLE
•Journal Club: Body pain diagram to describe nonarticular pain evolution in 1st year of RA dx
acr.tw/4hLtPzi
#Medsky
We're going to EULAR 25! ✨
March 27, 2025 at 10:40 AM
We're going to EULAR 25! ✨
Reposted by Javi Martínez-López
Good news! I will be presenting at EULAR 25 our new work about the genetics of GCA-related clinical manifestations ✨
March 27, 2025 at 10:09 AM
Good news! I will be presenting at EULAR 25 our new work about the genetics of GCA-related clinical manifestations ✨
Reposted by Javi Martínez-López
🎓En el WIP de hoy, nuestra compañera, la doctora Miriam Cerván ha explicado sus últimos resultados del análisis del perfil molecular de la enfermedad de #ErdheimChester a partir de la integración del #metiloma y el #transcriptoma de pacientes🧬
March 25, 2025 at 11:38 AM
🎓En el WIP de hoy, nuestra compañera, la doctora Miriam Cerván ha explicado sus últimos resultados del análisis del perfil molecular de la enfermedad de #ErdheimChester a partir de la integración del #metiloma y el #transcriptoma de pacientes🧬
Reposted by Javi Martínez-López
📢 ESTA SEMANA EN EL IPBLN:
#WIPSeminar de Miriam Cerván Martín:
‘Unraveling the Molecular Landscape of Erdheim-Chester Disease: New insights from Methylome and Transcriptome Integration’
📅 Martes 25 de marzo
🕙 10:00h
#WIPSeminar de Miriam Cerván Martín:
‘Unraveling the Molecular Landscape of Erdheim-Chester Disease: New insights from Methylome and Transcriptome Integration’
📅 Martes 25 de marzo
🕙 10:00h
March 24, 2025 at 9:54 AM
📢 ESTA SEMANA EN EL IPBLN:
#WIPSeminar de Miriam Cerván Martín:
‘Unraveling the Molecular Landscape of Erdheim-Chester Disease: New insights from Methylome and Transcriptome Integration’
📅 Martes 25 de marzo
🕙 10:00h
#WIPSeminar de Miriam Cerván Martín:
‘Unraveling the Molecular Landscape of Erdheim-Chester Disease: New insights from Methylome and Transcriptome Integration’
📅 Martes 25 de marzo
🕙 10:00h
Reposted by Javi Martínez-López
Mike spotted this before the rest of us. 🫡
Publications from 2025 are shared more on Bluesky than on X/Twitter.
Publications from 2025 are shared more on Bluesky than on X/Twitter.
About to talk to medical affairs colleagues, with the news that Bluesky is carrying more posts about new journal publications than X #bluesky #altmetrics #x #xparrot
March 13, 2025 at 3:51 PM
Mike spotted this before the rest of us. 🫡
Publications from 2025 are shared more on Bluesky than on X/Twitter.
Publications from 2025 are shared more on Bluesky than on X/Twitter.