ISAR International Society for Antiviral Research
@isaricar.bsky.social
International Society for Antiviral Research #ISAR. Scientists in basic, applied, and clinical #Antiviral research. Host of #ICAR2025.
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Save the date! #ICAR2026
Reposted by ISAR International Society for Antiviral Research
Latest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...
An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo
A human inborn error of immunity guided discovery and development of a prophylactic, mRNA-based antiviral.
www.science.org
August 13, 2025 at 8:06 PM
Latest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...
Antiviral research needs new models for assessing efficacy! A new exciting paper from ISAR members evaluates human liver spheroids for hemorrhagic viruses
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Assessing human liver spheroids as a model for antiviral drug evaluation against BSL-3 haemorrhagic fever viruses
Haemorrhagic fever viruses (HFVs) cause highly lethal syndromes with limited therapeutic options. Increasingly, 3D cell culture models are becoming an…
www.sciencedirect.com
June 3, 2025 at 7:19 AM
Antiviral research needs new models for assessing efficacy! A new exciting paper from ISAR members evaluates human liver spheroids for hemorrhagic viruses
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by ISAR International Society for Antiviral Research
@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/...
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase
May 15, 2025 at 11:12 PM
@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/...
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase
Reposted by ISAR International Society for Antiviral Research
📢 Calling PhD students 📢 we want to hear from you!
Help shape the future of PhD education. Take our survey to tell us all about your experiences
https://go.nature.com/43iJAsi
Help shape the future of PhD education. Take our survey to tell us all about your experiences
https://go.nature.com/43iJAsi
PhD students in STEM: Nature wants to hear from you
Buried in lab work or drowning in data? Take a break and help shape the future of PhD education.
go.nature.com
May 15, 2025 at 11:36 AM
📢 Calling PhD students 📢 we want to hear from you!
Help shape the future of PhD education. Take our survey to tell us all about your experiences
https://go.nature.com/43iJAsi
Help shape the future of PhD education. Take our survey to tell us all about your experiences
https://go.nature.com/43iJAsi
Reposted by ISAR International Society for Antiviral Research
Islolation of a new merbecovirus from sick mink on a Chinese fur farm. Broad generalist species tropism including for human cells via using ACE2, not DPP4, as an entry receptor.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor - Nature
Nature - A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor
www.nature.com
May 1, 2025 at 11:03 AM
Islolation of a new merbecovirus from sick mink on a Chinese fur farm. Broad generalist species tropism including for human cells via using ACE2, not DPP4, as an entry receptor.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new contribution from ISAR members:
Mechanisms of action of repurposed Ebola virus antivirals – the roles of phospholipidosis and cholesterol homeostasis
www.sciencedirect.com/science/arti...
Mechanisms of action of repurposed Ebola virus antivirals – the roles of phospholipidosis and cholesterol homeostasis
www.sciencedirect.com/science/arti...
Mechanisms of action of repurposed Ebola virus antivirals – the roles of phospholipidosis and cholesterol homeostasis
Cell-based drug repurposing screens have been a common approach to identifying compounds with antiviral properties. For Ebola virus (EBOV), such scree…
www.sciencedirect.com
April 23, 2025 at 7:23 AM
A new contribution from ISAR members:
Mechanisms of action of repurposed Ebola virus antivirals – the roles of phospholipidosis and cholesterol homeostasis
www.sciencedirect.com/science/arti...
Mechanisms of action of repurposed Ebola virus antivirals – the roles of phospholipidosis and cholesterol homeostasis
www.sciencedirect.com/science/arti...
A review on the management of herpes infections www.sciencedirect.com/science/arti...
Overview on the management of herpes simplex virus infections: Current therapies and future directions
Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent, infecting approximately 64 % and 13 % of the world's population, respecti…
www.sciencedirect.com
April 20, 2025 at 6:03 AM
A review on the management of herpes infections www.sciencedirect.com/science/arti...
Reposted by ISAR International Society for Antiviral Research
Just published! Here we report immunogenicity and efficacy of our replicon RNA vaccine against Crimean-Congo hemorrhagic fever in a cynomolgus macaque model of #CCHFV infection. Stay tuned as we advance this candidate in clinical trials.
