Jakub Rohlena
@jakubrohlena.bsky.social
OXPHOS is cool, and the rest of metabolism is also fun:-) Cancer and endothelium researcher based in Prague
Reposted by Jakub Rohlena
Uridine: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...
a great not-to-miss piece from the @lyssiotislab.bsky.social
a great not-to-miss piece from the @lyssiotislab.bsky.social
Uridine
Uridine is a pyrimidine nucleoside composed of an uracil base and a ribose sugar.
In cells, uridine is predominantly present in RNA (as uridine monophosphate, UMP).
Uridine can be produced through de ...
www.cell.com
June 15, 2025 at 6:43 AM
Uridine: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...
a great not-to-miss piece from the @lyssiotislab.bsky.social
a great not-to-miss piece from the @lyssiotislab.bsky.social
Reposted by Jakub Rohlena
📢🚨Deadline to submit an abstract for the 2025 Showcase is this Friday, March 21st!📢🚨
Registration free!
Speakers chosen from abstracts and non-faculty only!
Amazing poster session and workshops!
Sign up today at: www.cancermetabolismshowcase.org
Registration free!
Speakers chosen from abstracts and non-faculty only!
Amazing poster session and workshops!
Sign up today at: www.cancermetabolismshowcase.org
9:30 AM - 3 PM EST, May 5th and 6th, 2025
www.cancermetabolismshowcase.org
March 17, 2025 at 6:35 PM
📢🚨Deadline to submit an abstract for the 2025 Showcase is this Friday, March 21st!📢🚨
Registration free!
Speakers chosen from abstracts and non-faculty only!
Amazing poster session and workshops!
Sign up today at: www.cancermetabolismshowcase.org
Registration free!
Speakers chosen from abstracts and non-faculty only!
Amazing poster session and workshops!
Sign up today at: www.cancermetabolismshowcase.org
Reposted by Jakub Rohlena
🚨 New preprint available! Third and final in the #CRISPR screen series!🚨
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
www.biorxiv.org
March 14, 2025 at 8:14 AM
🚨 New preprint available! Third and final in the #CRISPR screen series!🚨
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
Reposted by Jakub Rohlena
Exciting 4-year PhD opportunity in my group, available from October this year! See rb.gy/7p0syj for details. Come and join an exciting research group to study some really cool aspects of metabolism. Please see advert below for details, including contact details and eligibility criteria.
Defining the metabolism of SDH-deficient tumours – a bedside to bench approach towards new biomarkers and therapies at University of Birmingham on FindAPhD.com
PhD Project - Defining the metabolism of SDH-deficient tumours – a bedside to bench approach towards new biomarkers and therapies at University of Birmingham, listed on FindAPhD.com
rb.gy
March 5, 2025 at 11:27 AM
Exciting 4-year PhD opportunity in my group, available from October this year! See rb.gy/7p0syj for details. Come and join an exciting research group to study some really cool aspects of metabolism. Please see advert below for details, including contact details and eligibility criteria.
Reposted by Jakub Rohlena
We’re Hiring: 18 PhD Positions Available!
👉MENTOR is a cutting-edge multi-disciplinary training network focused on mTOR signaling
👉We aim to recruit talented doctoral candidates to contribute to groundbreaking research on mTORopathies and their therapeutic potential.
#PhDPositions #mTORResearch
👉MENTOR is a cutting-edge multi-disciplinary training network focused on mTOR signaling
👉We aim to recruit talented doctoral candidates to contribute to groundbreaking research on mTORopathies and their therapeutic potential.
#PhDPositions #mTORResearch
February 28, 2025 at 10:35 AM
Reposted by Jakub Rohlena
The abstract deadline for #EACR2025 is fast approaching!
Don't miss the exciting opportunity to showcase your research to other attendees in numerous ways, including being featured in the main programme through proffered paper presentations.
You have until 06 March: 2025.eacr.org
Don't miss the exciting opportunity to showcase your research to other attendees in numerous ways, including being featured in the main programme through proffered paper presentations.
You have until 06 March: 2025.eacr.org
February 21, 2025 at 1:04 PM
The abstract deadline for #EACR2025 is fast approaching!
Don't miss the exciting opportunity to showcase your research to other attendees in numerous ways, including being featured in the main programme through proffered paper presentations.
