Alexander Jais
@jaislab.bsky.social
Group leader @HIMAG_Leipzig | Neurobiology & Metabolic Research | Neural circuits linking food intake, brain function and metabolism in obesity
Reposted by Alexander Jais
I reread this over and over again and this absolutely breaks my brain
Look at this crazy thing!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
www.nature.com
September 4, 2025 at 5:33 AM
I reread this over and over again and this absolutely breaks my brain
Reposted by Alexander Jais
🧠Meet Dr Alexander Jais ( @www.helmholtz-munich.de ), #EFSD/@novonordiskfond Future Leaders Awardee.
Don't miss his presentation on sucrose-responsive neurons & glucose metabolism at the EFSD/NNF Future Leaders Symposium at #EASD2025:
📅Thurs, 18 Sept 2025 | 🕛12:45 CEST
📖 doi.org/10.1016/j.is...
Don't miss his presentation on sucrose-responsive neurons & glucose metabolism at the EFSD/NNF Future Leaders Symposium at #EASD2025:
📅Thurs, 18 Sept 2025 | 🕛12:45 CEST
📖 doi.org/10.1016/j.is...
August 12, 2025 at 12:07 PM
🧠Meet Dr Alexander Jais ( @www.helmholtz-munich.de ), #EFSD/@novonordiskfond Future Leaders Awardee.
Don't miss his presentation on sucrose-responsive neurons & glucose metabolism at the EFSD/NNF Future Leaders Symposium at #EASD2025:
📅Thurs, 18 Sept 2025 | 🕛12:45 CEST
📖 doi.org/10.1016/j.is...
Don't miss his presentation on sucrose-responsive neurons & glucose metabolism at the EFSD/NNF Future Leaders Symposium at #EASD2025:
📅Thurs, 18 Sept 2025 | 🕛12:45 CEST
📖 doi.org/10.1016/j.is...
Brain lithium levels drop early in AD before symptoms fully emerge
Lithium deficiency and the onset of Alzheimer’s disease
Nature - Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the...
rdcu.be
August 11, 2025 at 6:39 AM
Brain lithium levels drop early in AD before symptoms fully emerge
Reposted by Alexander Jais
Congratulations 🎉
New iScience paper by PhD student Stephanie Puente‑Ruiz:
The non-classical opioid peptide N/OFQ promotes macrophage recruitment and metabolic inflammation
www.cell.com/iscience/ful...
New iScience paper by PhD student Stephanie Puente‑Ruiz:
The non-classical opioid peptide N/OFQ promotes macrophage recruitment and metabolic inflammation
www.cell.com/iscience/ful...
B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity
Biological sciences; Endocrinology; Natural sciences; Physiology
www.cell.com
June 26, 2025 at 1:00 PM
Congratulations 🎉
New iScience paper by PhD student Stephanie Puente‑Ruiz:
The non-classical opioid peptide N/OFQ promotes macrophage recruitment and metabolic inflammation
www.cell.com/iscience/ful...
New iScience paper by PhD student Stephanie Puente‑Ruiz:
The non-classical opioid peptide N/OFQ promotes macrophage recruitment and metabolic inflammation
www.cell.com/iscience/ful...
Reposted by Alexander Jais
The biology of eating disorders www.nature.com/articles/s41...
Examining the biological causes of eating disorders to inform treatment strategies - Nature Reviews Neuroscience
Recent years have seen a growth in our understanding of the biological drivers of eating disorders and their interactions with environmental and psychosocial factors. Foldi and Griffiths consider how ...
www.nature.com
June 23, 2025 at 10:18 AM
The biology of eating disorders www.nature.com/articles/s41...
Reposted by Alexander Jais
This was a really fun project: We blocked obesity in mice by making them do a tiny bit of work for their food. www.sciencedirect.com/science/arti...
A simple action reduces high-fat diet intake and obesity in mice
Diets that are high in fat cause overeating and weight gain in multiple species of animals, suggesting that high dietary fat is sufficient to cause ob…
www.sciencedirect.com
June 19, 2025 at 3:05 PM
This was a really fun project: We blocked obesity in mice by making them do a tiny bit of work for their food. www.sciencedirect.com/science/arti...
