Jan Nolta, PhD
LightNews LightNews
banner
jannolta.bsky.social
Jan Nolta, PhD
@jannolta.bsky.social
1.9K followers 1.8K following 130 posts
Director, Cell and Gene Therapy at University of California Davis Health in Sacramento.
Editor of the journal Stem Cells.
#Firstgen #celltherapy #stemcells #GeneTherapy

https://orcid.org/0000-0003-4576-8542
Posts Replies Media Videos
jannolta.bsky.social
Thank you Judge Lin!

“As a part of Friday’s ruling, Judge Lin said the defendants in the case, including Mr. Trump and an array of government agencies, could not link federal funding “to any measures” that would violate the First Amendment.”

www.nytimes.com/2025/11/14/u...
Judge Orders Trump Not to Threaten University of California’s Funding
www.nytimes.com
November 15, 2025 at 4:16 PM
jannolta.bsky.social
Baby KJ; doctors will ask FDA this winter to OK a clinical trial of pioneering gene editing approach.
#genetherapy
#baseediting
#crispr
#geneediting

www.statnews.com/2025/10/16/b... via @statnews.com
Baby KJ's doctors will ask FDA this winter to OK a clinical trial of pioneering gene editing approach
Baby KJ's medical team intend to ask the FDA to start a clinical trial that would be open to patients with seven different urea cycle disorders.
www.statnews.com
October 22, 2025 at 6:55 PM
Reposted by Jan Nolta, PhD
rarediseaseadvisor.bsky.social
#NORDSummit: Lee Greenwood, whose 5-year-old daughter Noa was born with #CanavanDisease, a severe #GeneticDisorder found mainly among Ashkenazi Jews. In June 2022, the girl received lifesaving #GeneTherapy and is now developing normally.
@nordrare.bsky.social

#RareDisease #RareSky #MedSky
October 21, 2025 at 6:26 PM
Reposted by Jan Nolta, PhD
genesndiseases.bsky.social
A new review highlights the advances in DNA nucleases and delivery vectors for in vivo #GeneTherapy, outlining key developments, challenges, and their future potential to treat diverse #Diseases. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...
October 20, 2025 at 12:49 PM
Reposted by Jan Nolta, PhD
hemehub.bsky.social
This Month on HemeHub: SCD and Gene Therapy

Join us as we explore advances in the treatment of #sicklecelldisease through #genetherapy, featuring pivotal trials of Lyfgenia and Casgevy.

Stay tuned for our upcoming session featuring Dr. John Tisdale, Senior Investigator at the NHLBI.
October 4, 2025 at 8:57 PM
Reposted by Jan Nolta, PhD
daniahbeleford.bsky.social
basicscience.ucdmc.ucdavis.edu/beleford-lab...
Opportunities | Beleford Lab
basicscience.ucdmc.ucdavis.edu
October 2, 2025 at 1:50 AM
jannolta.bsky.social
Congratulations to ⁦‪UniQure and to the #huntingtonsdisease community! 💙💜

www.uniqure.com/investors-me...
Press Releases | Investors & Media
Reimagining the future of healthcare through the power of gene therapy.
www.uniqure.com
September 24, 2025 at 2:21 PM
Reposted by Jan Nolta, PhD
bioinformant.bsky.social
AABB’s Cell and Gene Therapy Standards for Pharmacy, First Edition, Takes Effect October 1 - bioinformant.com/aabbs-cell-a...
@aabbupdates.bsky.social
AABB’s Cell and Gene Therapy Standards for Pharmacy, First Edition, Takes Effect October 1 | BioInformant
Sept 8, 2025, Bethesda, MD – The Association for the Advancement of Blood & Biotherapies (AABB) is pleased to announce the release of the first edition of Cell and Gene Therapy Standards for Pharmacy,...
bioinformant.com
September 19, 2025 at 6:18 PM
jannolta.bsky.social
Congratulations to Brian Fury, our GMP Facility Director at UC Davis Health @ucdavis.bsky.social, and to all of the other recipients of these G-Rex grant awards from ScaleReady.

