Vignuzzi Lab
@vignuzzilab.bsky.social
Antiviral therapeutics and virology. ASTAR ID Labs in Singapore.
Excellent morning of vaccine talks at the EMBO Lecture Course on RNA Virus Infection and Immune Responses meeting at the Regional Centre for Biotechnology India. With my friends Giovanna Barba Spaeth and Tineke Cantaert from the Pasteur Network.
February 13, 2026 at 5:56 AM
Excellent morning of vaccine talks at the EMBO Lecture Course on RNA Virus Infection and Immune Responses meeting at the Regional Centre for Biotechnology India. With my friends Giovanna Barba Spaeth and Tineke Cantaert from the Pasteur Network.
Ready to fly. See you in Faridabad for the EMBO RNA viruses meeting! Looking forward to meeting my colleagues from around the world and young Indian scientists attending the meeting!
February 10, 2026 at 8:12 AM
Ready to fly. See you in Faridabad for the EMBO RNA viruses meeting! Looking forward to meeting my colleagues from around the world and young Indian scientists attending the meeting!
I’m heading out today to present and attend the EMBO RNA virus meeting in India. See you all soon!
meetings.embo.org/event/26-rna...
meetings.embo.org/event/26-rna...
February 9, 2026 at 10:58 PM
I’m heading out today to present and attend the EMBO RNA virus meeting in India. See you all soon!
meetings.embo.org/event/26-rna...
meetings.embo.org/event/26-rna...
watch this video for instant happiness
www.science.org/content/arti...
www.science.org/content/arti...
No bull: This Austrian cow has learned to use tools
First evidence for tool use in cattle includes a skill previously seen only in humans and chimpanzees
www.science.org
January 29, 2026 at 10:14 AM
watch this video for instant happiness
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Vignuzzi Lab
Frequent presymptomatic household transmission of influenza A but not influenza B virus
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Frequent presymptomatic household transmission of influenza A but not influenza B virus - Nature Health
Based on two waves of data collection from 748 households in Hong Kong, this analysis sheds light on the number of transmission events that occurred before manifestation of symptoms in influenza A and...
www.nature.com
January 28, 2026 at 2:07 PM
Frequent presymptomatic household transmission of influenza A but not influenza B virus
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by Vignuzzi Lab
A prophage-encoded abortive infection protein preserves host and prophage spread www.nature.com/articles/s41...
A prophage-encoded abortive infection protein preserves host and prophage spread - Nature
A Gifsy-1 prophage–encoded higher eukaryotes and prokaryotes nucleotide-binding protein, HepS, senses Siphoviridae infection, activates abortive defence by cleaving host transfer RNAs, blocks rival ph...
www.nature.com
January 28, 2026 at 7:13 PM
A prophage-encoded abortive infection protein preserves host and prophage spread www.nature.com/articles/s41...
Reposted by Vignuzzi Lab
Decoding influenza virus: From polymerase mechanisms to translational therapeutics
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
January 27, 2026 at 7:10 PM
Decoding influenza virus: From polymerase mechanisms to translational therapeutics
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Thank you to the International Meeting on Respiratory Pathogens (IMRP) for hosting a dinner for the locals involved in the meeting held this year in Singapore.
A chance for Fadi and me to meet up with the national players in public health and clinical sciences.
A chance for Fadi and me to meet up with the national players in public health and clinical sciences.
January 28, 2026 at 12:19 AM
Thank you to the International Meeting on Respiratory Pathogens (IMRP) for hosting a dinner for the locals involved in the meeting held this year in Singapore.
A chance for Fadi and me to meet up with the national players in public health and clinical sciences.
A chance for Fadi and me to meet up with the national players in public health and clinical sciences.
Another thing I love about Singapore. Create fun spaces in public where people can interact. New installation of racket game net in Tanjong Pagar. Pick a racket or a pan !
January 26, 2026 at 2:52 AM
Another thing I love about Singapore. Create fun spaces in public where people can interact. New installation of racket game net in Tanjong Pagar. Pick a racket or a pan !
The future of vaccines is the future of vaccines itself!
Listen to Apriori Bio CEO Craig Williams lay out how new vaccines will improve public health and better outbreak response.
Our group is partnering with them in a match made in 🤩 science heaven 🤩.
youtu.be/iskugkfU2hc
Listen to Apriori Bio CEO Craig Williams lay out how new vaccines will improve public health and better outbreak response.
Our group is partnering with them in a match made in 🤩 science heaven 🤩.
youtu.be/iskugkfU2hc
2026 CEO Chat: Craig Williams, CEO of Apriori Bio
YouTube video by Flagship Pioneering
youtu.be
January 22, 2026 at 11:53 PM
The future of vaccines is the future of vaccines itself!
