Inmaculada Rodriguez-Martin
@inmaculadaroma.bsky.social
PhD student at Institute of Parasitology and Biomedicine López-Neyra in Granada, Spain
Researching on sex differences in systemic sclerosis
Researching on sex differences in systemic sclerosis
Reposted by Inmaculada Rodriguez-Martin
Now out! 🎉 We asked: why is GCA an age-related disease?
Our approach: a cross-trait GWAS to explore shared genetic predisposition between GCA and markers of biological aging
Excited to share this one! 🧬⏳
www.aginganddisease.org/EN/10.14336/...
cc @inmaculadaroma.bsky.social @ipblncsic.bsky.social
Our approach: a cross-trait GWAS to explore shared genetic predisposition between GCA and markers of biological aging
Excited to share this one! 🧬⏳
www.aginganddisease.org/EN/10.14336/...
cc @inmaculadaroma.bsky.social @ipblncsic.bsky.social
Cross-Trait Meta-Analysis Reveals a Genetic Link between Inflammation and Aging in Giant Cell Arteritis
<p>Giant cell arteritis (GCA) is a complex inflammatory disease affecting individuals over 50 suggesting a strong link with aging-related immune and vascular changes. However, the precise mechanisms u...
www.aginganddisease.org
September 1, 2025 at 10:02 AM
Now out! 🎉 We asked: why is GCA an age-related disease?
Our approach: a cross-trait GWAS to explore shared genetic predisposition between GCA and markers of biological aging
Excited to share this one! 🧬⏳
www.aginganddisease.org/EN/10.14336/...
cc @inmaculadaroma.bsky.social @ipblncsic.bsky.social
Our approach: a cross-trait GWAS to explore shared genetic predisposition between GCA and markers of biological aging
Excited to share this one! 🧬⏳
www.aginganddisease.org/EN/10.14336/...
cc @inmaculadaroma.bsky.social @ipblncsic.bsky.social
Reposted by Inmaculada Rodriguez-Martin
¡DESPEDIMOS el curso con una gran felicitación a nuestros compañeros @javiml221098.bsky.social, Marialbert Acosta-Herrera, Carlos de la Rosa Báez e @inmaculadaroma.bsky.social del IPBLN por su notable presencia en el 19th International Workshop on Scleroderma Research! 👏🎊🥳🎉
August 8, 2025 at 9:50 AM
¡DESPEDIMOS el curso con una gran felicitación a nuestros compañeros @javiml221098.bsky.social, Marialbert Acosta-Herrera, Carlos de la Rosa Báez e @inmaculadaroma.bsky.social del IPBLN por su notable presencia en el 19th International Workshop on Scleroderma Research! 👏🎊🥳🎉
Reposted by Inmaculada Rodriguez-Martin
New paper just out (online first) in Arthritis & Rheumatology! 🎉
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
Genome‐wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients
Objectives Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by ...
doi.org
August 28, 2025 at 10:40 AM
New paper just out (online first) in Arthritis & Rheumatology! 🎉
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
These past days I had the amazing opportunity to attend the International Workshop on Scleroderma Research in Cambridge. Thanks to the SCTC for awarding me with a Workshop Travel Award 🙌🏻
July 31, 2025 at 8:41 PM
These past days I had the amazing opportunity to attend the International Workshop on Scleroderma Research in Cambridge. Thanks to the SCTC for awarding me with a Workshop Travel Award 🙌🏻
Reposted by Inmaculada Rodriguez-Martin
So excited to share our latest study on defining the function of disease variants by editing single cells, and assuming them with CRAFT-seq! Special thanks to @zpmu.bsky.social and @baglaenkolab.bsky.social! @broadinstitute.org
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Precisely defining disease variant effects in CRISPR-edited single cells - Nature
A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of CRISPR edits to test the functional effects of genetic variants o...