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaques
Our data demonstrate that our repNP vaccine and NP-specific antibody can protect against
CCHFV in non-human primates.
www.thelancet.com
April 15, 2025 at 1:27 AM
Just published! Here we report immunogenicity and efficacy of our replicon RNA vaccine against Crimean-Congo hemorrhagic fever in a cynomolgus macaque model of #CCHFV infection. Stay tuned as we advance this candidate in clinical trials.
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
Reposted by ISAR International Society for Antiviral Research
Join us! We are looking for a highly motivated PhD Student to join our teams and investigate glycan-virus interaction at @erasmusmc.bsky.social
🍬Glycans
🦠Viruses
🫁🧠Organoids
🧬 Genetic Engineering
Apply here 👇
www.werkenbijerasmusmc.nl/en/vacancy/1...
🍬Glycans
🦠Viruses
🫁🧠Organoids
🧬 Genetic Engineering
Apply here 👇
www.werkenbijerasmusmc.nl/en/vacancy/1...
Vacature: PhD position Virology
The department of Viroscience at the Erasmus MC and the department of Chemical Biology & Drug discovery at Utrecht University have joined forces to identify functional glycan receptors for influenza A...
www.werkenbijerasmusmc.nl
April 9, 2025 at 7:06 AM
Join us! We are looking for a highly motivated PhD Student to join our teams and investigate glycan-virus interaction at @erasmusmc.bsky.social
🍬Glycans
🦠Viruses
🫁🧠Organoids
🧬 Genetic Engineering
Apply here 👇
www.werkenbijerasmusmc.nl/en/vacancy/1...
🍬Glycans
🦠Viruses
🫁🧠Organoids
🧬 Genetic Engineering
Apply here 👇
www.werkenbijerasmusmc.nl/en/vacancy/1...
Reposted by ISAR International Society for Antiviral Research
Researchers have been trying for a long time to nail down where in nature mpox lurks.
Now they appear to have caught the virus that causes mpox in the act of spilling over from squirrels to monkeys.
“It is the best clue so far for what the reservoir might be”, says @kgandersen.bsky.social
#IDsky 🧪
Now they appear to have caught the virus that causes mpox in the act of spilling over from squirrels to monkeys.
“It is the best clue so far for what the reservoir might be”, says @kgandersen.bsky.social
#IDsky 🧪
How do mpox outbreaks start? Dead baby monkey provides important clue
“Landmark” study fingers fire-footed rope squirrel as a reservoir of fatal disease
www.science.org
April 8, 2025 at 2:05 PM
Researchers have been trying for a long time to nail down where in nature mpox lurks.
Now they appear to have caught the virus that causes mpox in the act of spilling over from squirrels to monkeys.
“It is the best clue so far for what the reservoir might be”, says @kgandersen.bsky.social
#IDsky 🧪
Now they appear to have caught the virus that causes mpox in the act of spilling over from squirrels to monkeys.
“It is the best clue so far for what the reservoir might be”, says @kgandersen.bsky.social
#IDsky 🧪
Reposted by ISAR International Society for Antiviral Research
Please share with people interested in arbovirology. We are looking for an enthusiastic colleague to strengthen our team please share if you know of scientists interested in arbovirology, ready to make a move to Rotterdam! www.academictransfer.com/en/jobs/3508...
Assistant professor Arbovirology
We are looking for a passionate researcher interested in basic arbovirology to join our team!
www.academictransfer.com
April 4, 2025 at 4:45 PM
Please share with people interested in arbovirology. We are looking for an enthusiastic colleague to strengthen our team please share if you know of scientists interested in arbovirology, ready to make a move to Rotterdam! www.academictransfer.com/en/jobs/3508...
Reposted by ISAR International Society for Antiviral Research
Read the full adjoining paper here:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow’s milk - Nature Microbiology
The FDA-approved antiviral baloxavir improves disease outcomes in mice compared with oseltamivir after ocular and intranasal challenge with A(H5N1)-contaminated cow milk.
www.nature.com
April 4, 2025 at 2:33 AM
Read the full adjoining paper here:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by ISAR International Society for Antiviral Research
Our paper on the effect of herpes zoster vaccination on dementia is now out in Nature! 🎉
Huge thanks to Felix Michalik, Seunghun Chung, @pascalge.bsky.social and especially Min Xie (@minxiesci.bsky.social) & Simon Heß (@hesss.org) making the analysis so much fun!
www.nature.com/articles/s41...