Listen to Apriori Bio CEO Craig Williams lay out how new vaccines will improve public health and better outbreak response.
Our group is partnering with them in a match made in 🤩 science heaven 🤩.
youtu.be/iskugkfU2hc
Listen to Apriori Bio CEO Craig Williams lay out how new vaccines will improve public health and better outbreak response.
Our group is partnering with them in a match made in 🤩 science heaven 🤩.
youtu.be/iskugkfU2hc
Today, Fish Hui Xian Poh presented this work by groups at the Chinese Academy of Sciences in Beijing. They dissected alpha virus SFV into nsPs, Capsid, Envelope to make VLPs for RNA or protein delivery - in some cases to target the blood-brain barrier. Very cool work!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Engineering a streamlined virus-like particle for programmable tissue-specific gene delivery - Nature Communications
Virus-like particles (VLPs) offer powerful gene delivery but face limits in targeting and complexity. Here, the authors create a streamlined SFV-based VLP platform that delivers mRNA, protein, or RNP ...
doi.org
January 21, 2026 at 10:30 AM
Today, Fish Hui Xian Poh presented this work by groups at the Chinese Academy of Sciences in Beijing. They dissected alpha virus SFV into nsPs, Capsid, Envelope to make VLPs for RNA or protein delivery - in some cases to target the blood-brain barrier. Very cool work!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
A wonderful visit from Peggy, our lab’s retired admin assistant. She brought me my own name stamp in Chinese characters handmade in Shanghai ! ❤️
January 20, 2026 at 4:56 AM
A wonderful visit from Peggy, our lab’s retired admin assistant. She brought me my own name stamp in Chinese characters handmade in Shanghai ! ❤️
Reposted by Vignuzzi Lab
Viral theft of light: A cyanophage protein dismantles cyanobacterial photosynthesis to accelerate infection www.cell.com/cell-host-mi...
Viral theft of light: A cyanophage protein dismantles cyanobacterial photosynthesis to accelerate infection
Auxiliary metabolic genes, acquired by cyanobacterial viruses (cyanophages) from their
hosts, are thought to manipulate host metabolism during infection. A recent study
by Nadel et al. performed in vi...
www.cell.com
January 17, 2026 at 7:25 PM
Viral theft of light: A cyanophage protein dismantles cyanobacterial photosynthesis to accelerate infection www.cell.com/cell-host-mi...
Happy birthday to Judy and Dinh! Celebrating with Galette des rois and Kouign amann during lab meeting.
January 17, 2026 at 1:54 AM
Happy birthday to Judy and Dinh! Celebrating with Galette des rois and Kouign amann during lab meeting.
Reposted by Vignuzzi Lab
A*STAR/KCL PhD scholarship available!
Dream of doing cutting-edge research, travelling between continents, and becoming obsessed with modelling infections in zebrafish?
My lab and @oehlerslab.org are looking for you!
Project details: 👉 shorturl.at/mkt1a
Catalogue page 6, project 2.1!
Dream of doing cutting-edge research, travelling between continents, and becoming obsessed with modelling infections in zebrafish?
My lab and @oehlerslab.org are looking for you!
Project details: 👉 shorturl.at/mkt1a
Catalogue page 6, project 2.1!
Joint A*STAR - King’s College London PhD Studentships in Biomedical Science 2026/27
King's College London is seeking outstanding and motivated students to join our university and the Agency for Science, Technology and Research (A*STAR).
shorturl.at
January 15, 2026 at 5:47 PM
A*STAR/KCL PhD scholarship available!
Dream of doing cutting-edge research, travelling between continents, and becoming obsessed with modelling infections in zebrafish?
My lab and @oehlerslab.org are looking for you!
Project details: 👉 shorturl.at/mkt1a
Catalogue page 6, project 2.1!
Dream of doing cutting-edge research, travelling between continents, and becoming obsessed with modelling infections in zebrafish?
My lab and @oehlerslab.org are looking for you!
Project details: 👉 shorturl.at/mkt1a
Catalogue page 6, project 2.1!
www.linkedin.com/posts/isar-i...
Voting for the international society for antiviral research board members is open! Vote for me, if you want me aboard, or vote any of the great colleagues that have added their names. Join ISAR and attend the annual conference we hold around the world.
Voting for the international society for antiviral research board members is open! Vote for me, if you want me aboard, or vote any of the great colleagues that have added their names. Join ISAR and attend the annual conference we hold around the world.
International society for antiviral research | International Society for Antiviral Research (ISAR)
Do you want to shape the future of antiviral research and development? This is your opportunity to become a member of the International Society for Antiviral Research (ISAR) and vote for the next Pres...
www.linkedin.com
January 14, 2026 at 10:43 PM
www.linkedin.com/posts/isar-i...