Reposted by Alexander Jais
Astrocytes as regulators of neuromodulatory signaling
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Astrocytes, hidden puppet masters of the brain
Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators
www.science.org
May 16, 2025 at 6:47 AM
Astrocytes as regulators of neuromodulatory signaling
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Alexander Jais
Based on studies in mice selective, durable AgRP neuron inhibition may prove an attractive strategy for the future treatment of T2D in humans www.jci.org/articles/vie...
May 15, 2025 at 4:31 PM
Based on studies in mice selective, durable AgRP neuron inhibition may prove an attractive strategy for the future treatment of T2D in humans www.jci.org/articles/vie...
Reposted by Alexander Jais
Aus Deutschland sprechen sich 110 Wissenschaftlerinnen und Wissenschaftler öffentlich für Tierversuche aus. Frank Kirchhoff, Initiator der Aktion, sagt, warum Experimente an Mäusen, Ratten und Fischen immer noch sein müssen.
Tierversuche: Warum sich mehr als 110 Forschende zu den Experimenten bekennen
Aus Deutschland sprechen sich 110 Wissenschaftlerinnen und Wissenschaftler öffentlich für Tierversuche aus. Frank Kirchhoff, Initiator der Aktion, sagt, warum Experimente an Mäusen, Ratten und Fischen immer noch sein müssen.
www.spiegel.de
April 24, 2025 at 4:19 PM
Aus Deutschland sprechen sich 110 Wissenschaftlerinnen und Wissenschaftler öffentlich für Tierversuche aus. Frank Kirchhoff, Initiator der Aktion, sagt, warum Experimente an Mäusen, Ratten und Fischen immer noch sein müssen.
Reposted by Alexander Jais
Check out the roadmap to the first consensus atlas of human and mouse #adiposetissue.
Great initiative by the adipose bionetwork of #humancellatlas!
@humancellatlas.org @humancellatlas.bsky.social
Great initiative by the adipose bionetwork of #humancellatlas!
@humancellatlas.org @humancellatlas.bsky.social
May 13, 2025 at 8:50 PM
Check out the roadmap to the first consensus atlas of human and mouse #adiposetissue.
Great initiative by the adipose bionetwork of #humancellatlas!
@humancellatlas.org @humancellatlas.bsky.social
Great initiative by the adipose bionetwork of #humancellatlas!
@humancellatlas.org @humancellatlas.bsky.social
Reposted by Alexander Jais
Is increased hunger really a primary driver of obesity?
In this Letter to the Editor in @nejm.org, Thorkild Sørensen, Mark Friedman and I question the widespread idea that many develop obesity because they overeat 👇 1/5
www.nejm.org/doi/full/10....
@cbmr.science
In this Letter to the Editor in @nejm.org, Thorkild Sørensen, Mark Friedman and I question the widespread idea that many develop obesity because they overeat 👇 1/5
www.nejm.org/doi/full/10....
@cbmr.science
The Physiology of Hunger | NEJM
To the Editor: The review article by Fasano (Jan. 23 issue)1 concerning human nutrition
and hunger regulation omits the crucial role of autophagy, a cellular recycling process
vital for maintaining...
www.nejm.org
May 8, 2025 at 7:53 AM
Is increased hunger really a primary driver of obesity?
In this Letter to the Editor in @nejm.org, Thorkild Sørensen, Mark Friedman and I question the widespread idea that many develop obesity because they overeat 👇 1/5
www.nejm.org/doi/full/10....
@cbmr.science
In this Letter to the Editor in @nejm.org, Thorkild Sørensen, Mark Friedman and I question the widespread idea that many develop obesity because they overeat 👇 1/5
www.nejm.org/doi/full/10....
@cbmr.science
GABAergic, Non-AgRP neurons are critical for the regulation of overnutrition 🍟🍔 - this new study shows that leptin exerts a substantial portion of its appetite- and body-weight-regulatory effects via PNOC/NPY-expressing neurons!
@cp-cell.bsky.social @mpi-metabolism.bsky.social
@cp-cell.bsky.social @mpi-metabolism.bsky.social
Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis
Activation of PNOCARC neurons promotes feeding. Here, Solheim et al. describe PNOC
neurons in the murine ARC as mediators of leptin action in body weight maintenance.
Moreover, they molecularly and fu...
www.cell.com
April 25, 2025 at 9:26 AM
GABAergic, Non-AgRP neurons are critical for the regulation of overnutrition 🍟🍔 - this new study shows that leptin exerts a substantial portion of its appetite- and body-weight-regulatory effects via PNOC/NPY-expressing neurons!