Huge thanks to Felix Michalik, Seunghun Chung, @pascalge.bsky.social and especially Min Xie (@minxiesci.bsky.social) & Simon Heß (@hesss.org) making the analysis so much fun!
www.nature.com/articles/s41...
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...
www.nature.com
April 2, 2025 at 4:41 PM
Our paper on the effect of herpes zoster vaccination on dementia is now out in Nature! 🎉
Huge thanks to Felix Michalik, Seunghun Chung, @pascalge.bsky.social and especially Min Xie (@minxiesci.bsky.social) & Simon Heß (@hesss.org) making the analysis so much fun!
www.nature.com/articles/s41...
Huge thanks to Felix Michalik, Seunghun Chung, @pascalge.bsky.social and especially Min Xie (@minxiesci.bsky.social) & Simon Heß (@hesss.org) making the analysis so much fun!
www.nature.com/articles/s41...
Reposted by ISAR International Society for Antiviral Research
Another zoonotic (alpha) coronavirus. Closely related to the rodent virus AcCoV-JC34 that contains a putative furin cleavage site. www.tandfonline.com/doi/full/10....
Novel human coronavirus in an infant patient with pneumonia, Republic of Korea
Coronaviruses (CoVs) pose a significant threat to public health, causing a wide spectrum of clinical manifestations and outcomes. Beyond precipitating global outbreaks, Human CoVs (HCoVs) are frequ...
www.tandfonline.com
April 2, 2025 at 11:48 PM
Another zoonotic (alpha) coronavirus. Closely related to the rodent virus AcCoV-JC34 that contains a putative furin cleavage site. www.tandfonline.com/doi/full/10....
We had the chance to have a preview of this work at ICAR!
A demonstration of how phenotypic screenings and an excellent team of scientists can identify promising antivirals with a completely new mechanism of action! www.nature.com/articles/s41...
#science @nature.com @neytsjohan.bsky.social
A demonstration of how phenotypic screenings and an excellent team of scientists can identify promising antivirals with a completely new mechanism of action! www.nature.com/articles/s41...
#science @nature.com @neytsjohan.bsky.social
A coronavirus assembly inhibitor that targets the viral membrane protein - Nature
High-throughput screening and hit optimization have led to the development of a small molecule, CIM-834, that targets the SARS-CoV-2 membrane protein and blocks assembly of the virus.
www.nature.com
March 26, 2025 at 7:28 PM
We had the chance to have a preview of this work at ICAR!
A demonstration of how phenotypic screenings and an excellent team of scientists can identify promising antivirals with a completely new mechanism of action! www.nature.com/articles/s41...
#science @nature.com @neytsjohan.bsky.social
A demonstration of how phenotypic screenings and an excellent team of scientists can identify promising antivirals with a completely new mechanism of action! www.nature.com/articles/s41...
#science @nature.com @neytsjohan.bsky.social
Reposted by ISAR International Society for Antiviral Research
The conference is over, but the good memories remain! @leendelang.bsky.social won the prusoff award and gave an amazing lecture on how to study arboviruses with different mosquito models and the influence of skin microbiota in mosquito bites and arbovirus transmission.
#ICAR2025 #science
#ICAR2025 #science
March 23, 2025 at 8:43 PM
The conference is over, but the good memories remain! @leendelang.bsky.social won the prusoff award and gave an amazing lecture on how to study arboviruses with different mosquito models and the influence of skin microbiota in mosquito bites and arbovirus transmission.
#ICAR2025 #science
#ICAR2025 #science
Today we had a very interesting session about AI in antiviral research. Small molecule discovery, mutation prediction and phenotypic screening with bright field images. Thanks to the speakers and we are looking forward to the future advancements in the field!!!
#AI #antiviral #ICAR2025
#AI #antiviral #ICAR2025
March 20, 2025 at 7:24 PM
Today we had a very interesting session about AI in antiviral research. Small molecule discovery, mutation prediction and phenotypic screening with bright field images. Thanks to the speakers and we are looking forward to the future advancements in the field!!!