Voting for the international society for antiviral research board members is open! Vote for me, if you want me aboard, or vote any of the great colleagues that have added their names. Join ISAR and attend the annual conference we hold around the world.
Voting for the international society for antiviral research board members is open! Vote for me, if you want me aboard, or vote any of the great colleagues that have added their names. Join ISAR and attend the annual conference we hold around the world.
I’m happy and proud to be part of this scientist’s career. First as research assistant, seeing him through an engineer’s degree, and now passing his PhD qualifying exam!
Bravo Thomas!
Bravo Thomas!
January 13, 2026 at 10:28 AM
I’m happy and proud to be part of this scientist’s career. First as research assistant, seeing him through an engineer’s degree, and now passing his PhD qualifying exam!
Bravo Thomas!
Bravo Thomas!
www.stemcell.com/forms/organo...
One day meeting on organoids. Come see and share on who’s doing what with organoids in SG!
One day meeting on organoids. Come see and share on who’s doing what with organoids in SG!
Back for the Third Time: Organoid Day 2026!
Organoid Day returns with expert talks and the latest research in 3D cell culture. Sign up now—spaces are limited!
www.stemcell.com
January 13, 2026 at 3:46 AM
www.stemcell.com/forms/organo...
One day meeting on organoids. Come see and share on who’s doing what with organoids in SG!
One day meeting on organoids. Come see and share on who’s doing what with organoids in SG!
Check out this miniReview by Guisheng Zeng from @astar-idlabs.bsky.social and his colleagues in Nanjing, China on nanomaterial-based antimicrobials to reactivate dormant bacteria and eliminate persistent bugs.
www.frontiersin.org/journals/mic...
www.frontiersin.org/journals/mic...
Frontiers | Antibacterial nanoagents: an emerging arsenal against bacterial persisters
Bacterial persisters represent a metabolically dormant or slow-growing subpopulation within bacterial communities that exhibit resistance to antibiotics. The...
www.frontiersin.org
January 11, 2026 at 12:31 AM
Check out this miniReview by Guisheng Zeng from @astar-idlabs.bsky.social and his colleagues in Nanjing, China on nanomaterial-based antimicrobials to reactivate dormant bacteria and eliminate persistent bugs.
www.frontiersin.org/journals/mic...
www.frontiersin.org/journals/mic...
First lab meeting of 2026! And it was a great one, with beautiful results! These folks are brilliant! Bravo to Judy and Denzel for their beautiful work on alphavirus proteomics and flavivirus antivirals!
January 9, 2026 at 5:03 AM
First lab meeting of 2026! And it was a great one, with beautiful results! These folks are brilliant! Bravo to Judy and Denzel for their beautiful work on alphavirus proteomics and flavivirus antivirals!
Welcome to our lab Dylan Kwan, a coop exchange student from
Simon Fraser University in Canada!
Simon Fraser University in Canada!
January 5, 2026 at 6:50 AM
Welcome to our lab Dylan Kwan, a coop exchange student from
Simon Fraser University in Canada!
Simon Fraser University in Canada!
Reposted by Vignuzzi Lab
My first lead author paper is out with Ben Kerr and @alisonfeder.bsky.social! We found that making an antiviral too strong can sometimes make resistance easier to evolve. This has implications for how we design drugs, choose doses, and think about viral evolution in the face of treatment. (1/n)
Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback - Nature Ecology & Evolution
A model of intrahost poliovirus replication shows that, after several rounds of replication, pocapavir, a poliovirus capsid inhibitor, collapses viral density, preventing intracellular interactions th...
www.nature.com
December 8, 2025 at 5:15 PM
My first lead author paper is out with Ben Kerr and @alisonfeder.bsky.social! We found that making an antiviral too strong can sometimes make resistance easier to evolve. This has implications for how we design drugs, choose doses, and think about viral evolution in the face of treatment. (1/n)
Congratulations to Wei Hao and our own postdoctoral Fish Hui Xian Poh for winning the best poster award at this year’s Singapore Scientific Conference!
December 12, 2025 at 8:53 AM
Congratulations to Wei Hao and our own postdoctoral Fish Hui Xian Poh for winning the best poster award at this year’s Singapore Scientific Conference!
Weekend in Tokyo ahead of meeting up with colleagues.
December 8, 2025 at 10:52 PM
Weekend in Tokyo ahead of meeting up with colleagues.
Congratulations to our phd student Thomas for winning the best poster prize at the Pasteur Cambodia Immunology course!!
November 30, 2025 at 4:03 AM
Congratulations to our phd student Thomas for winning the best poster prize at the Pasteur Cambodia Immunology course!!