@cp-cell.bsky.social @mpi-metabolism.bsky.social
@cp-cell.bsky.social @mpi-metabolism.bsky.social
Reposted by Alexander Jais
A critical role of Notch signalling in brain endothelial cells in the pleiotropic effects of short-term dietary transitions on blood brain barrier functionality @cp-cellreports.bsky.social www.cell.com/cell-reports...
Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling
Zhu et al. describe a rapid downregulation of Notch1 expression in hypothalamic blood-brain
barrier (BBB) endothelial cells after high-fat diet (HFD) feeding. Notch activation
prevents HFD-induced red...
www.cell.com
April 16, 2025 at 1:05 AM
A critical role of Notch signalling in brain endothelial cells in the pleiotropic effects of short-term dietary transitions on blood brain barrier functionality @cp-cellreports.bsky.social www.cell.com/cell-reports...
Reposted by Alexander Jais
Trem2 is more flexible than we thought, and likes to bind to ApoE4! Congrats #EmmaLietzke and #KaylaSprenger on your work! It's a privilege to work with you!! @cuendocrinology.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Synergistic reduction in interfacial flexibility of TREM2R47H and ApoE4 may underlie AD pathology
BACKGROUND
The strongest genetic drivers of late-onset Alzheimer's disease (AD) are apolipoprotein E4 (ApoE4) and TREM2R47H. Despite their critical roles, the mechanisms underlying their interaction.....
alz-journals.onlinelibrary.wiley.com
April 15, 2025 at 6:22 PM
Trem2 is more flexible than we thought, and likes to bind to ApoE4! Congrats #EmmaLietzke and #KaylaSprenger on your work! It's a privilege to work with you!! @cuendocrinology.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
A thread 🧵: Our study redefines current concepts of insulin entry into the brain under conditions of nutritional excess.
www.sciencedirect.com/science/arti...
@www.helmholtz-munich.de @mpi-metabolism.bsky.social
www.sciencedirect.com/science/arti...
@www.helmholtz-munich.de @mpi-metabolism.bsky.social
Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling
Short-term transition to high-fat diet (HFD) feeding causes rapid changes in the molecular architecture of the blood-brain barrier (BBB), BBB permeabi…
www.sciencedirect.com
April 9, 2025 at 7:30 AM
A thread 🧵: Our study redefines current concepts of insulin entry into the brain under conditions of nutritional excess.
www.sciencedirect.com/science/arti...
@www.helmholtz-munich.de @mpi-metabolism.bsky.social
www.sciencedirect.com/science/arti...
@www.helmholtz-munich.de @mpi-metabolism.bsky.social
Reposted by Alexander Jais
Our latest study
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...
Brain sensing of metabolic state regulates circulating monocytes
Brain-initiated hunger signals control circulating monocyte dynamics.
www.science.org
April 7, 2025 at 2:33 PM
Our latest study
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...
Congratulations, Yiyi! 🎉
We find that high-fat diet rapidly reduces Notch signaling in the brain, affecting glucose uptake and insulin sensitivity. Our study also highlights the role of caveolae in blood-brain barrier permeability and insulin transport:
www.sciencedirect.com/science/arti...
We find that high-fat diet rapidly reduces Notch signaling in the brain, affecting glucose uptake and insulin sensitivity. Our study also highlights the role of caveolae in blood-brain barrier permeability and insulin transport:
www.sciencedirect.com/science/arti...
Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling
Short-term transition to high-fat diet (HFD) feeding causes rapid changes in the molecular architecture of the blood-brain barrier (BBB), BBB permeabi…
www.sciencedirect.com
April 7, 2025 at 8:00 AM
Congratulations, Yiyi! 🎉
We find that high-fat diet rapidly reduces Notch signaling in the brain, affecting glucose uptake and insulin sensitivity. Our study also highlights the role of caveolae in blood-brain barrier permeability and insulin transport:
www.sciencedirect.com/science/arti...
We find that high-fat diet rapidly reduces Notch signaling in the brain, affecting glucose uptake and insulin sensitivity. Our study also highlights the role of caveolae in blood-brain barrier permeability and insulin transport:
www.sciencedirect.com/science/arti...