#AI #antiviral #ICAR2025
#AI #antiviral #ICAR2025
Yesterday we had an amazing lecture from @vignuzzilab.bsky.social that is what the diversity award is made for!
Thank you @isaricar.bsky.social for this special recognition for my career achievements and my contribution to helping others get ahead!
March 20, 2025 at 6:11 PM
Yesterday we had an amazing lecture from @vignuzzilab.bsky.social that is what the diversity award is made for!
New paper out by an ISAR member lab
www.sciencedirect.com/science/arti...
Bemnifosbuvir and ruzavir are potent inhibitors of hepatitis C virus.
And act synergistically in vitro when combined.
www.sciencedirect.com/science/arti...
Bemnifosbuvir and ruzavir are potent inhibitors of hepatitis C virus.
And act synergistically in vitro when combined.
Bemnifosbuvir and ruzasvir in combination exhibit potent synergistic antiviral activity in vitro while maintaining a favorable nonclinical safety profile in vivo
Bemnifosbuvir (BEM), the orally available hemisulfate salt of the double prodrug of a guanosine nucleotide analog, is a potent, selective, and pan-gen…
www.sciencedirect.com
March 11, 2025 at 1:49 PM
New paper out by an ISAR member lab
www.sciencedirect.com/science/arti...
Bemnifosbuvir and ruzavir are potent inhibitors of hepatitis C virus.
And act synergistically in vitro when combined.
www.sciencedirect.com/science/arti...
Bemnifosbuvir and ruzavir are potent inhibitors of hepatitis C virus.
And act synergistically in vitro when combined.
New paper: GS-1 blocks entry of herpes viruses and more broadly inhibits enveloped viruses
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
March 10, 2025 at 12:23 AM
New paper: GS-1 blocks entry of herpes viruses and more broadly inhibits enveloped viruses
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
New review on antiviral approaches targeting lipids, written by one of our society members.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
March 10, 2025 at 12:19 AM
New review on antiviral approaches targeting lipids, written by one of our society members.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
considering whether to attend the 38th annual conference on Antiviral Research (#ICAR25), the annual meeting of International Society for Antiviral Research (ISAR)?
check the outstanding program and then join us on March 17-21 in lasvegas!
Last minute registration still open:
lnkd.in/gK_iTn-u
check the outstanding program and then join us on March 17-21 in lasvegas!
Last minute registration still open:
lnkd.in/gK_iTn-u
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
March 5, 2025 at 12:54 AM
considering whether to attend the 38th annual conference on Antiviral Research (#ICAR25), the annual meeting of International Society for Antiviral Research (ISAR)?
check the outstanding program and then join us on March 17-21 in lasvegas!
Last minute registration still open:
lnkd.in/gK_iTn-u
check the outstanding program and then join us on March 17-21 in lasvegas!
Last minute registration still open:
lnkd.in/gK_iTn-u
new review article out from the Univ of Parma and Univ of Lausanne
compounds targeting the lipid kinase phosphatidylinositol 4-kinase IIIβ (PI4KB) and the tyrosine kinase proteins Src and Abl
link here:
www.sciencedirect.com/science/arti...
compounds targeting the lipid kinase phosphatidylinositol 4-kinase IIIβ (PI4KB) and the tyrosine kinase proteins Src and Abl
link here:
www.sciencedirect.com/science/arti...
Targeting PI4KB and Src/Abl host kinases as broad-spectrum antiviral strategy: Myth or real opportunity?
Viruses pose a continuous threat to human health. Limited treatment options exist for current viruses, and the risk of infections with newly emerging …
www.sciencedirect.com
February 18, 2025 at 4:49 AM
new review article out from the Univ of Parma and Univ of Lausanne
compounds targeting the lipid kinase phosphatidylinositol 4-kinase IIIβ (PI4KB) and the tyrosine kinase proteins Src and Abl
link here:
www.sciencedirect.com/science/arti...
compounds targeting the lipid kinase phosphatidylinositol 4-kinase IIIβ (PI4KB) and the tyrosine kinase proteins Src and Abl
link here:
www.sciencedirect.com/science/arti...