www.nature.com
July 23, 2025 at 11:34 PM
So excited to share our latest study on defining the function of disease variants by editing single cells, and assuming them with CRAFT-seq! Special thanks to @zpmu.bsky.social and @baglaenkolab.bsky.social! @broadinstitute.org
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Inmaculada Rodriguez-Martin
🚀Join us on our #EULAR and #EMEUNET Webinar: "Gender-specific differences in rheumatic diseases"
💻Wednesday, 13 Aug 2025, 18:00-18:45 CEST
Register here👉https://pulse.ly/m5gtytw87m
#eularEMEUNET #Rheumatology
💻Wednesday, 13 Aug 2025, 18:00-18:45 CEST
Register here👉https://pulse.ly/m5gtytw87m
#eularEMEUNET #Rheumatology
July 14, 2025 at 8:00 AM
🚀Join us on our #EULAR and #EMEUNET Webinar: "Gender-specific differences in rheumatic diseases"
💻Wednesday, 13 Aug 2025, 18:00-18:45 CEST
Register here👉https://pulse.ly/m5gtytw87m
#eularEMEUNET #Rheumatology
💻Wednesday, 13 Aug 2025, 18:00-18:45 CEST
Register here👉https://pulse.ly/m5gtytw87m
#eularEMEUNET #Rheumatology
Reposted by Inmaculada Rodriguez-Martin
🎓 #Taller interactivo y foro de puesta en común por Eva Luna Díaz García, Investigadora en Antropología y Sociología en la Universidad Complutense de Madrid y profesora/colaboradora de @prismaciencia.bsky.social
'Diversidad LGTBIQA+ en Ciencia, Tecnología e Innovación'
🕛12h
📅 Viernes 27
📍 IPBLN
'Diversidad LGTBIQA+ en Ciencia, Tecnología e Innovación'
🕛12h
📅 Viernes 27
📍 IPBLN
June 23, 2025 at 12:42 PM
🎓 #Taller interactivo y foro de puesta en común por Eva Luna Díaz García, Investigadora en Antropología y Sociología en la Universidad Complutense de Madrid y profesora/colaboradora de @prismaciencia.bsky.social
'Diversidad LGTBIQA+ en Ciencia, Tecnología e Innovación'
🕛12h
📅 Viernes 27
📍 IPBLN
'Diversidad LGTBIQA+ en Ciencia, Tecnología e Innovación'
🕛12h
📅 Viernes 27
📍 IPBLN
Reposted by Inmaculada Rodriguez-Martin
@raungar.bsky.social, @sbmontgom.bsky.social, & co. examine the impact of rare variants & sex on gene expression across the X-chromosome & autosomes, identifying 700+ rare variants w/ predicted functional differences in males & females: www.cell.com/hgg-advances... #ASHG @hggadvances.bsky.social
June 12, 2025 at 3:53 PM
@raungar.bsky.social, @sbmontgom.bsky.social, & co. examine the impact of rare variants & sex on gene expression across the X-chromosome & autosomes, identifying 700+ rare variants w/ predicted functional differences in males & females: www.cell.com/hgg-advances... #ASHG @hggadvances.bsky.social
Reposted by Inmaculada Rodriguez-Martin
🎓 En el #WIPSeminar de hoy, Inma ha explicado los resultados preliminares de su investigación acerca del perfil genético con enfoque de sexo que revela la relevancia de IL12RB2 como un locus específico en mujeres en la #EsclerosisSistemica 🧬
June 10, 2025 at 9:35 AM
🎓 En el #WIPSeminar de hoy, Inma ha explicado los resultados preliminares de su investigación acerca del perfil genético con enfoque de sexo que revela la relevancia de IL12RB2 como un locus específico en mujeres en la #EsclerosisSistemica 🧬
Reposted by Inmaculada Rodriguez-Martin
Great presentation by my lab mate @inmaculadaroma.bsky.social ✨
Sex-aware science is something to stand strong for ✊
Sex-aware science is something to stand strong for ✊
🎓 En el #WIPSeminar de hoy, Inma ha explicado los resultados preliminares de su investigación acerca del perfil genético con enfoque de sexo que revela la relevancia de IL12RB2 como un locus específico en mujeres en la #EsclerosisSistemica 🧬
June 10, 2025 at 10:07 AM
Great presentation by my lab mate @inmaculadaroma.bsky.social ✨
Sex-aware science is something to stand strong for ✊
Sex-aware science is something to stand strong for ✊
Thank you so much! 🙏 I really appreciate your kind words and support. And big thanks to everyone who came to the talk and engaged with such thoughtful questions!
Grateful to be in a lab that values rigorous, sex-aware science. Let’s keep pushing for better, more inclusive research! 💪✨
Grateful to be in a lab that values rigorous, sex-aware science. Let’s keep pushing for better, more inclusive research! 💪✨
Great presentation by my lab mate @inmaculadaroma.bsky.social ✨
Sex-aware science is something to stand strong for ✊
Sex-aware science is something to stand strong for ✊
🎓 En el #WIPSeminar de hoy, Inma ha explicado los resultados preliminares de su investigación acerca del perfil genético con enfoque de sexo que revela la relevancia de IL12RB2 como un locus específico en mujeres en la #EsclerosisSistemica 🧬
June 10, 2025 at 12:03 PM
Thank you so much! 🙏 I really appreciate your kind words and support. And big thanks to everyone who came to the talk and engaged with such thoughtful questions!