www.prnewswire.com/news-release...
ScaleReady Awards G-Rex® Grants to Support Cell and Gene Therapy Manufacturing in California
/PRNewswire/ -- ScaleReady, in collaboration with Wilson Wolf Manufacturing, Bio-Techne Corporation (NASDAQ: TECH) and CellReady, today announced that eight...
www.prnewswire.com
September 12, 2025 at 5:18 PM
Reposted by Jan Nolta, PhD
ucdavis.bsky.social
UC Davis & @ucsanfrancisco.bsky.social scientists completed a clinical trial on a new cancer drug for pet cats with squamous cell carcinoma. Researchers believe it will also be effective for humans with similar head and neck cancers. Read more about the clinical trial: ucdav.is/46dxcfM
A calico cat looks out from a box with text below stating a new cancer drug could help both cats and people, credited to UC Davis.
September 2, 2025 at 6:54 PM
jannolta.bsky.social
Momentary break for a much-needed palate cleanser. 🫠
Never knew these adorable creatures existed until this moment. (and nope, it is not AI- they are real! 🥰)
cephalopodsdaily.bsky.social Cephalopods Daily @cephalopodsdaily.bsky.social · Sep 11
Piglet squids (genus Helicocranchia) are a genus of small cranchiids known for their goofy appearance. They have a rather large siphon that make them look like a pig with a snout.

Well I guess with their arms raised up cranchiid style, they look like a pig with a crazy hairdo.

#SQUIDtember
A piglet squid (Helicocranchia sp.) floating in the ocean. Its entire body is translucent and is oriented horizontally. Its limbs being held upwards, making it look like it has crazy hairdo. It has a relatively large siphon that is below its head sticking straight out, making it look like a pig with a snout. The picture is from the side. Two In situ photographs of the same female piglet squid (Helicocranchia sp.), anterolateral views, from an ROV photographed floating in front of oil pumping equipment in the Gulf of Guinea at a depth of 1015 m. Arrow in upper photograph points to stub of tentacle. The squid is a slightly translucent beige pink. Its limbs being held upwards, making it look like it has crazy hairdo. It has a relatively large siphon that is below its head sticking straight out, making it look like a pig with a snout, especially since the opening is closed in a way that resembles nostrils. A piglet squid (Helicocranchia sp.) swimming in the ocean. Its limbs are spread out and pointing up, and its mantle is going back. It has black eyes and its siphon is large and going past its head, making it look like a pig with a snout. A floating piglet squid (Helicocranchia sp.). Its body is completely translucent, except for a single, thin, vertically oriented organ. Its limbs being held upwards, making it look like it has crazy hairdo. It has a relatively large siphon that is below its head sticking straight out, making it look like a pig with a snout
September 11, 2025 at 5:04 PM
jannolta.bsky.social
I am so honored to be a part of this team. Thank you to the NIH for starting up their funding again. Please hang in there, fellow scientists!
health.ucdavis.edu/medical-scho...
Dream team to develop in utero gene editing therapy for a rare neurological genetic disorder
Professor Aijun Wang won a $3.2 million NIH grant to develop a cure to Dup15q syndrome using an in-utero gene editing formula.
health.ucdavis.edu
September 11, 2025 at 4:00 PM
Reposted by Jan Nolta, PhD
gladstoneinst.bsky.social
🚨 NEW PUBLICATION 🚨 "Human brain vascular multi-omics elucidates disease-risk associations"

www.cell.com/neuron/abstr...

@ucsanfrancisco.bsky.social
@madiganreid.bsky.social
@cellpress.bsky.social
Human brain vascular multi-omics elucidates disease-risk associations
Reid et al. develop MultiVINE-seq to map thousands of non-coding disease variants to genes in human brain vascular cells. Cerebrovascular disease variants compromise vessel integrity, whereas Alzheime...
www.cell.com
August 5, 2025 at 6:15 PM
Reposted by Jan Nolta, PhD
intlbrainlab.bsky.social
Want to collaborate with the International Brain Laboratory on your own project? We have funding to work with groups anywhere in the world to do new large-scale projects and we are looking for new partners! Learn more and apply: www.internationalbrainlab.com/ibl-core-apply
September 11, 2025 at 12:27 PM
jannolta.bsky.social
House appropriators snub Kennedy, include mRNA vaccine funding in spending bill www.statnews.com/2025/09/10/m... via @statnews.com
House appropriators snub Kennedy, include mRNA vaccine funding in spending bill
Lawmakers have snubbed health secretary RFK Jr. by including an amendment in a spending bill mandating that an agency under his purview continue to research messenger RNA vaccines.
www.statnews.com
September 11, 2025 at 3:48 PM
Reposted by Jan Nolta, PhD
jannolta.bsky.social
The regime halted all federal grants then told UC administration if they pay $1 billion they could have them back.
It’s like ransomware.
UC is a public university system and we cannot do this.
So, no grants = no research and labs will shut down.
Are we great yet?