You have until 06 March: 2025.eacr.org
Don't miss the exciting opportunity to showcase your research to other attendees in numerous ways, including being featured in the main programme through proffered paper presentations.
You have until 06 March: 2025.eacr.org
Reposted by Jakub Rohlena
Happy to share the final version of this work where we incorporated isotope labeled CO2 data into mass spectrometry based flux analysis, resulting in a flux model that depicts at the whole-body level functioning of energy metabolism in health and disease.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
An organism-level quantitative flux model of energy metabolism in mice
Mammalian tissues feed on nutrients in the blood circulation. At the organism level, mammalian energy metabolism is comprised of the oxidation, storag…
www.sciencedirect.com
February 20, 2025 at 5:31 PM
Happy to share the final version of this work where we incorporated isotope labeled CO2 data into mass spectrometry based flux analysis, resulting in a flux model that depicts at the whole-body level functioning of energy metabolism in health and disease.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jakub Rohlena
Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis https://www.biorxiv.org/content/10.1101/2025.02.18.638948v1
February 20, 2025 at 10:25 PM
Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Reposted by Jakub Rohlena
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation https://www.biorxiv.org/content/10.1101/2025.02.12.637975v1
February 20, 2025 at 2:43 AM
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
Reposted by Jakub Rohlena
Registration is open for our summer FASEB #Ferroptosis Conference July 27 - 31, 2025. We have a terrific line up of speakers and it's going to be amazzzing! Come join us for this historic first meeting! Please help us to spread the word. 🤩
shorturl.at/QA6T1
shorturl.at/QA6T1
February 13, 2025 at 6:27 AM
Registration is open for our summer FASEB #Ferroptosis Conference July 27 - 31, 2025. We have a terrific line up of speakers and it's going to be amazzzing! Come join us for this historic first meeting! Please help us to spread the word. 🤩
shorturl.at/QA6T1
shorturl.at/QA6T1
Reposted by Jakub Rohlena
🚨 We're hiring! A 2.5-year (full-time) #Postdoc position available in my lab @uebscimuni.bsky.social in Brno, Czechia. 👇 Apply now & join us to study mitochondrial synthetic lethality in MYC-driven tumors. 📅 Deadline: 21 March 2025. (official e-application link will follow)
Please repost 💚
Please repost 💚
February 5, 2025 at 8:07 PM
🚨 We're hiring! A 2.5-year (full-time) #Postdoc position available in my lab @uebscimuni.bsky.social in Brno, Czechia. 👇 Apply now & join us to study mitochondrial synthetic lethality in MYC-driven tumors. 📅 Deadline: 21 March 2025. (official e-application link will follow)
Please repost 💚
Please repost 💚
Reposted by Jakub Rohlena
We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
February 5, 2025 at 3:35 PM
We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Reposted by Jakub Rohlena
Congratulations to Jessica Spienelli and her lab for the groundbreaking work.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Rhodoquinone carries electrons in the mammalian electron transport chain
Ubiquinone (UQ), the only known electron carrier in the mammalian electron transport chain (ETC), preferentially delivers electrons to the terminal el…
www.sciencedirect.com
February 5, 2025 at 7:14 PM
Congratulations to Jessica Spienelli and her lab for the groundbreaking work.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jakub Rohlena
Mark your agendas for the 2nd ISEH mini-symposium organized by the Junior Faculty Committee! Submit an abstract by February 26th for a chance to speak at this event. The top abstract selected from the speakers will get a travel grant for the Annual Meeting in Kumamoto, Japan in Sept 2025!!!
Take advantage of the opportunity to speak at the Mini Symposium by submitting an abstract by 26 February. Learn how and register today ➡️ https://buff.ly/3WLixTV
February 4, 2025 at 3:45 PM
Mark your agendas for the 2nd ISEH mini-symposium organized by the Junior Faculty Committee! Submit an abstract by February 26th for a chance to speak at this event. The top abstract selected from the speakers will get a travel grant for the Annual Meeting in Kumamoto, Japan in Sept 2025!!!