Grateful to be in a lab that values rigorous, sex-aware science. Let’s keep pushing for better, more inclusive research! 💪✨
Grateful to be in a lab that values rigorous, sex-aware science. Let’s keep pushing for better, more inclusive research! 💪✨
Reposted by Inmaculada Rodriguez-Martin
One thing still missing in many GWAS pipelines: chrX analysis... In this study from @ajhgnews.bsky.social, Mefford et al. explore X-GWAS across 48 UKBB traits and as expected, ~3% of trait heritability comes from chrX.
Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...
Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...
Role of X chromosome and dosage-compensation mechanisms in complex trait genetics
We show that the X chromosome, understudied in genome-wide association studies, contributes
to complex traits in a manner shaped by dosage-compensation mechanisms. We find near-full
X inactivation bal...
www.cell.com
June 6, 2025 at 9:32 AM
One thing still missing in many GWAS pipelines: chrX analysis... In this study from @ajhgnews.bsky.social, Mefford et al. explore X-GWAS across 48 UKBB traits and as expected, ~3% of trait heritability comes from chrX.
Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...
Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...
Reposted by Inmaculada Rodriguez-Martin
Excited to share that our abstract for #EULAR was selected as one of the Top 10 Abstracts at EULAR 2025 by EMEUNET! 🙌🥰
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
May 28, 2025 at 3:13 PM
Excited to share that our abstract for #EULAR was selected as one of the Top 10 Abstracts at EULAR 2025 by EMEUNET! 🙌🥰
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
Reposted by Inmaculada Rodriguez-Martin
FYI: New online! Methodological opportunities in genomic data analysis to advance health equity
Methodological opportunities in genomic data analysis to advance health equity
Nature Reviews Genetics, Published online: 15 May 2025; doi:10.1038/s41576-025-00839-wNew statistical and machine learning techniques to understand, quantify and correct for the impact of biases in genomic data are emerging. The authors review how the choice of analytical methods used to process, analyse and interpret genomic data can influence genomic research, as well as existing methodological approaches to promote equity and fairness in genomics.
www.nature.com
June 5, 2025 at 12:19 AM
FYI: New online! Methodological opportunities in genomic data analysis to advance health equity
Reposted by Inmaculada Rodriguez-Martin
Estamos buscando candidatos para un contrato predoctoral en nuestro grupo! 🔝 A desarrollar en el IPBLN-CSIC (Granada), estudiando el perfil epigenético de los pacientes con arteritis de células gigantes 🧬 Mas info de nuestro grupo:
www.ipb.csic.es/departamento...
www.ipb.csic.es/departamento...
April 10, 2025 at 10:55 AM
Estamos buscando candidatos para un contrato predoctoral en nuestro grupo! 🔝 A desarrollar en el IPBLN-CSIC (Granada), estudiando el perfil epigenético de los pacientes con arteritis de células gigantes 🧬 Mas info de nuestro grupo:
www.ipb.csic.es/departamento...
www.ipb.csic.es/departamento...
Reposted by Inmaculada Rodriguez-Martin
In This Issue:
•Epigenetic myeloid dysregulation in SSc
•Incidence of JIA increases with latitude in Norway cohort
•FoxO1 deficiency in M-MDSCs exacerbates B cell dysfunction in SLE
•Journal Club: Body pain diagram to describe nonarticular pain evolution in 1st year of RA dx
acr.tw/4hLtPzi
#Medsky
•Epigenetic myeloid dysregulation in SSc
•Incidence of JIA increases with latitude in Norway cohort
•FoxO1 deficiency in M-MDSCs exacerbates B cell dysfunction in SLE
•Journal Club: Body pain diagram to describe nonarticular pain evolution in 1st year of RA dx
acr.tw/4hLtPzi
#Medsky
April 1, 2025 at 12:31 PM
In This Issue:
•Epigenetic myeloid dysregulation in SSc
•Incidence of JIA increases with latitude in Norway cohort
•FoxO1 deficiency in M-MDSCs exacerbates B cell dysfunction in SLE
•Journal Club: Body pain diagram to describe nonarticular pain evolution in 1st year of RA dx
acr.tw/4hLtPzi
#Medsky
•Epigenetic myeloid dysregulation in SSc
•Incidence of JIA increases with latitude in Norway cohort
•FoxO1 deficiency in M-MDSCs exacerbates B cell dysfunction in SLE
•Journal Club: Body pain diagram to describe nonarticular pain evolution in 1st year of RA dx
acr.tw/4hLtPzi
#Medsky
Reposted by Inmaculada Rodriguez-Martin
🏆 ¡Hoy ha sido la entrega de premios de la III Edición Concurso 11F!