dailybruin.com/2025/08/09/a...
'An attack on knowledge': UCLA researchers say lifesaving research is in jeopardy - Daily Bruin
Dr. Jerzy Kupiec-Weglinski has led organ transplant research at UCLA for nearly three decades. Kupiec-Weglinski, the vice chairman of basic science research in the David Geffen School of Medicine’s su...
dailybruin.com
August 10, 2025 at 1:06 PM
jannolta.bsky.social
The regime halted all federal grants then told UC administration if they pay $1 billion they could have them back.
It’s like ransomware.
UC is a public university system and we cannot do this.
So, no grants = no research and labs will shut down.
Are we great yet?

dailybruin.com/2025/08/09/a...
'An attack on knowledge': UCLA researchers say lifesaving research is in jeopardy - Daily Bruin
Dr. Jerzy Kupiec-Weglinski has led organ transplant research at UCLA for nearly three decades. Kupiec-Weglinski, the vice chairman of basic science research in the David Geffen School of Medicine’s su...
dailybruin.com
August 10, 2025 at 1:06 PM
jannolta.bsky.social
Trump administration violated impoundment law by canceling NIH grants, slowing new awards, GAO finds www.statnews.com/2025/08/05/g... via @statnews.com
Trump administration violated impoundment law by canceling NIH grants, slowing new awards, GAO finds
The Government Accountability Office found that the Trump administration, by abruptly canceling NIH grants, had violated a 1974 federal law
www.statnews.com
August 5, 2025 at 9:46 PM
jannolta.bsky.social
Good morning and happy Saturday. Take a deep breath and keep riding those waves. 🙏
July 26, 2025 at 12:08 PM
Reposted by Jan Nolta, PhD
braithwaiteat.bsky.social
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
July 3, 2025 at 3:39 PM
Reposted by Jan Nolta, PhD
bllphd.bsky.social
Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T cell therapy for leukaemia. #Tcell #immunotherapy #organonachip 🧪https://www.nature.com/articles/s41551-025-01428-2
Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T cell therapy for leukaemia - Nature Biomedical Engineering
An ex vivo organotypic and immunocompetent human leukaemia chip system is used for CAR T cell therapy modelling and screening of patient response.
www.nature.com
July 2, 2025 at 12:04 PM
Reposted by Jan Nolta, PhD
kffhealthnews.org
After spearheading a 34% cut in cancer mortality, the National Cancer Institute at the NIH is bleeding resources and staff and could see its budget cut by nearly 40%. kffhealthnews.org/news/article...
World’s Premier Cancer Institute Faces Crippling Cuts and Chaos - KFF Health News
After spearheading a 34% cut in cancer mortality, the National Cancer Institute at the NIH is bleeding resources and staff and could see its budget cut by nearly 40%.
kffhealthnews.org
July 9, 2025 at 1:52 PM
jannolta.bsky.social
www.cnn.com/2025/06/20/p...
Federal judge indefinitely blocks Trump administration from cutting off Harvard’s ability to host foreign students | CNN Politics
A federal judge on Friday indefinitely blocked the Trump administration from revoking Harvard University��s ability to host international students and scholars while legal challenges continue.
www.cnn.com
June 20, 2025 at 7:44 PM
Reposted by Jan Nolta, PhD
grumpyoldscientist.bsky.social
Explore this gift article from The New York Times. You can read it for free without a subscription.

www.nytimes.com/2025/06/05/h...

And this is your new improved FDA. Into everyone’s medical life, a few charlatans must fall.
Kennedy Says ‘Charlatans’ Are No Reason to Block Unproven Stem Cell Treatments
www.nytimes.com
June 5, 2025 at 6:50 PM
Reposted by Jan Nolta, PhD
cellpress.bsky.social
"Specific targeting of brain endothelial cells using enhancer AAV vectors"
www.cell.com/neuron/fullt...

Xiangmin Xu & colleagues
@cp-neuron.bsky.social
Specific targeting of brain endothelial cells using enhancer AAV vectors
Velazquez-Rivera et al. have developed and validated a set of new BEC-enhancer AAV vectors that allow for selective genetic labeling of, and access to, brain endothelial cells (BECs). These useful too...
www.cell.com
May 22, 2025 at 4:41 PM