Reposted by Jakub Rohlena
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
January 30, 2025 at 7:58 AM
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
Reposted by Jakub Rohlena
1/🧵for our latest research now out as a preprint on #biorxiv, led by @EloiseMLMrqs 💫
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses[1][1]–[6][2], but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we a...
www.biorxiv.org
January 10, 2025 at 7:45 AM
1/🧵for our latest research now out as a preprint on #biorxiv, led by @EloiseMLMrqs 💫
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
Reposted by Jakub Rohlena
Excited to share our new preprint! Exceptional work by @mikelangelipid.bsky.social identifies the first #LipidDroplet lipid quality control pathway! LD-localized FSP1 safeguards neutral lipids from peroxidation and prevents #ferroptosis. 🤩https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis
Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of L...
www.biorxiv.org
January 8, 2025 at 4:23 PM
Excited to share our new preprint! Exceptional work by @mikelangelipid.bsky.social identifies the first #LipidDroplet lipid quality control pathway! LD-localized FSP1 safeguards neutral lipids from peroxidation and prevents #ferroptosis. 🤩https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1
Reposted by Jakub Rohlena
Looking for exciting opportunities? 🎓 Apply for PhD positions in my lab and others in this fantastic program! 🚀
If you're seeking a postdoc or senior lab scientist role, feel free to DM or email me. Let's connect!
@imprs-cbp.bsky.social #PhDPositions #PostdocJobs
If you're seeking a postdoc or senior lab scientist role, feel free to DM or email me. Let's connect!
@imprs-cbp.bsky.social #PhDPositions #PostdocJobs
December 9, 2024 at 10:55 PM
Looking for exciting opportunities? 🎓 Apply for PhD positions in my lab and others in this fantastic program! 🚀
If you're seeking a postdoc or senior lab scientist role, feel free to DM or email me. Let's connect!
@imprs-cbp.bsky.social #PhDPositions #PostdocJobs
If you're seeking a postdoc or senior lab scientist role, feel free to DM or email me. Let's connect!
@imprs-cbp.bsky.social #PhDPositions #PostdocJobs
Reposted by Jakub Rohlena
I’m excited to share new work out of the lab in Nature Metabolism today on the impact of tumor-relevant glucose concentrations on the response to pyrimidine synthesis inhibitors. t.co/9hOGW4x97T. PDF: rdcu.be/d1vkV
https://www.nature.com/articles/s42255-024-01166-w
t.co
November 26, 2024 at 7:58 PM
I’m excited to share new work out of the lab in Nature Metabolism today on the impact of tumor-relevant glucose concentrations on the response to pyrimidine synthesis inhibitors. t.co/9hOGW4x97T. PDF: rdcu.be/d1vkV
Reposted by Jakub Rohlena
Pls RT: Are you studying the multifaceted MAPK pathway? We would love to hear about your exciting research!
Abstract Deadline 👉16.12.2024 for the #virtualmeeting on "Drugging and regulating the #MAPKpathway"
organised with @EACRnews with @Boehringer eacr.org/conference/boe…
Abstract Deadline 👉16.12.2024 for the #virtualmeeting on "Drugging and regulating the #MAPKpathway"
organised with @EACRnews with @Boehringer eacr.org/conference/boe…
https://eacr.org/conference/boe…
November 22, 2024 at 2:44 PM
Pls RT: Are you studying the multifaceted MAPK pathway? We would love to hear about your exciting research!
Abstract Deadline 👉16.12.2024 for the #virtualmeeting on "Drugging and regulating the #MAPKpathway"
organised with @EACRnews with @Boehringer eacr.org/conference/boe…
Abstract Deadline 👉16.12.2024 for the #virtualmeeting on "Drugging and regulating the #MAPKpathway"
organised with @EACRnews with @Boehringer eacr.org/conference/boe…
Reposted by Jakub Rohlena
I have initiated this #StarterPack with #RedoxBio researchers.
Feel free to suggest other users, or yourself, to be included!
go.bsky.app/UoVRtXp
Feel free to suggest other users, or yourself, to be included!
go.bsky.app/UoVRtXp
November 19, 2024 at 11:52 AM
I have initiated this #StarterPack with #RedoxBio researchers.
Feel free to suggest other users, or yourself, to be included!
go.bsky.app/UoVRtXp
Feel free to suggest other users, or yourself, to be included!
go.bsky.app/UoVRtXp