👩🔬 Los centros educativos de las ganadoras han asistido al evento, ¡donde han tenido la oportunidad de conocer a las investigadoras que representaron en sus fantásticos dibujos!
👩🔬 Los centros educativos de las ganadoras han asistido al evento, ¡donde han tenido la oportunidad de conocer a las investigadoras que representaron en sus fantásticos dibujos!
February 14, 2025 at 12:57 PM
🏆 ¡Hoy ha sido la entrega de premios de la III Edición Concurso 11F!
👩🔬 Los centros educativos de las ganadoras han asistido al evento, ¡donde han tenido la oportunidad de conocer a las investigadoras que representaron en sus fantásticos dibujos!
👩🔬 Los centros educativos de las ganadoras han asistido al evento, ¡donde han tenido la oportunidad de conocer a las investigadoras que representaron en sus fantásticos dibujos!
Reposted by Inmaculada Rodriguez-Martin
📢ESTA SEMANA EN EL IPBLN:
#WIPSeminar de Ana Reyes Blázquez
"Mesenchymal stem cells expressing anti-inflammatory and anti-fibrotic neuropeptides: a new advanced therapy for autoinmune myocarditis"
📅 Martes 18 de Febrero
🕙 10:00h
#WIPSeminar de Ana Reyes Blázquez
"Mesenchymal stem cells expressing anti-inflammatory and anti-fibrotic neuropeptides: a new advanced therapy for autoinmune myocarditis"
📅 Martes 18 de Febrero
🕙 10:00h
February 17, 2025 at 11:11 AM
📢ESTA SEMANA EN EL IPBLN:
#WIPSeminar de Ana Reyes Blázquez
"Mesenchymal stem cells expressing anti-inflammatory and anti-fibrotic neuropeptides: a new advanced therapy for autoinmune myocarditis"
📅 Martes 18 de Febrero
🕙 10:00h
#WIPSeminar de Ana Reyes Blázquez
"Mesenchymal stem cells expressing anti-inflammatory and anti-fibrotic neuropeptides: a new advanced therapy for autoinmune myocarditis"
📅 Martes 18 de Febrero
🕙 10:00h
Reposted by Inmaculada Rodriguez-Martin
February 11, 2025 at 7:46 AM
Reposted by Inmaculada Rodriguez-Martin
🏅 #Concurso11F: Entrega de premios del concurso 11-F, con motivo del "Día Internacional de la Mujer y la Niña en la Ciencia".
February 10, 2025 at 9:29 AM
🏅 #Concurso11F: Entrega de premios del concurso 11-F, con motivo del "Día Internacional de la Mujer y la Niña en la Ciencia".
Reposted by Inmaculada Rodriguez-Martin
Reposted by Inmaculada Rodriguez-Martin
Reposted by Inmaculada Rodriguez-Martin
Recently, both Science Immunology (@science.org) and @natimmunol.bsky.social have highlighted the relevance of the aging in the immune system in their covers. It's great to see this topic getting attention, and the artwork is absolutely stunning! Two of the most beautiful covers I've seen so far!✨
February 4, 2025 at 11:52 AM
Recently, both Science Immunology (@science.org) and @natimmunol.bsky.social have highlighted the relevance of the aging in the immune system in their covers. It's great to see this topic getting attention, and the artwork is absolutely stunning! Two of the most beautiful covers I've seen so far!✨
Congrats! I love seeing the use of genetics results to help drug discovery in scleroderma!
New paper 🚨
What can COVID-19 teach us about systemic sclerosis (SSc)? 🤔
In our newly accepted paper in Rheumatology(Oxford) we explored the shared genetic component between COVID-19 and SSc to better understand their immune mechanisms and lung involvement 🧵👇
academic.oup.com/rheumatology...
What can COVID-19 teach us about systemic sclerosis (SSc)? 🤔
In our newly accepted paper in Rheumatology(Oxford) we explored the shared genetic component between COVID-19 and SSc to better understand their immune mechanisms and lung involvement 🧵👇
academic.oup.com/rheumatology...
Cross-trait GWAS in COVID-19 and systemic sclerosis reveals novel genes implicated in fibrotic and inflammation pathways
AbstractObjectives. COVID-19 and systemic sclerosis (SSc) share multiple similarities in their clinical manifestations, alterations in immune response, and
academic.oup.com
January 31, 2025 at 10:45 AM
Congrats! I love seeing the use of genetics results to help drug discovery in scleroderma!